Influence of b2-adrenergic receptor polymorphisms on asthma exacerbation in children with severe asthma regularly receiving salmeterol

Autores
Giubergia, Verónica; Castaños, Claudio; Gravina, Luis; Chertkoff, Lilien Patricia
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: New evidence suggests that different β2-adrenergic receptor (β2AR) polymorphisms may influence asthma control in patients receiving long-acting β2-agonists (LABAs) as regular therapy. Objectives: To determine the influence of β2AR polymorphisms on asthma exacerbations in children with severe asthma from Argentina receiving inhaled corticosteroid (ICS) and LABAs regularly. Methods: Ninety-seven children with severe asthma were genotyped for polymorphisms of β2AR at codons 16 and 27. The number of severe exacerbations, the time of first asthma exacerbation, and the number of hospitalizations during 12 months were assessed. Changes on pulmonary function from the beginning to the end of the study were also evaluated. Results: The number of overall asthma exacerbations and the proportion of children with these events were similar among β2AR genotypes at position 16 (Arg/Arg, Arg/Gly, and Gly/Gly) and at position 27 (Gln/Gln, Gln/Glu, and Glu/Glu). The time to first asthma exacerbation was similar among individuals carrying different β2AR polymorphisms. No β2AR genotype association was found in relation to the number of hospitalizations. Longitudinal analysis of forced expiratory volume in 1 second from baseline to the end of the study also showed no differences among β2AR genotypes at position 16 or 27. No association was observed among the 3 most common haplotypes (Arg/Arg-Gln/Gln, Gly/Gly-Gln/Gln, and Gly/Gly-Glu/Glu) and the number of participants with asthmatic crisis or with the overall number of exacerbations. Conclusion: β2AR polymorphisms were not associated with an increased risk of having asthma exacerbations or lung function decline in a population of Argentinian children with severe asthma receiving ICS and LABAs regularly.
Fil: Giubergia, Verónica. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Castaños, Claudio. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Gravina, Luis. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Chertkoff, Lilien Patricia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
B2-Adrenergic
Salmeterol
Asthma
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/3865
Acceder
id CONICETDig_440d8dea40cc7ff5ee4696145ebb2659
oai_identifier_str oai:ri.conicet.gov.ar:11336/3865
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Influence of b2-adrenergic receptor polymorphisms on asthma exacerbation in children with severe asthma regularly receiving salmeterolGiubergia, VerónicaCastaños, ClaudioGravina, LuisChertkoff, Lilien PatriciaB2-AdrenergicSalmeterolAsthmahttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: New evidence suggests that different β2-adrenergic receptor (β2AR) polymorphisms may influence asthma control in patients receiving long-acting β2-agonists (LABAs) as regular therapy. Objectives: To determine the influence of β2AR polymorphisms on asthma exacerbations in children with severe asthma from Argentina receiving inhaled corticosteroid (ICS) and LABAs regularly. Methods: Ninety-seven children with severe asthma were genotyped for polymorphisms of β2AR at codons 16 and 27. The number of severe exacerbations, the time of first asthma exacerbation, and the number of hospitalizations during 12 months were assessed. Changes on pulmonary function from the beginning to the end of the study were also evaluated. Results: The number of overall asthma exacerbations and the proportion of children with these events were similar among β2AR genotypes at position 16 (Arg/Arg, Arg/Gly, and Gly/Gly) and at position 27 (Gln/Gln, Gln/Glu, and Glu/Glu). The time to first asthma exacerbation was similar among individuals carrying different β2AR polymorphisms. No β2AR genotype association was found in relation to the number of hospitalizations. Longitudinal analysis of forced expiratory volume in 1 second from baseline to the end of the study also showed no differences among β2AR genotypes at position 16 or 27. No association was observed among the 3 most common haplotypes (Arg/Arg-Gln/Gln, Gly/Gly-Gln/Gln, and Gly/Gly-Glu/Glu) and the number of participants with asthmatic crisis or with the overall number of exacerbations. Conclusion: β2AR polymorphisms were not associated with an increased risk of having asthma exacerbations or lung function decline in a population of Argentinian children with severe asthma receiving ICS and LABAs regularly.Fil: Giubergia, Verónica. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Castaños, Claudio. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Gravina, Luis. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Chertkoff, Lilien Patricia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/3865Giubergia, Verónica; Castaños, Claudio; Gravina, Luis; Chertkoff, Lilien Patricia; Influence of b2-adrenergic receptor polymorphisms on asthma exacerbation in children with severe asthma regularly receiving salmeterol; Elsevier; Annals of Allergy, Asthama & Immunology; 110; 3; 3-2013; 156-1601081-1206enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1081120612010332info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1016/j.anai.2012.12.018info:eu-repo/semantics/altIdentifier/issn/1081-1206info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:47:18Zoai:ri.conicet.gov.ar:11336/3865instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:47:19.215CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Influence of b2-adrenergic receptor polymorphisms on asthma exacerbation in children with severe asthma regularly receiving salmeterol
title Influence of b2-adrenergic receptor polymorphisms on asthma exacerbation in children with severe asthma regularly receiving salmeterol
spellingShingle Influence of b2-adrenergic receptor polymorphisms on asthma exacerbation in children with severe asthma regularly receiving salmeterol
Giubergia, Verónica
B2-Adrenergic
Salmeterol
Asthma
title_short Influence of b2-adrenergic receptor polymorphisms on asthma exacerbation in children with severe asthma regularly receiving salmeterol
title_full Influence of b2-adrenergic receptor polymorphisms on asthma exacerbation in children with severe asthma regularly receiving salmeterol
title_fullStr Influence of b2-adrenergic receptor polymorphisms on asthma exacerbation in children with severe asthma regularly receiving salmeterol
title_full_unstemmed Influence of b2-adrenergic receptor polymorphisms on asthma exacerbation in children with severe asthma regularly receiving salmeterol
title_sort Influence of b2-adrenergic receptor polymorphisms on asthma exacerbation in children with severe asthma regularly receiving salmeterol
dc.creator.none.fl_str_mv Giubergia, Verónica
Castaños, Claudio
Gravina, Luis
Chertkoff, Lilien Patricia
author Giubergia, Verónica
author_facet Giubergia, Verónica
Castaños, Claudio
Gravina, Luis
Chertkoff, Lilien Patricia
author_role author
author2 Castaños, Claudio
Gravina, Luis
Chertkoff, Lilien Patricia
author2_role author
author
author
dc.subject.none.fl_str_mv B2-Adrenergic
Salmeterol
Asthma
topic B2-Adrenergic
Salmeterol
Asthma
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: New evidence suggests that different β2-adrenergic receptor (β2AR) polymorphisms may influence asthma control in patients receiving long-acting β2-agonists (LABAs) as regular therapy. Objectives: To determine the influence of β2AR polymorphisms on asthma exacerbations in children with severe asthma from Argentina receiving inhaled corticosteroid (ICS) and LABAs regularly. Methods: Ninety-seven children with severe asthma were genotyped for polymorphisms of β2AR at codons 16 and 27. The number of severe exacerbations, the time of first asthma exacerbation, and the number of hospitalizations during 12 months were assessed. Changes on pulmonary function from the beginning to the end of the study were also evaluated. Results: The number of overall asthma exacerbations and the proportion of children with these events were similar among β2AR genotypes at position 16 (Arg/Arg, Arg/Gly, and Gly/Gly) and at position 27 (Gln/Gln, Gln/Glu, and Glu/Glu). The time to first asthma exacerbation was similar among individuals carrying different β2AR polymorphisms. No β2AR genotype association was found in relation to the number of hospitalizations. Longitudinal analysis of forced expiratory volume in 1 second from baseline to the end of the study also showed no differences among β2AR genotypes at position 16 or 27. No association was observed among the 3 most common haplotypes (Arg/Arg-Gln/Gln, Gly/Gly-Gln/Gln, and Gly/Gly-Glu/Glu) and the number of participants with asthmatic crisis or with the overall number of exacerbations. Conclusion: β2AR polymorphisms were not associated with an increased risk of having asthma exacerbations or lung function decline in a population of Argentinian children with severe asthma receiving ICS and LABAs regularly.
Fil: Giubergia, Verónica. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Castaños, Claudio. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Gravina, Luis. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Chertkoff, Lilien Patricia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Background: New evidence suggests that different β2-adrenergic receptor (β2AR) polymorphisms may influence asthma control in patients receiving long-acting β2-agonists (LABAs) as regular therapy. Objectives: To determine the influence of β2AR polymorphisms on asthma exacerbations in children with severe asthma from Argentina receiving inhaled corticosteroid (ICS) and LABAs regularly. Methods: Ninety-seven children with severe asthma were genotyped for polymorphisms of β2AR at codons 16 and 27. The number of severe exacerbations, the time of first asthma exacerbation, and the number of hospitalizations during 12 months were assessed. Changes on pulmonary function from the beginning to the end of the study were also evaluated. Results: The number of overall asthma exacerbations and the proportion of children with these events were similar among β2AR genotypes at position 16 (Arg/Arg, Arg/Gly, and Gly/Gly) and at position 27 (Gln/Gln, Gln/Glu, and Glu/Glu). The time to first asthma exacerbation was similar among individuals carrying different β2AR polymorphisms. No β2AR genotype association was found in relation to the number of hospitalizations. Longitudinal analysis of forced expiratory volume in 1 second from baseline to the end of the study also showed no differences among β2AR genotypes at position 16 or 27. No association was observed among the 3 most common haplotypes (Arg/Arg-Gln/Gln, Gly/Gly-Gln/Gln, and Gly/Gly-Glu/Glu) and the number of participants with asthmatic crisis or with the overall number of exacerbations. Conclusion: β2AR polymorphisms were not associated with an increased risk of having asthma exacerbations or lung function decline in a population of Argentinian children with severe asthma receiving ICS and LABAs regularly.
publishDate 2013
dc.date.none.fl_str_mv 2013-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/3865
Giubergia, Verónica; Castaños, Claudio; Gravina, Luis; Chertkoff, Lilien Patricia; Influence of b2-adrenergic receptor polymorphisms on asthma exacerbation in children with severe asthma regularly receiving salmeterol; Elsevier; Annals of Allergy, Asthama & Immunology; 110; 3; 3-2013; 156-160
1081-1206
url http://hdl.handle.net/11336/3865
identifier_str_mv Giubergia, Verónica; Castaños, Claudio; Gravina, Luis; Chertkoff, Lilien Patricia; Influence of b2-adrenergic receptor polymorphisms on asthma exacerbation in children with severe asthma regularly receiving salmeterol; Elsevier; Annals of Allergy, Asthama & Immunology; 110; 3; 3-2013; 156-160
1081-1206
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1081120612010332
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1016/j.anai.2012.12.018
info:eu-repo/semantics/altIdentifier/issn/1081-1206
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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