Metabolite transporters in trypanosomatid parasites: promising therapeutic targets but... How to deal with them?

Autores
Pereira, Claudio Alejandro; Martínez Sayé, Melisa Soledad; Wrenger, C.; Miranda, Mariana Reneé
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Infections caused by protozoan parasites are one of the most important public health problems in developing countries. One approach to design new drugs for these parasitic diseases relies on metabolic and molecular features which are ideally absent in mammalian hosts. Out of them, nutrient transporters play an important role since they were subjected to millions of years of adaptation to parasitism, in which this protozoan replaced many biosynthetic routes for transport systems. Here we address the current knowledge of trypanosomatids transport systems and the molecules related to such processes, including a description of permeases involved in drug uptake, and also those responsible of drug resistance. The latter process produces, in many cases, the treatment failure due to the loss of the transporter function, as is the case of eflornithine, as well as by increasing the extrusion of drugs, in which usually ABC-type transporters are involved. All these aspects and the perspectives on this topic are briefly updated in this review.
Fil: Pereira, Claudio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Martínez Sayé, Melisa Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Wrenger, C.. Universidade de Sao Paulo; Brasil
Fil: Miranda, Mariana Reneé. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Materia
Permeases
Transporters
Drug Resistence
Protozoan Parasites
Trypanosoma
Leishmania
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20402
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Metabolite transporters in trypanosomatid parasites: promising therapeutic targets but... How to deal with them?Pereira, Claudio AlejandroMartínez Sayé, Melisa SoledadWrenger, C.Miranda, Mariana ReneéPermeasesTransportersDrug ResistenceProtozoan ParasitesTrypanosomaLeishmaniahttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Infections caused by protozoan parasites are one of the most important public health problems in developing countries. One approach to design new drugs for these parasitic diseases relies on metabolic and molecular features which are ideally absent in mammalian hosts. Out of them, nutrient transporters play an important role since they were subjected to millions of years of adaptation to parasitism, in which this protozoan replaced many biosynthetic routes for transport systems. Here we address the current knowledge of trypanosomatids transport systems and the molecules related to such processes, including a description of permeases involved in drug uptake, and also those responsible of drug resistance. The latter process produces, in many cases, the treatment failure due to the loss of the transporter function, as is the case of eflornithine, as well as by increasing the extrusion of drugs, in which usually ABC-type transporters are involved. All these aspects and the perspectives on this topic are briefly updated in this review.Fil: Pereira, Claudio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Martínez Sayé, Melisa Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Wrenger, C.. Universidade de Sao Paulo; BrasilFil: Miranda, Mariana Reneé. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaBentham Science Publishers2014-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20402Pereira, Claudio Alejandro; Martínez Sayé, Melisa Soledad; Wrenger, C.; Miranda, Mariana Reneé; Metabolite transporters in trypanosomatid parasites: promising therapeutic targets but... How to deal with them?; Bentham Science Publishers; Current Medicinal Chemistry; 21; 15; 5-2014; 1707-17120929-86731875-533XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/114575/articleinfo:eu-repo/semantics/altIdentifier/doi/10.2174/09298673113209990228info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:14:31Zoai:ri.conicet.gov.ar:11336/20402instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:14:31.667CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Metabolite transporters in trypanosomatid parasites: promising therapeutic targets but... How to deal with them?
title Metabolite transporters in trypanosomatid parasites: promising therapeutic targets but... How to deal with them?
spellingShingle Metabolite transporters in trypanosomatid parasites: promising therapeutic targets but... How to deal with them?
Pereira, Claudio Alejandro
Permeases
Transporters
Drug Resistence
Protozoan Parasites
Trypanosoma
Leishmania
title_short Metabolite transporters in trypanosomatid parasites: promising therapeutic targets but... How to deal with them?
title_full Metabolite transporters in trypanosomatid parasites: promising therapeutic targets but... How to deal with them?
title_fullStr Metabolite transporters in trypanosomatid parasites: promising therapeutic targets but... How to deal with them?
title_full_unstemmed Metabolite transporters in trypanosomatid parasites: promising therapeutic targets but... How to deal with them?
title_sort Metabolite transporters in trypanosomatid parasites: promising therapeutic targets but... How to deal with them?
dc.creator.none.fl_str_mv Pereira, Claudio Alejandro
Martínez Sayé, Melisa Soledad
Wrenger, C.
Miranda, Mariana Reneé
author Pereira, Claudio Alejandro
author_facet Pereira, Claudio Alejandro
Martínez Sayé, Melisa Soledad
Wrenger, C.
Miranda, Mariana Reneé
author_role author
author2 Martínez Sayé, Melisa Soledad
Wrenger, C.
Miranda, Mariana Reneé
author2_role author
author
author
dc.subject.none.fl_str_mv Permeases
Transporters
Drug Resistence
Protozoan Parasites
Trypanosoma
Leishmania
topic Permeases
Transporters
Drug Resistence
Protozoan Parasites
Trypanosoma
Leishmania
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Infections caused by protozoan parasites are one of the most important public health problems in developing countries. One approach to design new drugs for these parasitic diseases relies on metabolic and molecular features which are ideally absent in mammalian hosts. Out of them, nutrient transporters play an important role since they were subjected to millions of years of adaptation to parasitism, in which this protozoan replaced many biosynthetic routes for transport systems. Here we address the current knowledge of trypanosomatids transport systems and the molecules related to such processes, including a description of permeases involved in drug uptake, and also those responsible of drug resistance. The latter process produces, in many cases, the treatment failure due to the loss of the transporter function, as is the case of eflornithine, as well as by increasing the extrusion of drugs, in which usually ABC-type transporters are involved. All these aspects and the perspectives on this topic are briefly updated in this review.
Fil: Pereira, Claudio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Martínez Sayé, Melisa Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Wrenger, C.. Universidade de Sao Paulo; Brasil
Fil: Miranda, Mariana Reneé. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
description Infections caused by protozoan parasites are one of the most important public health problems in developing countries. One approach to design new drugs for these parasitic diseases relies on metabolic and molecular features which are ideally absent in mammalian hosts. Out of them, nutrient transporters play an important role since they were subjected to millions of years of adaptation to parasitism, in which this protozoan replaced many biosynthetic routes for transport systems. Here we address the current knowledge of trypanosomatids transport systems and the molecules related to such processes, including a description of permeases involved in drug uptake, and also those responsible of drug resistance. The latter process produces, in many cases, the treatment failure due to the loss of the transporter function, as is the case of eflornithine, as well as by increasing the extrusion of drugs, in which usually ABC-type transporters are involved. All these aspects and the perspectives on this topic are briefly updated in this review.
publishDate 2014
dc.date.none.fl_str_mv 2014-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20402
Pereira, Claudio Alejandro; Martínez Sayé, Melisa Soledad; Wrenger, C.; Miranda, Mariana Reneé; Metabolite transporters in trypanosomatid parasites: promising therapeutic targets but... How to deal with them?; Bentham Science Publishers; Current Medicinal Chemistry; 21; 15; 5-2014; 1707-1712
0929-8673
1875-533X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20402
identifier_str_mv Pereira, Claudio Alejandro; Martínez Sayé, Melisa Soledad; Wrenger, C.; Miranda, Mariana Reneé; Metabolite transporters in trypanosomatid parasites: promising therapeutic targets but... How to deal with them?; Bentham Science Publishers; Current Medicinal Chemistry; 21; 15; 5-2014; 1707-1712
0929-8673
1875-533X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/114575/article
info:eu-repo/semantics/altIdentifier/doi/10.2174/09298673113209990228
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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