Local and systemic cellular immunity in early renal artery atherosclerosis

Autores
Kotliar, Carol Virginia; Juncos, Luis Isaias; Inserra, Felipe; de Cavanagh, Elena M. V.; Chuluyan, Hector Eduardo; Aquino, Jorge Benjamin; Hita, Alejandro; Navarri, Carlos; Sanchez, Ramiro Pedro
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
BACKGROUND AND OBJECTIVES: Modern imaging techniques have increased the incidental detection of renal atherosclerotic disease (RAD). Because immune activation may hasten RAD progression, identifying cellular immune markers might provide clues to clinical activity. In this study, cellular immune markers were assessed in early RAD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Immune cell markers in peripheral blood of two groups of hypertensive patients with normal carotid and coronary arteries were evaluated: 28 patients had incidental RAD and 22 patients had normal renal arteries; 21 renal arteries obtained at necropsy from individuals with history of hypertension and tissue evidence of RAD were examined and matched with 21 individuals with normal renal arteries. Cell subpopulations were measured by flow cytometry in peripheral blood and direct cell count, respectively, using T and dendritic cells monoclonal antibodies. RESULTS: Peripheral blood of RAD patients showed increased numbers of cells expressing CD3, CD4, CD83, and CD86. CD4 to CD8 ratio was 8.3 ± 1.4 (RAD) to 3.4 ± 0.9 (normal; P<0.001). No differences were found in CD25, CD8, and S100 among groups. Postmortem samples from RAD showed increased CD3+, CD4+, CD86+, and S100+ cells, whereas CD25+ and CD8+ were unmodified between groups. CD4+ to CD8+ ratio was higher in the RAD(PM) group. CONCLUSIONS: These results are consistent with an increased expression of immune cell markers in early RAD. Additional studies will explore if they may potentially turn into treatment targets to prevent disease progression.
Fil: Kotliar, Carol Virginia. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Juncos, Luis Isaias. Universidad Nacional de Córdoba; Argentina
Fil: Inserra, Felipe. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
Fil: de Cavanagh, Elena M. V.. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
Fil: Chuluyan, Hector Eduardo. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aquino, Jorge Benjamin. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Hita, Alejandro. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
Fil: Navarri, Carlos. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
Fil: Sanchez, Ramiro Pedro. Universidad Favaloro; Argentina
Materia
Atherosclerosis
Immune Activation
Inflammatory Activation
Renovascular Disease
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/17611
Acceder
id CONICETDig_4268c6951722f566678eea375b51847f
oai_identifier_str oai:ri.conicet.gov.ar:11336/17611
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Local and systemic cellular immunity in early renal artery atherosclerosisKotliar, Carol VirginiaJuncos, Luis IsaiasInserra, Felipede Cavanagh, Elena M. V.Chuluyan, Hector EduardoAquino, Jorge BenjaminHita, AlejandroNavarri, CarlosSanchez, Ramiro PedroAtherosclerosisImmune ActivationInflammatory ActivationRenovascular Diseasehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3BACKGROUND AND OBJECTIVES: Modern imaging techniques have increased the incidental detection of renal atherosclerotic disease (RAD). Because immune activation may hasten RAD progression, identifying cellular immune markers might provide clues to clinical activity. In this study, cellular immune markers were assessed in early RAD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Immune cell markers in peripheral blood of two groups of hypertensive patients with normal carotid and coronary arteries were evaluated: 28 patients had incidental RAD and 22 patients had normal renal arteries; 21 renal arteries obtained at necropsy from individuals with history of hypertension and tissue evidence of RAD were examined and matched with 21 individuals with normal renal arteries. Cell subpopulations were measured by flow cytometry in peripheral blood and direct cell count, respectively, using T and dendritic cells monoclonal antibodies. RESULTS: Peripheral blood of RAD patients showed increased numbers of cells expressing CD3, CD4, CD83, and CD86. CD4 to CD8 ratio was 8.3 ± 1.4 (RAD) to 3.4 ± 0.9 (normal; P<0.001). No differences were found in CD25, CD8, and S100 among groups. Postmortem samples from RAD showed increased CD3+, CD4+, CD86+, and S100+ cells, whereas CD25+ and CD8+ were unmodified between groups. CD4+ to CD8+ ratio was higher in the RAD(PM) group. CONCLUSIONS: These results are consistent with an increased expression of immune cell markers in early RAD. Additional studies will explore if they may potentially turn into treatment targets to prevent disease progression.Fil: Kotliar, Carol Virginia. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Juncos, Luis Isaias. Universidad Nacional de Córdoba; ArgentinaFil: Inserra, Felipe. Universidad Austral. Facultad de Ciencias Biomédicas; ArgentinaFil: de Cavanagh, Elena M. V.. Universidad Austral. Facultad de Ciencias Biomédicas; ArgentinaFil: Chuluyan, Hector Eduardo. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aquino, Jorge Benjamin. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Hita, Alejandro. Universidad Austral. Facultad de Ciencias Biomédicas; ArgentinaFil: Navarri, Carlos. Universidad Austral. Facultad de Ciencias Biomédicas; ArgentinaFil: Sanchez, Ramiro Pedro. Universidad Favaloro; ArgentinaAmer Soc Nephrology2012-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/17611Kotliar, Carol Virginia; Juncos, Luis Isaias; Inserra, Felipe; de Cavanagh, Elena M. V.; Chuluyan, Hector Eduardo; et al.; Local and systemic cellular immunity in early renal artery atherosclerosis; Amer Soc Nephrology; Clinical Journal Of The American Society Of Nephrology; 7; 2; 2-2012; 224-2301555-90411555-905Xenginfo:eu-repo/semantics/altIdentifier/url/http://cjasn.asnjournals.org/content/7/2/224.longinfo:eu-repo/semantics/altIdentifier/doi/10.2215/CJN.06270611info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:07:06Zoai:ri.conicet.gov.ar:11336/17611instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:07:07.103CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Local and systemic cellular immunity in early renal artery atherosclerosis
title Local and systemic cellular immunity in early renal artery atherosclerosis
spellingShingle Local and systemic cellular immunity in early renal artery atherosclerosis
Kotliar, Carol Virginia
Atherosclerosis
Immune Activation
Inflammatory Activation
Renovascular Disease
title_short Local and systemic cellular immunity in early renal artery atherosclerosis
title_full Local and systemic cellular immunity in early renal artery atherosclerosis
title_fullStr Local and systemic cellular immunity in early renal artery atherosclerosis
title_full_unstemmed Local and systemic cellular immunity in early renal artery atherosclerosis
title_sort Local and systemic cellular immunity in early renal artery atherosclerosis
dc.creator.none.fl_str_mv Kotliar, Carol Virginia
Juncos, Luis Isaias
Inserra, Felipe
de Cavanagh, Elena M. V.
Chuluyan, Hector Eduardo
Aquino, Jorge Benjamin
Hita, Alejandro
Navarri, Carlos
Sanchez, Ramiro Pedro
author Kotliar, Carol Virginia
author_facet Kotliar, Carol Virginia
Juncos, Luis Isaias
Inserra, Felipe
de Cavanagh, Elena M. V.
Chuluyan, Hector Eduardo
Aquino, Jorge Benjamin
Hita, Alejandro
Navarri, Carlos
Sanchez, Ramiro Pedro
author_role author
author2 Juncos, Luis Isaias
Inserra, Felipe
de Cavanagh, Elena M. V.
Chuluyan, Hector Eduardo
Aquino, Jorge Benjamin
Hita, Alejandro
Navarri, Carlos
Sanchez, Ramiro Pedro
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Atherosclerosis
Immune Activation
Inflammatory Activation
Renovascular Disease
topic Atherosclerosis
Immune Activation
Inflammatory Activation
Renovascular Disease
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv BACKGROUND AND OBJECTIVES: Modern imaging techniques have increased the incidental detection of renal atherosclerotic disease (RAD). Because immune activation may hasten RAD progression, identifying cellular immune markers might provide clues to clinical activity. In this study, cellular immune markers were assessed in early RAD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Immune cell markers in peripheral blood of two groups of hypertensive patients with normal carotid and coronary arteries were evaluated: 28 patients had incidental RAD and 22 patients had normal renal arteries; 21 renal arteries obtained at necropsy from individuals with history of hypertension and tissue evidence of RAD were examined and matched with 21 individuals with normal renal arteries. Cell subpopulations were measured by flow cytometry in peripheral blood and direct cell count, respectively, using T and dendritic cells monoclonal antibodies. RESULTS: Peripheral blood of RAD patients showed increased numbers of cells expressing CD3, CD4, CD83, and CD86. CD4 to CD8 ratio was 8.3 ± 1.4 (RAD) to 3.4 ± 0.9 (normal; P<0.001). No differences were found in CD25, CD8, and S100 among groups. Postmortem samples from RAD showed increased CD3+, CD4+, CD86+, and S100+ cells, whereas CD25+ and CD8+ were unmodified between groups. CD4+ to CD8+ ratio was higher in the RAD(PM) group. CONCLUSIONS: These results are consistent with an increased expression of immune cell markers in early RAD. Additional studies will explore if they may potentially turn into treatment targets to prevent disease progression.
Fil: Kotliar, Carol Virginia. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Juncos, Luis Isaias. Universidad Nacional de Córdoba; Argentina
Fil: Inserra, Felipe. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
Fil: de Cavanagh, Elena M. V.. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
Fil: Chuluyan, Hector Eduardo. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aquino, Jorge Benjamin. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Hita, Alejandro. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
Fil: Navarri, Carlos. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
Fil: Sanchez, Ramiro Pedro. Universidad Favaloro; Argentina
description BACKGROUND AND OBJECTIVES: Modern imaging techniques have increased the incidental detection of renal atherosclerotic disease (RAD). Because immune activation may hasten RAD progression, identifying cellular immune markers might provide clues to clinical activity. In this study, cellular immune markers were assessed in early RAD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Immune cell markers in peripheral blood of two groups of hypertensive patients with normal carotid and coronary arteries were evaluated: 28 patients had incidental RAD and 22 patients had normal renal arteries; 21 renal arteries obtained at necropsy from individuals with history of hypertension and tissue evidence of RAD were examined and matched with 21 individuals with normal renal arteries. Cell subpopulations were measured by flow cytometry in peripheral blood and direct cell count, respectively, using T and dendritic cells monoclonal antibodies. RESULTS: Peripheral blood of RAD patients showed increased numbers of cells expressing CD3, CD4, CD83, and CD86. CD4 to CD8 ratio was 8.3 ± 1.4 (RAD) to 3.4 ± 0.9 (normal; P<0.001). No differences were found in CD25, CD8, and S100 among groups. Postmortem samples from RAD showed increased CD3+, CD4+, CD86+, and S100+ cells, whereas CD25+ and CD8+ were unmodified between groups. CD4+ to CD8+ ratio was higher in the RAD(PM) group. CONCLUSIONS: These results are consistent with an increased expression of immune cell markers in early RAD. Additional studies will explore if they may potentially turn into treatment targets to prevent disease progression.
publishDate 2012
dc.date.none.fl_str_mv 2012-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/17611
Kotliar, Carol Virginia; Juncos, Luis Isaias; Inserra, Felipe; de Cavanagh, Elena M. V.; Chuluyan, Hector Eduardo; et al.; Local and systemic cellular immunity in early renal artery atherosclerosis; Amer Soc Nephrology; Clinical Journal Of The American Society Of Nephrology; 7; 2; 2-2012; 224-230
1555-9041
1555-905X
url http://hdl.handle.net/11336/17611
identifier_str_mv Kotliar, Carol Virginia; Juncos, Luis Isaias; Inserra, Felipe; de Cavanagh, Elena M. V.; Chuluyan, Hector Eduardo; et al.; Local and systemic cellular immunity in early renal artery atherosclerosis; Amer Soc Nephrology; Clinical Journal Of The American Society Of Nephrology; 7; 2; 2-2012; 224-230
1555-9041
1555-905X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://cjasn.asnjournals.org/content/7/2/224.long
info:eu-repo/semantics/altIdentifier/doi/10.2215/CJN.06270611
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Amer Soc Nephrology
publisher.none.fl_str_mv Amer Soc Nephrology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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