Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation

Autores
Blake, Mariano Guillermo; Boccia, Mariano Martin; Krawczyk, Maria del Carmen; Delorenzi, Alejandro; Baratti, Carlos Maria
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It is widely known that pre-training systemic administration of the muscarinic antagonist scopolamine (SCP) (0.5 mg/kg, i.p.) leads to anterograde memory impairment in retention tests. The administration of the α7-nicotinic receptor agonist choline (Ch) in the dorsal hippocampus (0.8 μg/hippocampus) immediately after memory reactivation allowed recovery from scopolamine-induced memory impairment. This effect of Ch was time-dependent, and retention performance was not affected in drug-treated mice that were not subjected to memory reactivation, suggesting that the performance effects are not due to non-specific effects of the drug. The effects of Ch also depended on the age of the reactivated memory. Altogether, our results suggest that Ch exerts its effects by modulating memory reconsolidation, and that the memory impairment induced by low doses of SCP is a memory expression failure and not a storage deficit. Therefore, reconsolidation, among other functions, might serve to change memory expression in later tests. Summarizing, our results open new avenues about the behavioral significance and the physiological functions of memory reconsolidation, providing new strategies for recovering memories from some types of amnesia.
Fil: Blake, Mariano Guillermo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Boccia, Mariano Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Krawczyk, Maria del Carmen. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Delorenzi, Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Baratti, Carlos Maria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
CHOLINE
RECONSOLIDATION
SCOPOLAMINE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20276
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/20276
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Choline reverses scopolamine-induced memory impairment by improving memory reconsolidationBlake, Mariano GuillermoBoccia, Mariano MartinKrawczyk, Maria del CarmenDelorenzi, AlejandroBaratti, Carlos MariaCHOLINERECONSOLIDATIONSCOPOLAMINEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3It is widely known that pre-training systemic administration of the muscarinic antagonist scopolamine (SCP) (0.5 mg/kg, i.p.) leads to anterograde memory impairment in retention tests. The administration of the α7-nicotinic receptor agonist choline (Ch) in the dorsal hippocampus (0.8 μg/hippocampus) immediately after memory reactivation allowed recovery from scopolamine-induced memory impairment. This effect of Ch was time-dependent, and retention performance was not affected in drug-treated mice that were not subjected to memory reactivation, suggesting that the performance effects are not due to non-specific effects of the drug. The effects of Ch also depended on the age of the reactivated memory. Altogether, our results suggest that Ch exerts its effects by modulating memory reconsolidation, and that the memory impairment induced by low doses of SCP is a memory expression failure and not a storage deficit. Therefore, reconsolidation, among other functions, might serve to change memory expression in later tests. Summarizing, our results open new avenues about the behavioral significance and the physiological functions of memory reconsolidation, providing new strategies for recovering memories from some types of amnesia.Fil: Blake, Mariano Guillermo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Boccia, Mariano Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Krawczyk, Maria del Carmen. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Delorenzi, Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Baratti, Carlos Maria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Inc2012-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20276Blake, Mariano Guillermo; Boccia, Mariano Martin; Krawczyk, Maria del Carmen; Delorenzi, Alejandro; Baratti, Carlos Maria; Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation; Elsevier Inc; Neurobiology of Learning and Memory; 98; 2; 7-2012; 112-1211074-7427CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.nlm.2012.07.001info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1074742712000913info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:02:22Zoai:ri.conicet.gov.ar:11336/20276instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:02:22.285CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation
title Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation
spellingShingle Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation
Blake, Mariano Guillermo
CHOLINE
RECONSOLIDATION
SCOPOLAMINE
title_short Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation
title_full Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation
title_fullStr Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation
title_full_unstemmed Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation
title_sort Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation
dc.creator.none.fl_str_mv Blake, Mariano Guillermo
Boccia, Mariano Martin
Krawczyk, Maria del Carmen
Delorenzi, Alejandro
Baratti, Carlos Maria
author Blake, Mariano Guillermo
author_facet Blake, Mariano Guillermo
Boccia, Mariano Martin
Krawczyk, Maria del Carmen
Delorenzi, Alejandro
Baratti, Carlos Maria
author_role author
author2 Boccia, Mariano Martin
Krawczyk, Maria del Carmen
Delorenzi, Alejandro
Baratti, Carlos Maria
author2_role author
author
author
author
dc.subject.none.fl_str_mv CHOLINE
RECONSOLIDATION
SCOPOLAMINE
topic CHOLINE
RECONSOLIDATION
SCOPOLAMINE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv It is widely known that pre-training systemic administration of the muscarinic antagonist scopolamine (SCP) (0.5 mg/kg, i.p.) leads to anterograde memory impairment in retention tests. The administration of the α7-nicotinic receptor agonist choline (Ch) in the dorsal hippocampus (0.8 μg/hippocampus) immediately after memory reactivation allowed recovery from scopolamine-induced memory impairment. This effect of Ch was time-dependent, and retention performance was not affected in drug-treated mice that were not subjected to memory reactivation, suggesting that the performance effects are not due to non-specific effects of the drug. The effects of Ch also depended on the age of the reactivated memory. Altogether, our results suggest that Ch exerts its effects by modulating memory reconsolidation, and that the memory impairment induced by low doses of SCP is a memory expression failure and not a storage deficit. Therefore, reconsolidation, among other functions, might serve to change memory expression in later tests. Summarizing, our results open new avenues about the behavioral significance and the physiological functions of memory reconsolidation, providing new strategies for recovering memories from some types of amnesia.
Fil: Blake, Mariano Guillermo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Boccia, Mariano Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Krawczyk, Maria del Carmen. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Delorenzi, Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Baratti, Carlos Maria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description It is widely known that pre-training systemic administration of the muscarinic antagonist scopolamine (SCP) (0.5 mg/kg, i.p.) leads to anterograde memory impairment in retention tests. The administration of the α7-nicotinic receptor agonist choline (Ch) in the dorsal hippocampus (0.8 μg/hippocampus) immediately after memory reactivation allowed recovery from scopolamine-induced memory impairment. This effect of Ch was time-dependent, and retention performance was not affected in drug-treated mice that were not subjected to memory reactivation, suggesting that the performance effects are not due to non-specific effects of the drug. The effects of Ch also depended on the age of the reactivated memory. Altogether, our results suggest that Ch exerts its effects by modulating memory reconsolidation, and that the memory impairment induced by low doses of SCP is a memory expression failure and not a storage deficit. Therefore, reconsolidation, among other functions, might serve to change memory expression in later tests. Summarizing, our results open new avenues about the behavioral significance and the physiological functions of memory reconsolidation, providing new strategies for recovering memories from some types of amnesia.
publishDate 2012
dc.date.none.fl_str_mv 2012-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20276
Blake, Mariano Guillermo; Boccia, Mariano Martin; Krawczyk, Maria del Carmen; Delorenzi, Alejandro; Baratti, Carlos Maria; Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation; Elsevier Inc; Neurobiology of Learning and Memory; 98; 2; 7-2012; 112-121
1074-7427
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20276
identifier_str_mv Blake, Mariano Guillermo; Boccia, Mariano Martin; Krawczyk, Maria del Carmen; Delorenzi, Alejandro; Baratti, Carlos Maria; Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation; Elsevier Inc; Neurobiology of Learning and Memory; 98; 2; 7-2012; 112-121
1074-7427
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nlm.2012.07.001
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1074742712000913
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Inc
publisher.none.fl_str_mv Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.001348

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