Population attributable fractions for risk factors for dementia in seven Latin American countries: An analysis using cross-sectional survey data

Autores
Silva Paradela, Regina; Calandri, Ismael; Pozo Castro, Natalia; Garat, Emanuel; Delgado, Carolina; Crivelli, Lucía; Yaffe, Kristine; Ferri, Cleusa P; Mukadam, Naaheed; Livingston, Gill; Suemoto, Claudia Kimie
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Approximately 40% of dementia cases worldwide are attributable to 12 potentially modifiable risk factors. However, the proportion attributable to these risks in Latin America remains unknown. We aimed to determine the population attributable fraction (PAF) of 12 modifiable risk factors for dementia in seven countries in Latin America. Methods: We used data from seven cross-sectional, nationally representative surveys with measurements of 12 modifiable risk factors for dementia (less education, hearing loss, hypertension, obesity, smoking, depression, social isolation, physical inactivity, diabetes, excessive alcohol intake, air pollution, and traumatic brain injury) donein Argentina, Brazil, Bolivia, Chile, Honduras, Mexico, and Peru. Data were collected between 2015 and 2021. Sample sizes ranged from 5995 to 107907 participants (aged ≥18 years). We calculated risk factor prevalence and communalities in each country and used relative risks from previous meta-analyses to derive weighted PAFs. Pooled PAFs for Latin America were obtained using random effect meta-analyses. Findings: The overall proportion of dementia cases attributed to 12 modifiable risk factors varied across Latin American countries: weighted PAF 61·8% (95% CI 37·9–79·5) in Chile, 59·6% (35·8–77·3) in Argentina, 55·8% (35·7–71·5) in Mexico, 55·5% (35·9–70·4) in Bolivia, 53·6% (33·0–69·3) in Honduras, 48·2% (28·1–63·9) in Brazil, and 44·9% (25·8–61·2) in Peru. The overall PAF for dementia was 54·0% (48·8–59·6) for Latin America. The highest weighted PAFs in Latin American countries overall were for obesity (7%), physical inactivity (6%), and depression (5%). Interpretation: The estimated PAFs for Latin American countries were higher than previous global estimates. Obesity, physical inactivity, and depression were the main risk factors for dementia across seven Latin American countries. These findings have implications for public health and individually targeted dementia prevention strategies in Latin America. Although these results provide new information about Latin American countries, demographics and representativeness variations across surveys should be considered when interpreting these findings.
Fil: Silva Paradela, Regina. University of California; Estados Unidos. Universidade de Sao Paulo; Brasil
Fil: Calandri, Ismael. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Pozo Castro, Natalia. University of California; Estados Unidos. Universidad de Chile; Chile. Universidad de Santiago de Chile. Hospital Clinico San Borja Arriaran; Chile
Fil: Garat, Emanuel. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Delgado, Carolina. Universidad de Chile; Chile
Fil: Crivelli, Lucía. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; Argentina
Fil: Yaffe, Kristine. University of California; Estados Unidos
Fil: Ferri, Cleusa P. Universidade Federal de Sao Paulo; Brasil. Hospital Alemão Oswaldo Cruz; Brasil
Fil: Mukadam, Naaheed. University College London; Estados Unidos
Fil: Livingston, Gill. University College London; Estados Unidos. Camden and Islington NHS Foundation Trust; Estados Unidos
Fil: Suemoto, Claudia Kimie. Universidade de Sao Paulo; Brasil
Materia
DEMENTIA
RISK FACTORS
LATIN AMERICA
PUBLIC HEALTH
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/265969
Acceder
id CONICETDig_3e9ef5de751b19eb6cdd72a435615030
oai_identifier_str oai:ri.conicet.gov.ar:11336/265969
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Population attributable fractions for risk factors for dementia in seven Latin American countries: An analysis using cross-sectional survey dataSilva Paradela, ReginaCalandri, IsmaelPozo Castro, NataliaGarat, EmanuelDelgado, CarolinaCrivelli, LucíaYaffe, KristineFerri, Cleusa PMukadam, NaaheedLivingston, GillSuemoto, Claudia KimieDEMENTIARISK FACTORSLATIN AMERICAPUBLIC HEALTHhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: Approximately 40% of dementia cases worldwide are attributable to 12 potentially modifiable risk factors. However, the proportion attributable to these risks in Latin America remains unknown. We aimed to determine the population attributable fraction (PAF) of 12 modifiable risk factors for dementia in seven countries in Latin America. Methods: We used data from seven cross-sectional, nationally representative surveys with measurements of 12 modifiable risk factors for dementia (less education, hearing loss, hypertension, obesity, smoking, depression, social isolation, physical inactivity, diabetes, excessive alcohol intake, air pollution, and traumatic brain injury) donein Argentina, Brazil, Bolivia, Chile, Honduras, Mexico, and Peru. Data were collected between 2015 and 2021. Sample sizes ranged from 5995 to 107907 participants (aged ≥18 years). We calculated risk factor prevalence and communalities in each country and used relative risks from previous meta-analyses to derive weighted PAFs. Pooled PAFs for Latin America were obtained using random effect meta-analyses. Findings: The overall proportion of dementia cases attributed to 12 modifiable risk factors varied across Latin American countries: weighted PAF 61·8% (95% CI 37·9–79·5) in Chile, 59·6% (35·8–77·3) in Argentina, 55·8% (35·7–71·5) in Mexico, 55·5% (35·9–70·4) in Bolivia, 53·6% (33·0–69·3) in Honduras, 48·2% (28·1–63·9) in Brazil, and 44·9% (25·8–61·2) in Peru. The overall PAF for dementia was 54·0% (48·8–59·6) for Latin America. The highest weighted PAFs in Latin American countries overall were for obesity (7%), physical inactivity (6%), and depression (5%). Interpretation: The estimated PAFs for Latin American countries were higher than previous global estimates. Obesity, physical inactivity, and depression were the main risk factors for dementia across seven Latin American countries. These findings have implications for public health and individually targeted dementia prevention strategies in Latin America. Although these results provide new information about Latin American countries, demographics and representativeness variations across surveys should be considered when interpreting these findings.Fil: Silva Paradela, Regina. University of California; Estados Unidos. Universidade de Sao Paulo; BrasilFil: Calandri, Ismael. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Pozo Castro, Natalia. University of California; Estados Unidos. Universidad de Chile; Chile. Universidad de Santiago de Chile. Hospital Clinico San Borja Arriaran; ChileFil: Garat, Emanuel. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Delgado, Carolina. Universidad de Chile; ChileFil: Crivelli, Lucía. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; ArgentinaFil: Yaffe, Kristine. University of California; Estados UnidosFil: Ferri, Cleusa P. Universidade Federal de Sao Paulo; Brasil. Hospital Alemão Oswaldo Cruz; BrasilFil: Mukadam, Naaheed. University College London; Estados UnidosFil: Livingston, Gill. University College London; Estados Unidos. Camden and Islington NHS Foundation Trust; Estados UnidosFil: Suemoto, Claudia Kimie. Universidade de Sao Paulo; BrasilElsevier2024-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/265969Silva Paradela, Regina; Calandri, Ismael; Pozo Castro, Natalia; Garat, Emanuel; Delgado, Carolina; et al.; Population attributable fractions for risk factors for dementia in seven Latin American countries: An analysis using cross-sectional survey data; Elsevier; The Lancet Global Health; 12; 10; 10-2024; e1600-e16102214-109XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2214109X24002754info:eu-repo/semantics/altIdentifier/doi/10.1016/S2214-109X(24)00275-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:29Zoai:ri.conicet.gov.ar:11336/265969instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:30.071CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Population attributable fractions for risk factors for dementia in seven Latin American countries: An analysis using cross-sectional survey data
title Population attributable fractions for risk factors for dementia in seven Latin American countries: An analysis using cross-sectional survey data
spellingShingle Population attributable fractions for risk factors for dementia in seven Latin American countries: An analysis using cross-sectional survey data
Silva Paradela, Regina
DEMENTIA
RISK FACTORS
LATIN AMERICA
PUBLIC HEALTH
title_short Population attributable fractions for risk factors for dementia in seven Latin American countries: An analysis using cross-sectional survey data
title_full Population attributable fractions for risk factors for dementia in seven Latin American countries: An analysis using cross-sectional survey data
title_fullStr Population attributable fractions for risk factors for dementia in seven Latin American countries: An analysis using cross-sectional survey data
title_full_unstemmed Population attributable fractions for risk factors for dementia in seven Latin American countries: An analysis using cross-sectional survey data
title_sort Population attributable fractions for risk factors for dementia in seven Latin American countries: An analysis using cross-sectional survey data
dc.creator.none.fl_str_mv Silva Paradela, Regina
Calandri, Ismael
Pozo Castro, Natalia
Garat, Emanuel
Delgado, Carolina
Crivelli, Lucía
Yaffe, Kristine
Ferri, Cleusa P
Mukadam, Naaheed
Livingston, Gill
Suemoto, Claudia Kimie
author Silva Paradela, Regina
author_facet Silva Paradela, Regina
Calandri, Ismael
Pozo Castro, Natalia
Garat, Emanuel
Delgado, Carolina
Crivelli, Lucía
Yaffe, Kristine
Ferri, Cleusa P
Mukadam, Naaheed
Livingston, Gill
Suemoto, Claudia Kimie
author_role author
author2 Calandri, Ismael
Pozo Castro, Natalia
Garat, Emanuel
Delgado, Carolina
Crivelli, Lucía
Yaffe, Kristine
Ferri, Cleusa P
Mukadam, Naaheed
Livingston, Gill
Suemoto, Claudia Kimie
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv DEMENTIA
RISK FACTORS
LATIN AMERICA
PUBLIC HEALTH
topic DEMENTIA
RISK FACTORS
LATIN AMERICA
PUBLIC HEALTH
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Approximately 40% of dementia cases worldwide are attributable to 12 potentially modifiable risk factors. However, the proportion attributable to these risks in Latin America remains unknown. We aimed to determine the population attributable fraction (PAF) of 12 modifiable risk factors for dementia in seven countries in Latin America. Methods: We used data from seven cross-sectional, nationally representative surveys with measurements of 12 modifiable risk factors for dementia (less education, hearing loss, hypertension, obesity, smoking, depression, social isolation, physical inactivity, diabetes, excessive alcohol intake, air pollution, and traumatic brain injury) donein Argentina, Brazil, Bolivia, Chile, Honduras, Mexico, and Peru. Data were collected between 2015 and 2021. Sample sizes ranged from 5995 to 107907 participants (aged ≥18 years). We calculated risk factor prevalence and communalities in each country and used relative risks from previous meta-analyses to derive weighted PAFs. Pooled PAFs for Latin America were obtained using random effect meta-analyses. Findings: The overall proportion of dementia cases attributed to 12 modifiable risk factors varied across Latin American countries: weighted PAF 61·8% (95% CI 37·9–79·5) in Chile, 59·6% (35·8–77·3) in Argentina, 55·8% (35·7–71·5) in Mexico, 55·5% (35·9–70·4) in Bolivia, 53·6% (33·0–69·3) in Honduras, 48·2% (28·1–63·9) in Brazil, and 44·9% (25·8–61·2) in Peru. The overall PAF for dementia was 54·0% (48·8–59·6) for Latin America. The highest weighted PAFs in Latin American countries overall were for obesity (7%), physical inactivity (6%), and depression (5%). Interpretation: The estimated PAFs for Latin American countries were higher than previous global estimates. Obesity, physical inactivity, and depression were the main risk factors for dementia across seven Latin American countries. These findings have implications for public health and individually targeted dementia prevention strategies in Latin America. Although these results provide new information about Latin American countries, demographics and representativeness variations across surveys should be considered when interpreting these findings.
Fil: Silva Paradela, Regina. University of California; Estados Unidos. Universidade de Sao Paulo; Brasil
Fil: Calandri, Ismael. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Pozo Castro, Natalia. University of California; Estados Unidos. Universidad de Chile; Chile. Universidad de Santiago de Chile. Hospital Clinico San Borja Arriaran; Chile
Fil: Garat, Emanuel. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Delgado, Carolina. Universidad de Chile; Chile
Fil: Crivelli, Lucía. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; Argentina
Fil: Yaffe, Kristine. University of California; Estados Unidos
Fil: Ferri, Cleusa P. Universidade Federal de Sao Paulo; Brasil. Hospital Alemão Oswaldo Cruz; Brasil
Fil: Mukadam, Naaheed. University College London; Estados Unidos
Fil: Livingston, Gill. University College London; Estados Unidos. Camden and Islington NHS Foundation Trust; Estados Unidos
Fil: Suemoto, Claudia Kimie. Universidade de Sao Paulo; Brasil
description Background: Approximately 40% of dementia cases worldwide are attributable to 12 potentially modifiable risk factors. However, the proportion attributable to these risks in Latin America remains unknown. We aimed to determine the population attributable fraction (PAF) of 12 modifiable risk factors for dementia in seven countries in Latin America. Methods: We used data from seven cross-sectional, nationally representative surveys with measurements of 12 modifiable risk factors for dementia (less education, hearing loss, hypertension, obesity, smoking, depression, social isolation, physical inactivity, diabetes, excessive alcohol intake, air pollution, and traumatic brain injury) donein Argentina, Brazil, Bolivia, Chile, Honduras, Mexico, and Peru. Data were collected between 2015 and 2021. Sample sizes ranged from 5995 to 107907 participants (aged ≥18 years). We calculated risk factor prevalence and communalities in each country and used relative risks from previous meta-analyses to derive weighted PAFs. Pooled PAFs for Latin America were obtained using random effect meta-analyses. Findings: The overall proportion of dementia cases attributed to 12 modifiable risk factors varied across Latin American countries: weighted PAF 61·8% (95% CI 37·9–79·5) in Chile, 59·6% (35·8–77·3) in Argentina, 55·8% (35·7–71·5) in Mexico, 55·5% (35·9–70·4) in Bolivia, 53·6% (33·0–69·3) in Honduras, 48·2% (28·1–63·9) in Brazil, and 44·9% (25·8–61·2) in Peru. The overall PAF for dementia was 54·0% (48·8–59·6) for Latin America. The highest weighted PAFs in Latin American countries overall were for obesity (7%), physical inactivity (6%), and depression (5%). Interpretation: The estimated PAFs for Latin American countries were higher than previous global estimates. Obesity, physical inactivity, and depression were the main risk factors for dementia across seven Latin American countries. These findings have implications for public health and individually targeted dementia prevention strategies in Latin America. Although these results provide new information about Latin American countries, demographics and representativeness variations across surveys should be considered when interpreting these findings.
publishDate 2024
dc.date.none.fl_str_mv 2024-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/265969
Silva Paradela, Regina; Calandri, Ismael; Pozo Castro, Natalia; Garat, Emanuel; Delgado, Carolina; et al.; Population attributable fractions for risk factors for dementia in seven Latin American countries: An analysis using cross-sectional survey data; Elsevier; The Lancet Global Health; 12; 10; 10-2024; e1600-e1610
2214-109X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/265969
identifier_str_mv Silva Paradela, Regina; Calandri, Ismael; Pozo Castro, Natalia; Garat, Emanuel; Delgado, Carolina; et al.; Population attributable fractions for risk factors for dementia in seven Latin American countries: An analysis using cross-sectional survey data; Elsevier; The Lancet Global Health; 12; 10; 10-2024; e1600-e1610
2214-109X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2214109X24002754
info:eu-repo/semantics/altIdentifier/doi/10.1016/S2214-109X(24)00275-4
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268670394368000
score 13.13397

Publicaciones similares