The effects of endogenous melatonin on brain tissue oxidative stress induced by photoperiodic alterations and iron overloading in rats

Autores
Hernando, Marcelo Pablo; Cogo Pagella, Joaquín; Cervino, Claudio Osvaldo
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Melatonin is a potent endogenously occurring antioxidant with the pleiotropic activities to neurodegenerative diseases associated with brain oxidative damage. In this study, we examined the prolonged photoperiodic alterations and iron (Fe) overload on melatonin production and brain oxidative stress in rats. The result showed that the 15 days of constant light (CL) exposure did not low the melatonin production but the 15 days of constant darkness (CD) significantly increased serum melatonin level in rats. The Fe treatment in both CL and CD conditions significantly reduced endogenous melatonin levels and increased brain tissue lipid peroxidation. Fe as a toxic transition metal can induce Fenton reaction to generated hydroxyl radical which can damage the neuronal cell membrane and impair the brain antioxidant system. In the current study, we observed the imbalanced antioxidant defense alterations upon Fe treatment in rat brain including the increased levels of alpha-tocopherol (α-T) and total thiols and the reduced melatonin level and catalase (CAT) activity. We speculated that the reduced melatonin level caused by Fe was due to its consumption since melatonin served as a metal chelator and antioxidant. Understanding these aspects enhances knowledge of brain Fe metabolism and its role in neurodegenerative disorders as well as the potential protective effects of melatonin on this metal.
Fil: Hernando, Marcelo Pablo. Universidad de Moron. Secretaria de Ciencia y Tecnologia. Instituto de Fisiologia y Neurociencias.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cogo Pagella, Joaquín. Universidad de Moron. Secretaria de Ciencia y Tecnologia. Instituto de Fisiologia y Neurociencias.; Argentina
Fil: Cervino, Claudio Osvaldo. Universidad de Moron. Secretaria de Ciencia y Tecnologia. Instituto de Fisiologia y Neurociencias.; Argentina
Materia
MELATONIN
IRON DEXTRAN
OXIDANT/ANTIOXIDANT
BRAIN
RATS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/243177
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The effects of endogenous melatonin on brain tissue oxidative stress induced by photoperiodic alterations and iron overloading in ratsHernando, Marcelo PabloCogo Pagella, JoaquínCervino, Claudio OsvaldoMELATONINIRON DEXTRANOXIDANT/ANTIOXIDANTBRAINRATShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Melatonin is a potent endogenously occurring antioxidant with the pleiotropic activities to neurodegenerative diseases associated with brain oxidative damage. In this study, we examined the prolonged photoperiodic alterations and iron (Fe) overload on melatonin production and brain oxidative stress in rats. The result showed that the 15 days of constant light (CL) exposure did not low the melatonin production but the 15 days of constant darkness (CD) significantly increased serum melatonin level in rats. The Fe treatment in both CL and CD conditions significantly reduced endogenous melatonin levels and increased brain tissue lipid peroxidation. Fe as a toxic transition metal can induce Fenton reaction to generated hydroxyl radical which can damage the neuronal cell membrane and impair the brain antioxidant system. In the current study, we observed the imbalanced antioxidant defense alterations upon Fe treatment in rat brain including the increased levels of alpha-tocopherol (α-T) and total thiols and the reduced melatonin level and catalase (CAT) activity. We speculated that the reduced melatonin level caused by Fe was due to its consumption since melatonin served as a metal chelator and antioxidant. Understanding these aspects enhances knowledge of brain Fe metabolism and its role in neurodegenerative disorders as well as the potential protective effects of melatonin on this metal.Fil: Hernando, Marcelo Pablo. Universidad de Moron. Secretaria de Ciencia y Tecnologia. Instituto de Fisiologia y Neurociencias.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cogo Pagella, Joaquín. Universidad de Moron. Secretaria de Ciencia y Tecnologia. Instituto de Fisiologia y Neurociencias.; ArgentinaFil: Cervino, Claudio Osvaldo. Universidad de Moron. Secretaria de Ciencia y Tecnologia. Instituto de Fisiologia y Neurociencias.; ArgentinaST-Bio-Life LLC2024-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/243177Hernando, Marcelo Pablo; Cogo Pagella, Joaquín; Cervino, Claudio Osvaldo; The effects of endogenous melatonin on brain tissue oxidative stress induced by photoperiodic alterations and iron overloading in rats; ST-Bio-Life LLC; Melatonin Research; 7; 1; 4-2024; 103-1192641-0281CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.melatonin-research.net/index.php/MR/article/view/262info:eu-repo/semantics/altIdentifier/doi/10.32794/mr112500170info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:30:09Zoai:ri.conicet.gov.ar:11336/243177instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:30:10.198CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The effects of endogenous melatonin on brain tissue oxidative stress induced by photoperiodic alterations and iron overloading in rats
title The effects of endogenous melatonin on brain tissue oxidative stress induced by photoperiodic alterations and iron overloading in rats
spellingShingle The effects of endogenous melatonin on brain tissue oxidative stress induced by photoperiodic alterations and iron overloading in rats
Hernando, Marcelo Pablo
MELATONIN
IRON DEXTRAN
OXIDANT/ANTIOXIDANT
BRAIN
RATS
title_short The effects of endogenous melatonin on brain tissue oxidative stress induced by photoperiodic alterations and iron overloading in rats
title_full The effects of endogenous melatonin on brain tissue oxidative stress induced by photoperiodic alterations and iron overloading in rats
title_fullStr The effects of endogenous melatonin on brain tissue oxidative stress induced by photoperiodic alterations and iron overloading in rats
title_full_unstemmed The effects of endogenous melatonin on brain tissue oxidative stress induced by photoperiodic alterations and iron overloading in rats
title_sort The effects of endogenous melatonin on brain tissue oxidative stress induced by photoperiodic alterations and iron overloading in rats
dc.creator.none.fl_str_mv Hernando, Marcelo Pablo
Cogo Pagella, Joaquín
Cervino, Claudio Osvaldo
author Hernando, Marcelo Pablo
author_facet Hernando, Marcelo Pablo
Cogo Pagella, Joaquín
Cervino, Claudio Osvaldo
author_role author
author2 Cogo Pagella, Joaquín
Cervino, Claudio Osvaldo
author2_role author
author
dc.subject.none.fl_str_mv MELATONIN
IRON DEXTRAN
OXIDANT/ANTIOXIDANT
BRAIN
RATS
topic MELATONIN
IRON DEXTRAN
OXIDANT/ANTIOXIDANT
BRAIN
RATS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Melatonin is a potent endogenously occurring antioxidant with the pleiotropic activities to neurodegenerative diseases associated with brain oxidative damage. In this study, we examined the prolonged photoperiodic alterations and iron (Fe) overload on melatonin production and brain oxidative stress in rats. The result showed that the 15 days of constant light (CL) exposure did not low the melatonin production but the 15 days of constant darkness (CD) significantly increased serum melatonin level in rats. The Fe treatment in both CL and CD conditions significantly reduced endogenous melatonin levels and increased brain tissue lipid peroxidation. Fe as a toxic transition metal can induce Fenton reaction to generated hydroxyl radical which can damage the neuronal cell membrane and impair the brain antioxidant system. In the current study, we observed the imbalanced antioxidant defense alterations upon Fe treatment in rat brain including the increased levels of alpha-tocopherol (α-T) and total thiols and the reduced melatonin level and catalase (CAT) activity. We speculated that the reduced melatonin level caused by Fe was due to its consumption since melatonin served as a metal chelator and antioxidant. Understanding these aspects enhances knowledge of brain Fe metabolism and its role in neurodegenerative disorders as well as the potential protective effects of melatonin on this metal.
Fil: Hernando, Marcelo Pablo. Universidad de Moron. Secretaria de Ciencia y Tecnologia. Instituto de Fisiologia y Neurociencias.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cogo Pagella, Joaquín. Universidad de Moron. Secretaria de Ciencia y Tecnologia. Instituto de Fisiologia y Neurociencias.; Argentina
Fil: Cervino, Claudio Osvaldo. Universidad de Moron. Secretaria de Ciencia y Tecnologia. Instituto de Fisiologia y Neurociencias.; Argentina
description Melatonin is a potent endogenously occurring antioxidant with the pleiotropic activities to neurodegenerative diseases associated with brain oxidative damage. In this study, we examined the prolonged photoperiodic alterations and iron (Fe) overload on melatonin production and brain oxidative stress in rats. The result showed that the 15 days of constant light (CL) exposure did not low the melatonin production but the 15 days of constant darkness (CD) significantly increased serum melatonin level in rats. The Fe treatment in both CL and CD conditions significantly reduced endogenous melatonin levels and increased brain tissue lipid peroxidation. Fe as a toxic transition metal can induce Fenton reaction to generated hydroxyl radical which can damage the neuronal cell membrane and impair the brain antioxidant system. In the current study, we observed the imbalanced antioxidant defense alterations upon Fe treatment in rat brain including the increased levels of alpha-tocopherol (α-T) and total thiols and the reduced melatonin level and catalase (CAT) activity. We speculated that the reduced melatonin level caused by Fe was due to its consumption since melatonin served as a metal chelator and antioxidant. Understanding these aspects enhances knowledge of brain Fe metabolism and its role in neurodegenerative disorders as well as the potential protective effects of melatonin on this metal.
publishDate 2024
dc.date.none.fl_str_mv 2024-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/243177
Hernando, Marcelo Pablo; Cogo Pagella, Joaquín; Cervino, Claudio Osvaldo; The effects of endogenous melatonin on brain tissue oxidative stress induced by photoperiodic alterations and iron overloading in rats; ST-Bio-Life LLC; Melatonin Research; 7; 1; 4-2024; 103-119
2641-0281
CONICET Digital
CONICET
url http://hdl.handle.net/11336/243177
identifier_str_mv Hernando, Marcelo Pablo; Cogo Pagella, Joaquín; Cervino, Claudio Osvaldo; The effects of endogenous melatonin on brain tissue oxidative stress induced by photoperiodic alterations and iron overloading in rats; ST-Bio-Life LLC; Melatonin Research; 7; 1; 4-2024; 103-119
2641-0281
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.melatonin-research.net/index.php/MR/article/view/262
info:eu-repo/semantics/altIdentifier/doi/10.32794/mr112500170
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv ST-Bio-Life LLC
publisher.none.fl_str_mv ST-Bio-Life LLC
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082776842895360
score 13.22299

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