Duplications and functional convergence of intestinal carbohydrate-digesting enzymes

Autores
Brun, Antonio; Mendez Aranda, Daniel; Magallanes Alba, Melisa Eliana; Karasov, William H.; Martínez del Rio, Carlos; Baldwin, Maude W.; Caviedes Vidal, Enrique Juan Raul
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Vertebrate diets and digestive physiologies vary tremendously. Although the contribution of ecological and behavioral features to such diversity is well documented, the roles and identities of individual intestinal enzymes shaping digestive traits remain largely unexplored. Here, we show that the sucrase-isomaltase (SI)/maltase-glucoamylase (MGAM) dual enzyme system long assumed to be the conserved disaccharide and starch digestion framework in all vertebrates is absent in many lineages. Our analyses indicate that independent duplications of an ancestral SI gave rise to the mammalianspecific MGAM, as well as to other duplicates in fish and birds. Strikingly, the duplicated avian enzyme exhibits similar activities to MGAM, revealing an unexpected case of functional convergence. Our results highlight digestive enzyme variation as a key uncharacterized component of dietary diversity in vertebrates.
Fil: Brun, Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Mendez Aranda, Daniel. Max Planck Institute für Ornithologie; Alemania
Fil: Magallanes Alba, Melisa Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Karasov, William H.. University of Wisconsin; Estados Unidos
Fil: Martínez del Rio, Carlos. University of Wyoming; Estados Unidos
Fil: Baldwin, Maude W.. Max Planck Institute für Ornithologie; Alemania
Fil: Caviedes Vidal, Enrique Juan Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Materia
CARBOHYDRATE DIGESTION
EVOLUTION
FUNCTIONAL CONVERGENCE
GENE DUPLICATIONS
PHYSIOLOGY
SUCRASE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/145004
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/145004
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Duplications and functional convergence of intestinal carbohydrate-digesting enzymesBrun, AntonioMendez Aranda, DanielMagallanes Alba, Melisa ElianaKarasov, William H.Martínez del Rio, CarlosBaldwin, Maude W.Caviedes Vidal, Enrique Juan RaulCARBOHYDRATE DIGESTIONEVOLUTIONFUNCTIONAL CONVERGENCEGENE DUPLICATIONSPHYSIOLOGYSUCRASEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Vertebrate diets and digestive physiologies vary tremendously. Although the contribution of ecological and behavioral features to such diversity is well documented, the roles and identities of individual intestinal enzymes shaping digestive traits remain largely unexplored. Here, we show that the sucrase-isomaltase (SI)/maltase-glucoamylase (MGAM) dual enzyme system long assumed to be the conserved disaccharide and starch digestion framework in all vertebrates is absent in many lineages. Our analyses indicate that independent duplications of an ancestral SI gave rise to the mammalianspecific MGAM, as well as to other duplicates in fish and birds. Strikingly, the duplicated avian enzyme exhibits similar activities to MGAM, revealing an unexpected case of functional convergence. Our results highlight digestive enzyme variation as a key uncharacterized component of dietary diversity in vertebrates.Fil: Brun, Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Mendez Aranda, Daniel. Max Planck Institute für Ornithologie; AlemaniaFil: Magallanes Alba, Melisa Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Karasov, William H.. University of Wisconsin; Estados UnidosFil: Martínez del Rio, Carlos. University of Wyoming; Estados UnidosFil: Baldwin, Maude W.. Max Planck Institute für Ornithologie; AlemaniaFil: Caviedes Vidal, Enrique Juan Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaOxford University Press2020-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/145004Brun, Antonio; Mendez Aranda, Daniel; Magallanes Alba, Melisa Eliana; Karasov, William H.; Martínez del Rio, Carlos; et al.; Duplications and functional convergence of intestinal carbohydrate-digesting enzymes; Oxford University Press; Molecular Biology and Evolution; 37; 6; 2-2020; 1657-16660737-4038CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msaa034/5736553info:eu-repo/semantics/altIdentifier/doi/10.1093/molbev/msaa034info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:30:25Zoai:ri.conicet.gov.ar:11336/145004instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:30:25.531CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Duplications and functional convergence of intestinal carbohydrate-digesting enzymes
title Duplications and functional convergence of intestinal carbohydrate-digesting enzymes
spellingShingle Duplications and functional convergence of intestinal carbohydrate-digesting enzymes
Brun, Antonio
CARBOHYDRATE DIGESTION
EVOLUTION
FUNCTIONAL CONVERGENCE
GENE DUPLICATIONS
PHYSIOLOGY
SUCRASE
title_short Duplications and functional convergence of intestinal carbohydrate-digesting enzymes
title_full Duplications and functional convergence of intestinal carbohydrate-digesting enzymes
title_fullStr Duplications and functional convergence of intestinal carbohydrate-digesting enzymes
title_full_unstemmed Duplications and functional convergence of intestinal carbohydrate-digesting enzymes
title_sort Duplications and functional convergence of intestinal carbohydrate-digesting enzymes
dc.creator.none.fl_str_mv Brun, Antonio
Mendez Aranda, Daniel
Magallanes Alba, Melisa Eliana
Karasov, William H.
Martínez del Rio, Carlos
Baldwin, Maude W.
Caviedes Vidal, Enrique Juan Raul
author Brun, Antonio
author_facet Brun, Antonio
Mendez Aranda, Daniel
Magallanes Alba, Melisa Eliana
Karasov, William H.
Martínez del Rio, Carlos
Baldwin, Maude W.
Caviedes Vidal, Enrique Juan Raul
author_role author
author2 Mendez Aranda, Daniel
Magallanes Alba, Melisa Eliana
Karasov, William H.
Martínez del Rio, Carlos
Baldwin, Maude W.
Caviedes Vidal, Enrique Juan Raul
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CARBOHYDRATE DIGESTION
EVOLUTION
FUNCTIONAL CONVERGENCE
GENE DUPLICATIONS
PHYSIOLOGY
SUCRASE
topic CARBOHYDRATE DIGESTION
EVOLUTION
FUNCTIONAL CONVERGENCE
GENE DUPLICATIONS
PHYSIOLOGY
SUCRASE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Vertebrate diets and digestive physiologies vary tremendously. Although the contribution of ecological and behavioral features to such diversity is well documented, the roles and identities of individual intestinal enzymes shaping digestive traits remain largely unexplored. Here, we show that the sucrase-isomaltase (SI)/maltase-glucoamylase (MGAM) dual enzyme system long assumed to be the conserved disaccharide and starch digestion framework in all vertebrates is absent in many lineages. Our analyses indicate that independent duplications of an ancestral SI gave rise to the mammalianspecific MGAM, as well as to other duplicates in fish and birds. Strikingly, the duplicated avian enzyme exhibits similar activities to MGAM, revealing an unexpected case of functional convergence. Our results highlight digestive enzyme variation as a key uncharacterized component of dietary diversity in vertebrates.
Fil: Brun, Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Mendez Aranda, Daniel. Max Planck Institute für Ornithologie; Alemania
Fil: Magallanes Alba, Melisa Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Karasov, William H.. University of Wisconsin; Estados Unidos
Fil: Martínez del Rio, Carlos. University of Wyoming; Estados Unidos
Fil: Baldwin, Maude W.. Max Planck Institute für Ornithologie; Alemania
Fil: Caviedes Vidal, Enrique Juan Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
description Vertebrate diets and digestive physiologies vary tremendously. Although the contribution of ecological and behavioral features to such diversity is well documented, the roles and identities of individual intestinal enzymes shaping digestive traits remain largely unexplored. Here, we show that the sucrase-isomaltase (SI)/maltase-glucoamylase (MGAM) dual enzyme system long assumed to be the conserved disaccharide and starch digestion framework in all vertebrates is absent in many lineages. Our analyses indicate that independent duplications of an ancestral SI gave rise to the mammalianspecific MGAM, as well as to other duplicates in fish and birds. Strikingly, the duplicated avian enzyme exhibits similar activities to MGAM, revealing an unexpected case of functional convergence. Our results highlight digestive enzyme variation as a key uncharacterized component of dietary diversity in vertebrates.
publishDate 2020
dc.date.none.fl_str_mv 2020-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/145004
Brun, Antonio; Mendez Aranda, Daniel; Magallanes Alba, Melisa Eliana; Karasov, William H.; Martínez del Rio, Carlos; et al.; Duplications and functional convergence of intestinal carbohydrate-digesting enzymes; Oxford University Press; Molecular Biology and Evolution; 37; 6; 2-2020; 1657-1666
0737-4038
CONICET Digital
CONICET
url http://hdl.handle.net/11336/145004
identifier_str_mv Brun, Antonio; Mendez Aranda, Daniel; Magallanes Alba, Melisa Eliana; Karasov, William H.; Martínez del Rio, Carlos; et al.; Duplications and functional convergence of intestinal carbohydrate-digesting enzymes; Oxford University Press; Molecular Biology and Evolution; 37; 6; 2-2020; 1657-1666
0737-4038
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msaa034/5736553
info:eu-repo/semantics/altIdentifier/doi/10.1093/molbev/msaa034
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082780904030208
score 13.22299

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