Formulation and in vivo evaluation of the extract of flower of corpo gel for topical aplication

Autores
Daud, Adriana del Valle; Reynoso, M. A.; Aristimuño Ficoseco, Maria Eugenia del Milagro; Sánchez Riera, A.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
The flowers of Thrypodanthus acutifolius (corpo) are commonly used in folk medicine for the treatment of pain and inflammation associated with musculoskeletal disorders. Recently, we demonstrated antinflammatory and antinociceptive activities. The aim of the present research was to develop a transdermal gel formulation of the flower aqueous extract. The in vivo antinflammatory activity of the gel formulation was studied using a rat model. The gel was prepared with carbopol 940. The physical appearance, homogeneity, stability, extensibility and pH were tested. The antinflammatory activity was performed using carrageenan induced rats hind pawoedema model. From the results it is evident that the gel formulation showed good homogeneity, extensibility and stability for 60 days. The physical appearance of the gel formulation was bright and brown like the extract. The pH was in the range of 5,5 to 6,5 which lies within the normal pH range of the skin and would not produce skin irritation. The antinflammatory topical activity in rats revealed that the corpo extract inhibited the inflammation sited at a controlled level over a period of 4,5 hours of treatment. These results suggest the feasibility of the topical gel formulation of the flower of Thrypodanthus acutifolius.
Fil: Daud, Adriana del Valle. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina
Fil: Reynoso, M. A.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina
Fil: Aristimuño Ficoseco, Maria Eugenia del Milagro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina
Fil: Sánchez Riera, A.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina
XXVII Jornadas Científicas de la Asociación de Biología de Tucumán
Tafi del Valle
Argentina
Asociación de Biología de Tucumán
Materia
Gel
Antiinflamatorio
Thrypodanthus acutifolius
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/258992
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Formulation and in vivo evaluation of the extract of flower of corpo gel for topical aplicationDaud, Adriana del ValleReynoso, M. A.Aristimuño Ficoseco, Maria Eugenia del MilagroSánchez Riera, A.GelAntiinflamatorioThrypodanthus acutifoliushttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The flowers of Thrypodanthus acutifolius (corpo) are commonly used in folk medicine for the treatment of pain and inflammation associated with musculoskeletal disorders. Recently, we demonstrated antinflammatory and antinociceptive activities. The aim of the present research was to develop a transdermal gel formulation of the flower aqueous extract. The in vivo antinflammatory activity of the gel formulation was studied using a rat model. The gel was prepared with carbopol 940. The physical appearance, homogeneity, stability, extensibility and pH were tested. The antinflammatory activity was performed using carrageenan induced rats hind pawoedema model. From the results it is evident that the gel formulation showed good homogeneity, extensibility and stability for 60 days. The physical appearance of the gel formulation was bright and brown like the extract. The pH was in the range of 5,5 to 6,5 which lies within the normal pH range of the skin and would not produce skin irritation. The antinflammatory topical activity in rats revealed that the corpo extract inhibited the inflammation sited at a controlled level over a period of 4,5 hours of treatment. These results suggest the feasibility of the topical gel formulation of the flower of Thrypodanthus acutifolius.Fil: Daud, Adriana del Valle. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; ArgentinaFil: Reynoso, M. A.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; ArgentinaFil: Aristimuño Ficoseco, Maria Eugenia del Milagro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; ArgentinaFil: Sánchez Riera, A.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; ArgentinaXXVII Jornadas Científicas de la Asociación de Biología de TucumánTafi del ValleArgentinaAsociación de Biología de TucumánTech Science Press2011info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectJornadaJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/258992Formulation and in vivo evaluation of the extract of flower of corpo gel for topical aplication; XXVII Jornadas Científicas de la Asociación de Biología de Tucumán; Tafi del Valle; Argentina; 2010; 140-1400327-9545CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.asobioltuc.com/listado.php?id=2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:35:22Zoai:ri.conicet.gov.ar:11336/258992instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:35:22.743CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Formulation and in vivo evaluation of the extract of flower of corpo gel for topical aplication
title Formulation and in vivo evaluation of the extract of flower of corpo gel for topical aplication
spellingShingle Formulation and in vivo evaluation of the extract of flower of corpo gel for topical aplication
Daud, Adriana del Valle
Gel
Antiinflamatorio
Thrypodanthus acutifolius
title_short Formulation and in vivo evaluation of the extract of flower of corpo gel for topical aplication
title_full Formulation and in vivo evaluation of the extract of flower of corpo gel for topical aplication
title_fullStr Formulation and in vivo evaluation of the extract of flower of corpo gel for topical aplication
title_full_unstemmed Formulation and in vivo evaluation of the extract of flower of corpo gel for topical aplication
title_sort Formulation and in vivo evaluation of the extract of flower of corpo gel for topical aplication
dc.creator.none.fl_str_mv Daud, Adriana del Valle
Reynoso, M. A.
Aristimuño Ficoseco, Maria Eugenia del Milagro
Sánchez Riera, A.
author Daud, Adriana del Valle
author_facet Daud, Adriana del Valle
Reynoso, M. A.
Aristimuño Ficoseco, Maria Eugenia del Milagro
Sánchez Riera, A.
author_role author
author2 Reynoso, M. A.
Aristimuño Ficoseco, Maria Eugenia del Milagro
Sánchez Riera, A.
author2_role author
author
author
dc.subject.none.fl_str_mv Gel
Antiinflamatorio
Thrypodanthus acutifolius
topic Gel
Antiinflamatorio
Thrypodanthus acutifolius
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The flowers of Thrypodanthus acutifolius (corpo) are commonly used in folk medicine for the treatment of pain and inflammation associated with musculoskeletal disorders. Recently, we demonstrated antinflammatory and antinociceptive activities. The aim of the present research was to develop a transdermal gel formulation of the flower aqueous extract. The in vivo antinflammatory activity of the gel formulation was studied using a rat model. The gel was prepared with carbopol 940. The physical appearance, homogeneity, stability, extensibility and pH were tested. The antinflammatory activity was performed using carrageenan induced rats hind pawoedema model. From the results it is evident that the gel formulation showed good homogeneity, extensibility and stability for 60 days. The physical appearance of the gel formulation was bright and brown like the extract. The pH was in the range of 5,5 to 6,5 which lies within the normal pH range of the skin and would not produce skin irritation. The antinflammatory topical activity in rats revealed that the corpo extract inhibited the inflammation sited at a controlled level over a period of 4,5 hours of treatment. These results suggest the feasibility of the topical gel formulation of the flower of Thrypodanthus acutifolius.
Fil: Daud, Adriana del Valle. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina
Fil: Reynoso, M. A.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina
Fil: Aristimuño Ficoseco, Maria Eugenia del Milagro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina
Fil: Sánchez Riera, A.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina
XXVII Jornadas Científicas de la Asociación de Biología de Tucumán
Tafi del Valle
Argentina
Asociación de Biología de Tucumán
description The flowers of Thrypodanthus acutifolius (corpo) are commonly used in folk medicine for the treatment of pain and inflammation associated with musculoskeletal disorders. Recently, we demonstrated antinflammatory and antinociceptive activities. The aim of the present research was to develop a transdermal gel formulation of the flower aqueous extract. The in vivo antinflammatory activity of the gel formulation was studied using a rat model. The gel was prepared with carbopol 940. The physical appearance, homogeneity, stability, extensibility and pH were tested. The antinflammatory activity was performed using carrageenan induced rats hind pawoedema model. From the results it is evident that the gel formulation showed good homogeneity, extensibility and stability for 60 days. The physical appearance of the gel formulation was bright and brown like the extract. The pH was in the range of 5,5 to 6,5 which lies within the normal pH range of the skin and would not produce skin irritation. The antinflammatory topical activity in rats revealed that the corpo extract inhibited the inflammation sited at a controlled level over a period of 4,5 hours of treatment. These results suggest the feasibility of the topical gel formulation of the flower of Thrypodanthus acutifolius.
publishDate 2011
dc.date.none.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Jornada
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/258992
Formulation and in vivo evaluation of the extract of flower of corpo gel for topical aplication; XXVII Jornadas Científicas de la Asociación de Biología de Tucumán; Tafi del Valle; Argentina; 2010; 140-140
0327-9545
CONICET Digital
CONICET
url http://hdl.handle.net/11336/258992
identifier_str_mv Formulation and in vivo evaluation of the extract of flower of corpo gel for topical aplication; XXVII Jornadas Científicas de la Asociación de Biología de Tucumán; Tafi del Valle; Argentina; 2010; 140-140
0327-9545
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.asobioltuc.com/listado.php?id=2
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Tech Science Press
publisher.none.fl_str_mv Tech Science Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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