In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels
- Autores
- Desimone, Martín Federico; Hélary, Christophe; Quignard, Sandrine; Rietveld, Ivo B; Bataille, Clement; Copello, Guillermo Javier; Mosser, Gervaise; Giraud Guille, Marie-Madeleine; Livage, Jacques; Meddahi Pellé, Anne; Coradin, Thibaud
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Hybrid and nanocomposite silicacollagen materials derived from concentrated collagen hydrogels were evaluated in vitro and in vivo to establish their potentialities for biological dressings. Silicification significantly improved the mechanical and thermal stability of the collagen network within the hybrid systems. Nanocomposites were found to favor the metabolic activity of immobilized human dermal fibroblastswhile decreasing the hydrogel contraction. Cell adhesion experiments suggested that in vitro cell behavior was dictated by mechanical properties and surface structure of the scaffold. First-to-date in vivo implantation of bulk hydrogels in subcutaneous sites of rats was performed over the vascular inflammatory period. These materials were colonized and vascularized without inducing strong inflammatory response. These data raise reasonable hope for the future application of silicacollagen biomaterials as biological dressings.
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Hélary, Christophe. Université Pierre et Marie Curie; Francia
Fil: Quignard, Sandrine. Université Pierre et Marie Curie; Francia
Fil: Rietveld, Ivo B. Universite de Paris; Francia
Fil: Bataille, Clement. Université de Versailles Saint-quentin-en-yvelines.; Francia
Fil: Copello, Guillermo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Mosser, Gervaise. Université Pierre et Marie Curie; Francia
Fil: Giraud Guille, Marie-Madeleine. Université Pierre et Marie Curie; Francia
Fil: Livage, Jacques. Université Pierre et Marie Curie; Francia
Fil: Meddahi Pellé, Anne. Université de Versailles Saint-quentin-en-yvelines.; Francia
Fil: Coradin, Thibaud. Université Pierre et Marie Curie; Francia - Materia
-
silicified collagen
hybrid materials
nanocomposites
biomaterials; - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/134085
Ver los metadatos del registro completo
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In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogelsDesimone, Martín FedericoHélary, ChristopheQuignard, SandrineRietveld, Ivo BBataille, ClementCopello, Guillermo JavierMosser, GervaiseGiraud Guille, Marie-MadeleineLivage, JacquesMeddahi Pellé, AnneCoradin, Thibaudsilicified collagenhybrid materialsnanocompositesbiomaterials;https://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Hybrid and nanocomposite silicacollagen materials derived from concentrated collagen hydrogels were evaluated in vitro and in vivo to establish their potentialities for biological dressings. Silicification significantly improved the mechanical and thermal stability of the collagen network within the hybrid systems. Nanocomposites were found to favor the metabolic activity of immobilized human dermal fibroblastswhile decreasing the hydrogel contraction. Cell adhesion experiments suggested that in vitro cell behavior was dictated by mechanical properties and surface structure of the scaffold. First-to-date in vivo implantation of bulk hydrogels in subcutaneous sites of rats was performed over the vascular inflammatory period. These materials were colonized and vascularized without inducing strong inflammatory response. These data raise reasonable hope for the future application of silicacollagen biomaterials as biological dressings.Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Hélary, Christophe. Université Pierre et Marie Curie; FranciaFil: Quignard, Sandrine. Université Pierre et Marie Curie; FranciaFil: Rietveld, Ivo B. Universite de Paris; FranciaFil: Bataille, Clement. Université de Versailles Saint-quentin-en-yvelines.; FranciaFil: Copello, Guillermo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Mosser, Gervaise. Université Pierre et Marie Curie; FranciaFil: Giraud Guille, Marie-Madeleine. Université Pierre et Marie Curie; FranciaFil: Livage, Jacques. Université Pierre et Marie Curie; FranciaFil: Meddahi Pellé, Anne. Université de Versailles Saint-quentin-en-yvelines.; FranciaFil: Coradin, Thibaud. Université Pierre et Marie Curie; FranciaAmerican Chemical Society2011-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/134085Desimone, Martín Federico; Hélary, Christophe; Quignard, Sandrine; Rietveld, Ivo B; Bataille, Clement; et al.; In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels; American Chemical Society; ACS Applied Materials & Interfaces; 3; 10; 9-2011; 3831-38381944-8244CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1021/am2009844info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/am2009844info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:09:29Zoai:ri.conicet.gov.ar:11336/134085instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:09:29.617CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels |
title |
In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels |
spellingShingle |
In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels Desimone, Martín Federico silicified collagen hybrid materials nanocomposites biomaterials; |
title_short |
In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels |
title_full |
In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels |
title_fullStr |
In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels |
title_full_unstemmed |
In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels |
title_sort |
In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels |
dc.creator.none.fl_str_mv |
Desimone, Martín Federico Hélary, Christophe Quignard, Sandrine Rietveld, Ivo B Bataille, Clement Copello, Guillermo Javier Mosser, Gervaise Giraud Guille, Marie-Madeleine Livage, Jacques Meddahi Pellé, Anne Coradin, Thibaud |
author |
Desimone, Martín Federico |
author_facet |
Desimone, Martín Federico Hélary, Christophe Quignard, Sandrine Rietveld, Ivo B Bataille, Clement Copello, Guillermo Javier Mosser, Gervaise Giraud Guille, Marie-Madeleine Livage, Jacques Meddahi Pellé, Anne Coradin, Thibaud |
author_role |
author |
author2 |
Hélary, Christophe Quignard, Sandrine Rietveld, Ivo B Bataille, Clement Copello, Guillermo Javier Mosser, Gervaise Giraud Guille, Marie-Madeleine Livage, Jacques Meddahi Pellé, Anne Coradin, Thibaud |
author2_role |
author author author author author author author author author author |
dc.subject.none.fl_str_mv |
silicified collagen hybrid materials nanocomposites biomaterials; |
topic |
silicified collagen hybrid materials nanocomposites biomaterials; |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.4 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Hybrid and nanocomposite silicacollagen materials derived from concentrated collagen hydrogels were evaluated in vitro and in vivo to establish their potentialities for biological dressings. Silicification significantly improved the mechanical and thermal stability of the collagen network within the hybrid systems. Nanocomposites were found to favor the metabolic activity of immobilized human dermal fibroblastswhile decreasing the hydrogel contraction. Cell adhesion experiments suggested that in vitro cell behavior was dictated by mechanical properties and surface structure of the scaffold. First-to-date in vivo implantation of bulk hydrogels in subcutaneous sites of rats was performed over the vascular inflammatory period. These materials were colonized and vascularized without inducing strong inflammatory response. These data raise reasonable hope for the future application of silicacollagen biomaterials as biological dressings. Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina Fil: Hélary, Christophe. Université Pierre et Marie Curie; Francia Fil: Quignard, Sandrine. Université Pierre et Marie Curie; Francia Fil: Rietveld, Ivo B. Universite de Paris; Francia Fil: Bataille, Clement. Université de Versailles Saint-quentin-en-yvelines.; Francia Fil: Copello, Guillermo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina Fil: Mosser, Gervaise. Université Pierre et Marie Curie; Francia Fil: Giraud Guille, Marie-Madeleine. Université Pierre et Marie Curie; Francia Fil: Livage, Jacques. Université Pierre et Marie Curie; Francia Fil: Meddahi Pellé, Anne. Université de Versailles Saint-quentin-en-yvelines.; Francia Fil: Coradin, Thibaud. Université Pierre et Marie Curie; Francia |
description |
Hybrid and nanocomposite silicacollagen materials derived from concentrated collagen hydrogels were evaluated in vitro and in vivo to establish their potentialities for biological dressings. Silicification significantly improved the mechanical and thermal stability of the collagen network within the hybrid systems. Nanocomposites were found to favor the metabolic activity of immobilized human dermal fibroblastswhile decreasing the hydrogel contraction. Cell adhesion experiments suggested that in vitro cell behavior was dictated by mechanical properties and surface structure of the scaffold. First-to-date in vivo implantation of bulk hydrogels in subcutaneous sites of rats was performed over the vascular inflammatory period. These materials were colonized and vascularized without inducing strong inflammatory response. These data raise reasonable hope for the future application of silicacollagen biomaterials as biological dressings. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/134085 Desimone, Martín Federico; Hélary, Christophe; Quignard, Sandrine; Rietveld, Ivo B; Bataille, Clement; et al.; In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels; American Chemical Society; ACS Applied Materials & Interfaces; 3; 10; 9-2011; 3831-3838 1944-8244 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/134085 |
identifier_str_mv |
Desimone, Martín Federico; Hélary, Christophe; Quignard, Sandrine; Rietveld, Ivo B; Bataille, Clement; et al.; In vitro studies and preliminary in vivo evaluation of silicified concentrated collagen hydrogels; American Chemical Society; ACS Applied Materials & Interfaces; 3; 10; 9-2011; 3831-3838 1944-8244 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1021/am2009844 info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/am2009844 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Chemical Society |
publisher.none.fl_str_mv |
American Chemical Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613973797765120 |
score |
13.070432 |