Variations in macrophage migration inhibitory factor gene are not associated with visceral leishmaniasis in India
- Autores
- Mishra, Anshuman; Sundaravadivel, Pandarisamy; Tripathi, Sunil Kumar; Jha, Rajan Kumar; Badrukhiya, Jaydeep; Basak, Nipa; Anerao, Isha; Sharma, A. Surja; Ajayi, Ebenezer Idowu O; Mishra, Abhishek; Pandey, Sonika; Kumar, Umesh; Singh, Sakshi; Nizamuddin, Sheikh; Tupperwar, Nitin C.; Jha, Aditya Nath; Thangaraj, Kumarasamy
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The host genetic factors play important role in determining the outcome of visceral leishmaniasis (VL). Macrophage migration inhibitory factor (MIF) is an important host cytokine, which is a key regulator of innate immune system. Genetic variants in MIF gene have been found to be associated with several inflammatory and infectious diseases. Role of MIF is well documented in leishmaniasis diseases, including Indian visceral leishmaniasis, where elevated level of serum MIF has been associated with VL phenotypes. However, there was no genetic study to correlate MIF variants in VL, therefore, we aimed to study the possible association of three reported MIF gene variants −794 CATT, −173G > C and non-coding RNA gene LOC284889 in Indian VL phenotype. Methods: Study subjects comprised of 214 VL patients along with ethnically and demographically matched 220 controls from VL endemic regions of Bihar state in India. Results: We found no significant difference between cases and controls in allelic, genotypic and haplotype frequency of the markers analysed [-794 CATT repeats (χ2 = 0.86; p = 0.35; OR = 0.85; 95% CI = 0.61?1.19); −173 G > C polymorphism (χ2 = 1.11; p = 0.29; OR = 0.83; 95% CI = 0.59?1.16); and LOC284889 (χ2 = 0.78; p = 0.37; OR = 0.86; 95% CI = 0.61?1.20)]. Conclusion: Since we did not find any significant differences between case and control groups, we conclude that sequencing of complete MIF gene and extensive study on innate and adaptive immunity genes may help in identifying genetic variations that are associated with VL susceptibility/resistance among Indians.
Fil: Mishra, Anshuman. Vinoba Bhave Research Institute; India. Centre For Cellular And Molecular Biology India; India
Fil: Sundaravadivel, Pandarisamy. Centre For Cellular And Molecular Biology India; India
Fil: Tripathi, Sunil Kumar. Centre For Cellular And Molecular Biology India; India
Fil: Jha, Rajan Kumar. Centre For Cellular And Molecular Biology India; India
Fil: Badrukhiya, Jaydeep. Centre For Cellular And Molecular Biology India; India
Fil: Basak, Nipa. Academy Of Scientific And Innovative Research; India. Centre For Cellular And Molecular Biology India; India
Fil: Anerao, Isha. Centre For Cellular And Molecular Biology India; India
Fil: Sharma, A. Surja. Centre For Cellular And Molecular Biology India; India
Fil: Ajayi, Ebenezer Idowu O. Centre For Cellular And Molecular Biology India; India. Osun State University; Nigeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Mishra, Abhishek. Institute Of Basic Sciences Agra; India
Fil: Pandey, Sonika. Banaras Hindu University; India
Fil: Kumar, Umesh. Centre For Cellular And Molecular Biology India; India
Fil: Singh, Sakshi. Centre For Cellular And Molecular Biology India; India
Fil: Nizamuddin, Sheikh. Centre For Cellular And Molecular Biology India; India
Fil: Tupperwar, Nitin C.. Centre For Cellular And Molecular Biology India; India
Fil: Jha, Aditya Nath. Sickle Cell Institute Chhattisgarh; India. Centre For Cellular And Molecular Biology India; India
Fil: Thangaraj, Kumarasamy. Centre For Cellular And Molecular Biology India; India - Materia
-
GENETIC POLYMORPHISM
INDIAN POPULATION
LEISHMANIA MAJOR, LEISHMANIA DONOVANI
MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)
VISCERAL LEISHMANIASIS (VL) - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/128711
Ver los metadatos del registro completo
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Variations in macrophage migration inhibitory factor gene are not associated with visceral leishmaniasis in IndiaMishra, AnshumanSundaravadivel, PandarisamyTripathi, Sunil KumarJha, Rajan KumarBadrukhiya, JaydeepBasak, NipaAnerao, IshaSharma, A. SurjaAjayi, Ebenezer Idowu OMishra, AbhishekPandey, SonikaKumar, UmeshSingh, SakshiNizamuddin, SheikhTupperwar, Nitin C.Jha, Aditya NathThangaraj, KumarasamyGENETIC POLYMORPHISMINDIAN POPULATIONLEISHMANIA MAJOR, LEISHMANIA DONOVANIMACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)VISCERAL LEISHMANIASIS (VL)https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The host genetic factors play important role in determining the outcome of visceral leishmaniasis (VL). Macrophage migration inhibitory factor (MIF) is an important host cytokine, which is a key regulator of innate immune system. Genetic variants in MIF gene have been found to be associated with several inflammatory and infectious diseases. Role of MIF is well documented in leishmaniasis diseases, including Indian visceral leishmaniasis, where elevated level of serum MIF has been associated with VL phenotypes. However, there was no genetic study to correlate MIF variants in VL, therefore, we aimed to study the possible association of three reported MIF gene variants −794 CATT, −173G > C and non-coding RNA gene LOC284889 in Indian VL phenotype. Methods: Study subjects comprised of 214 VL patients along with ethnically and demographically matched 220 controls from VL endemic regions of Bihar state in India. Results: We found no significant difference between cases and controls in allelic, genotypic and haplotype frequency of the markers analysed [-794 CATT repeats (χ2 = 0.86; p = 0.35; OR = 0.85; 95% CI = 0.61?1.19); −173 G > C polymorphism (χ2 = 1.11; p = 0.29; OR = 0.83; 95% CI = 0.59?1.16); and LOC284889 (χ2 = 0.78; p = 0.37; OR = 0.86; 95% CI = 0.61?1.20)]. Conclusion: Since we did not find any significant differences between case and control groups, we conclude that sequencing of complete MIF gene and extensive study on innate and adaptive immunity genes may help in identifying genetic variations that are associated with VL susceptibility/resistance among Indians.Fil: Mishra, Anshuman. Vinoba Bhave Research Institute; India. Centre For Cellular And Molecular Biology India; IndiaFil: Sundaravadivel, Pandarisamy. Centre For Cellular And Molecular Biology India; IndiaFil: Tripathi, Sunil Kumar. Centre For Cellular And Molecular Biology India; IndiaFil: Jha, Rajan Kumar. Centre For Cellular And Molecular Biology India; IndiaFil: Badrukhiya, Jaydeep. Centre For Cellular And Molecular Biology India; IndiaFil: Basak, Nipa. Academy Of Scientific And Innovative Research; India. Centre For Cellular And Molecular Biology India; IndiaFil: Anerao, Isha. Centre For Cellular And Molecular Biology India; IndiaFil: Sharma, A. Surja. Centre For Cellular And Molecular Biology India; IndiaFil: Ajayi, Ebenezer Idowu O. Centre For Cellular And Molecular Biology India; India. Osun State University; Nigeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Mishra, Abhishek. Institute Of Basic Sciences Agra; IndiaFil: Pandey, Sonika. Banaras Hindu University; IndiaFil: Kumar, Umesh. Centre For Cellular And Molecular Biology India; IndiaFil: Singh, Sakshi. Centre For Cellular And Molecular Biology India; IndiaFil: Nizamuddin, Sheikh. Centre For Cellular And Molecular Biology India; IndiaFil: Tupperwar, Nitin C.. Centre For Cellular And Molecular Biology India; IndiaFil: Jha, Aditya Nath. Sickle Cell Institute Chhattisgarh; India. Centre For Cellular And Molecular Biology India; IndiaFil: Thangaraj, Kumarasamy. Centre For Cellular And Molecular Biology India; IndiaElsevier Ltd2019-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/128711Mishra, Anshuman; Sundaravadivel, Pandarisamy; Tripathi, Sunil Kumar; Jha, Rajan Kumar; Badrukhiya, Jaydeep; et al.; Variations in macrophage migration inhibitory factor gene are not associated with visceral leishmaniasis in India; Elsevier Ltd; Journal of Infection and Public Health; 12; 3; 5-2019; 380-3871876-03411876-035XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1876034118303435?via%3Dihubinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jiph.2018.12.011info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:18Zoai:ri.conicet.gov.ar:11336/128711instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:18.959CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Variations in macrophage migration inhibitory factor gene are not associated with visceral leishmaniasis in India |
| title |
Variations in macrophage migration inhibitory factor gene are not associated with visceral leishmaniasis in India |
| spellingShingle |
Variations in macrophage migration inhibitory factor gene are not associated with visceral leishmaniasis in India Mishra, Anshuman GENETIC POLYMORPHISM INDIAN POPULATION LEISHMANIA MAJOR, LEISHMANIA DONOVANI MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) VISCERAL LEISHMANIASIS (VL) |
| title_short |
Variations in macrophage migration inhibitory factor gene are not associated with visceral leishmaniasis in India |
| title_full |
Variations in macrophage migration inhibitory factor gene are not associated with visceral leishmaniasis in India |
| title_fullStr |
Variations in macrophage migration inhibitory factor gene are not associated with visceral leishmaniasis in India |
| title_full_unstemmed |
Variations in macrophage migration inhibitory factor gene are not associated with visceral leishmaniasis in India |
| title_sort |
Variations in macrophage migration inhibitory factor gene are not associated with visceral leishmaniasis in India |
| dc.creator.none.fl_str_mv |
Mishra, Anshuman Sundaravadivel, Pandarisamy Tripathi, Sunil Kumar Jha, Rajan Kumar Badrukhiya, Jaydeep Basak, Nipa Anerao, Isha Sharma, A. Surja Ajayi, Ebenezer Idowu O Mishra, Abhishek Pandey, Sonika Kumar, Umesh Singh, Sakshi Nizamuddin, Sheikh Tupperwar, Nitin C. Jha, Aditya Nath Thangaraj, Kumarasamy |
| author |
Mishra, Anshuman |
| author_facet |
Mishra, Anshuman Sundaravadivel, Pandarisamy Tripathi, Sunil Kumar Jha, Rajan Kumar Badrukhiya, Jaydeep Basak, Nipa Anerao, Isha Sharma, A. Surja Ajayi, Ebenezer Idowu O Mishra, Abhishek Pandey, Sonika Kumar, Umesh Singh, Sakshi Nizamuddin, Sheikh Tupperwar, Nitin C. Jha, Aditya Nath Thangaraj, Kumarasamy |
| author_role |
author |
| author2 |
Sundaravadivel, Pandarisamy Tripathi, Sunil Kumar Jha, Rajan Kumar Badrukhiya, Jaydeep Basak, Nipa Anerao, Isha Sharma, A. Surja Ajayi, Ebenezer Idowu O Mishra, Abhishek Pandey, Sonika Kumar, Umesh Singh, Sakshi Nizamuddin, Sheikh Tupperwar, Nitin C. Jha, Aditya Nath Thangaraj, Kumarasamy |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
GENETIC POLYMORPHISM INDIAN POPULATION LEISHMANIA MAJOR, LEISHMANIA DONOVANI MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) VISCERAL LEISHMANIASIS (VL) |
| topic |
GENETIC POLYMORPHISM INDIAN POPULATION LEISHMANIA MAJOR, LEISHMANIA DONOVANI MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) VISCERAL LEISHMANIASIS (VL) |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
The host genetic factors play important role in determining the outcome of visceral leishmaniasis (VL). Macrophage migration inhibitory factor (MIF) is an important host cytokine, which is a key regulator of innate immune system. Genetic variants in MIF gene have been found to be associated with several inflammatory and infectious diseases. Role of MIF is well documented in leishmaniasis diseases, including Indian visceral leishmaniasis, where elevated level of serum MIF has been associated with VL phenotypes. However, there was no genetic study to correlate MIF variants in VL, therefore, we aimed to study the possible association of three reported MIF gene variants −794 CATT, −173G > C and non-coding RNA gene LOC284889 in Indian VL phenotype. Methods: Study subjects comprised of 214 VL patients along with ethnically and demographically matched 220 controls from VL endemic regions of Bihar state in India. Results: We found no significant difference between cases and controls in allelic, genotypic and haplotype frequency of the markers analysed [-794 CATT repeats (χ2 = 0.86; p = 0.35; OR = 0.85; 95% CI = 0.61?1.19); −173 G > C polymorphism (χ2 = 1.11; p = 0.29; OR = 0.83; 95% CI = 0.59?1.16); and LOC284889 (χ2 = 0.78; p = 0.37; OR = 0.86; 95% CI = 0.61?1.20)]. Conclusion: Since we did not find any significant differences between case and control groups, we conclude that sequencing of complete MIF gene and extensive study on innate and adaptive immunity genes may help in identifying genetic variations that are associated with VL susceptibility/resistance among Indians. Fil: Mishra, Anshuman. Vinoba Bhave Research Institute; India. Centre For Cellular And Molecular Biology India; India Fil: Sundaravadivel, Pandarisamy. Centre For Cellular And Molecular Biology India; India Fil: Tripathi, Sunil Kumar. Centre For Cellular And Molecular Biology India; India Fil: Jha, Rajan Kumar. Centre For Cellular And Molecular Biology India; India Fil: Badrukhiya, Jaydeep. Centre For Cellular And Molecular Biology India; India Fil: Basak, Nipa. Academy Of Scientific And Innovative Research; India. Centre For Cellular And Molecular Biology India; India Fil: Anerao, Isha. Centre For Cellular And Molecular Biology India; India Fil: Sharma, A. Surja. Centre For Cellular And Molecular Biology India; India Fil: Ajayi, Ebenezer Idowu O. Centre For Cellular And Molecular Biology India; India. Osun State University; Nigeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina Fil: Mishra, Abhishek. Institute Of Basic Sciences Agra; India Fil: Pandey, Sonika. Banaras Hindu University; India Fil: Kumar, Umesh. Centre For Cellular And Molecular Biology India; India Fil: Singh, Sakshi. Centre For Cellular And Molecular Biology India; India Fil: Nizamuddin, Sheikh. Centre For Cellular And Molecular Biology India; India Fil: Tupperwar, Nitin C.. Centre For Cellular And Molecular Biology India; India Fil: Jha, Aditya Nath. Sickle Cell Institute Chhattisgarh; India. Centre For Cellular And Molecular Biology India; India Fil: Thangaraj, Kumarasamy. Centre For Cellular And Molecular Biology India; India |
| description |
The host genetic factors play important role in determining the outcome of visceral leishmaniasis (VL). Macrophage migration inhibitory factor (MIF) is an important host cytokine, which is a key regulator of innate immune system. Genetic variants in MIF gene have been found to be associated with several inflammatory and infectious diseases. Role of MIF is well documented in leishmaniasis diseases, including Indian visceral leishmaniasis, where elevated level of serum MIF has been associated with VL phenotypes. However, there was no genetic study to correlate MIF variants in VL, therefore, we aimed to study the possible association of three reported MIF gene variants −794 CATT, −173G > C and non-coding RNA gene LOC284889 in Indian VL phenotype. Methods: Study subjects comprised of 214 VL patients along with ethnically and demographically matched 220 controls from VL endemic regions of Bihar state in India. Results: We found no significant difference between cases and controls in allelic, genotypic and haplotype frequency of the markers analysed [-794 CATT repeats (χ2 = 0.86; p = 0.35; OR = 0.85; 95% CI = 0.61?1.19); −173 G > C polymorphism (χ2 = 1.11; p = 0.29; OR = 0.83; 95% CI = 0.59?1.16); and LOC284889 (χ2 = 0.78; p = 0.37; OR = 0.86; 95% CI = 0.61?1.20)]. Conclusion: Since we did not find any significant differences between case and control groups, we conclude that sequencing of complete MIF gene and extensive study on innate and adaptive immunity genes may help in identifying genetic variations that are associated with VL susceptibility/resistance among Indians. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019-05 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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http://hdl.handle.net/11336/128711 Mishra, Anshuman; Sundaravadivel, Pandarisamy; Tripathi, Sunil Kumar; Jha, Rajan Kumar; Badrukhiya, Jaydeep; et al.; Variations in macrophage migration inhibitory factor gene are not associated with visceral leishmaniasis in India; Elsevier Ltd; Journal of Infection and Public Health; 12; 3; 5-2019; 380-387 1876-0341 1876-035X CONICET Digital CONICET |
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http://hdl.handle.net/11336/128711 |
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Mishra, Anshuman; Sundaravadivel, Pandarisamy; Tripathi, Sunil Kumar; Jha, Rajan Kumar; Badrukhiya, Jaydeep; et al.; Variations in macrophage migration inhibitory factor gene are not associated with visceral leishmaniasis in India; Elsevier Ltd; Journal of Infection and Public Health; 12; 3; 5-2019; 380-387 1876-0341 1876-035X CONICET Digital CONICET |
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eng |
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eng |
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Elsevier Ltd |
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