Yoghurt feeding inhibits promotion and progression of experimental colorectal cancer

Autores
de Moreno, Maria Alejandra; Perdigon, Gabriela del Valle
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: In BALB/c mice, a yogurt diet given before and after the carcinogen 1, 2 dymethylhydrazine (DMH) inhibited colon cancer. This paper studied at which stage of tumor development (initiation, promotion or progression) yogurt exerts its antitumor activity. Material/Methods: Six experimental groups were used: 1) non-treatment control; 2) DMH control; 3) yogurt- DMH-yogurt: yogurt administered before and after DMH. 4) yogurt-DMH: yogurt given only 10 days before DMH; 5) DMH-yogurt: yogurt given cyclically after DMH; and 6) yogurt control. The groups DMH-yogurt and yogurt-DMH were compared histologically and TNFα, INFγ, IL-10 and IL-4 cytokines, CD4[sup]+[/sup]/CD25[sup]+[/sup] T cells, and apoptotic cells were determined in large intestine biopsies. TNFα and INFγ were also determined in cells isolated from large intestine nodules and from Peyer’s patches. Results: The DMH-yogurt group did not develop tumor. The yogurt-DMH group showed only tumor delay; TNFα, INFγ and IL-10 increasing in this group in all the periods assayed. These results agree with those already reported for DMH control and yogurt-DMH-yogurt. There was no correlation between the high levels of IL-10 and CD4[sup]+[/sup]/CD25+ T regulatory population. IL-4 and apoptotic cells increased in the yogurt-DMH group only in the first months. In the DMHyogurt group, cellular apoptosis increased during the whole treatment. Yogurt feeding induced TNFα and INFγ increases in cells isolated from large intestine nodules. These cytokines also increased in cells from Peyer’s patches of the yogurt control group. Conclusions: These results show that yogurt inhibited tumor progression and promotion by modulating the immune response and stimulating cellular apoptosis.
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Materia
Yoghurt
Colon Cancer
Immune Response
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/56507
Acceder
id CONICETDig_4747cfce7fcacf00ce5e3692d5b263ac
oai_identifier_str oai:ri.conicet.gov.ar:11336/56507
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Yoghurt feeding inhibits promotion and progression of experimental colorectal cancerde Moreno, Maria AlejandraPerdigon, Gabriela del ValleYoghurtColon CancerImmune Responsehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: In BALB/c mice, a yogurt diet given before and after the carcinogen 1, 2 dymethylhydrazine (DMH) inhibited colon cancer. This paper studied at which stage of tumor development (initiation, promotion or progression) yogurt exerts its antitumor activity. Material/Methods: Six experimental groups were used: 1) non-treatment control; 2) DMH control; 3) yogurt- DMH-yogurt: yogurt administered before and after DMH. 4) yogurt-DMH: yogurt given only 10 days before DMH; 5) DMH-yogurt: yogurt given cyclically after DMH; and 6) yogurt control. The groups DMH-yogurt and yogurt-DMH were compared histologically and TNFα, INFγ, IL-10 and IL-4 cytokines, CD4[sup]+[/sup]/CD25[sup]+[/sup] T cells, and apoptotic cells were determined in large intestine biopsies. TNFα and INFγ were also determined in cells isolated from large intestine nodules and from Peyer’s patches. Results: The DMH-yogurt group did not develop tumor. The yogurt-DMH group showed only tumor delay; TNFα, INFγ and IL-10 increasing in this group in all the periods assayed. These results agree with those already reported for DMH control and yogurt-DMH-yogurt. There was no correlation between the high levels of IL-10 and CD4[sup]+[/sup]/CD25+ T regulatory population. IL-4 and apoptotic cells increased in the yogurt-DMH group only in the first months. In the DMHyogurt group, cellular apoptosis increased during the whole treatment. Yogurt feeding induced TNFα and INFγ increases in cells isolated from large intestine nodules. These cytokines also increased in cells from Peyer’s patches of the yogurt control group. Conclusions: These results show that yogurt inhibited tumor progression and promotion by modulating the immune response and stimulating cellular apoptosis.Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaInternational Scientific Information, Inc.2004-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/56507de Moreno, Maria Alejandra; Perdigon, Gabriela del Valle; Yoghurt feeding inhibits promotion and progression of experimental colorectal cancer; International Scientific Information, Inc.; Medical Science Monitor; 10; 4; 4-2004; 96-1041234-10101643-3750CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.medscimonit.com/download/index/idArt/11626info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:23:27Zoai:ri.conicet.gov.ar:11336/56507instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:23:27.724CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Yoghurt feeding inhibits promotion and progression of experimental colorectal cancer
title Yoghurt feeding inhibits promotion and progression of experimental colorectal cancer
spellingShingle Yoghurt feeding inhibits promotion and progression of experimental colorectal cancer
de Moreno, Maria Alejandra
Yoghurt
Colon Cancer
Immune Response
title_short Yoghurt feeding inhibits promotion and progression of experimental colorectal cancer
title_full Yoghurt feeding inhibits promotion and progression of experimental colorectal cancer
title_fullStr Yoghurt feeding inhibits promotion and progression of experimental colorectal cancer
title_full_unstemmed Yoghurt feeding inhibits promotion and progression of experimental colorectal cancer
title_sort Yoghurt feeding inhibits promotion and progression of experimental colorectal cancer
dc.creator.none.fl_str_mv de Moreno, Maria Alejandra
Perdigon, Gabriela del Valle
author de Moreno, Maria Alejandra
author_facet de Moreno, Maria Alejandra
Perdigon, Gabriela del Valle
author_role author
author2 Perdigon, Gabriela del Valle
author2_role author
dc.subject.none.fl_str_mv Yoghurt
Colon Cancer
Immune Response
topic Yoghurt
Colon Cancer
Immune Response
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: In BALB/c mice, a yogurt diet given before and after the carcinogen 1, 2 dymethylhydrazine (DMH) inhibited colon cancer. This paper studied at which stage of tumor development (initiation, promotion or progression) yogurt exerts its antitumor activity. Material/Methods: Six experimental groups were used: 1) non-treatment control; 2) DMH control; 3) yogurt- DMH-yogurt: yogurt administered before and after DMH. 4) yogurt-DMH: yogurt given only 10 days before DMH; 5) DMH-yogurt: yogurt given cyclically after DMH; and 6) yogurt control. The groups DMH-yogurt and yogurt-DMH were compared histologically and TNFα, INFγ, IL-10 and IL-4 cytokines, CD4[sup]+[/sup]/CD25[sup]+[/sup] T cells, and apoptotic cells were determined in large intestine biopsies. TNFα and INFγ were also determined in cells isolated from large intestine nodules and from Peyer’s patches. Results: The DMH-yogurt group did not develop tumor. The yogurt-DMH group showed only tumor delay; TNFα, INFγ and IL-10 increasing in this group in all the periods assayed. These results agree with those already reported for DMH control and yogurt-DMH-yogurt. There was no correlation between the high levels of IL-10 and CD4[sup]+[/sup]/CD25+ T regulatory population. IL-4 and apoptotic cells increased in the yogurt-DMH group only in the first months. In the DMHyogurt group, cellular apoptosis increased during the whole treatment. Yogurt feeding induced TNFα and INFγ increases in cells isolated from large intestine nodules. These cytokines also increased in cells from Peyer’s patches of the yogurt control group. Conclusions: These results show that yogurt inhibited tumor progression and promotion by modulating the immune response and stimulating cellular apoptosis.
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
description Background: In BALB/c mice, a yogurt diet given before and after the carcinogen 1, 2 dymethylhydrazine (DMH) inhibited colon cancer. This paper studied at which stage of tumor development (initiation, promotion or progression) yogurt exerts its antitumor activity. Material/Methods: Six experimental groups were used: 1) non-treatment control; 2) DMH control; 3) yogurt- DMH-yogurt: yogurt administered before and after DMH. 4) yogurt-DMH: yogurt given only 10 days before DMH; 5) DMH-yogurt: yogurt given cyclically after DMH; and 6) yogurt control. The groups DMH-yogurt and yogurt-DMH were compared histologically and TNFα, INFγ, IL-10 and IL-4 cytokines, CD4[sup]+[/sup]/CD25[sup]+[/sup] T cells, and apoptotic cells were determined in large intestine biopsies. TNFα and INFγ were also determined in cells isolated from large intestine nodules and from Peyer’s patches. Results: The DMH-yogurt group did not develop tumor. The yogurt-DMH group showed only tumor delay; TNFα, INFγ and IL-10 increasing in this group in all the periods assayed. These results agree with those already reported for DMH control and yogurt-DMH-yogurt. There was no correlation between the high levels of IL-10 and CD4[sup]+[/sup]/CD25+ T regulatory population. IL-4 and apoptotic cells increased in the yogurt-DMH group only in the first months. In the DMHyogurt group, cellular apoptosis increased during the whole treatment. Yogurt feeding induced TNFα and INFγ increases in cells isolated from large intestine nodules. These cytokines also increased in cells from Peyer’s patches of the yogurt control group. Conclusions: These results show that yogurt inhibited tumor progression and promotion by modulating the immune response and stimulating cellular apoptosis.
publishDate 2004
dc.date.none.fl_str_mv 2004-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/56507
de Moreno, Maria Alejandra; Perdigon, Gabriela del Valle; Yoghurt feeding inhibits promotion and progression of experimental colorectal cancer; International Scientific Information, Inc.; Medical Science Monitor; 10; 4; 4-2004; 96-104
1234-1010
1643-3750
CONICET Digital
CONICET
url http://hdl.handle.net/11336/56507
identifier_str_mv de Moreno, Maria Alejandra; Perdigon, Gabriela del Valle; Yoghurt feeding inhibits promotion and progression of experimental colorectal cancer; International Scientific Information, Inc.; Medical Science Monitor; 10; 4; 4-2004; 96-104
1234-1010
1643-3750
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.medscimonit.com/download/index/idArt/11626
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv International Scientific Information, Inc.
publisher.none.fl_str_mv International Scientific Information, Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614228981317632
score 13.070432

Publicaciones similares