Potential Pharmacokinetic Drug-Drug Interactions between Cannabinoids and Drugs Used for Chronic Pain

Autores
Vázquez, Marta Mabel; Guevara, Natalia; Maldonado, Cecilia; Caceres Guido, Paulo Arturo; Schaiquevich, Paula Susana
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Choosing an appropriate treatment for chronic pain remains problematic, and despite the available medication for its treatment, still, many patients complain about pain and appeal to the use of cannabis derivatives for pain control. However, few data have been provided to clinicians about the pharmacokinetic drug-drug interactions of cannabinoids with other concomitant administered medications. Therefore, the aim of this brief review is to assess the interactions between cannabinoids and pain medication through drug transporters (ATP-binding cassette superfamily members) and/or metabolizing enzymes (cytochromes P450 and glucuronyl transferases).
Fil: Vázquez, Marta Mabel. Universidad de la República; Uruguay
Fil: Guevara, Natalia. Universidad de la República; Uruguay
Fil: Maldonado, Cecilia. Universidad de la República; Uruguay
Fil: Caceres Guido, Paulo Arturo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Schaiquevich, Paula Susana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
CANNABIS
DRUG DRUG INTERACTION
PAIN
CHRONIC
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/171500
Acceder
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spelling Potential Pharmacokinetic Drug-Drug Interactions between Cannabinoids and Drugs Used for Chronic PainVázquez, Marta MabelGuevara, NataliaMaldonado, CeciliaCaceres Guido, Paulo ArturoSchaiquevich, Paula SusanaCANNABISDRUG DRUG INTERACTIONPAINCHRONIChttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Choosing an appropriate treatment for chronic pain remains problematic, and despite the available medication for its treatment, still, many patients complain about pain and appeal to the use of cannabis derivatives for pain control. However, few data have been provided to clinicians about the pharmacokinetic drug-drug interactions of cannabinoids with other concomitant administered medications. Therefore, the aim of this brief review is to assess the interactions between cannabinoids and pain medication through drug transporters (ATP-binding cassette superfamily members) and/or metabolizing enzymes (cytochromes P450 and glucuronyl transferases).Fil: Vázquez, Marta Mabel. Universidad de la República; UruguayFil: Guevara, Natalia. Universidad de la República; UruguayFil: Maldonado, Cecilia. Universidad de la República; UruguayFil: Caceres Guido, Paulo Arturo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Schaiquevich, Paula Susana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaHindawi Publishing Corporation2020-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/171500Vázquez, Marta Mabel; Guevara, Natalia; Maldonado, Cecilia; Caceres Guido, Paulo Arturo; Schaiquevich, Paula Susana; Potential Pharmacokinetic Drug-Drug Interactions between Cannabinoids and Drugs Used for Chronic Pain; Hindawi Publishing Corporation; BioMed Research International; 2020; 8-2020; 1-92314-61332314-6141CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2020/3902740/info:eu-repo/semantics/altIdentifier/doi/10.1155/2020/3902740info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:12:05Zoai:ri.conicet.gov.ar:11336/171500instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:12:05.312CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Potential Pharmacokinetic Drug-Drug Interactions between Cannabinoids and Drugs Used for Chronic Pain
title Potential Pharmacokinetic Drug-Drug Interactions between Cannabinoids and Drugs Used for Chronic Pain
spellingShingle Potential Pharmacokinetic Drug-Drug Interactions between Cannabinoids and Drugs Used for Chronic Pain
Vázquez, Marta Mabel
CANNABIS
DRUG DRUG INTERACTION
PAIN
CHRONIC
title_short Potential Pharmacokinetic Drug-Drug Interactions between Cannabinoids and Drugs Used for Chronic Pain
title_full Potential Pharmacokinetic Drug-Drug Interactions between Cannabinoids and Drugs Used for Chronic Pain
title_fullStr Potential Pharmacokinetic Drug-Drug Interactions between Cannabinoids and Drugs Used for Chronic Pain
title_full_unstemmed Potential Pharmacokinetic Drug-Drug Interactions between Cannabinoids and Drugs Used for Chronic Pain
title_sort Potential Pharmacokinetic Drug-Drug Interactions between Cannabinoids and Drugs Used for Chronic Pain
dc.creator.none.fl_str_mv Vázquez, Marta Mabel
Guevara, Natalia
Maldonado, Cecilia
Caceres Guido, Paulo Arturo
Schaiquevich, Paula Susana
author Vázquez, Marta Mabel
author_facet Vázquez, Marta Mabel
Guevara, Natalia
Maldonado, Cecilia
Caceres Guido, Paulo Arturo
Schaiquevich, Paula Susana
author_role author
author2 Guevara, Natalia
Maldonado, Cecilia
Caceres Guido, Paulo Arturo
Schaiquevich, Paula Susana
author2_role author
author
author
author
dc.subject.none.fl_str_mv CANNABIS
DRUG DRUG INTERACTION
PAIN
CHRONIC
topic CANNABIS
DRUG DRUG INTERACTION
PAIN
CHRONIC
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Choosing an appropriate treatment for chronic pain remains problematic, and despite the available medication for its treatment, still, many patients complain about pain and appeal to the use of cannabis derivatives for pain control. However, few data have been provided to clinicians about the pharmacokinetic drug-drug interactions of cannabinoids with other concomitant administered medications. Therefore, the aim of this brief review is to assess the interactions between cannabinoids and pain medication through drug transporters (ATP-binding cassette superfamily members) and/or metabolizing enzymes (cytochromes P450 and glucuronyl transferases).
Fil: Vázquez, Marta Mabel. Universidad de la República; Uruguay
Fil: Guevara, Natalia. Universidad de la República; Uruguay
Fil: Maldonado, Cecilia. Universidad de la República; Uruguay
Fil: Caceres Guido, Paulo Arturo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Schaiquevich, Paula Susana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Choosing an appropriate treatment for chronic pain remains problematic, and despite the available medication for its treatment, still, many patients complain about pain and appeal to the use of cannabis derivatives for pain control. However, few data have been provided to clinicians about the pharmacokinetic drug-drug interactions of cannabinoids with other concomitant administered medications. Therefore, the aim of this brief review is to assess the interactions between cannabinoids and pain medication through drug transporters (ATP-binding cassette superfamily members) and/or metabolizing enzymes (cytochromes P450 and glucuronyl transferases).
publishDate 2020
dc.date.none.fl_str_mv 2020-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/171500
Vázquez, Marta Mabel; Guevara, Natalia; Maldonado, Cecilia; Caceres Guido, Paulo Arturo; Schaiquevich, Paula Susana; Potential Pharmacokinetic Drug-Drug Interactions between Cannabinoids and Drugs Used for Chronic Pain; Hindawi Publishing Corporation; BioMed Research International; 2020; 8-2020; 1-9
2314-6133
2314-6141
CONICET Digital
CONICET
url http://hdl.handle.net/11336/171500
identifier_str_mv Vázquez, Marta Mabel; Guevara, Natalia; Maldonado, Cecilia; Caceres Guido, Paulo Arturo; Schaiquevich, Paula Susana; Potential Pharmacokinetic Drug-Drug Interactions between Cannabinoids and Drugs Used for Chronic Pain; Hindawi Publishing Corporation; BioMed Research International; 2020; 8-2020; 1-9
2314-6133
2314-6141
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2020/3902740/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2020/3902740
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.004268

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