The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer

Autores
Ferronato, María Julia; Obiol, Diego Javier; Fermento, María Eugenia; Gandini, Norberto Ariel; Alonso, Eliana Noelia; Salomón, Débora Gisele; Vitale, Cristian Alejandro; Mascaro, Evangelina; Fall, Yagamare; Raimondi, Ana Rosa; Curino, Alejandro Carlos; Facchinetti, Maria Marta
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The active form of vitamin D3, calcitriol, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and prodifferentiating agent. However, when effective antitumor doses of calcitriol are employed, hypercalcemic effects are observed, thus precluding its therapeutic application. To overcome this problem, structural analogues have been designed with the aim at retaining or even increasing the antitumor effects while decreasing its calcemic activity. This report shows the biological evaluation of an alkynylphosphonate vitamin D less-calcemic analogue in amurine model of breast cancer. We demonstrate that this compound has potent anti-metastatic effects through its action over cellular migration and invasion likely mediated through the up-regulation of Ecadherin expression. Based on the current in vitro and in vivo results, EM1 is a promising candidate as atherapeutic agent in breast cancer.
Fil: Ferronato, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina
Fil: Obiol, Diego Javier. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.Bioquimicas Bahia Blanca (i); Argentina
Fil: Fermento, María Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.Bioquimicas Bahia Blanca (i); Argentina
Fil: Gandini, Norberto Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.Bioquimicas Bahia Blanca (i); Argentina
Fil: Alonso, Eliana Noelia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.Bioquimicas Bahia Blanca (i); Argentina
Fil: Salomón, Débora Gisele. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.Bioquimicas Bahia Blanca (i); Argentina
Fil: Vitale, Cristian Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina
Fil: Mascaro, Evangelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina
Fil: Fall, Yagamare. Universidad de Vigo; España
Fil: Raimondi, Ana Rosa. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina
Fil: Curino, Alejandro Carlos. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
Fil: Facchinetti, Maria Marta. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
Materia
Breast Cancer
Analogue
Calcitriol
Vitamin D
Alkynylphosphonate
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/4376
Acceder
id CONICETDig_4252960d04b05a728886d2f92b7f7345
oai_identifier_str oai:ri.conicet.gov.ar:11336/4376
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancerFerronato, María JuliaObiol, Diego JavierFermento, María EugeniaGandini, Norberto ArielAlonso, Eliana NoeliaSalomón, Débora GiseleVitale, Cristian AlejandroMascaro, EvangelinaFall, YagamareRaimondi, Ana RosaCurino, Alejandro CarlosFacchinetti, Maria MartaBreast CancerAnalogueCalcitriolVitamin DAlkynylphosphonatehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The active form of vitamin D3, calcitriol, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and prodifferentiating agent. However, when effective antitumor doses of calcitriol are employed, hypercalcemic effects are observed, thus precluding its therapeutic application. To overcome this problem, structural analogues have been designed with the aim at retaining or even increasing the antitumor effects while decreasing its calcemic activity. This report shows the biological evaluation of an alkynylphosphonate vitamin D less-calcemic analogue in amurine model of breast cancer. We demonstrate that this compound has potent anti-metastatic effects through its action over cellular migration and invasion likely mediated through the up-regulation of Ecadherin expression. Based on the current in vitro and in vivo results, EM1 is a promising candidate as atherapeutic agent in breast cancer.Fil: Ferronato, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); ArgentinaFil: Obiol, Diego Javier. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.Bioquimicas Bahia Blanca (i); ArgentinaFil: Fermento, María Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.Bioquimicas Bahia Blanca (i); ArgentinaFil: Gandini, Norberto Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.Bioquimicas Bahia Blanca (i); ArgentinaFil: Alonso, Eliana Noelia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.Bioquimicas Bahia Blanca (i); ArgentinaFil: Salomón, Débora Gisele. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.Bioquimicas Bahia Blanca (i); ArgentinaFil: Vitale, Cristian Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; ArgentinaFil: Mascaro, Evangelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; ArgentinaFil: Fall, Yagamare. Universidad de Vigo; EspañaFil: Raimondi, Ana Rosa. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; ArgentinaFil: Curino, Alejandro Carlos. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); ArgentinaFil: Facchinetti, Maria Marta. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); ArgentinaPergamon-elsevier Science Ltd2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/4376Ferronato, María Julia; Obiol, Diego Javier; Fermento, María Eugenia; Gandini, Norberto Ariel; Alonso, Eliana Noelia; et al.; The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer; Pergamon-elsevier Science Ltd; Journal Of Steroid Biochemistry And Molecular Biology; 154; 9-2015; 285-2930960-0760enginfo:eu-repo/semantics/altIdentifier/pmid/PMID: 26365558info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jsbmb.2015.09.009info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/url/www.ncbi.nlm.nih.gov/pubmed/26365558info:eu-repo/semantics/altIdentifier/ark/http://www.sciencedirect.com/science/article/pii/S0960076015300698info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:06Zoai:ri.conicet.gov.ar:11336/4376instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:06.699CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer
title The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer
spellingShingle The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer
Ferronato, María Julia
Breast Cancer
Analogue
Calcitriol
Vitamin D
Alkynylphosphonate
title_short The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer
title_full The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer
title_fullStr The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer
title_full_unstemmed The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer
title_sort The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer
dc.creator.none.fl_str_mv Ferronato, María Julia
Obiol, Diego Javier
Fermento, María Eugenia
Gandini, Norberto Ariel
Alonso, Eliana Noelia
Salomón, Débora Gisele
Vitale, Cristian Alejandro
Mascaro, Evangelina
Fall, Yagamare
Raimondi, Ana Rosa
Curino, Alejandro Carlos
Facchinetti, Maria Marta
author Ferronato, María Julia
author_facet Ferronato, María Julia
Obiol, Diego Javier
Fermento, María Eugenia
Gandini, Norberto Ariel
Alonso, Eliana Noelia
Salomón, Débora Gisele
Vitale, Cristian Alejandro
Mascaro, Evangelina
Fall, Yagamare
Raimondi, Ana Rosa
Curino, Alejandro Carlos
Facchinetti, Maria Marta
author_role author
author2 Obiol, Diego Javier
Fermento, María Eugenia
Gandini, Norberto Ariel
Alonso, Eliana Noelia
Salomón, Débora Gisele
Vitale, Cristian Alejandro
Mascaro, Evangelina
Fall, Yagamare
Raimondi, Ana Rosa
Curino, Alejandro Carlos
Facchinetti, Maria Marta
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Breast Cancer
Analogue
Calcitriol
Vitamin D
Alkynylphosphonate
topic Breast Cancer
Analogue
Calcitriol
Vitamin D
Alkynylphosphonate
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The active form of vitamin D3, calcitriol, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and prodifferentiating agent. However, when effective antitumor doses of calcitriol are employed, hypercalcemic effects are observed, thus precluding its therapeutic application. To overcome this problem, structural analogues have been designed with the aim at retaining or even increasing the antitumor effects while decreasing its calcemic activity. This report shows the biological evaluation of an alkynylphosphonate vitamin D less-calcemic analogue in amurine model of breast cancer. We demonstrate that this compound has potent anti-metastatic effects through its action over cellular migration and invasion likely mediated through the up-regulation of Ecadherin expression. Based on the current in vitro and in vivo results, EM1 is a promising candidate as atherapeutic agent in breast cancer.
Fil: Ferronato, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina
Fil: Obiol, Diego Javier. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.Bioquimicas Bahia Blanca (i); Argentina
Fil: Fermento, María Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.Bioquimicas Bahia Blanca (i); Argentina
Fil: Gandini, Norberto Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.Bioquimicas Bahia Blanca (i); Argentina
Fil: Alonso, Eliana Noelia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.Bioquimicas Bahia Blanca (i); Argentina
Fil: Salomón, Débora Gisele. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.Bioquimicas Bahia Blanca (i); Argentina
Fil: Vitale, Cristian Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina
Fil: Mascaro, Evangelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina
Fil: Fall, Yagamare. Universidad de Vigo; España
Fil: Raimondi, Ana Rosa. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina
Fil: Curino, Alejandro Carlos. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
Fil: Facchinetti, Maria Marta. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Invest.bioquimicas Bahia Blanca (i); Argentina
description The active form of vitamin D3, calcitriol, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and prodifferentiating agent. However, when effective antitumor doses of calcitriol are employed, hypercalcemic effects are observed, thus precluding its therapeutic application. To overcome this problem, structural analogues have been designed with the aim at retaining or even increasing the antitumor effects while decreasing its calcemic activity. This report shows the biological evaluation of an alkynylphosphonate vitamin D less-calcemic analogue in amurine model of breast cancer. We demonstrate that this compound has potent anti-metastatic effects through its action over cellular migration and invasion likely mediated through the up-regulation of Ecadherin expression. Based on the current in vitro and in vivo results, EM1 is a promising candidate as atherapeutic agent in breast cancer.
publishDate 2015
dc.date.none.fl_str_mv 2015-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/4376
Ferronato, María Julia; Obiol, Diego Javier; Fermento, María Eugenia; Gandini, Norberto Ariel; Alonso, Eliana Noelia; et al.; The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer; Pergamon-elsevier Science Ltd; Journal Of Steroid Biochemistry And Molecular Biology; 154; 9-2015; 285-293
0960-0760
url http://hdl.handle.net/11336/4376
identifier_str_mv Ferronato, María Julia; Obiol, Diego Javier; Fermento, María Eugenia; Gandini, Norberto Ariel; Alonso, Eliana Noelia; et al.; The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer; Pergamon-elsevier Science Ltd; Journal Of Steroid Biochemistry And Molecular Biology; 154; 9-2015; 285-293
0960-0760
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/pmid/PMID: 26365558
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jsbmb.2015.09.009
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/url/www.ncbi.nlm.nih.gov/pubmed/26365558
info:eu-repo/semantics/altIdentifier/ark/http://www.sciencedirect.com/science/article/pii/S0960076015300698
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Pergamon-elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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