Beta-minus emitters dose point kernel estimation model comprising different tissues for nuclear medicine dosimetry applications

Autores
Pérez, Pedro Antonio; Geser, Federico Alejandro; Scarinci, Ignacio Emanuel; Malano, Francisco Mauricio; Valente, Mauro Andres
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The use of β-emitters for therapy purposes is one of the most extended procedures for tumor treatments in nuclear medicine practices over the last years. The constantly increasing dose delivery to healthy tissues in this practices, due to their high linear energy transfer and their radiobiological characteristics, might lead to complications in radiosensitive organs/tissues. Research efforts should be conducted to the development of tools and methods devoted to perform precise dosimetric calculations to deal with this issue and assess accurately dosimetric estimations on patients treated regions.When performing dosimetry at organ level it is usual to assume some approximations on calculations, like uniformity in activity distribution within source regions, homogeneous media distribution for patient treated regions and uniform delivered dose on target organs. In this work, a formula to obtain Dose Point Kernel for different biological media is presented. Results are collated with Monte Carlo simulations suggesting a behavior that can be splitted in three groups, in accordance to their differences against the stochastic estimations: a) skin, blood and brain present differences within the 5% in comparison with the reference data; b) skeletal muscle, soft tissue, striated muscle and adipose tissue have differences lower than 20%; and c) compact bone, cortical bone and lung tissue differences are found above 50%.This introduction of a medium-specific Dose Point Kernel calculation method could potentially lead to future improvements on dosimetric systems, limiting for now this model to tissues with effective atomic number closed to liquid water.
Fil: Pérez, Pedro Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Geser, Federico Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Scarinci, Ignacio Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Malano, Francisco Mauricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Valente, Mauro Andres. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad de La Frontera; Chile
Materia
DOSE POINT KERNEL
RADIOISOTOPE
MONTE CARLO SIMULATION
THEORETICAL MODELS
TARGETED RADIONUCLIDE THERAPY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/186251
Acceder
id CONICETDig_40cc613c006878264a978ba5c30d1bee
oai_identifier_str oai:ri.conicet.gov.ar:11336/186251
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Beta-minus emitters dose point kernel estimation model comprising different tissues for nuclear medicine dosimetry applicationsPérez, Pedro AntonioGeser, Federico AlejandroScarinci, Ignacio EmanuelMalano, Francisco MauricioValente, Mauro AndresDOSE POINT KERNELRADIOISOTOPEMONTE CARLO SIMULATIONTHEORETICAL MODELSTARGETED RADIONUCLIDE THERAPYhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1The use of β-emitters for therapy purposes is one of the most extended procedures for tumor treatments in nuclear medicine practices over the last years. The constantly increasing dose delivery to healthy tissues in this practices, due to their high linear energy transfer and their radiobiological characteristics, might lead to complications in radiosensitive organs/tissues. Research efforts should be conducted to the development of tools and methods devoted to perform precise dosimetric calculations to deal with this issue and assess accurately dosimetric estimations on patients treated regions.When performing dosimetry at organ level it is usual to assume some approximations on calculations, like uniformity in activity distribution within source regions, homogeneous media distribution for patient treated regions and uniform delivered dose on target organs. In this work, a formula to obtain Dose Point Kernel for different biological media is presented. Results are collated with Monte Carlo simulations suggesting a behavior that can be splitted in three groups, in accordance to their differences against the stochastic estimations: a) skin, blood and brain present differences within the 5% in comparison with the reference data; b) skeletal muscle, soft tissue, striated muscle and adipose tissue have differences lower than 20%; and c) compact bone, cortical bone and lung tissue differences are found above 50%.This introduction of a medium-specific Dose Point Kernel calculation method could potentially lead to future improvements on dosimetric systems, limiting for now this model to tissues with effective atomic number closed to liquid water.Fil: Pérez, Pedro Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaFil: Geser, Federico Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Scarinci, Ignacio Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaFil: Malano, Francisco Mauricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaFil: Valente, Mauro Andres. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad de La Frontera; ChileCosmos Scholars Publishing House2016-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/186251Pérez, Pedro Antonio; Geser, Federico Alejandro; Scarinci, Ignacio Emanuel; Malano, Francisco Mauricio; Valente, Mauro Andres; Beta-minus emitters dose point kernel estimation model comprising different tissues for nuclear medicine dosimetry applications; Cosmos Scholars Publishing House; International Journal of Nuclear Medicine Research; 3; 2; 9-2016; 45-552408-9788CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.cosmosscholars.com/previous-issue-ijnmr/46-abstracts/ijnmr/593-abstract-beta-minus-emitters-dose-point-kernel-estimation-model-comprising-different-tissues-for-nuclear-medicine-dosimetry-applicationsinfo:eu-repo/semantics/altIdentifier/doi/10.15379/2408-9788.2016.03.02.02info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)https://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:24:07Zoai:ri.conicet.gov.ar:11336/186251instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:24:08.207CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Beta-minus emitters dose point kernel estimation model comprising different tissues for nuclear medicine dosimetry applications
title Beta-minus emitters dose point kernel estimation model comprising different tissues for nuclear medicine dosimetry applications
spellingShingle Beta-minus emitters dose point kernel estimation model comprising different tissues for nuclear medicine dosimetry applications
Pérez, Pedro Antonio
DOSE POINT KERNEL
RADIOISOTOPE
MONTE CARLO SIMULATION
THEORETICAL MODELS
TARGETED RADIONUCLIDE THERAPY
title_short Beta-minus emitters dose point kernel estimation model comprising different tissues for nuclear medicine dosimetry applications
title_full Beta-minus emitters dose point kernel estimation model comprising different tissues for nuclear medicine dosimetry applications
title_fullStr Beta-minus emitters dose point kernel estimation model comprising different tissues for nuclear medicine dosimetry applications
title_full_unstemmed Beta-minus emitters dose point kernel estimation model comprising different tissues for nuclear medicine dosimetry applications
title_sort Beta-minus emitters dose point kernel estimation model comprising different tissues for nuclear medicine dosimetry applications
dc.creator.none.fl_str_mv Pérez, Pedro Antonio
Geser, Federico Alejandro
Scarinci, Ignacio Emanuel
Malano, Francisco Mauricio
Valente, Mauro Andres
author Pérez, Pedro Antonio
author_facet Pérez, Pedro Antonio
Geser, Federico Alejandro
Scarinci, Ignacio Emanuel
Malano, Francisco Mauricio
Valente, Mauro Andres
author_role author
author2 Geser, Federico Alejandro
Scarinci, Ignacio Emanuel
Malano, Francisco Mauricio
Valente, Mauro Andres
author2_role author
author
author
author
dc.subject.none.fl_str_mv DOSE POINT KERNEL
RADIOISOTOPE
MONTE CARLO SIMULATION
THEORETICAL MODELS
TARGETED RADIONUCLIDE THERAPY
topic DOSE POINT KERNEL
RADIOISOTOPE
MONTE CARLO SIMULATION
THEORETICAL MODELS
TARGETED RADIONUCLIDE THERAPY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The use of β-emitters for therapy purposes is one of the most extended procedures for tumor treatments in nuclear medicine practices over the last years. The constantly increasing dose delivery to healthy tissues in this practices, due to their high linear energy transfer and their radiobiological characteristics, might lead to complications in radiosensitive organs/tissues. Research efforts should be conducted to the development of tools and methods devoted to perform precise dosimetric calculations to deal with this issue and assess accurately dosimetric estimations on patients treated regions.When performing dosimetry at organ level it is usual to assume some approximations on calculations, like uniformity in activity distribution within source regions, homogeneous media distribution for patient treated regions and uniform delivered dose on target organs. In this work, a formula to obtain Dose Point Kernel for different biological media is presented. Results are collated with Monte Carlo simulations suggesting a behavior that can be splitted in three groups, in accordance to their differences against the stochastic estimations: a) skin, blood and brain present differences within the 5% in comparison with the reference data; b) skeletal muscle, soft tissue, striated muscle and adipose tissue have differences lower than 20%; and c) compact bone, cortical bone and lung tissue differences are found above 50%.This introduction of a medium-specific Dose Point Kernel calculation method could potentially lead to future improvements on dosimetric systems, limiting for now this model to tissues with effective atomic number closed to liquid water.
Fil: Pérez, Pedro Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Geser, Federico Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Scarinci, Ignacio Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Malano, Francisco Mauricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Valente, Mauro Andres. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad de La Frontera; Chile
description The use of β-emitters for therapy purposes is one of the most extended procedures for tumor treatments in nuclear medicine practices over the last years. The constantly increasing dose delivery to healthy tissues in this practices, due to their high linear energy transfer and their radiobiological characteristics, might lead to complications in radiosensitive organs/tissues. Research efforts should be conducted to the development of tools and methods devoted to perform precise dosimetric calculations to deal with this issue and assess accurately dosimetric estimations on patients treated regions.When performing dosimetry at organ level it is usual to assume some approximations on calculations, like uniformity in activity distribution within source regions, homogeneous media distribution for patient treated regions and uniform delivered dose on target organs. In this work, a formula to obtain Dose Point Kernel for different biological media is presented. Results are collated with Monte Carlo simulations suggesting a behavior that can be splitted in three groups, in accordance to their differences against the stochastic estimations: a) skin, blood and brain present differences within the 5% in comparison with the reference data; b) skeletal muscle, soft tissue, striated muscle and adipose tissue have differences lower than 20%; and c) compact bone, cortical bone and lung tissue differences are found above 50%.This introduction of a medium-specific Dose Point Kernel calculation method could potentially lead to future improvements on dosimetric systems, limiting for now this model to tissues with effective atomic number closed to liquid water.
publishDate 2016
dc.date.none.fl_str_mv 2016-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/186251
Pérez, Pedro Antonio; Geser, Federico Alejandro; Scarinci, Ignacio Emanuel; Malano, Francisco Mauricio; Valente, Mauro Andres; Beta-minus emitters dose point kernel estimation model comprising different tissues for nuclear medicine dosimetry applications; Cosmos Scholars Publishing House; International Journal of Nuclear Medicine Research; 3; 2; 9-2016; 45-55
2408-9788
CONICET Digital
CONICET
url http://hdl.handle.net/11336/186251
identifier_str_mv Pérez, Pedro Antonio; Geser, Federico Alejandro; Scarinci, Ignacio Emanuel; Malano, Francisco Mauricio; Valente, Mauro Andres; Beta-minus emitters dose point kernel estimation model comprising different tissues for nuclear medicine dosimetry applications; Cosmos Scholars Publishing House; International Journal of Nuclear Medicine Research; 3; 2; 9-2016; 45-55
2408-9788
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.cosmosscholars.com/previous-issue-ijnmr/46-abstracts/ijnmr/593-abstract-beta-minus-emitters-dose-point-kernel-estimation-model-comprising-different-tissues-for-nuclear-medicine-dosimetry-applications
info:eu-repo/semantics/altIdentifier/doi/10.15379/2408-9788.2016.03.02.02
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cosmos Scholars Publishing House
publisher.none.fl_str_mv Cosmos Scholars Publishing House
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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