Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools

Autores
Sabin, Guilherme P.; Lozano, Valeria Antonella; Rocha, Werickson F. C.; Romão, Wanderson; Ortiz, Rafael S.; Poppi, Ronei J.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The chemical imaging technique by near infrared spectroscopy was applied for characterization of formulations in tablets of sildenafil citrate of six different sources. Five formulations were provided by Brazilian Federal Police and correspond to several trademarks of prohibited marketing and one was an authentic sample of Viagra. In a first step of the study, multivariate curve resolution was properly chosen for the estimation of the distribution map of concentration of the active ingredient in tablets of different sources, where the chemical composition of all excipients constituents was not truly known. In such cases, it is very difficult to establish an appropriate calibration technique, so that only the information of sildenafil is considered independently of the excipients. This determination was possible only by reaching the second-order advantage, where the analyte quantification can be performed in the presence of unknown interferences. In a second step, the normalized histograms of images from active ingredient were grouped according to their similarities by hierarchical cluster analysis. Finally it was possible to recognize the patterns of distribution maps of concentration of sildenafil citrate, distinguishing the true formulation of Viagra. This concept can be used to improve the knowledge of industrial products and processes, as well as, for characterization of counterfeit drugs.
Fil: Sabin, Guilherme P.. Universidade Estadual de Campinas; Brasil
Fil: Lozano, Valeria Antonella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Rocha, Werickson F. C.. National Institute of Metrology, Quality and Technology. Directorate of Industrial and Scientific Metrology. Chemical Metrology Division; Brasil
Fil: Romão, Wanderson. Instituto Federal de Educação, Ciência e Tecnologia do Spirito Santo; Brasil
Fil: Ortiz, Rafael S.. Policia Federal Brasileira; Brasil
Fil: Poppi, Ronei J.. Universidade Estadual de Campinas; Brasil
Materia
Sildenafil Citrate
Chemical Imaging
Near Infrared Spectroscopy
Multivariate Curve Resolution
Classification
Pattern Recognition
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6028
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/6028
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric toolsSabin, Guilherme P.Lozano, Valeria AntonellaRocha, Werickson F. C.Romão, WandersonOrtiz, Rafael S.Poppi, Ronei J.Sildenafil CitrateChemical ImagingNear Infrared SpectroscopyMultivariate Curve ResolutionClassificationPattern Recognitionhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The chemical imaging technique by near infrared spectroscopy was applied for characterization of formulations in tablets of sildenafil citrate of six different sources. Five formulations were provided by Brazilian Federal Police and correspond to several trademarks of prohibited marketing and one was an authentic sample of Viagra. In a first step of the study, multivariate curve resolution was properly chosen for the estimation of the distribution map of concentration of the active ingredient in tablets of different sources, where the chemical composition of all excipients constituents was not truly known. In such cases, it is very difficult to establish an appropriate calibration technique, so that only the information of sildenafil is considered independently of the excipients. This determination was possible only by reaching the second-order advantage, where the analyte quantification can be performed in the presence of unknown interferences. In a second step, the normalized histograms of images from active ingredient were grouped according to their similarities by hierarchical cluster analysis. Finally it was possible to recognize the patterns of distribution maps of concentration of sildenafil citrate, distinguishing the true formulation of Viagra. This concept can be used to improve the knowledge of industrial products and processes, as well as, for characterization of counterfeit drugs.Fil: Sabin, Guilherme P.. Universidade Estadual de Campinas; BrasilFil: Lozano, Valeria Antonella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaFil: Rocha, Werickson F. C.. National Institute of Metrology, Quality and Technology. Directorate of Industrial and Scientific Metrology. Chemical Metrology Division; BrasilFil: Romão, Wanderson. Instituto Federal de Educação, Ciência e Tecnologia do Spirito Santo; BrasilFil: Ortiz, Rafael S.. Policia Federal Brasileira; BrasilFil: Poppi, Ronei J.. Universidade Estadual de Campinas; BrasilElsevier2013-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6028Sabin, Guilherme P.; Lozano, Valeria Antonella; Rocha, Werickson F. C.; Romão, Wanderson; Ortiz, Rafael S.; et al.; Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools; Elsevier; Journal of Pharmaceutical and Biomedical Analysis; 85; 11-2013; 207-2120731-7085enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0731708513003427info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpba.2013.07.036info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:01:07Zoai:ri.conicet.gov.ar:11336/6028instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:01:07.374CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools
title Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools
spellingShingle Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools
Sabin, Guilherme P.
Sildenafil Citrate
Chemical Imaging
Near Infrared Spectroscopy
Multivariate Curve Resolution
Classification
Pattern Recognition
title_short Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools
title_full Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools
title_fullStr Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools
title_full_unstemmed Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools
title_sort Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools
dc.creator.none.fl_str_mv Sabin, Guilherme P.
Lozano, Valeria Antonella
Rocha, Werickson F. C.
Romão, Wanderson
Ortiz, Rafael S.
Poppi, Ronei J.
author Sabin, Guilherme P.
author_facet Sabin, Guilherme P.
Lozano, Valeria Antonella
Rocha, Werickson F. C.
Romão, Wanderson
Ortiz, Rafael S.
Poppi, Ronei J.
author_role author
author2 Lozano, Valeria Antonella
Rocha, Werickson F. C.
Romão, Wanderson
Ortiz, Rafael S.
Poppi, Ronei J.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Sildenafil Citrate
Chemical Imaging
Near Infrared Spectroscopy
Multivariate Curve Resolution
Classification
Pattern Recognition
topic Sildenafil Citrate
Chemical Imaging
Near Infrared Spectroscopy
Multivariate Curve Resolution
Classification
Pattern Recognition
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The chemical imaging technique by near infrared spectroscopy was applied for characterization of formulations in tablets of sildenafil citrate of six different sources. Five formulations were provided by Brazilian Federal Police and correspond to several trademarks of prohibited marketing and one was an authentic sample of Viagra. In a first step of the study, multivariate curve resolution was properly chosen for the estimation of the distribution map of concentration of the active ingredient in tablets of different sources, where the chemical composition of all excipients constituents was not truly known. In such cases, it is very difficult to establish an appropriate calibration technique, so that only the information of sildenafil is considered independently of the excipients. This determination was possible only by reaching the second-order advantage, where the analyte quantification can be performed in the presence of unknown interferences. In a second step, the normalized histograms of images from active ingredient were grouped according to their similarities by hierarchical cluster analysis. Finally it was possible to recognize the patterns of distribution maps of concentration of sildenafil citrate, distinguishing the true formulation of Viagra. This concept can be used to improve the knowledge of industrial products and processes, as well as, for characterization of counterfeit drugs.
Fil: Sabin, Guilherme P.. Universidade Estadual de Campinas; Brasil
Fil: Lozano, Valeria Antonella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Rocha, Werickson F. C.. National Institute of Metrology, Quality and Technology. Directorate of Industrial and Scientific Metrology. Chemical Metrology Division; Brasil
Fil: Romão, Wanderson. Instituto Federal de Educação, Ciência e Tecnologia do Spirito Santo; Brasil
Fil: Ortiz, Rafael S.. Policia Federal Brasileira; Brasil
Fil: Poppi, Ronei J.. Universidade Estadual de Campinas; Brasil
description The chemical imaging technique by near infrared spectroscopy was applied for characterization of formulations in tablets of sildenafil citrate of six different sources. Five formulations were provided by Brazilian Federal Police and correspond to several trademarks of prohibited marketing and one was an authentic sample of Viagra. In a first step of the study, multivariate curve resolution was properly chosen for the estimation of the distribution map of concentration of the active ingredient in tablets of different sources, where the chemical composition of all excipients constituents was not truly known. In such cases, it is very difficult to establish an appropriate calibration technique, so that only the information of sildenafil is considered independently of the excipients. This determination was possible only by reaching the second-order advantage, where the analyte quantification can be performed in the presence of unknown interferences. In a second step, the normalized histograms of images from active ingredient were grouped according to their similarities by hierarchical cluster analysis. Finally it was possible to recognize the patterns of distribution maps of concentration of sildenafil citrate, distinguishing the true formulation of Viagra. This concept can be used to improve the knowledge of industrial products and processes, as well as, for characterization of counterfeit drugs.
publishDate 2013
dc.date.none.fl_str_mv 2013-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6028
Sabin, Guilherme P.; Lozano, Valeria Antonella; Rocha, Werickson F. C.; Romão, Wanderson; Ortiz, Rafael S.; et al.; Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools; Elsevier; Journal of Pharmaceutical and Biomedical Analysis; 85; 11-2013; 207-212
0731-7085
url http://hdl.handle.net/11336/6028
identifier_str_mv Sabin, Guilherme P.; Lozano, Valeria Antonella; Rocha, Werickson F. C.; Romão, Wanderson; Ortiz, Rafael S.; et al.; Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools; Elsevier; Journal of Pharmaceutical and Biomedical Analysis; 85; 11-2013; 207-212
0731-7085
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0731708513003427
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpba.2013.07.036
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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