Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal
- Autores
- Di Bella, Daniela Jesica; Carcagno, Abel Luis; Bartolomeu, M. Lucía; Pardi, Belén; Löhr, Heiko; Siegel, Nicole; Hammerschmidt, Matthias; Marin Burgin, Antonia; Lanuza, Guillermo Marcos
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Generation of neuronal types at the right time, location, and number is essential for building a functional nervous system. Significant progress has been reached in understanding the mechanisms that govern neuronal diversity. Cerebrospinal fluid-contacting neurons (CSF-cNs), an intriguing spinal cord central canal population, are produced during advanced developmental stages, simultaneous with glial and ependymal cells. It is unknown how CSF-cNs are specified after the neurogenesis-to-gliogenesis switch. Here, we identify delayed Ascl1 expression in mouse spinal progenitors during the gliogenic phase as key in CSF-cN differentiation. With fate mappings and time-controlled deletions, we demonstrate that CSF-cNs derive from Ascl1-expressing cells and that Ascl1 triggers late neurogenesis in the amniote spinal cord. Ascl1 abrogation transforms prospective CSF-cN progenitors into ependymocytes. These results demonstrate that late spinal progenitors have the potential to produce neurons and that Ascl1 initiates CSF-cN differentiation, controlling the precise neuronal and nonneuronal composition of the spinal central canal.
Fil: Di Bella, Daniela Jesica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Instituto Leloir; Argentina
Fil: Carcagno, Abel Luis. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bartolomeu, M. Lucía. Fundación Instituto Leloir; Argentina
Fil: Pardi, Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
Fil: Löhr, Heiko. University of Cologne; Alemania
Fil: Siegel, Nicole. Fundación Instituto Leloir; Argentina
Fil: Hammerschmidt, Matthias. University of Cologne; Alemania
Fil: Marin Burgin, Antonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Instituto Leloir; Argentina - Materia
-
ASCL1
CENTRAL CANAL
CSF-CN
CSF-CONTACTING NEURONS
EPENDYMOCYTES
LATE NEUROGENESIS
NEURAL PROGENITOR
NEURON SPECIFICATION
SPINAL CORD
TRANSCRIPTION FACTOR - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/94162
Ver los metadatos del registro completo
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3498 |
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CONICET Digital (CONICET) |
spelling |
Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central CanalDi Bella, Daniela JesicaCarcagno, Abel LuisBartolomeu, M. LucíaPardi, BelénLöhr, HeikoSiegel, NicoleHammerschmidt, MatthiasMarin Burgin, AntoniaLanuza, Guillermo MarcosASCL1CENTRAL CANALCSF-CNCSF-CONTACTING NEURONSEPENDYMOCYTESLATE NEUROGENESISNEURAL PROGENITORNEURON SPECIFICATIONSPINAL CORDTRANSCRIPTION FACTORhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Generation of neuronal types at the right time, location, and number is essential for building a functional nervous system. Significant progress has been reached in understanding the mechanisms that govern neuronal diversity. Cerebrospinal fluid-contacting neurons (CSF-cNs), an intriguing spinal cord central canal population, are produced during advanced developmental stages, simultaneous with glial and ependymal cells. It is unknown how CSF-cNs are specified after the neurogenesis-to-gliogenesis switch. Here, we identify delayed Ascl1 expression in mouse spinal progenitors during the gliogenic phase as key in CSF-cN differentiation. With fate mappings and time-controlled deletions, we demonstrate that CSF-cNs derive from Ascl1-expressing cells and that Ascl1 triggers late neurogenesis in the amniote spinal cord. Ascl1 abrogation transforms prospective CSF-cN progenitors into ependymocytes. These results demonstrate that late spinal progenitors have the potential to produce neurons and that Ascl1 initiates CSF-cN differentiation, controlling the precise neuronal and nonneuronal composition of the spinal central canal.Fil: Di Bella, Daniela Jesica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Instituto Leloir; ArgentinaFil: Carcagno, Abel Luis. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bartolomeu, M. Lucía. Fundación Instituto Leloir; ArgentinaFil: Pardi, Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; ArgentinaFil: Löhr, Heiko. University of Cologne; AlemaniaFil: Siegel, Nicole. Fundación Instituto Leloir; ArgentinaFil: Hammerschmidt, Matthias. University of Cologne; AlemaniaFil: Marin Burgin, Antonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; ArgentinaFil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Instituto Leloir; ArgentinaElsevier2019-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/94162Di Bella, Daniela Jesica; Carcagno, Abel Luis; Bartolomeu, M. Lucía; Pardi, Belén; Löhr, Heiko; et al.; Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal; Elsevier; Cell Reports; 28; 9; 8-2019; 2264-2274.e32211-1247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2019.07.087info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211124719310034info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:16Zoai:ri.conicet.gov.ar:11336/94162instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:16.933CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal |
title |
Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal |
spellingShingle |
Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal Di Bella, Daniela Jesica ASCL1 CENTRAL CANAL CSF-CN CSF-CONTACTING NEURONS EPENDYMOCYTES LATE NEUROGENESIS NEURAL PROGENITOR NEURON SPECIFICATION SPINAL CORD TRANSCRIPTION FACTOR |
title_short |
Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal |
title_full |
Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal |
title_fullStr |
Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal |
title_full_unstemmed |
Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal |
title_sort |
Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal |
dc.creator.none.fl_str_mv |
Di Bella, Daniela Jesica Carcagno, Abel Luis Bartolomeu, M. Lucía Pardi, Belén Löhr, Heiko Siegel, Nicole Hammerschmidt, Matthias Marin Burgin, Antonia Lanuza, Guillermo Marcos |
author |
Di Bella, Daniela Jesica |
author_facet |
Di Bella, Daniela Jesica Carcagno, Abel Luis Bartolomeu, M. Lucía Pardi, Belén Löhr, Heiko Siegel, Nicole Hammerschmidt, Matthias Marin Burgin, Antonia Lanuza, Guillermo Marcos |
author_role |
author |
author2 |
Carcagno, Abel Luis Bartolomeu, M. Lucía Pardi, Belén Löhr, Heiko Siegel, Nicole Hammerschmidt, Matthias Marin Burgin, Antonia Lanuza, Guillermo Marcos |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
ASCL1 CENTRAL CANAL CSF-CN CSF-CONTACTING NEURONS EPENDYMOCYTES LATE NEUROGENESIS NEURAL PROGENITOR NEURON SPECIFICATION SPINAL CORD TRANSCRIPTION FACTOR |
topic |
ASCL1 CENTRAL CANAL CSF-CN CSF-CONTACTING NEURONS EPENDYMOCYTES LATE NEUROGENESIS NEURAL PROGENITOR NEURON SPECIFICATION SPINAL CORD TRANSCRIPTION FACTOR |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Generation of neuronal types at the right time, location, and number is essential for building a functional nervous system. Significant progress has been reached in understanding the mechanisms that govern neuronal diversity. Cerebrospinal fluid-contacting neurons (CSF-cNs), an intriguing spinal cord central canal population, are produced during advanced developmental stages, simultaneous with glial and ependymal cells. It is unknown how CSF-cNs are specified after the neurogenesis-to-gliogenesis switch. Here, we identify delayed Ascl1 expression in mouse spinal progenitors during the gliogenic phase as key in CSF-cN differentiation. With fate mappings and time-controlled deletions, we demonstrate that CSF-cNs derive from Ascl1-expressing cells and that Ascl1 triggers late neurogenesis in the amniote spinal cord. Ascl1 abrogation transforms prospective CSF-cN progenitors into ependymocytes. These results demonstrate that late spinal progenitors have the potential to produce neurons and that Ascl1 initiates CSF-cN differentiation, controlling the precise neuronal and nonneuronal composition of the spinal central canal. Fil: Di Bella, Daniela Jesica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Instituto Leloir; Argentina Fil: Carcagno, Abel Luis. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Bartolomeu, M. Lucía. Fundación Instituto Leloir; Argentina Fil: Pardi, Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina Fil: Löhr, Heiko. University of Cologne; Alemania Fil: Siegel, Nicole. Fundación Instituto Leloir; Argentina Fil: Hammerschmidt, Matthias. University of Cologne; Alemania Fil: Marin Burgin, Antonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Instituto Leloir; Argentina |
description |
Generation of neuronal types at the right time, location, and number is essential for building a functional nervous system. Significant progress has been reached in understanding the mechanisms that govern neuronal diversity. Cerebrospinal fluid-contacting neurons (CSF-cNs), an intriguing spinal cord central canal population, are produced during advanced developmental stages, simultaneous with glial and ependymal cells. It is unknown how CSF-cNs are specified after the neurogenesis-to-gliogenesis switch. Here, we identify delayed Ascl1 expression in mouse spinal progenitors during the gliogenic phase as key in CSF-cN differentiation. With fate mappings and time-controlled deletions, we demonstrate that CSF-cNs derive from Ascl1-expressing cells and that Ascl1 triggers late neurogenesis in the amniote spinal cord. Ascl1 abrogation transforms prospective CSF-cN progenitors into ependymocytes. These results demonstrate that late spinal progenitors have the potential to produce neurons and that Ascl1 initiates CSF-cN differentiation, controlling the precise neuronal and nonneuronal composition of the spinal central canal. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/94162 Di Bella, Daniela Jesica; Carcagno, Abel Luis; Bartolomeu, M. Lucía; Pardi, Belén; Löhr, Heiko; et al.; Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal; Elsevier; Cell Reports; 28; 9; 8-2019; 2264-2274.e3 2211-1247 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/94162 |
identifier_str_mv |
Di Bella, Daniela Jesica; Carcagno, Abel Luis; Bartolomeu, M. Lucía; Pardi, Belén; Löhr, Heiko; et al.; Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal; Elsevier; Cell Reports; 28; 9; 8-2019; 2264-2274.e3 2211-1247 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2019.07.087 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211124719310034 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269748241367040 |
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13.13397 |