Selective Attention to Visual Stimuli Using Auditory Distractors Is Altered in Alpha-9 Nicotinic Receptor Subunit Knock-Out Mice

Autores
Terreros, Gonzalo; Jorratt, Pascal; Aedo, Cristian; Elgoyhen, Ana Belen; Delano, Paul H.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
During selective attention, subjects voluntarily focus their cognitive resources on a specific stimulus while ignoring others. Top-downfiltering of peripheral sensory responses by higher structures of the brain has been proposed as one of the mechanisms responsible forselective attention. A prerequisite to accomplish top-down modulation of the activity of peripheral structures is the presence of corticofugalpathways. The mammalian auditory efferent system is a unique neural network that originates in the auditory cortex and projectstothe cochlear receptorthroughthe olivocochlear bundle, and it has been proposedtofunction as atop-downfilter of peripheral auditoryresponses during attention to cross-modal stimuli. However, to date, there is no conclusive evidence of the involvement of olivocochlearneurons in selective attention paradigms. Here, wetrained wild-type and-9 nicotinic receptor subunit knock-out (KO) mice, which lackcholinergic transmission between medial olivocochlear neurons and outer hair cells, in a two-choice visual discrimination task andstudied the behavioral consequences of adding different types of auditory distractors. In addition, we evaluated the effects of contralateralnoise on auditory nerve responses as a measure of the individual strength of the olivocochlear reflex. We demonstrate that KO micehave a reduced olivocochlear reflex strength and perform poorly in a visual selective attention paradigm. These results confirm that anintact medial olivocochlear transmission aids in ignoring auditory distraction during selective attention to visual stimuli.
Fil: Terreros, Gonzalo. Universidad de Santiago de Chile; Chile
Fil: Jorratt, Pascal. Universidad de Santiago de Chile; Chile
Fil: Aedo, Cristian. Universidad de Santiago de Chile; Chile. Universidad de Chile; Chile
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Delano, Paul H.. Universidad de Santiago de Chile; Chile. Universidad de Chile; Chile
Materia
Coclea
Audición
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/44254
Acceder
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spelling Selective Attention to Visual Stimuli Using Auditory Distractors Is Altered in Alpha-9 Nicotinic Receptor Subunit Knock-Out MiceTerreros, GonzaloJorratt, PascalAedo, CristianElgoyhen, Ana BelenDelano, Paul H.CocleaAudiciónhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1During selective attention, subjects voluntarily focus their cognitive resources on a specific stimulus while ignoring others. Top-downfiltering of peripheral sensory responses by higher structures of the brain has been proposed as one of the mechanisms responsible forselective attention. A prerequisite to accomplish top-down modulation of the activity of peripheral structures is the presence of corticofugalpathways. The mammalian auditory efferent system is a unique neural network that originates in the auditory cortex and projectstothe cochlear receptorthroughthe olivocochlear bundle, and it has been proposedtofunction as atop-downfilter of peripheral auditoryresponses during attention to cross-modal stimuli. However, to date, there is no conclusive evidence of the involvement of olivocochlearneurons in selective attention paradigms. Here, wetrained wild-type and-9 nicotinic receptor subunit knock-out (KO) mice, which lackcholinergic transmission between medial olivocochlear neurons and outer hair cells, in a two-choice visual discrimination task andstudied the behavioral consequences of adding different types of auditory distractors. In addition, we evaluated the effects of contralateralnoise on auditory nerve responses as a measure of the individual strength of the olivocochlear reflex. We demonstrate that KO micehave a reduced olivocochlear reflex strength and perform poorly in a visual selective attention paradigm. These results confirm that anintact medial olivocochlear transmission aids in ignoring auditory distraction during selective attention to visual stimuli.Fil: Terreros, Gonzalo. Universidad de Santiago de Chile; ChileFil: Jorratt, Pascal. Universidad de Santiago de Chile; ChileFil: Aedo, Cristian. Universidad de Santiago de Chile; Chile. Universidad de Chile; ChileFil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Delano, Paul H.. Universidad de Santiago de Chile; Chile. Universidad de Chile; ChileSociety for Neuroscience2016-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/44254Terreros, Gonzalo; Jorratt, Pascal; Aedo, Cristian; Elgoyhen, Ana Belen; Delano, Paul H.; Selective Attention to Visual Stimuli Using Auditory Distractors Is Altered in Alpha-9 Nicotinic Receptor Subunit Knock-Out Mice; Society for Neuroscience; Journal of Neuroscience; 36; 27; 7-2016; 7198-72090270-6474CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/36/27/7198.longinfo:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.4031-15.2016info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:09:25Zoai:ri.conicet.gov.ar:11336/44254instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:09:25.788CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Selective Attention to Visual Stimuli Using Auditory Distractors Is Altered in Alpha-9 Nicotinic Receptor Subunit Knock-Out Mice
title Selective Attention to Visual Stimuli Using Auditory Distractors Is Altered in Alpha-9 Nicotinic Receptor Subunit Knock-Out Mice
spellingShingle Selective Attention to Visual Stimuli Using Auditory Distractors Is Altered in Alpha-9 Nicotinic Receptor Subunit Knock-Out Mice
Terreros, Gonzalo
Coclea
Audición
title_short Selective Attention to Visual Stimuli Using Auditory Distractors Is Altered in Alpha-9 Nicotinic Receptor Subunit Knock-Out Mice
title_full Selective Attention to Visual Stimuli Using Auditory Distractors Is Altered in Alpha-9 Nicotinic Receptor Subunit Knock-Out Mice
title_fullStr Selective Attention to Visual Stimuli Using Auditory Distractors Is Altered in Alpha-9 Nicotinic Receptor Subunit Knock-Out Mice
title_full_unstemmed Selective Attention to Visual Stimuli Using Auditory Distractors Is Altered in Alpha-9 Nicotinic Receptor Subunit Knock-Out Mice
title_sort Selective Attention to Visual Stimuli Using Auditory Distractors Is Altered in Alpha-9 Nicotinic Receptor Subunit Knock-Out Mice
dc.creator.none.fl_str_mv Terreros, Gonzalo
Jorratt, Pascal
Aedo, Cristian
Elgoyhen, Ana Belen
Delano, Paul H.
author Terreros, Gonzalo
author_facet Terreros, Gonzalo
Jorratt, Pascal
Aedo, Cristian
Elgoyhen, Ana Belen
Delano, Paul H.
author_role author
author2 Jorratt, Pascal
Aedo, Cristian
Elgoyhen, Ana Belen
Delano, Paul H.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Coclea
Audición
topic Coclea
Audición
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv During selective attention, subjects voluntarily focus their cognitive resources on a specific stimulus while ignoring others. Top-downfiltering of peripheral sensory responses by higher structures of the brain has been proposed as one of the mechanisms responsible forselective attention. A prerequisite to accomplish top-down modulation of the activity of peripheral structures is the presence of corticofugalpathways. The mammalian auditory efferent system is a unique neural network that originates in the auditory cortex and projectstothe cochlear receptorthroughthe olivocochlear bundle, and it has been proposedtofunction as atop-downfilter of peripheral auditoryresponses during attention to cross-modal stimuli. However, to date, there is no conclusive evidence of the involvement of olivocochlearneurons in selective attention paradigms. Here, wetrained wild-type and-9 nicotinic receptor subunit knock-out (KO) mice, which lackcholinergic transmission between medial olivocochlear neurons and outer hair cells, in a two-choice visual discrimination task andstudied the behavioral consequences of adding different types of auditory distractors. In addition, we evaluated the effects of contralateralnoise on auditory nerve responses as a measure of the individual strength of the olivocochlear reflex. We demonstrate that KO micehave a reduced olivocochlear reflex strength and perform poorly in a visual selective attention paradigm. These results confirm that anintact medial olivocochlear transmission aids in ignoring auditory distraction during selective attention to visual stimuli.
Fil: Terreros, Gonzalo. Universidad de Santiago de Chile; Chile
Fil: Jorratt, Pascal. Universidad de Santiago de Chile; Chile
Fil: Aedo, Cristian. Universidad de Santiago de Chile; Chile. Universidad de Chile; Chile
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Delano, Paul H.. Universidad de Santiago de Chile; Chile. Universidad de Chile; Chile
description During selective attention, subjects voluntarily focus their cognitive resources on a specific stimulus while ignoring others. Top-downfiltering of peripheral sensory responses by higher structures of the brain has been proposed as one of the mechanisms responsible forselective attention. A prerequisite to accomplish top-down modulation of the activity of peripheral structures is the presence of corticofugalpathways. The mammalian auditory efferent system is a unique neural network that originates in the auditory cortex and projectstothe cochlear receptorthroughthe olivocochlear bundle, and it has been proposedtofunction as atop-downfilter of peripheral auditoryresponses during attention to cross-modal stimuli. However, to date, there is no conclusive evidence of the involvement of olivocochlearneurons in selective attention paradigms. Here, wetrained wild-type and-9 nicotinic receptor subunit knock-out (KO) mice, which lackcholinergic transmission between medial olivocochlear neurons and outer hair cells, in a two-choice visual discrimination task andstudied the behavioral consequences of adding different types of auditory distractors. In addition, we evaluated the effects of contralateralnoise on auditory nerve responses as a measure of the individual strength of the olivocochlear reflex. We demonstrate that KO micehave a reduced olivocochlear reflex strength and perform poorly in a visual selective attention paradigm. These results confirm that anintact medial olivocochlear transmission aids in ignoring auditory distraction during selective attention to visual stimuli.
publishDate 2016
dc.date.none.fl_str_mv 2016-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/44254
Terreros, Gonzalo; Jorratt, Pascal; Aedo, Cristian; Elgoyhen, Ana Belen; Delano, Paul H.; Selective Attention to Visual Stimuli Using Auditory Distractors Is Altered in Alpha-9 Nicotinic Receptor Subunit Knock-Out Mice; Society for Neuroscience; Journal of Neuroscience; 36; 27; 7-2016; 7198-7209
0270-6474
CONICET Digital
CONICET
url http://hdl.handle.net/11336/44254
identifier_str_mv Terreros, Gonzalo; Jorratt, Pascal; Aedo, Cristian; Elgoyhen, Ana Belen; Delano, Paul H.; Selective Attention to Visual Stimuli Using Auditory Distractors Is Altered in Alpha-9 Nicotinic Receptor Subunit Knock-Out Mice; Society for Neuroscience; Journal of Neuroscience; 36; 27; 7-2016; 7198-7209
0270-6474
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/36/27/7198.long
info:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.4031-15.2016
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Society for Neuroscience
publisher.none.fl_str_mv Society for Neuroscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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