In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats

Autores
Toblli, Jorge Eduardo; Cao, Gabriel Fernando; Casas, Gabriel; Mazza, Osvaldo Néstor
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Erectile dysfunction is associated with high blood pressure and antihypertensive treatment, especially diuretics and traditional β-blockers. Nevertheless, new β-blockers such as nebivolol present some differences with respect to the classic β-blockers. The aim of this study was to determine the functional and morphologic effects of nebivolol on penile structures in hypertensive rats. Methods: During a 6-month period, male spontaneously hypertensive rat (SHR) and Wistar-Kyoto (WKY) rats were studied. The groups were as follows: 1) untreated SHR (Untreated-SHR); 2) SHR given nebivolol 10 mg/kg/day (SHR+N); 3) SHR given amlodipine 3 mg/kg/day (SHR+AML); and 4) untreated WKY (untreated-WKY). Cavernous smooth muscle (CSM) and vascular smooth muscle (VSM) from cavernous arteries, as well as collagen type III (COL III) in cavernous tissue, were evaluated. Results: After 6 months, SHR groups given nebivolol and amlodipine showed similar reductions in blood pressure compared with untreated SHR. However, only SHR+N and control WKY showed significantly lower values of CSM (P < 01), VSM (P < 01), and COL III (P < 01) when compared with untreated SHR and SHR+AML. In addition SHR+N showed a higher endothelial nitric oxide synthase expression in sinusoidal endothelium compared with SHR, and SHR+AML (P < 01). In vitro studies revealed that SHR+N displayed a better relaxation response to acetylcholine than untreated-SHR and SHR+AML (P < 01). Conclusion: Nebivolol presented equivalent BP control compared with amlodipine. However, only nebivolol showed a significant better functional outcome with a protective role against structural changes in erectile tissue that are caused by arterial hypertension.
Fil: Toblli, Jorge Eduardo. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cao, Gabriel Fernando. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Casas, Gabriel. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina
Fil: Mazza, Osvaldo Néstor. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina
Materia
Β-BLOCKERS
AMLODIPINE
MALE ERECTILE DYSFUNCTION
NEBIVOLOL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96238
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/96238
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive RatsToblli, Jorge EduardoCao, Gabriel FernandoCasas, GabrielMazza, Osvaldo NéstorΒ-BLOCKERSAMLODIPINEMALE ERECTILE DYSFUNCTIONNEBIVOLOLhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: Erectile dysfunction is associated with high blood pressure and antihypertensive treatment, especially diuretics and traditional β-blockers. Nevertheless, new β-blockers such as nebivolol present some differences with respect to the classic β-blockers. The aim of this study was to determine the functional and morphologic effects of nebivolol on penile structures in hypertensive rats. Methods: During a 6-month period, male spontaneously hypertensive rat (SHR) and Wistar-Kyoto (WKY) rats were studied. The groups were as follows: 1) untreated SHR (Untreated-SHR); 2) SHR given nebivolol 10 mg/kg/day (SHR+N); 3) SHR given amlodipine 3 mg/kg/day (SHR+AML); and 4) untreated WKY (untreated-WKY). Cavernous smooth muscle (CSM) and vascular smooth muscle (VSM) from cavernous arteries, as well as collagen type III (COL III) in cavernous tissue, were evaluated. Results: After 6 months, SHR groups given nebivolol and amlodipine showed similar reductions in blood pressure compared with untreated SHR. However, only SHR+N and control WKY showed significantly lower values of CSM (P < 01), VSM (P < 01), and COL III (P < 01) when compared with untreated SHR and SHR+AML. In addition SHR+N showed a higher endothelial nitric oxide synthase expression in sinusoidal endothelium compared with SHR, and SHR+AML (P < 01). In vitro studies revealed that SHR+N displayed a better relaxation response to acetylcholine than untreated-SHR and SHR+AML (P < 01). Conclusion: Nebivolol presented equivalent BP control compared with amlodipine. However, only nebivolol showed a significant better functional outcome with a protective role against structural changes in erectile tissue that are caused by arterial hypertension.Fil: Toblli, Jorge Eduardo. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cao, Gabriel Fernando. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Casas, Gabriel. Hospital Aleman. Laboratorio de Medicina Experimental; ArgentinaFil: Mazza, Osvaldo Néstor. Hospital Aleman. Laboratorio de Medicina Experimental; ArgentinaOxford University Press2006-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96238Toblli, Jorge Eduardo; Cao, Gabriel Fernando; Casas, Gabriel; Mazza, Osvaldo Néstor; In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats; Oxford University Press; American Journal Of Hypertension; 19; 12; 12-2006; 1226-12320895-7061CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/ajh/article-lookup/doi/10.1016/j.amjhyper.2006.05.016info:eu-repo/semantics/altIdentifier/doi/10.1016/j.amjhyper.2006.05.016info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:02:33Zoai:ri.conicet.gov.ar:11336/96238instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:02:33.649CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats
title In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats
spellingShingle In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats
Toblli, Jorge Eduardo
Β-BLOCKERS
AMLODIPINE
MALE ERECTILE DYSFUNCTION
NEBIVOLOL
title_short In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats
title_full In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats
title_fullStr In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats
title_full_unstemmed In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats
title_sort In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats
dc.creator.none.fl_str_mv Toblli, Jorge Eduardo
Cao, Gabriel Fernando
Casas, Gabriel
Mazza, Osvaldo Néstor
author Toblli, Jorge Eduardo
author_facet Toblli, Jorge Eduardo
Cao, Gabriel Fernando
Casas, Gabriel
Mazza, Osvaldo Néstor
author_role author
author2 Cao, Gabriel Fernando
Casas, Gabriel
Mazza, Osvaldo Néstor
author2_role author
author
author
dc.subject.none.fl_str_mv Β-BLOCKERS
AMLODIPINE
MALE ERECTILE DYSFUNCTION
NEBIVOLOL
topic Β-BLOCKERS
AMLODIPINE
MALE ERECTILE DYSFUNCTION
NEBIVOLOL
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Erectile dysfunction is associated with high blood pressure and antihypertensive treatment, especially diuretics and traditional β-blockers. Nevertheless, new β-blockers such as nebivolol present some differences with respect to the classic β-blockers. The aim of this study was to determine the functional and morphologic effects of nebivolol on penile structures in hypertensive rats. Methods: During a 6-month period, male spontaneously hypertensive rat (SHR) and Wistar-Kyoto (WKY) rats were studied. The groups were as follows: 1) untreated SHR (Untreated-SHR); 2) SHR given nebivolol 10 mg/kg/day (SHR+N); 3) SHR given amlodipine 3 mg/kg/day (SHR+AML); and 4) untreated WKY (untreated-WKY). Cavernous smooth muscle (CSM) and vascular smooth muscle (VSM) from cavernous arteries, as well as collagen type III (COL III) in cavernous tissue, were evaluated. Results: After 6 months, SHR groups given nebivolol and amlodipine showed similar reductions in blood pressure compared with untreated SHR. However, only SHR+N and control WKY showed significantly lower values of CSM (P < 01), VSM (P < 01), and COL III (P < 01) when compared with untreated SHR and SHR+AML. In addition SHR+N showed a higher endothelial nitric oxide synthase expression in sinusoidal endothelium compared with SHR, and SHR+AML (P < 01). In vitro studies revealed that SHR+N displayed a better relaxation response to acetylcholine than untreated-SHR and SHR+AML (P < 01). Conclusion: Nebivolol presented equivalent BP control compared with amlodipine. However, only nebivolol showed a significant better functional outcome with a protective role against structural changes in erectile tissue that are caused by arterial hypertension.
Fil: Toblli, Jorge Eduardo. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cao, Gabriel Fernando. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Casas, Gabriel. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina
Fil: Mazza, Osvaldo Néstor. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina
description Background: Erectile dysfunction is associated with high blood pressure and antihypertensive treatment, especially diuretics and traditional β-blockers. Nevertheless, new β-blockers such as nebivolol present some differences with respect to the classic β-blockers. The aim of this study was to determine the functional and morphologic effects of nebivolol on penile structures in hypertensive rats. Methods: During a 6-month period, male spontaneously hypertensive rat (SHR) and Wistar-Kyoto (WKY) rats were studied. The groups were as follows: 1) untreated SHR (Untreated-SHR); 2) SHR given nebivolol 10 mg/kg/day (SHR+N); 3) SHR given amlodipine 3 mg/kg/day (SHR+AML); and 4) untreated WKY (untreated-WKY). Cavernous smooth muscle (CSM) and vascular smooth muscle (VSM) from cavernous arteries, as well as collagen type III (COL III) in cavernous tissue, were evaluated. Results: After 6 months, SHR groups given nebivolol and amlodipine showed similar reductions in blood pressure compared with untreated SHR. However, only SHR+N and control WKY showed significantly lower values of CSM (P < 01), VSM (P < 01), and COL III (P < 01) when compared with untreated SHR and SHR+AML. In addition SHR+N showed a higher endothelial nitric oxide synthase expression in sinusoidal endothelium compared with SHR, and SHR+AML (P < 01). In vitro studies revealed that SHR+N displayed a better relaxation response to acetylcholine than untreated-SHR and SHR+AML (P < 01). Conclusion: Nebivolol presented equivalent BP control compared with amlodipine. However, only nebivolol showed a significant better functional outcome with a protective role against structural changes in erectile tissue that are caused by arterial hypertension.
publishDate 2006
dc.date.none.fl_str_mv 2006-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96238
Toblli, Jorge Eduardo; Cao, Gabriel Fernando; Casas, Gabriel; Mazza, Osvaldo Néstor; In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats; Oxford University Press; American Journal Of Hypertension; 19; 12; 12-2006; 1226-1232
0895-7061
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96238
identifier_str_mv Toblli, Jorge Eduardo; Cao, Gabriel Fernando; Casas, Gabriel; Mazza, Osvaldo Néstor; In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats; Oxford University Press; American Journal Of Hypertension; 19; 12; 12-2006; 1226-1232
0895-7061
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/ajh/article-lookup/doi/10.1016/j.amjhyper.2006.05.016
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.amjhyper.2006.05.016
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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