An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome

Autores
Gutierrez, Leandro German; Noriega, Maria Fernanda; Laudicina, Alejandro; Quatrin, Mariana; Bengió, Raquel María; Larripa, Irene Beatriz
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chronic myeloid leukemia is characterized by the translocation t(9;22)(q34;q11) (Philadelphia chromosome). Although it is not frequent, additional chromosome abnormalities can be detected at diagnosis and some of them have been associated with adverse cytogenetic and molecular outcome. We report a case of Chronic myeloid leukemia presenting the translocation t(1;11)(q21;q23) and a cryptic Philadelphia chromosome. The presence of additional chromosome abnormalities could generate greater genetic instability, promoting the emergence of further alterations. Our findings suggest that t(1;11)(q21;q23) avoided good response to tyrosine kinase inhibitors therapy. The patient evolves with primary resistance and subsequently at the recent control the T315I mutation was detected.
Fil: Gutierrez, Leandro German. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Noriega, Maria Fernanda. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Laudicina, Alejandro. Lexel SRL; Argentina
Fil: Quatrin, Mariana. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de la Plata; Argentina
Fil: Bengió, Raquel María. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Larripa, Irene Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Materia
Lmc
Cromosoma Ph Criptico
T(1;11)
Aca
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/43267
Acceder
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network_name_str CONICET Digital (CONICET)
spelling An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosomeGutierrez, Leandro GermanNoriega, Maria FernandaLaudicina, AlejandroQuatrin, MarianaBengió, Raquel MaríaLarripa, Irene BeatrizLmcCromosoma Ph CripticoT(1;11)Acahttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Chronic myeloid leukemia is characterized by the translocation t(9;22)(q34;q11) (Philadelphia chromosome). Although it is not frequent, additional chromosome abnormalities can be detected at diagnosis and some of them have been associated with adverse cytogenetic and molecular outcome. We report a case of Chronic myeloid leukemia presenting the translocation t(1;11)(q21;q23) and a cryptic Philadelphia chromosome. The presence of additional chromosome abnormalities could generate greater genetic instability, promoting the emergence of further alterations. Our findings suggest that t(1;11)(q21;q23) avoided good response to tyrosine kinase inhibitors therapy. The patient evolves with primary resistance and subsequently at the recent control the T315I mutation was detected.Fil: Gutierrez, Leandro German. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Noriega, Maria Fernanda. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaFil: Laudicina, Alejandro. Lexel SRL; ArgentinaFil: Quatrin, Mariana. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de la Plata; ArgentinaFil: Bengió, Raquel María. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaFil: Larripa, Irene Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaSpandidos Publication2017-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/43267Gutierrez, Leandro German; Noriega, Maria Fernanda; Laudicina, Alejandro; Quatrin, Mariana; Bengió, Raquel María; et al.; An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome; Spandidos Publication; Oncology Letters; 13; 5; 5-2017; 3159-31621792-1082CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3892/ol.2017.5845info:eu-repo/semantics/altIdentifier/url/https://www.spandidos-publications.com/10.3892/ol.2017.5845info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:47:19Zoai:ri.conicet.gov.ar:11336/43267instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:47:19.715CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome
title An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome
spellingShingle An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome
Gutierrez, Leandro German
Lmc
Cromosoma Ph Criptico
T(1;11)
Aca
title_short An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome
title_full An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome
title_fullStr An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome
title_full_unstemmed An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome
title_sort An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome
dc.creator.none.fl_str_mv Gutierrez, Leandro German
Noriega, Maria Fernanda
Laudicina, Alejandro
Quatrin, Mariana
Bengió, Raquel María
Larripa, Irene Beatriz
author Gutierrez, Leandro German
author_facet Gutierrez, Leandro German
Noriega, Maria Fernanda
Laudicina, Alejandro
Quatrin, Mariana
Bengió, Raquel María
Larripa, Irene Beatriz
author_role author
author2 Noriega, Maria Fernanda
Laudicina, Alejandro
Quatrin, Mariana
Bengió, Raquel María
Larripa, Irene Beatriz
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Lmc
Cromosoma Ph Criptico
T(1;11)
Aca
topic Lmc
Cromosoma Ph Criptico
T(1;11)
Aca
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Chronic myeloid leukemia is characterized by the translocation t(9;22)(q34;q11) (Philadelphia chromosome). Although it is not frequent, additional chromosome abnormalities can be detected at diagnosis and some of them have been associated with adverse cytogenetic and molecular outcome. We report a case of Chronic myeloid leukemia presenting the translocation t(1;11)(q21;q23) and a cryptic Philadelphia chromosome. The presence of additional chromosome abnormalities could generate greater genetic instability, promoting the emergence of further alterations. Our findings suggest that t(1;11)(q21;q23) avoided good response to tyrosine kinase inhibitors therapy. The patient evolves with primary resistance and subsequently at the recent control the T315I mutation was detected.
Fil: Gutierrez, Leandro German. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Noriega, Maria Fernanda. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Laudicina, Alejandro. Lexel SRL; Argentina
Fil: Quatrin, Mariana. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de la Plata; Argentina
Fil: Bengió, Raquel María. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Larripa, Irene Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
description Chronic myeloid leukemia is characterized by the translocation t(9;22)(q34;q11) (Philadelphia chromosome). Although it is not frequent, additional chromosome abnormalities can be detected at diagnosis and some of them have been associated with adverse cytogenetic and molecular outcome. We report a case of Chronic myeloid leukemia presenting the translocation t(1;11)(q21;q23) and a cryptic Philadelphia chromosome. The presence of additional chromosome abnormalities could generate greater genetic instability, promoting the emergence of further alterations. Our findings suggest that t(1;11)(q21;q23) avoided good response to tyrosine kinase inhibitors therapy. The patient evolves with primary resistance and subsequently at the recent control the T315I mutation was detected.
publishDate 2017
dc.date.none.fl_str_mv 2017-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/43267
Gutierrez, Leandro German; Noriega, Maria Fernanda; Laudicina, Alejandro; Quatrin, Mariana; Bengió, Raquel María; et al.; An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome; Spandidos Publication; Oncology Letters; 13; 5; 5-2017; 3159-3162
1792-1082
CONICET Digital
CONICET
url http://hdl.handle.net/11336/43267
identifier_str_mv Gutierrez, Leandro German; Noriega, Maria Fernanda; Laudicina, Alejandro; Quatrin, Mariana; Bengió, Raquel María; et al.; An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome; Spandidos Publication; Oncology Letters; 13; 5; 5-2017; 3159-3162
1792-1082
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3892/ol.2017.5845
info:eu-repo/semantics/altIdentifier/url/https://www.spandidos-publications.com/10.3892/ol.2017.5845
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Spandidos Publication
publisher.none.fl_str_mv Spandidos Publication
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.976206

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