Structural chromosome instability: Types, origins, consequences, and therapeutic opportunities

Autores
Siri, Sebastian Omar; Martino, Julieta; Gottifredi, Vanesa
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chromosomal instability (CIN) refers to an increased rate of acquisition of numerical and structural changes in chromosomes and is considered an enabling characteristic of tumors. Given its role as a facilitator of genomic changes, CIN is increasingly being considered as a possible therapeutic target, raising the question of which variables may convert CIN into an ally instead of an enemy during cancer treatment. This review discusses the origins of structural chromosome abnormalities and the cellular mechanisms that prevent and resolve them, as well as how different CIN phenotypes relate to each other. We discuss the possible fates of cells containing structural CIN, focusing on how a few cell duplication cycles suffice to induce profound CIN-mediated genome alterations. Because such alterations can promote tumor adaptation to treatment, we discuss currently proposed strategies to either avoid CIN or enhance CIN to a level that is no longer compatible with cell survival.
Fil: Siri, Sebastian Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Martino, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Gottifredi, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Materia
CHROMOSOME ABERRATIONS
CHROMOSOME BRIDGES
CHROMOSOME INSTABILITY
DNA DAMAGE
DNA REPAIR
LAGGING CHROMO-SOMES
MICRONUCLEI
ULTRA-FINE BRIDGES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/147339
Acceder
id CONICETDig_472c57f80c5ae4cabb1929e0471ef01c
oai_identifier_str oai:ri.conicet.gov.ar:11336/147339
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Structural chromosome instability: Types, origins, consequences, and therapeutic opportunitiesSiri, Sebastian OmarMartino, JulietaGottifredi, VanesaCHROMOSOME ABERRATIONSCHROMOSOME BRIDGESCHROMOSOME INSTABILITYDNA DAMAGEDNA REPAIRLAGGING CHROMO-SOMESMICRONUCLEIULTRA-FINE BRIDGEShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Chromosomal instability (CIN) refers to an increased rate of acquisition of numerical and structural changes in chromosomes and is considered an enabling characteristic of tumors. Given its role as a facilitator of genomic changes, CIN is increasingly being considered as a possible therapeutic target, raising the question of which variables may convert CIN into an ally instead of an enemy during cancer treatment. This review discusses the origins of structural chromosome abnormalities and the cellular mechanisms that prevent and resolve them, as well as how different CIN phenotypes relate to each other. We discuss the possible fates of cells containing structural CIN, focusing on how a few cell duplication cycles suffice to induce profound CIN-mediated genome alterations. Because such alterations can promote tumor adaptation to treatment, we discuss currently proposed strategies to either avoid CIN or enhance CIN to a level that is no longer compatible with cell survival.Fil: Siri, Sebastian Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Martino, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Gottifredi, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaMolecular Diversity Preservation International2021-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/147339Siri, Sebastian Omar; Martino, Julieta; Gottifredi, Vanesa; Structural chromosome instability: Types, origins, consequences, and therapeutic opportunities; Molecular Diversity Preservation International; Cancers; 13; 12; 6-20212072-66942072-6694CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6694/13/12/3056info:eu-repo/semantics/altIdentifier/doi/10.3390/cancers13123056info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:27:15Zoai:ri.conicet.gov.ar:11336/147339instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:27:15.311CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Structural chromosome instability: Types, origins, consequences, and therapeutic opportunities
title Structural chromosome instability: Types, origins, consequences, and therapeutic opportunities
spellingShingle Structural chromosome instability: Types, origins, consequences, and therapeutic opportunities
Siri, Sebastian Omar
CHROMOSOME ABERRATIONS
CHROMOSOME BRIDGES
CHROMOSOME INSTABILITY
DNA DAMAGE
DNA REPAIR
LAGGING CHROMO-SOMES
MICRONUCLEI
ULTRA-FINE BRIDGES
title_short Structural chromosome instability: Types, origins, consequences, and therapeutic opportunities
title_full Structural chromosome instability: Types, origins, consequences, and therapeutic opportunities
title_fullStr Structural chromosome instability: Types, origins, consequences, and therapeutic opportunities
title_full_unstemmed Structural chromosome instability: Types, origins, consequences, and therapeutic opportunities
title_sort Structural chromosome instability: Types, origins, consequences, and therapeutic opportunities
dc.creator.none.fl_str_mv Siri, Sebastian Omar
Martino, Julieta
Gottifredi, Vanesa
author Siri, Sebastian Omar
author_facet Siri, Sebastian Omar
Martino, Julieta
Gottifredi, Vanesa
author_role author
author2 Martino, Julieta
Gottifredi, Vanesa
author2_role author
author
dc.subject.none.fl_str_mv CHROMOSOME ABERRATIONS
CHROMOSOME BRIDGES
CHROMOSOME INSTABILITY
DNA DAMAGE
DNA REPAIR
LAGGING CHROMO-SOMES
MICRONUCLEI
ULTRA-FINE BRIDGES
topic CHROMOSOME ABERRATIONS
CHROMOSOME BRIDGES
CHROMOSOME INSTABILITY
DNA DAMAGE
DNA REPAIR
LAGGING CHROMO-SOMES
MICRONUCLEI
ULTRA-FINE BRIDGES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Chromosomal instability (CIN) refers to an increased rate of acquisition of numerical and structural changes in chromosomes and is considered an enabling characteristic of tumors. Given its role as a facilitator of genomic changes, CIN is increasingly being considered as a possible therapeutic target, raising the question of which variables may convert CIN into an ally instead of an enemy during cancer treatment. This review discusses the origins of structural chromosome abnormalities and the cellular mechanisms that prevent and resolve them, as well as how different CIN phenotypes relate to each other. We discuss the possible fates of cells containing structural CIN, focusing on how a few cell duplication cycles suffice to induce profound CIN-mediated genome alterations. Because such alterations can promote tumor adaptation to treatment, we discuss currently proposed strategies to either avoid CIN or enhance CIN to a level that is no longer compatible with cell survival.
Fil: Siri, Sebastian Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Martino, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Gottifredi, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
description Chromosomal instability (CIN) refers to an increased rate of acquisition of numerical and structural changes in chromosomes and is considered an enabling characteristic of tumors. Given its role as a facilitator of genomic changes, CIN is increasingly being considered as a possible therapeutic target, raising the question of which variables may convert CIN into an ally instead of an enemy during cancer treatment. This review discusses the origins of structural chromosome abnormalities and the cellular mechanisms that prevent and resolve them, as well as how different CIN phenotypes relate to each other. We discuss the possible fates of cells containing structural CIN, focusing on how a few cell duplication cycles suffice to induce profound CIN-mediated genome alterations. Because such alterations can promote tumor adaptation to treatment, we discuss currently proposed strategies to either avoid CIN or enhance CIN to a level that is no longer compatible with cell survival.
publishDate 2021
dc.date.none.fl_str_mv 2021-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/147339
Siri, Sebastian Omar; Martino, Julieta; Gottifredi, Vanesa; Structural chromosome instability: Types, origins, consequences, and therapeutic opportunities; Molecular Diversity Preservation International; Cancers; 13; 12; 6-2021
2072-6694
2072-6694
CONICET Digital
CONICET
url http://hdl.handle.net/11336/147339
identifier_str_mv Siri, Sebastian Omar; Martino, Julieta; Gottifredi, Vanesa; Structural chromosome instability: Types, origins, consequences, and therapeutic opportunities; Molecular Diversity Preservation International; Cancers; 13; 12; 6-2021
2072-6694
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6694/13/12/3056
info:eu-repo/semantics/altIdentifier/doi/10.3390/cancers13123056
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614274473787392
score 13.070432

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