Social and non-social working memory in neurodegeneration

Autores
Legaz, Agustina; Prado, Pavel; Moguilner, Sebastian Gabriel; Báez, Sandra; Santamaria Garcia, Hernando; Birba, Agustina; Barttfeld, Pablo; García, Adolfo Martín; Fittipaldi, María Sol; Ibañez, Agustin Mariano
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Although social functioning relies on working memory, whether a social-specific mechanism exists remains unclear. This undermines the characterization of neurodegenerative conditions with both working memory and social deficits. We assessed working memory domain-specificity across behavioral, electrophysiological, and neuroimaging dimensions in 245 participants. A novel working memory task involving social and non-social stimuli with three load levels was assessed across controls and different neurodegenerative conditions with recognized impairments in: working memory and social cognition (behavioral-variant frontotemporal dementia); general cognition (Alzheimer’s disease); and unspecific patterns (Parkinson’s disease). We also examined resting-state theta oscillations and functional connectivity correlates of working memory domain-specificity. Results in controls and all groups together evidenced increased working memory demands for social stimuli associated with frontocinguloparietal theta oscillations and salience network connectivity. Canonical frontal theta oscillations and executive-default mode network anticorrelation indexed non-social stimuli. Behavioral-variant frontotemporal dementia presented generalized working memory deficits related to posterior theta oscillations, with social stimuli linked to salience network connectivity. In Alzheimer’s disease, generalized working memory impairments were related to temporoparietal theta oscillations, with non-social stimuli linked to the executive network. Parkinson’s disease showed spared working memory performance and canonical brain correlates. Findings support a social-specific working memory and related disease-selective pathophysiological mechanisms.
Fil: Legaz, Agustina. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
Fil: Prado, Pavel. Universidad Adolfo Ibañez; Chile. Universidad San Sebastián; Chile
Fil: Moguilner, Sebastian Gabriel. Trinity College Dublin; Irlanda. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. University of California; Estados Unidos
Fil: Báez, Sandra. Universidad de los Andes; Colombia
Fil: Santamaria Garcia, Hernando. Pontificia Universidad Javeriana; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Birba, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de La Laguna; España. Universidad de San Andrés; Argentina
Fil: Barttfeld, Pablo. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Santiago de Chile; Chile. Universidad de San Andrés; Argentina. Trinity College Dublin; Irlanda. University of California; Estados Unidos
Fil: Fittipaldi, María Sol. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of California; Estados Unidos. Trinity College Dublin; Irlanda. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile
Fil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibañez; Chile. University of California; Estados Unidos. Trinity College Dublin; Irlanda. Universidad de San Andrés; Argentina
Materia
WORKING MEMORY
SOCIAL PROCESSING
SOCIAL WORKING MEMORY
BEHAVIORAL-VARIANT FRONTOTEMPORAL DEMENTIA
ALZHEIMER'S DISEASE
PARKINSON'S DISEASE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/232754
Acceder
id CONICETDig_4345d3fb1edbfd416005343885a47258
oai_identifier_str oai:ri.conicet.gov.ar:11336/232754
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network_name_str CONICET Digital (CONICET)
spelling Social and non-social working memory in neurodegenerationLegaz, AgustinaPrado, PavelMoguilner, Sebastian GabrielBáez, SandraSantamaria Garcia, HernandoBirba, AgustinaBarttfeld, PabloGarcía, Adolfo MartínFittipaldi, María SolIbañez, Agustin MarianoWORKING MEMORYSOCIAL PROCESSINGSOCIAL WORKING MEMORYBEHAVIORAL-VARIANT FRONTOTEMPORAL DEMENTIAALZHEIMER'S DISEASEPARKINSON'S DISEASEhttps://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5Although social functioning relies on working memory, whether a social-specific mechanism exists remains unclear. This undermines the characterization of neurodegenerative conditions with both working memory and social deficits. We assessed working memory domain-specificity across behavioral, electrophysiological, and neuroimaging dimensions in 245 participants. A novel working memory task involving social and non-social stimuli with three load levels was assessed across controls and different neurodegenerative conditions with recognized impairments in: working memory and social cognition (behavioral-variant frontotemporal dementia); general cognition (Alzheimer’s disease); and unspecific patterns (Parkinson’s disease). We also examined resting-state theta oscillations and functional connectivity correlates of working memory domain-specificity. Results in controls and all groups together evidenced increased working memory demands for social stimuli associated with frontocinguloparietal theta oscillations and salience network connectivity. Canonical frontal theta oscillations and executive-default mode network anticorrelation indexed non-social stimuli. Behavioral-variant frontotemporal dementia presented generalized working memory deficits related to posterior theta oscillations, with social stimuli linked to salience network connectivity. In Alzheimer’s disease, generalized working memory impairments were related to temporoparietal theta oscillations, with non-social stimuli linked to the executive network. Parkinson’s disease showed spared working memory performance and canonical brain correlates. Findings support a social-specific working memory and related disease-selective pathophysiological mechanisms.Fil: Legaz, Agustina. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; ArgentinaFil: Prado, Pavel. Universidad Adolfo Ibañez; Chile. Universidad San Sebastián; ChileFil: Moguilner, Sebastian Gabriel. Trinity College Dublin; Irlanda. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. University of California; Estados UnidosFil: Báez, Sandra. Universidad de los Andes; ColombiaFil: Santamaria Garcia, Hernando. Pontificia Universidad Javeriana; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Birba, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de La Laguna; España. Universidad de San Andrés; ArgentinaFil: Barttfeld, Pablo. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Santiago de Chile; Chile. Universidad de San Andrés; Argentina. Trinity College Dublin; Irlanda. University of California; Estados UnidosFil: Fittipaldi, María Sol. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of California; Estados Unidos. Trinity College Dublin; Irlanda. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; ChileFil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibañez; Chile. University of California; Estados Unidos. Trinity College Dublin; Irlanda. Universidad de San Andrés; ArgentinaAcademic Press Inc.2023-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/232754Legaz, Agustina; Prado, Pavel; Moguilner, Sebastian Gabriel; Báez, Sandra; Santamaria Garcia, Hernando; et al.; Social and non-social working memory in neurodegeneration; Academic Press Inc.; Neurobiology of Disease; 183; 106171; 7-2023; 1-151095-953XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0969996123001869info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nbd.2023.106171info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:44Zoai:ri.conicet.gov.ar:11336/232754instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:44.376CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Social and non-social working memory in neurodegeneration
title Social and non-social working memory in neurodegeneration
spellingShingle Social and non-social working memory in neurodegeneration
Legaz, Agustina
WORKING MEMORY
SOCIAL PROCESSING
SOCIAL WORKING MEMORY
BEHAVIORAL-VARIANT FRONTOTEMPORAL DEMENTIA
ALZHEIMER'S DISEASE
PARKINSON'S DISEASE
title_short Social and non-social working memory in neurodegeneration
title_full Social and non-social working memory in neurodegeneration
title_fullStr Social and non-social working memory in neurodegeneration
title_full_unstemmed Social and non-social working memory in neurodegeneration
title_sort Social and non-social working memory in neurodegeneration
dc.creator.none.fl_str_mv Legaz, Agustina
Prado, Pavel
Moguilner, Sebastian Gabriel
Báez, Sandra
Santamaria Garcia, Hernando
Birba, Agustina
Barttfeld, Pablo
García, Adolfo Martín
Fittipaldi, María Sol
Ibañez, Agustin Mariano
author Legaz, Agustina
author_facet Legaz, Agustina
Prado, Pavel
Moguilner, Sebastian Gabriel
Báez, Sandra
Santamaria Garcia, Hernando
Birba, Agustina
Barttfeld, Pablo
García, Adolfo Martín
Fittipaldi, María Sol
Ibañez, Agustin Mariano
author_role author
author2 Prado, Pavel
Moguilner, Sebastian Gabriel
Báez, Sandra
Santamaria Garcia, Hernando
Birba, Agustina
Barttfeld, Pablo
García, Adolfo Martín
Fittipaldi, María Sol
Ibañez, Agustin Mariano
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv WORKING MEMORY
SOCIAL PROCESSING
SOCIAL WORKING MEMORY
BEHAVIORAL-VARIANT FRONTOTEMPORAL DEMENTIA
ALZHEIMER'S DISEASE
PARKINSON'S DISEASE
topic WORKING MEMORY
SOCIAL PROCESSING
SOCIAL WORKING MEMORY
BEHAVIORAL-VARIANT FRONTOTEMPORAL DEMENTIA
ALZHEIMER'S DISEASE
PARKINSON'S DISEASE
purl_subject.fl_str_mv https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
dc.description.none.fl_txt_mv Although social functioning relies on working memory, whether a social-specific mechanism exists remains unclear. This undermines the characterization of neurodegenerative conditions with both working memory and social deficits. We assessed working memory domain-specificity across behavioral, electrophysiological, and neuroimaging dimensions in 245 participants. A novel working memory task involving social and non-social stimuli with three load levels was assessed across controls and different neurodegenerative conditions with recognized impairments in: working memory and social cognition (behavioral-variant frontotemporal dementia); general cognition (Alzheimer’s disease); and unspecific patterns (Parkinson’s disease). We also examined resting-state theta oscillations and functional connectivity correlates of working memory domain-specificity. Results in controls and all groups together evidenced increased working memory demands for social stimuli associated with frontocinguloparietal theta oscillations and salience network connectivity. Canonical frontal theta oscillations and executive-default mode network anticorrelation indexed non-social stimuli. Behavioral-variant frontotemporal dementia presented generalized working memory deficits related to posterior theta oscillations, with social stimuli linked to salience network connectivity. In Alzheimer’s disease, generalized working memory impairments were related to temporoparietal theta oscillations, with non-social stimuli linked to the executive network. Parkinson’s disease showed spared working memory performance and canonical brain correlates. Findings support a social-specific working memory and related disease-selective pathophysiological mechanisms.
Fil: Legaz, Agustina. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
Fil: Prado, Pavel. Universidad Adolfo Ibañez; Chile. Universidad San Sebastián; Chile
Fil: Moguilner, Sebastian Gabriel. Trinity College Dublin; Irlanda. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. University of California; Estados Unidos
Fil: Báez, Sandra. Universidad de los Andes; Colombia
Fil: Santamaria Garcia, Hernando. Pontificia Universidad Javeriana; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Birba, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de La Laguna; España. Universidad de San Andrés; Argentina
Fil: Barttfeld, Pablo. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Santiago de Chile; Chile. Universidad de San Andrés; Argentina. Trinity College Dublin; Irlanda. University of California; Estados Unidos
Fil: Fittipaldi, María Sol. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of California; Estados Unidos. Trinity College Dublin; Irlanda. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile
Fil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Adolfo Ibañez; Chile. University of California; Estados Unidos. Trinity College Dublin; Irlanda. Universidad de San Andrés; Argentina
description Although social functioning relies on working memory, whether a social-specific mechanism exists remains unclear. This undermines the characterization of neurodegenerative conditions with both working memory and social deficits. We assessed working memory domain-specificity across behavioral, electrophysiological, and neuroimaging dimensions in 245 participants. A novel working memory task involving social and non-social stimuli with three load levels was assessed across controls and different neurodegenerative conditions with recognized impairments in: working memory and social cognition (behavioral-variant frontotemporal dementia); general cognition (Alzheimer’s disease); and unspecific patterns (Parkinson’s disease). We also examined resting-state theta oscillations and functional connectivity correlates of working memory domain-specificity. Results in controls and all groups together evidenced increased working memory demands for social stimuli associated with frontocinguloparietal theta oscillations and salience network connectivity. Canonical frontal theta oscillations and executive-default mode network anticorrelation indexed non-social stimuli. Behavioral-variant frontotemporal dementia presented generalized working memory deficits related to posterior theta oscillations, with social stimuli linked to salience network connectivity. In Alzheimer’s disease, generalized working memory impairments were related to temporoparietal theta oscillations, with non-social stimuli linked to the executive network. Parkinson’s disease showed spared working memory performance and canonical brain correlates. Findings support a social-specific working memory and related disease-selective pathophysiological mechanisms.
publishDate 2023
dc.date.none.fl_str_mv 2023-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/232754
Legaz, Agustina; Prado, Pavel; Moguilner, Sebastian Gabriel; Báez, Sandra; Santamaria Garcia, Hernando; et al.; Social and non-social working memory in neurodegeneration; Academic Press Inc.; Neurobiology of Disease; 183; 106171; 7-2023; 1-15
1095-953X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/232754
identifier_str_mv Legaz, Agustina; Prado, Pavel; Moguilner, Sebastian Gabriel; Báez, Sandra; Santamaria Garcia, Hernando; et al.; Social and non-social working memory in neurodegeneration; Academic Press Inc.; Neurobiology of Disease; 183; 106171; 7-2023; 1-15
1095-953X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0969996123001869
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nbd.2023.106171
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc.
publisher.none.fl_str_mv Academic Press Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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