Oxidation of ophthalmic drugs photopromoted by inorganic radicals

Autores
Criado, Susana Noemi; Rosso, Janina Alejandra; Cobos, Carlos Jorge; Garcia, Norman Andino; Martire, Daniel Osvaldo
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The rate constants of the reactions of the sulfate (SO4radical dot−) and hydrogen phosphate (HPO4radical dot−) radicals with the imidazoline derivatives naphazoline, tetrahydrozoline, oxymetazoline, xylometazoline, and the model compound 2-methyl-2-imidazoline (IZ), were measured by flash-photolysis. The experimental values of these rate constants are on the order of 108–109 M−1 s−1. The reactions with the sulfate radicals proceed by an initial attack on the aromatic rings, which leads to the formation of N-centered radicals of naphazoline and to phenoxyl radicals of the other substrates. The experimental absorption spectra of the intermediates were compared to those obtained from theoretical time-dependent density functional calculations with explicit account for bulk solvent effects.
Fil: Criado, Susana Noemi. Universidad Nacional de Rio Cuarto. Departamento de Química; Argentina
Fil: Rosso, Janina Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Cobos, Carlos Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Garcia, Norman Andino. Universidad Nacional de Rio Cuarto. Departamento de Química; Argentina
Fil: Martire, Daniel Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Materia
Ophthalmic Drugs
Inoirganic Radicals
Photodegradation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/5029
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Oxidation of ophthalmic drugs photopromoted by inorganic radicalsCriado, Susana NoemiRosso, Janina AlejandraCobos, Carlos JorgeGarcia, Norman AndinoMartire, Daniel OsvaldoOphthalmic DrugsInoirganic RadicalsPhotodegradationhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The rate constants of the reactions of the sulfate (SO4radical dot−) and hydrogen phosphate (HPO4radical dot−) radicals with the imidazoline derivatives naphazoline, tetrahydrozoline, oxymetazoline, xylometazoline, and the model compound 2-methyl-2-imidazoline (IZ), were measured by flash-photolysis. The experimental values of these rate constants are on the order of 108–109 M−1 s−1. The reactions with the sulfate radicals proceed by an initial attack on the aromatic rings, which leads to the formation of N-centered radicals of naphazoline and to phenoxyl radicals of the other substrates. The experimental absorption spectra of the intermediates were compared to those obtained from theoretical time-dependent density functional calculations with explicit account for bulk solvent effects.Fil: Criado, Susana Noemi. Universidad Nacional de Rio Cuarto. Departamento de Química; ArgentinaFil: Rosso, Janina Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Cobos, Carlos Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Garcia, Norman Andino. Universidad Nacional de Rio Cuarto. Departamento de Química; ArgentinaFil: Martire, Daniel Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; ArgentinaElsevier Science SA2012-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/5029Criado, Susana Noemi; Rosso, Janina Alejandra; Cobos, Carlos Jorge; Garcia, Norman Andino; Martire, Daniel Osvaldo; Oxidation of ophthalmic drugs photopromoted by inorganic radicals; Elsevier Science SA; Journal of Photochemistry and Photobiology A: Chemistry; 244; 9-2012; 32-371010-6030enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1010603012003310info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jphotochem.2012.06.018info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-26T08:51:51Zoai:ri.conicet.gov.ar:11336/5029instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-26 08:51:52.132CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Oxidation of ophthalmic drugs photopromoted by inorganic radicals
title Oxidation of ophthalmic drugs photopromoted by inorganic radicals
spellingShingle Oxidation of ophthalmic drugs photopromoted by inorganic radicals
Criado, Susana Noemi
Ophthalmic Drugs
Inoirganic Radicals
Photodegradation
title_short Oxidation of ophthalmic drugs photopromoted by inorganic radicals
title_full Oxidation of ophthalmic drugs photopromoted by inorganic radicals
title_fullStr Oxidation of ophthalmic drugs photopromoted by inorganic radicals
title_full_unstemmed Oxidation of ophthalmic drugs photopromoted by inorganic radicals
title_sort Oxidation of ophthalmic drugs photopromoted by inorganic radicals
dc.creator.none.fl_str_mv Criado, Susana Noemi
Rosso, Janina Alejandra
Cobos, Carlos Jorge
Garcia, Norman Andino
Martire, Daniel Osvaldo
author Criado, Susana Noemi
author_facet Criado, Susana Noemi
Rosso, Janina Alejandra
Cobos, Carlos Jorge
Garcia, Norman Andino
Martire, Daniel Osvaldo
author_role author
author2 Rosso, Janina Alejandra
Cobos, Carlos Jorge
Garcia, Norman Andino
Martire, Daniel Osvaldo
author2_role author
author
author
author
dc.subject.none.fl_str_mv Ophthalmic Drugs
Inoirganic Radicals
Photodegradation
topic Ophthalmic Drugs
Inoirganic Radicals
Photodegradation
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The rate constants of the reactions of the sulfate (SO4radical dot−) and hydrogen phosphate (HPO4radical dot−) radicals with the imidazoline derivatives naphazoline, tetrahydrozoline, oxymetazoline, xylometazoline, and the model compound 2-methyl-2-imidazoline (IZ), were measured by flash-photolysis. The experimental values of these rate constants are on the order of 108–109 M−1 s−1. The reactions with the sulfate radicals proceed by an initial attack on the aromatic rings, which leads to the formation of N-centered radicals of naphazoline and to phenoxyl radicals of the other substrates. The experimental absorption spectra of the intermediates were compared to those obtained from theoretical time-dependent density functional calculations with explicit account for bulk solvent effects.
Fil: Criado, Susana Noemi. Universidad Nacional de Rio Cuarto. Departamento de Química; Argentina
Fil: Rosso, Janina Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Cobos, Carlos Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
Fil: Garcia, Norman Andino. Universidad Nacional de Rio Cuarto. Departamento de Química; Argentina
Fil: Martire, Daniel Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; Argentina
description The rate constants of the reactions of the sulfate (SO4radical dot−) and hydrogen phosphate (HPO4radical dot−) radicals with the imidazoline derivatives naphazoline, tetrahydrozoline, oxymetazoline, xylometazoline, and the model compound 2-methyl-2-imidazoline (IZ), were measured by flash-photolysis. The experimental values of these rate constants are on the order of 108–109 M−1 s−1. The reactions with the sulfate radicals proceed by an initial attack on the aromatic rings, which leads to the formation of N-centered radicals of naphazoline and to phenoxyl radicals of the other substrates. The experimental absorption spectra of the intermediates were compared to those obtained from theoretical time-dependent density functional calculations with explicit account for bulk solvent effects.
publishDate 2012
dc.date.none.fl_str_mv 2012-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/5029
Criado, Susana Noemi; Rosso, Janina Alejandra; Cobos, Carlos Jorge; Garcia, Norman Andino; Martire, Daniel Osvaldo; Oxidation of ophthalmic drugs photopromoted by inorganic radicals; Elsevier Science SA; Journal of Photochemistry and Photobiology A: Chemistry; 244; 9-2012; 32-37
1010-6030
url http://hdl.handle.net/11336/5029
identifier_str_mv Criado, Susana Noemi; Rosso, Janina Alejandra; Cobos, Carlos Jorge; Garcia, Norman Andino; Martire, Daniel Osvaldo; Oxidation of ophthalmic drugs photopromoted by inorganic radicals; Elsevier Science SA; Journal of Photochemistry and Photobiology A: Chemistry; 244; 9-2012; 32-37
1010-6030
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1010603012003310
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jphotochem.2012.06.018
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science SA
publisher.none.fl_str_mv Elsevier Science SA
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.011256

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