MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient Deprivation

Autores
Barrio, Lara; Dekanty, Andres; Milán, Marco
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Multiple conserved mechanisms have evolved to sense nutritional conditions and to coordinate the corresponding metabolic changes of the whole organism. We unravel a role of Drosophila p53 (Dp53) in the fat body (FB), a functional analogue of vertebrate adipose and hepatic tissues, in metabolic adaptation to starvation. Under nutrient deprivation, FB-specific depletion of Dp53 accelerates the consumption of the main energy storages, and reduces the survival rates of adult flies. We show that Dp53 is regulated by the microRNA machinery in a nutrition-dependent manner and identify miR-305 as a major regulatory element. In well-fed animals, TOR signalling contributes to miR-305-mediated inhibition of Dp53. Nutrient deprivation reduces the levels of major elements of the miRNA machinery and leads to Dp53 de-repression. Our results reveal an organismal role of Dp53 in nutrient sensing and metabolic adaptation, and open up new avenues towards understanding the molecular mechanisms underlying p53 activation under nutrient deprivation.
Fil: Barrio, Lara. Institute for Reseach Biomedicine; España
Fil: Dekanty, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Agrobiotecnologia del Litoral; Argentina. Institute for Reseach Biomedicine; España
Fil: Milán, Marco. Institute for Reseach Biomedicine; España. Institució Catalana de Recerca i Estudis Avancats; España
Materia
DROSOPHILA p53
miRNA PATHWAY
METABOLISM
TARGET OF RAPAMYCIN
ADIPOSE TISSUE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13889
Acceder
id CONICETDig_45a73c2cf91f1f50dd2babe8316f9118
oai_identifier_str oai:ri.conicet.gov.ar:11336/13889
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient DeprivationBarrio, LaraDekanty, AndresMilán, MarcoDROSOPHILA p53miRNA PATHWAYMETABOLISMTARGET OF RAPAMYCINADIPOSE TISSUEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Multiple conserved mechanisms have evolved to sense nutritional conditions and to coordinate the corresponding metabolic changes of the whole organism. We unravel a role of Drosophila p53 (Dp53) in the fat body (FB), a functional analogue of vertebrate adipose and hepatic tissues, in metabolic adaptation to starvation. Under nutrient deprivation, FB-specific depletion of Dp53 accelerates the consumption of the main energy storages, and reduces the survival rates of adult flies. We show that Dp53 is regulated by the microRNA machinery in a nutrition-dependent manner and identify miR-305 as a major regulatory element. In well-fed animals, TOR signalling contributes to miR-305-mediated inhibition of Dp53. Nutrient deprivation reduces the levels of major elements of the miRNA machinery and leads to Dp53 de-repression. Our results reveal an organismal role of Dp53 in nutrient sensing and metabolic adaptation, and open up new avenues towards understanding the molecular mechanisms underlying p53 activation under nutrient deprivation.Fil: Barrio, Lara. Institute for Reseach Biomedicine; EspañaFil: Dekanty, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Agrobiotecnologia del Litoral; Argentina. Institute for Reseach Biomedicine; EspañaFil: Milán, Marco. Institute for Reseach Biomedicine; España. Institució Catalana de Recerca i Estudis Avancats; EspañaCell Press2014-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13889Barrio, Lara; Dekanty, Andres; Milán, Marco; MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient Deprivation; Cell Press; CELL REPORTS; 8; 2; 7-2014; 528-5412211-1247enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2014.06.020info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S2211124714004896info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:32:40Zoai:ri.conicet.gov.ar:11336/13889instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:32:40.337CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient Deprivation
title MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient Deprivation
spellingShingle MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient Deprivation
Barrio, Lara
DROSOPHILA p53
miRNA PATHWAY
METABOLISM
TARGET OF RAPAMYCIN
ADIPOSE TISSUE
title_short MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient Deprivation
title_full MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient Deprivation
title_fullStr MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient Deprivation
title_full_unstemmed MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient Deprivation
title_sort MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient Deprivation
dc.creator.none.fl_str_mv Barrio, Lara
Dekanty, Andres
Milán, Marco
author Barrio, Lara
author_facet Barrio, Lara
Dekanty, Andres
Milán, Marco
author_role author
author2 Dekanty, Andres
Milán, Marco
author2_role author
author
dc.subject.none.fl_str_mv DROSOPHILA p53
miRNA PATHWAY
METABOLISM
TARGET OF RAPAMYCIN
ADIPOSE TISSUE
topic DROSOPHILA p53
miRNA PATHWAY
METABOLISM
TARGET OF RAPAMYCIN
ADIPOSE TISSUE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Multiple conserved mechanisms have evolved to sense nutritional conditions and to coordinate the corresponding metabolic changes of the whole organism. We unravel a role of Drosophila p53 (Dp53) in the fat body (FB), a functional analogue of vertebrate adipose and hepatic tissues, in metabolic adaptation to starvation. Under nutrient deprivation, FB-specific depletion of Dp53 accelerates the consumption of the main energy storages, and reduces the survival rates of adult flies. We show that Dp53 is regulated by the microRNA machinery in a nutrition-dependent manner and identify miR-305 as a major regulatory element. In well-fed animals, TOR signalling contributes to miR-305-mediated inhibition of Dp53. Nutrient deprivation reduces the levels of major elements of the miRNA machinery and leads to Dp53 de-repression. Our results reveal an organismal role of Dp53 in nutrient sensing and metabolic adaptation, and open up new avenues towards understanding the molecular mechanisms underlying p53 activation under nutrient deprivation.
Fil: Barrio, Lara. Institute for Reseach Biomedicine; España
Fil: Dekanty, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Agrobiotecnologia del Litoral; Argentina. Institute for Reseach Biomedicine; España
Fil: Milán, Marco. Institute for Reseach Biomedicine; España. Institució Catalana de Recerca i Estudis Avancats; España
description Multiple conserved mechanisms have evolved to sense nutritional conditions and to coordinate the corresponding metabolic changes of the whole organism. We unravel a role of Drosophila p53 (Dp53) in the fat body (FB), a functional analogue of vertebrate adipose and hepatic tissues, in metabolic adaptation to starvation. Under nutrient deprivation, FB-specific depletion of Dp53 accelerates the consumption of the main energy storages, and reduces the survival rates of adult flies. We show that Dp53 is regulated by the microRNA machinery in a nutrition-dependent manner and identify miR-305 as a major regulatory element. In well-fed animals, TOR signalling contributes to miR-305-mediated inhibition of Dp53. Nutrient deprivation reduces the levels of major elements of the miRNA machinery and leads to Dp53 de-repression. Our results reveal an organismal role of Dp53 in nutrient sensing and metabolic adaptation, and open up new avenues towards understanding the molecular mechanisms underlying p53 activation under nutrient deprivation.
publishDate 2014
dc.date.none.fl_str_mv 2014-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13889
Barrio, Lara; Dekanty, Andres; Milán, Marco; MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient Deprivation; Cell Press; CELL REPORTS; 8; 2; 7-2014; 528-541
2211-1247
url http://hdl.handle.net/11336/13889
identifier_str_mv Barrio, Lara; Dekanty, Andres; Milán, Marco; MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient Deprivation; Cell Press; CELL REPORTS; 8; 2; 7-2014; 528-541
2211-1247
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2014.06.020
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S2211124714004896
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083458801074176
score 13.22299

Publicaciones similares