In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats
- Autores
- Toblli, Jorge Eduardo; Cao, Gabriel Fernando; Casas, Gabriel; Mazza, Osvaldo Néstor
- Año de publicación
- 2006
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: Erectile dysfunction is associated with high blood pressure and antihypertensive treatment, especially diuretics and traditional β-blockers. Nevertheless, new β-blockers such as nebivolol present some differences with respect to the classic β-blockers. The aim of this study was to determine the functional and morphologic effects of nebivolol on penile structures in hypertensive rats. Methods: During a 6-month period, male spontaneously hypertensive rat (SHR) and Wistar-Kyoto (WKY) rats were studied. The groups were as follows: 1) untreated SHR (Untreated-SHR); 2) SHR given nebivolol 10 mg/kg/day (SHR+N); 3) SHR given amlodipine 3 mg/kg/day (SHR+AML); and 4) untreated WKY (untreated-WKY). Cavernous smooth muscle (CSM) and vascular smooth muscle (VSM) from cavernous arteries, as well as collagen type III (COL III) in cavernous tissue, were evaluated. Results: After 6 months, SHR groups given nebivolol and amlodipine showed similar reductions in blood pressure compared with untreated SHR. However, only SHR+N and control WKY showed significantly lower values of CSM (P < 01), VSM (P < 01), and COL III (P < 01) when compared with untreated SHR and SHR+AML. In addition SHR+N showed a higher endothelial nitric oxide synthase expression in sinusoidal endothelium compared with SHR, and SHR+AML (P < 01). In vitro studies revealed that SHR+N displayed a better relaxation response to acetylcholine than untreated-SHR and SHR+AML (P < 01). Conclusion: Nebivolol presented equivalent BP control compared with amlodipine. However, only nebivolol showed a significant better functional outcome with a protective role against structural changes in erectile tissue that are caused by arterial hypertension.
Fil: Toblli, Jorge Eduardo. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cao, Gabriel Fernando. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Casas, Gabriel. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina
Fil: Mazza, Osvaldo Néstor. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina - Materia
-
Β-BLOCKERS
AMLODIPINE
MALE ERECTILE DYSFUNCTION
NEBIVOLOL - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/96238
Ver los metadatos del registro completo
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In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive RatsToblli, Jorge EduardoCao, Gabriel FernandoCasas, GabrielMazza, Osvaldo NéstorΒ-BLOCKERSAMLODIPINEMALE ERECTILE DYSFUNCTIONNEBIVOLOLhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: Erectile dysfunction is associated with high blood pressure and antihypertensive treatment, especially diuretics and traditional β-blockers. Nevertheless, new β-blockers such as nebivolol present some differences with respect to the classic β-blockers. The aim of this study was to determine the functional and morphologic effects of nebivolol on penile structures in hypertensive rats. Methods: During a 6-month period, male spontaneously hypertensive rat (SHR) and Wistar-Kyoto (WKY) rats were studied. The groups were as follows: 1) untreated SHR (Untreated-SHR); 2) SHR given nebivolol 10 mg/kg/day (SHR+N); 3) SHR given amlodipine 3 mg/kg/day (SHR+AML); and 4) untreated WKY (untreated-WKY). Cavernous smooth muscle (CSM) and vascular smooth muscle (VSM) from cavernous arteries, as well as collagen type III (COL III) in cavernous tissue, were evaluated. Results: After 6 months, SHR groups given nebivolol and amlodipine showed similar reductions in blood pressure compared with untreated SHR. However, only SHR+N and control WKY showed significantly lower values of CSM (P < 01), VSM (P < 01), and COL III (P < 01) when compared with untreated SHR and SHR+AML. In addition SHR+N showed a higher endothelial nitric oxide synthase expression in sinusoidal endothelium compared with SHR, and SHR+AML (P < 01). In vitro studies revealed that SHR+N displayed a better relaxation response to acetylcholine than untreated-SHR and SHR+AML (P < 01). Conclusion: Nebivolol presented equivalent BP control compared with amlodipine. However, only nebivolol showed a significant better functional outcome with a protective role against structural changes in erectile tissue that are caused by arterial hypertension.Fil: Toblli, Jorge Eduardo. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cao, Gabriel Fernando. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Casas, Gabriel. Hospital Aleman. Laboratorio de Medicina Experimental; ArgentinaFil: Mazza, Osvaldo Néstor. Hospital Aleman. Laboratorio de Medicina Experimental; ArgentinaOxford University Press2006-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96238Toblli, Jorge Eduardo; Cao, Gabriel Fernando; Casas, Gabriel; Mazza, Osvaldo Néstor; In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats; Oxford University Press; American Journal Of Hypertension; 19; 12; 12-2006; 1226-12320895-7061CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/ajh/article-lookup/doi/10.1016/j.amjhyper.2006.05.016info:eu-repo/semantics/altIdentifier/doi/10.1016/j.amjhyper.2006.05.016info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:57:08Zoai:ri.conicet.gov.ar:11336/96238instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:57:08.905CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats |
title |
In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats |
spellingShingle |
In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats Toblli, Jorge Eduardo Β-BLOCKERS AMLODIPINE MALE ERECTILE DYSFUNCTION NEBIVOLOL |
title_short |
In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats |
title_full |
In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats |
title_fullStr |
In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats |
title_full_unstemmed |
In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats |
title_sort |
In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats |
dc.creator.none.fl_str_mv |
Toblli, Jorge Eduardo Cao, Gabriel Fernando Casas, Gabriel Mazza, Osvaldo Néstor |
author |
Toblli, Jorge Eduardo |
author_facet |
Toblli, Jorge Eduardo Cao, Gabriel Fernando Casas, Gabriel Mazza, Osvaldo Néstor |
author_role |
author |
author2 |
Cao, Gabriel Fernando Casas, Gabriel Mazza, Osvaldo Néstor |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Β-BLOCKERS AMLODIPINE MALE ERECTILE DYSFUNCTION NEBIVOLOL |
topic |
Β-BLOCKERS AMLODIPINE MALE ERECTILE DYSFUNCTION NEBIVOLOL |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Background: Erectile dysfunction is associated with high blood pressure and antihypertensive treatment, especially diuretics and traditional β-blockers. Nevertheless, new β-blockers such as nebivolol present some differences with respect to the classic β-blockers. The aim of this study was to determine the functional and morphologic effects of nebivolol on penile structures in hypertensive rats. Methods: During a 6-month period, male spontaneously hypertensive rat (SHR) and Wistar-Kyoto (WKY) rats were studied. The groups were as follows: 1) untreated SHR (Untreated-SHR); 2) SHR given nebivolol 10 mg/kg/day (SHR+N); 3) SHR given amlodipine 3 mg/kg/day (SHR+AML); and 4) untreated WKY (untreated-WKY). Cavernous smooth muscle (CSM) and vascular smooth muscle (VSM) from cavernous arteries, as well as collagen type III (COL III) in cavernous tissue, were evaluated. Results: After 6 months, SHR groups given nebivolol and amlodipine showed similar reductions in blood pressure compared with untreated SHR. However, only SHR+N and control WKY showed significantly lower values of CSM (P < 01), VSM (P < 01), and COL III (P < 01) when compared with untreated SHR and SHR+AML. In addition SHR+N showed a higher endothelial nitric oxide synthase expression in sinusoidal endothelium compared with SHR, and SHR+AML (P < 01). In vitro studies revealed that SHR+N displayed a better relaxation response to acetylcholine than untreated-SHR and SHR+AML (P < 01). Conclusion: Nebivolol presented equivalent BP control compared with amlodipine. However, only nebivolol showed a significant better functional outcome with a protective role against structural changes in erectile tissue that are caused by arterial hypertension. Fil: Toblli, Jorge Eduardo. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Cao, Gabriel Fernando. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Casas, Gabriel. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina Fil: Mazza, Osvaldo Néstor. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina |
description |
Background: Erectile dysfunction is associated with high blood pressure and antihypertensive treatment, especially diuretics and traditional β-blockers. Nevertheless, new β-blockers such as nebivolol present some differences with respect to the classic β-blockers. The aim of this study was to determine the functional and morphologic effects of nebivolol on penile structures in hypertensive rats. Methods: During a 6-month period, male spontaneously hypertensive rat (SHR) and Wistar-Kyoto (WKY) rats were studied. The groups were as follows: 1) untreated SHR (Untreated-SHR); 2) SHR given nebivolol 10 mg/kg/day (SHR+N); 3) SHR given amlodipine 3 mg/kg/day (SHR+AML); and 4) untreated WKY (untreated-WKY). Cavernous smooth muscle (CSM) and vascular smooth muscle (VSM) from cavernous arteries, as well as collagen type III (COL III) in cavernous tissue, were evaluated. Results: After 6 months, SHR groups given nebivolol and amlodipine showed similar reductions in blood pressure compared with untreated SHR. However, only SHR+N and control WKY showed significantly lower values of CSM (P < 01), VSM (P < 01), and COL III (P < 01) when compared with untreated SHR and SHR+AML. In addition SHR+N showed a higher endothelial nitric oxide synthase expression in sinusoidal endothelium compared with SHR, and SHR+AML (P < 01). In vitro studies revealed that SHR+N displayed a better relaxation response to acetylcholine than untreated-SHR and SHR+AML (P < 01). Conclusion: Nebivolol presented equivalent BP control compared with amlodipine. However, only nebivolol showed a significant better functional outcome with a protective role against structural changes in erectile tissue that are caused by arterial hypertension. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/96238 Toblli, Jorge Eduardo; Cao, Gabriel Fernando; Casas, Gabriel; Mazza, Osvaldo Néstor; In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats; Oxford University Press; American Journal Of Hypertension; 19; 12; 12-2006; 1226-1232 0895-7061 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/96238 |
identifier_str_mv |
Toblli, Jorge Eduardo; Cao, Gabriel Fernando; Casas, Gabriel; Mazza, Osvaldo Néstor; In Vivo and in Vitro Effects of Nebivolol on Penile Structures in Hypertensive Rats; Oxford University Press; American Journal Of Hypertension; 19; 12; 12-2006; 1226-1232 0895-7061 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/ajh/article-lookup/doi/10.1016/j.amjhyper.2006.05.016 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.amjhyper.2006.05.016 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.13397 |