In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels

Autores
Desimone, Martín Federico; Hélary, Christophe; Quignard, Sandrine; Rietveld, Ivo B; Bataille, Clement; Copello, Guillermo Javier; Mosser, Gervaise; Giraud Guille, Marie-Madeleine; Livage, Jacques; Meddahi Pellé, Anne; Coradin, Thibaud
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Hybrid and nanocomposite silicacollagen materials derived from concentrated collagen hydrogels were evaluated in vitro and in vivo to establish their potentialities for biological dressings. Silicification significantly improved the mechanical and thermal stability of the collagen network within the hybrid systems. Nanocomposites were found to favor the metabolic activity of immobilized human dermal fibroblastswhile decreasing the hydrogel contraction. Cell adhesion experiments suggested that in vitro cell behavior was dictated by mechanical properties and surface structure of the scaffold. First-to-date in vivo implantation of bulk hydrogels in subcutaneous sites of rats was performed over the vascular inflammatory period. These materials were colonized and vascularized without inducing strong inflammatory response. These data raise reasonable hope for the future application of silicacollagen biomaterials as biological dressings.
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Hélary, Christophe. Université Pierre et Marie Curie; Francia
Fil: Quignard, Sandrine. Université Pierre et Marie Curie; Francia
Fil: Rietveld, Ivo B. Universite de Paris; Francia
Fil: Bataille, Clement. Université de Versailles Saint-quentin-en-yvelines.; Francia
Fil: Copello, Guillermo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Mosser, Gervaise. Université Pierre et Marie Curie; Francia
Fil: Giraud Guille, Marie-Madeleine. Université Pierre et Marie Curie; Francia
Fil: Livage, Jacques. Université Pierre et Marie Curie; Francia
Fil: Meddahi Pellé, Anne. Université de Versailles Saint-quentin-en-yvelines.; Francia
Fil: Coradin, Thibaud. Université Pierre et Marie Curie; Francia
Materia
silicified collagen
hybrid materials
nanocomposites
biomaterials;
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/134085

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network_name_str CONICET Digital (CONICET)
spelling In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogelsDesimone, Martín FedericoHélary, ChristopheQuignard, SandrineRietveld, Ivo BBataille, ClementCopello, Guillermo JavierMosser, GervaiseGiraud Guille, Marie-MadeleineLivage, JacquesMeddahi Pellé, AnneCoradin, Thibaudsilicified collagenhybrid materialsnanocompositesbiomaterials;https://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Hybrid and nanocomposite silicacollagen materials derived from concentrated collagen hydrogels were evaluated in vitro and in vivo to establish their potentialities for biological dressings. Silicification significantly improved the mechanical and thermal stability of the collagen network within the hybrid systems. Nanocomposites were found to favor the metabolic activity of immobilized human dermal fibroblastswhile decreasing the hydrogel contraction. Cell adhesion experiments suggested that in vitro cell behavior was dictated by mechanical properties and surface structure of the scaffold. First-to-date in vivo implantation of bulk hydrogels in subcutaneous sites of rats was performed over the vascular inflammatory period. These materials were colonized and vascularized without inducing strong inflammatory response. These data raise reasonable hope for the future application of silicacollagen biomaterials as biological dressings.Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Hélary, Christophe. Université Pierre et Marie Curie; FranciaFil: Quignard, Sandrine. Université Pierre et Marie Curie; FranciaFil: Rietveld, Ivo B. Universite de Paris; FranciaFil: Bataille, Clement. Université de Versailles Saint-quentin-en-yvelines.; FranciaFil: Copello, Guillermo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Mosser, Gervaise. Université Pierre et Marie Curie; FranciaFil: Giraud Guille, Marie-Madeleine. Université Pierre et Marie Curie; FranciaFil: Livage, Jacques. Université Pierre et Marie Curie; FranciaFil: Meddahi Pellé, Anne. Université de Versailles Saint-quentin-en-yvelines.; FranciaFil: Coradin, Thibaud. Université Pierre et Marie Curie; FranciaAmerican Chemical Society2011-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/134085Desimone, Martín Federico; Hélary, Christophe; Quignard, Sandrine; Rietveld, Ivo B; Bataille, Clement; et al.; In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels; American Chemical Society; ACS Applied Materials & Interfaces; 3; 10; 9-2011; 3831-38381944-8244CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1021/am2009844info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/am2009844info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:09:29Zoai:ri.conicet.gov.ar:11336/134085instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:09:29.617CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels
title In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels
spellingShingle In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels
Desimone, Martín Federico
silicified collagen
hybrid materials
nanocomposites
biomaterials;
title_short In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels
title_full In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels
title_fullStr In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels
title_full_unstemmed In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels
title_sort In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels
dc.creator.none.fl_str_mv Desimone, Martín Federico
Hélary, Christophe
Quignard, Sandrine
Rietveld, Ivo B
Bataille, Clement
Copello, Guillermo Javier
Mosser, Gervaise
Giraud Guille, Marie-Madeleine
Livage, Jacques
Meddahi Pellé, Anne
Coradin, Thibaud
author Desimone, Martín Federico
author_facet Desimone, Martín Federico
Hélary, Christophe
Quignard, Sandrine
Rietveld, Ivo B
Bataille, Clement
Copello, Guillermo Javier
Mosser, Gervaise
Giraud Guille, Marie-Madeleine
Livage, Jacques
Meddahi Pellé, Anne
Coradin, Thibaud
author_role author
author2 Hélary, Christophe
Quignard, Sandrine
Rietveld, Ivo B
Bataille, Clement
Copello, Guillermo Javier
Mosser, Gervaise
Giraud Guille, Marie-Madeleine
Livage, Jacques
Meddahi Pellé, Anne
Coradin, Thibaud
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv silicified collagen
hybrid materials
nanocomposites
biomaterials;
topic silicified collagen
hybrid materials
nanocomposites
biomaterials;
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Hybrid and nanocomposite silicacollagen materials derived from concentrated collagen hydrogels were evaluated in vitro and in vivo to establish their potentialities for biological dressings. Silicification significantly improved the mechanical and thermal stability of the collagen network within the hybrid systems. Nanocomposites were found to favor the metabolic activity of immobilized human dermal fibroblastswhile decreasing the hydrogel contraction. Cell adhesion experiments suggested that in vitro cell behavior was dictated by mechanical properties and surface structure of the scaffold. First-to-date in vivo implantation of bulk hydrogels in subcutaneous sites of rats was performed over the vascular inflammatory period. These materials were colonized and vascularized without inducing strong inflammatory response. These data raise reasonable hope for the future application of silicacollagen biomaterials as biological dressings.
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Hélary, Christophe. Université Pierre et Marie Curie; Francia
Fil: Quignard, Sandrine. Université Pierre et Marie Curie; Francia
Fil: Rietveld, Ivo B. Universite de Paris; Francia
Fil: Bataille, Clement. Université de Versailles Saint-quentin-en-yvelines.; Francia
Fil: Copello, Guillermo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Mosser, Gervaise. Université Pierre et Marie Curie; Francia
Fil: Giraud Guille, Marie-Madeleine. Université Pierre et Marie Curie; Francia
Fil: Livage, Jacques. Université Pierre et Marie Curie; Francia
Fil: Meddahi Pellé, Anne. Université de Versailles Saint-quentin-en-yvelines.; Francia
Fil: Coradin, Thibaud. Université Pierre et Marie Curie; Francia
description Hybrid and nanocomposite silicacollagen materials derived from concentrated collagen hydrogels were evaluated in vitro and in vivo to establish their potentialities for biological dressings. Silicification significantly improved the mechanical and thermal stability of the collagen network within the hybrid systems. Nanocomposites were found to favor the metabolic activity of immobilized human dermal fibroblastswhile decreasing the hydrogel contraction. Cell adhesion experiments suggested that in vitro cell behavior was dictated by mechanical properties and surface structure of the scaffold. First-to-date in vivo implantation of bulk hydrogels in subcutaneous sites of rats was performed over the vascular inflammatory period. These materials were colonized and vascularized without inducing strong inflammatory response. These data raise reasonable hope for the future application of silicacollagen biomaterials as biological dressings.
publishDate 2011
dc.date.none.fl_str_mv 2011-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/134085
Desimone, Martín Federico; Hélary, Christophe; Quignard, Sandrine; Rietveld, Ivo B; Bataille, Clement; et al.; In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels; American Chemical Society; ACS Applied Materials & Interfaces; 3; 10; 9-2011; 3831-3838
1944-8244
CONICET Digital
CONICET
url http://hdl.handle.net/11336/134085
identifier_str_mv Desimone, Martín Federico; Hélary, Christophe; Quignard, Sandrine; Rietveld, Ivo B; Bataille, Clement; et al.; In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels; American Chemical Society; ACS Applied Materials & Interfaces; 3; 10; 9-2011; 3831-3838
1944-8244
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1021/am2009844
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/am2009844
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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