Hydroalcoholic extract of Urtica circularis: A neuropharmacological profile

Autores
Anzoise, Maria Laura; Marrassini, Carla; Ferraro, Graciela Ester; Gorzalczany, Susana
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Context: The genus Urtica has been known since ancient times. It has known to be useful for the treatment of different human ailments. Objective: The present work evaluated the neuropharmacological effects of a hydroalcoholic extract of Urtica circularis (Hicken) Soraru´ (Urticaceae). Materials and method: The effect on central nervous system of U. circularis hydroalcoholic extract (from leaves and stems) administered by the intraperitoneal route in mice was evaluated by several tests: Pentobarbital- and midazolam-induced hypnosis, open field, hole board, elevated plus-maze and forced swimming. Phytochemical analysis was performed by high-performance liquid chromatography. Results: A total of 300 mg/kg i.p. of the extract produced a significant prolongation of pentobarbital- (40 mg/kg i.p.; 60.1 min versus 25.4 min) and midazolam- (50 mg/kg i.v.; 53.4 min versus 25.1 min) induced sleeping time. The extract?s administration caused a marked reduction of the head-dipping response (DE50: 373 mg/kg i.p.) in the hole-board test. Urtica circularis extract (DE50: 46 mg/kg i.p.) reduced the spontaneous locomotor activity in the open field test. Flumazenil and atropine significantly antagonized the extract?s effect on the locomotor activity. No motor coordination disturbance was observed in the rota rod test at any doses. In the forced swimming test, the extract did not produce any change in the immobility time and it had no significant effects in elevated plus maze test. The phytochemical analysis revealed the presence of chlorogenic acid, vanillic acid, caffeic acid, vicenin-2, p-cumaric acid, ferulic acid, vitexin and isovitexin. Conclusion: This study revealed that U. circularis hydroalcoholic extract possesses sedative activity, facilitating GABAergic and cholinergic transmission.
Fil: Anzoise, Maria Laura. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); Argentina
Fil: Marrassini, Carla. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); Argentina
Fil: Ferraro, Graciela Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); Argentina
Fil: Gorzalczany, Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); Argentina
Materia
Cholinergic System
Elevated Plus Maze
Forced Swimming Test
Gabaergic System
Hole Board
Motor Coordination
Open Field Test
Sedative
Urtica Circularis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/12549
Acceder
id CONICETDig_3e92374dfa898350433a5a8da754c98d
oai_identifier_str oai:ri.conicet.gov.ar:11336/12549
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hydroalcoholic extract of Urtica circularis: A neuropharmacological profileAnzoise, Maria LauraMarrassini, CarlaFerraro, Graciela EsterGorzalczany, SusanaCholinergic SystemElevated Plus MazeForced Swimming TestGabaergic SystemHole BoardMotor CoordinationOpen Field TestSedativeUrtica Circularishttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Context: The genus Urtica has been known since ancient times. It has known to be useful for the treatment of different human ailments. Objective: The present work evaluated the neuropharmacological effects of a hydroalcoholic extract of Urtica circularis (Hicken) Soraru´ (Urticaceae). Materials and method: The effect on central nervous system of U. circularis hydroalcoholic extract (from leaves and stems) administered by the intraperitoneal route in mice was evaluated by several tests: Pentobarbital- and midazolam-induced hypnosis, open field, hole board, elevated plus-maze and forced swimming. Phytochemical analysis was performed by high-performance liquid chromatography. Results: A total of 300 mg/kg i.p. of the extract produced a significant prolongation of pentobarbital- (40 mg/kg i.p.; 60.1 min versus 25.4 min) and midazolam- (50 mg/kg i.v.; 53.4 min versus 25.1 min) induced sleeping time. The extract?s administration caused a marked reduction of the head-dipping response (DE50: 373 mg/kg i.p.) in the hole-board test. Urtica circularis extract (DE50: 46 mg/kg i.p.) reduced the spontaneous locomotor activity in the open field test. Flumazenil and atropine significantly antagonized the extract?s effect on the locomotor activity. No motor coordination disturbance was observed in the rota rod test at any doses. In the forced swimming test, the extract did not produce any change in the immobility time and it had no significant effects in elevated plus maze test. The phytochemical analysis revealed the presence of chlorogenic acid, vanillic acid, caffeic acid, vicenin-2, p-cumaric acid, ferulic acid, vitexin and isovitexin. Conclusion: This study revealed that U. circularis hydroalcoholic extract possesses sedative activity, facilitating GABAergic and cholinergic transmission.Fil: Anzoise, Maria Laura. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); ArgentinaFil: Marrassini, Carla. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); ArgentinaFil: Ferraro, Graciela Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); ArgentinaFil: Gorzalczany, Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); ArgentinaTaylor & Francis2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12549Anzoise, Maria Laura; Marrassini, Carla; Ferraro, Graciela Ester; Gorzalczany, Susana; Hydroalcoholic extract of Urtica circularis: A neuropharmacological profile; Taylor & Francis; Pharmaceutical Biology; 51; 10; 7-2013; 1236-12421388-0209enginfo:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/13880209.2013.785574info:eu-repo/semantics/altIdentifier/doi/10.3109/13880209.2013.785574info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:19:21Zoai:ri.conicet.gov.ar:11336/12549instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:19:21.684CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hydroalcoholic extract of Urtica circularis: A neuropharmacological profile
title Hydroalcoholic extract of Urtica circularis: A neuropharmacological profile
spellingShingle Hydroalcoholic extract of Urtica circularis: A neuropharmacological profile
Anzoise, Maria Laura
Cholinergic System
Elevated Plus Maze
Forced Swimming Test
Gabaergic System
Hole Board
Motor Coordination
Open Field Test
Sedative
Urtica Circularis
title_short Hydroalcoholic extract of Urtica circularis: A neuropharmacological profile
title_full Hydroalcoholic extract of Urtica circularis: A neuropharmacological profile
title_fullStr Hydroalcoholic extract of Urtica circularis: A neuropharmacological profile
title_full_unstemmed Hydroalcoholic extract of Urtica circularis: A neuropharmacological profile
title_sort Hydroalcoholic extract of Urtica circularis: A neuropharmacological profile
dc.creator.none.fl_str_mv Anzoise, Maria Laura
Marrassini, Carla
Ferraro, Graciela Ester
Gorzalczany, Susana
author Anzoise, Maria Laura
author_facet Anzoise, Maria Laura
Marrassini, Carla
Ferraro, Graciela Ester
Gorzalczany, Susana
author_role author
author2 Marrassini, Carla
Ferraro, Graciela Ester
Gorzalczany, Susana
author2_role author
author
author
dc.subject.none.fl_str_mv Cholinergic System
Elevated Plus Maze
Forced Swimming Test
Gabaergic System
Hole Board
Motor Coordination
Open Field Test
Sedative
Urtica Circularis
topic Cholinergic System
Elevated Plus Maze
Forced Swimming Test
Gabaergic System
Hole Board
Motor Coordination
Open Field Test
Sedative
Urtica Circularis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Context: The genus Urtica has been known since ancient times. It has known to be useful for the treatment of different human ailments. Objective: The present work evaluated the neuropharmacological effects of a hydroalcoholic extract of Urtica circularis (Hicken) Soraru´ (Urticaceae). Materials and method: The effect on central nervous system of U. circularis hydroalcoholic extract (from leaves and stems) administered by the intraperitoneal route in mice was evaluated by several tests: Pentobarbital- and midazolam-induced hypnosis, open field, hole board, elevated plus-maze and forced swimming. Phytochemical analysis was performed by high-performance liquid chromatography. Results: A total of 300 mg/kg i.p. of the extract produced a significant prolongation of pentobarbital- (40 mg/kg i.p.; 60.1 min versus 25.4 min) and midazolam- (50 mg/kg i.v.; 53.4 min versus 25.1 min) induced sleeping time. The extract?s administration caused a marked reduction of the head-dipping response (DE50: 373 mg/kg i.p.) in the hole-board test. Urtica circularis extract (DE50: 46 mg/kg i.p.) reduced the spontaneous locomotor activity in the open field test. Flumazenil and atropine significantly antagonized the extract?s effect on the locomotor activity. No motor coordination disturbance was observed in the rota rod test at any doses. In the forced swimming test, the extract did not produce any change in the immobility time and it had no significant effects in elevated plus maze test. The phytochemical analysis revealed the presence of chlorogenic acid, vanillic acid, caffeic acid, vicenin-2, p-cumaric acid, ferulic acid, vitexin and isovitexin. Conclusion: This study revealed that U. circularis hydroalcoholic extract possesses sedative activity, facilitating GABAergic and cholinergic transmission.
Fil: Anzoise, Maria Laura. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); Argentina
Fil: Marrassini, Carla. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); Argentina
Fil: Ferraro, Graciela Ester. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); Argentina
Fil: Gorzalczany, Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); Argentina
description Context: The genus Urtica has been known since ancient times. It has known to be useful for the treatment of different human ailments. Objective: The present work evaluated the neuropharmacological effects of a hydroalcoholic extract of Urtica circularis (Hicken) Soraru´ (Urticaceae). Materials and method: The effect on central nervous system of U. circularis hydroalcoholic extract (from leaves and stems) administered by the intraperitoneal route in mice was evaluated by several tests: Pentobarbital- and midazolam-induced hypnosis, open field, hole board, elevated plus-maze and forced swimming. Phytochemical analysis was performed by high-performance liquid chromatography. Results: A total of 300 mg/kg i.p. of the extract produced a significant prolongation of pentobarbital- (40 mg/kg i.p.; 60.1 min versus 25.4 min) and midazolam- (50 mg/kg i.v.; 53.4 min versus 25.1 min) induced sleeping time. The extract?s administration caused a marked reduction of the head-dipping response (DE50: 373 mg/kg i.p.) in the hole-board test. Urtica circularis extract (DE50: 46 mg/kg i.p.) reduced the spontaneous locomotor activity in the open field test. Flumazenil and atropine significantly antagonized the extract?s effect on the locomotor activity. No motor coordination disturbance was observed in the rota rod test at any doses. In the forced swimming test, the extract did not produce any change in the immobility time and it had no significant effects in elevated plus maze test. The phytochemical analysis revealed the presence of chlorogenic acid, vanillic acid, caffeic acid, vicenin-2, p-cumaric acid, ferulic acid, vitexin and isovitexin. Conclusion: This study revealed that U. circularis hydroalcoholic extract possesses sedative activity, facilitating GABAergic and cholinergic transmission.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/12549
Anzoise, Maria Laura; Marrassini, Carla; Ferraro, Graciela Ester; Gorzalczany, Susana; Hydroalcoholic extract of Urtica circularis: A neuropharmacological profile; Taylor & Francis; Pharmaceutical Biology; 51; 10; 7-2013; 1236-1242
1388-0209
url http://hdl.handle.net/11336/12549
identifier_str_mv Anzoise, Maria Laura; Marrassini, Carla; Ferraro, Graciela Ester; Gorzalczany, Susana; Hydroalcoholic extract of Urtica circularis: A neuropharmacological profile; Taylor & Francis; Pharmaceutical Biology; 51; 10; 7-2013; 1236-1242
1388-0209
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/13880209.2013.785574
info:eu-repo/semantics/altIdentifier/doi/10.3109/13880209.2013.785574
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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