Local and systemic cellular immunity in early renal artery atherosclerosis
- Autores
- Kotliar, Carol Virginia; Juncos, Luis Isaias; Inserra, Felipe; de Cavanagh, Elena M. V.; Chuluyan, Hector Eduardo; Aquino, Jorge Benjamin; Hita, Alejandro; Navarri, Carlos; Sanchez, Ramiro Pedro
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- BACKGROUND AND OBJECTIVES: Modern imaging techniques have increased the incidental detection of renal atherosclerotic disease (RAD). Because immune activation may hasten RAD progression, identifying cellular immune markers might provide clues to clinical activity. In this study, cellular immune markers were assessed in early RAD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Immune cell markers in peripheral blood of two groups of hypertensive patients with normal carotid and coronary arteries were evaluated: 28 patients had incidental RAD and 22 patients had normal renal arteries; 21 renal arteries obtained at necropsy from individuals with history of hypertension and tissue evidence of RAD were examined and matched with 21 individuals with normal renal arteries. Cell subpopulations were measured by flow cytometry in peripheral blood and direct cell count, respectively, using T and dendritic cells monoclonal antibodies. RESULTS: Peripheral blood of RAD patients showed increased numbers of cells expressing CD3, CD4, CD83, and CD86. CD4 to CD8 ratio was 8.3 ± 1.4 (RAD) to 3.4 ± 0.9 (normal; P<0.001). No differences were found in CD25, CD8, and S100 among groups. Postmortem samples from RAD showed increased CD3+, CD4+, CD86+, and S100+ cells, whereas CD25+ and CD8+ were unmodified between groups. CD4+ to CD8+ ratio was higher in the RAD(PM) group. CONCLUSIONS: These results are consistent with an increased expression of immune cell markers in early RAD. Additional studies will explore if they may potentially turn into treatment targets to prevent disease progression.
Fil: Kotliar, Carol Virginia. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Juncos, Luis Isaias. Universidad Nacional de Córdoba; Argentina
Fil: Inserra, Felipe. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
Fil: de Cavanagh, Elena M. V.. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
Fil: Chuluyan, Hector Eduardo. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aquino, Jorge Benjamin. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Hita, Alejandro. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
Fil: Navarri, Carlos. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina
Fil: Sanchez, Ramiro Pedro. Universidad Favaloro; Argentina - Materia
-
Atherosclerosis
Immune Activation
Inflammatory Activation
Renovascular Disease - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/17611
Ver los metadatos del registro completo
id |
CONICETDig_4268c6951722f566678eea375b51847f |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/17611 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Local and systemic cellular immunity in early renal artery atherosclerosisKotliar, Carol VirginiaJuncos, Luis IsaiasInserra, Felipede Cavanagh, Elena M. V.Chuluyan, Hector EduardoAquino, Jorge BenjaminHita, AlejandroNavarri, CarlosSanchez, Ramiro PedroAtherosclerosisImmune ActivationInflammatory ActivationRenovascular Diseasehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3BACKGROUND AND OBJECTIVES: Modern imaging techniques have increased the incidental detection of renal atherosclerotic disease (RAD). Because immune activation may hasten RAD progression, identifying cellular immune markers might provide clues to clinical activity. In this study, cellular immune markers were assessed in early RAD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Immune cell markers in peripheral blood of two groups of hypertensive patients with normal carotid and coronary arteries were evaluated: 28 patients had incidental RAD and 22 patients had normal renal arteries; 21 renal arteries obtained at necropsy from individuals with history of hypertension and tissue evidence of RAD were examined and matched with 21 individuals with normal renal arteries. Cell subpopulations were measured by flow cytometry in peripheral blood and direct cell count, respectively, using T and dendritic cells monoclonal antibodies. RESULTS: Peripheral blood of RAD patients showed increased numbers of cells expressing CD3, CD4, CD83, and CD86. CD4 to CD8 ratio was 8.3 ± 1.4 (RAD) to 3.4 ± 0.9 (normal; P<0.001). No differences were found in CD25, CD8, and S100 among groups. Postmortem samples from RAD showed increased CD3+, CD4+, CD86+, and S100+ cells, whereas CD25+ and CD8+ were unmodified between groups. CD4+ to CD8+ ratio was higher in the RAD(PM) group. CONCLUSIONS: These results are consistent with an increased expression of immune cell markers in early RAD. Additional studies will explore if they may potentially turn into treatment targets to prevent disease progression.Fil: Kotliar, Carol Virginia. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Juncos, Luis Isaias. Universidad Nacional de Córdoba; ArgentinaFil: Inserra, Felipe. Universidad Austral. Facultad de Ciencias Biomédicas; ArgentinaFil: de Cavanagh, Elena M. V.. Universidad Austral. Facultad de Ciencias Biomédicas; ArgentinaFil: Chuluyan, Hector Eduardo. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aquino, Jorge Benjamin. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Hita, Alejandro. Universidad Austral. Facultad de Ciencias Biomédicas; ArgentinaFil: Navarri, Carlos. Universidad Austral. Facultad de Ciencias Biomédicas; ArgentinaFil: Sanchez, Ramiro Pedro. Universidad Favaloro; ArgentinaAmer Soc Nephrology2012-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/17611Kotliar, Carol Virginia; Juncos, Luis Isaias; Inserra, Felipe; de Cavanagh, Elena M. V.; Chuluyan, Hector Eduardo; et al.; Local and systemic cellular immunity in early renal artery atherosclerosis; Amer Soc Nephrology; Clinical Journal Of The American Society Of Nephrology; 7; 2; 2-2012; 224-2301555-90411555-905Xenginfo:eu-repo/semantics/altIdentifier/url/http://cjasn.asnjournals.org/content/7/2/224.longinfo:eu-repo/semantics/altIdentifier/doi/10.2215/CJN.06270611info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:34:43Zoai:ri.conicet.gov.ar:11336/17611instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:34:43.878CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Local and systemic cellular immunity in early renal artery atherosclerosis |
title |
Local and systemic cellular immunity in early renal artery atherosclerosis |
spellingShingle |
Local and systemic cellular immunity in early renal artery atherosclerosis Kotliar, Carol Virginia Atherosclerosis Immune Activation Inflammatory Activation Renovascular Disease |
title_short |
Local and systemic cellular immunity in early renal artery atherosclerosis |
title_full |
Local and systemic cellular immunity in early renal artery atherosclerosis |
title_fullStr |
Local and systemic cellular immunity in early renal artery atherosclerosis |
title_full_unstemmed |
Local and systemic cellular immunity in early renal artery atherosclerosis |
title_sort |
Local and systemic cellular immunity in early renal artery atherosclerosis |
dc.creator.none.fl_str_mv |
Kotliar, Carol Virginia Juncos, Luis Isaias Inserra, Felipe de Cavanagh, Elena M. V. Chuluyan, Hector Eduardo Aquino, Jorge Benjamin Hita, Alejandro Navarri, Carlos Sanchez, Ramiro Pedro |
author |
Kotliar, Carol Virginia |
author_facet |
Kotliar, Carol Virginia Juncos, Luis Isaias Inserra, Felipe de Cavanagh, Elena M. V. Chuluyan, Hector Eduardo Aquino, Jorge Benjamin Hita, Alejandro Navarri, Carlos Sanchez, Ramiro Pedro |
author_role |
author |
author2 |
Juncos, Luis Isaias Inserra, Felipe de Cavanagh, Elena M. V. Chuluyan, Hector Eduardo Aquino, Jorge Benjamin Hita, Alejandro Navarri, Carlos Sanchez, Ramiro Pedro |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Atherosclerosis Immune Activation Inflammatory Activation Renovascular Disease |
topic |
Atherosclerosis Immune Activation Inflammatory Activation Renovascular Disease |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
BACKGROUND AND OBJECTIVES: Modern imaging techniques have increased the incidental detection of renal atherosclerotic disease (RAD). Because immune activation may hasten RAD progression, identifying cellular immune markers might provide clues to clinical activity. In this study, cellular immune markers were assessed in early RAD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Immune cell markers in peripheral blood of two groups of hypertensive patients with normal carotid and coronary arteries were evaluated: 28 patients had incidental RAD and 22 patients had normal renal arteries; 21 renal arteries obtained at necropsy from individuals with history of hypertension and tissue evidence of RAD were examined and matched with 21 individuals with normal renal arteries. Cell subpopulations were measured by flow cytometry in peripheral blood and direct cell count, respectively, using T and dendritic cells monoclonal antibodies. RESULTS: Peripheral blood of RAD patients showed increased numbers of cells expressing CD3, CD4, CD83, and CD86. CD4 to CD8 ratio was 8.3 ± 1.4 (RAD) to 3.4 ± 0.9 (normal; P<0.001). No differences were found in CD25, CD8, and S100 among groups. Postmortem samples from RAD showed increased CD3+, CD4+, CD86+, and S100+ cells, whereas CD25+ and CD8+ were unmodified between groups. CD4+ to CD8+ ratio was higher in the RAD(PM) group. CONCLUSIONS: These results are consistent with an increased expression of immune cell markers in early RAD. Additional studies will explore if they may potentially turn into treatment targets to prevent disease progression. Fil: Kotliar, Carol Virginia. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Juncos, Luis Isaias. Universidad Nacional de Córdoba; Argentina Fil: Inserra, Felipe. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina Fil: de Cavanagh, Elena M. V.. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina Fil: Chuluyan, Hector Eduardo. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Aquino, Jorge Benjamin. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Hita, Alejandro. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina Fil: Navarri, Carlos. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina Fil: Sanchez, Ramiro Pedro. Universidad Favaloro; Argentina |
description |
BACKGROUND AND OBJECTIVES: Modern imaging techniques have increased the incidental detection of renal atherosclerotic disease (RAD). Because immune activation may hasten RAD progression, identifying cellular immune markers might provide clues to clinical activity. In this study, cellular immune markers were assessed in early RAD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Immune cell markers in peripheral blood of two groups of hypertensive patients with normal carotid and coronary arteries were evaluated: 28 patients had incidental RAD and 22 patients had normal renal arteries; 21 renal arteries obtained at necropsy from individuals with history of hypertension and tissue evidence of RAD were examined and matched with 21 individuals with normal renal arteries. Cell subpopulations were measured by flow cytometry in peripheral blood and direct cell count, respectively, using T and dendritic cells monoclonal antibodies. RESULTS: Peripheral blood of RAD patients showed increased numbers of cells expressing CD3, CD4, CD83, and CD86. CD4 to CD8 ratio was 8.3 ± 1.4 (RAD) to 3.4 ± 0.9 (normal; P<0.001). No differences were found in CD25, CD8, and S100 among groups. Postmortem samples from RAD showed increased CD3+, CD4+, CD86+, and S100+ cells, whereas CD25+ and CD8+ were unmodified between groups. CD4+ to CD8+ ratio was higher in the RAD(PM) group. CONCLUSIONS: These results are consistent with an increased expression of immune cell markers in early RAD. Additional studies will explore if they may potentially turn into treatment targets to prevent disease progression. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/17611 Kotliar, Carol Virginia; Juncos, Luis Isaias; Inserra, Felipe; de Cavanagh, Elena M. V.; Chuluyan, Hector Eduardo; et al.; Local and systemic cellular immunity in early renal artery atherosclerosis; Amer Soc Nephrology; Clinical Journal Of The American Society Of Nephrology; 7; 2; 2-2012; 224-230 1555-9041 1555-905X |
url |
http://hdl.handle.net/11336/17611 |
identifier_str_mv |
Kotliar, Carol Virginia; Juncos, Luis Isaias; Inserra, Felipe; de Cavanagh, Elena M. V.; Chuluyan, Hector Eduardo; et al.; Local and systemic cellular immunity in early renal artery atherosclerosis; Amer Soc Nephrology; Clinical Journal Of The American Society Of Nephrology; 7; 2; 2-2012; 224-230 1555-9041 1555-905X |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://cjasn.asnjournals.org/content/7/2/224.long info:eu-repo/semantics/altIdentifier/doi/10.2215/CJN.06270611 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Amer Soc Nephrology |
publisher.none.fl_str_mv |
Amer Soc Nephrology |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844614364043149312 |
score |
13.070432 |