Sesqui- and triterpenoids from the liverwort Lepidozia chordulifera inhibitors of bacterial biofilm and elastase activity of human pathogenic bacteria

Autores
Gilabert Valero, José Miguel; Marcinkevicius, Karenina; Andujar, Sebastian Antonio; Schiavone, M.; Arena, Mario Eduardo; Bardon, Alicia del Valle
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Five dammarane type triterpenoids,five pentacyclictriterpenoids(three of them carrying a carboxylicacid group),and two aromadendrane-type sesquiterpenoids were isolated from an Argentinian collection of th e liverwort Lepidozia chordulifera. Compounds were characterized by comparison of their spectral data with those previously reported and tested in their ability to control bacterial growth, biofilm formation, bacterial Quorum Sensing process(QS),and elastase activity of Pseudomonas aeruginosa,as well as bacterial growth and biofilm formation of Staphylococcus aureus.The key role played by biofilm and elastase activity in bacterial virulence make them a potential target for the development of antibacterial agents.Thearomadendrane-type sesquiterpenoid viridiflorol was the most potent biofilm formation inhibitor, producing 60% inhibition in P. aeruginosa and 40% in S. aureus at 50μg/ml. Ursolic and betulinicacids(two of the pentacyclic triterpenoids isolated) were able to reduce 96 and 92% the elastase activity of P. aeruginosa at 50μg/ml,respectively.Among the analyzed triterpenoids,those that carry a dammaraneskeleton were the most potent inhibitors of the P. aeruginosa biofilm formation and were active against both P. aeruginosa and S.aureus. Subsequently,a computer- assisted study of the triterpenoid compounds was carried out for a better understanding of the structure-activity relationships.
Fil: Gilabert Valero, José Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Marcinkevicius, Karenina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina
Fil: Andujar, Sebastian Antonio. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Schiavone, M.. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Arena, Mario Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Bardon, Alicia del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Materia
Lepidozia Chordulifera
Biofilm
Elastase
Pseudomonas Aeruginosa
Staphylococcus Aureus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6742
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/6742
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sesqui- and triterpenoids from the liverwort Lepidozia chordulifera inhibitors of bacterial biofilm and elastase activity of human pathogenic bacteriaGilabert Valero, José MiguelMarcinkevicius, KareninaAndujar, Sebastian AntonioSchiavone, M.Arena, Mario EduardoBardon, Alicia del ValleLepidozia ChorduliferaBiofilmElastasePseudomonas AeruginosaStaphylococcus Aureushttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Five dammarane type triterpenoids,five pentacyclictriterpenoids(three of them carrying a carboxylicacid group),and two aromadendrane-type sesquiterpenoids were isolated from an Argentinian collection of th e liverwort Lepidozia chordulifera. Compounds were characterized by comparison of their spectral data with those previously reported and tested in their ability to control bacterial growth, biofilm formation, bacterial Quorum Sensing process(QS),and elastase activity of Pseudomonas aeruginosa,as well as bacterial growth and biofilm formation of Staphylococcus aureus.The key role played by biofilm and elastase activity in bacterial virulence make them a potential target for the development of antibacterial agents.Thearomadendrane-type sesquiterpenoid viridiflorol was the most potent biofilm formation inhibitor, producing 60% inhibition in P. aeruginosa and 40% in S. aureus at 50μg/ml. Ursolic and betulinicacids(two of the pentacyclic triterpenoids isolated) were able to reduce 96 and 92% the elastase activity of P. aeruginosa at 50μg/ml,respectively.Among the analyzed triterpenoids,those that carry a dammaraneskeleton were the most potent inhibitors of the P. aeruginosa biofilm formation and were active against both P. aeruginosa and S.aureus. Subsequently,a computer- assisted study of the triterpenoid compounds was carried out for a better understanding of the structure-activity relationships.Fil: Gilabert Valero, José Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Marcinkevicius, Karenina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; ArgentinaFil: Andujar, Sebastian Antonio. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Schiavone, M.. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Arena, Mario Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Bardon, Alicia del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaElsevier Gmbh2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6742Gilabert Valero, José Miguel; Marcinkevicius, Karenina; Andujar, Sebastian Antonio; Schiavone, M.; Arena, Mario Eduardo; et al.; Sesqui- and triterpenoids from the liverwort Lepidozia chordulifera inhibitors of bacterial biofilm and elastase activity of human pathogenic bacteria; Elsevier Gmbh; Phytomedicine; 22; 1; 1-2015; 77-850944-7113enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.phymed.2014.10.006info:eu-repo/semantics/altIdentifier/pmid/25636875info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:39:30Zoai:ri.conicet.gov.ar:11336/6742instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:39:31.237CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sesqui- and triterpenoids from the liverwort Lepidozia chordulifera inhibitors of bacterial biofilm and elastase activity of human pathogenic bacteria
title Sesqui- and triterpenoids from the liverwort Lepidozia chordulifera inhibitors of bacterial biofilm and elastase activity of human pathogenic bacteria
spellingShingle Sesqui- and triterpenoids from the liverwort Lepidozia chordulifera inhibitors of bacterial biofilm and elastase activity of human pathogenic bacteria
Gilabert Valero, José Miguel
Lepidozia Chordulifera
Biofilm
Elastase
Pseudomonas Aeruginosa
Staphylococcus Aureus
title_short Sesqui- and triterpenoids from the liverwort Lepidozia chordulifera inhibitors of bacterial biofilm and elastase activity of human pathogenic bacteria
title_full Sesqui- and triterpenoids from the liverwort Lepidozia chordulifera inhibitors of bacterial biofilm and elastase activity of human pathogenic bacteria
title_fullStr Sesqui- and triterpenoids from the liverwort Lepidozia chordulifera inhibitors of bacterial biofilm and elastase activity of human pathogenic bacteria
title_full_unstemmed Sesqui- and triterpenoids from the liverwort Lepidozia chordulifera inhibitors of bacterial biofilm and elastase activity of human pathogenic bacteria
title_sort Sesqui- and triterpenoids from the liverwort Lepidozia chordulifera inhibitors of bacterial biofilm and elastase activity of human pathogenic bacteria
dc.creator.none.fl_str_mv Gilabert Valero, José Miguel
Marcinkevicius, Karenina
Andujar, Sebastian Antonio
Schiavone, M.
Arena, Mario Eduardo
Bardon, Alicia del Valle
author Gilabert Valero, José Miguel
author_facet Gilabert Valero, José Miguel
Marcinkevicius, Karenina
Andujar, Sebastian Antonio
Schiavone, M.
Arena, Mario Eduardo
Bardon, Alicia del Valle
author_role author
author2 Marcinkevicius, Karenina
Andujar, Sebastian Antonio
Schiavone, M.
Arena, Mario Eduardo
Bardon, Alicia del Valle
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Lepidozia Chordulifera
Biofilm
Elastase
Pseudomonas Aeruginosa
Staphylococcus Aureus
topic Lepidozia Chordulifera
Biofilm
Elastase
Pseudomonas Aeruginosa
Staphylococcus Aureus
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Five dammarane type triterpenoids,five pentacyclictriterpenoids(three of them carrying a carboxylicacid group),and two aromadendrane-type sesquiterpenoids were isolated from an Argentinian collection of th e liverwort Lepidozia chordulifera. Compounds were characterized by comparison of their spectral data with those previously reported and tested in their ability to control bacterial growth, biofilm formation, bacterial Quorum Sensing process(QS),and elastase activity of Pseudomonas aeruginosa,as well as bacterial growth and biofilm formation of Staphylococcus aureus.The key role played by biofilm and elastase activity in bacterial virulence make them a potential target for the development of antibacterial agents.Thearomadendrane-type sesquiterpenoid viridiflorol was the most potent biofilm formation inhibitor, producing 60% inhibition in P. aeruginosa and 40% in S. aureus at 50μg/ml. Ursolic and betulinicacids(two of the pentacyclic triterpenoids isolated) were able to reduce 96 and 92% the elastase activity of P. aeruginosa at 50μg/ml,respectively.Among the analyzed triterpenoids,those that carry a dammaraneskeleton were the most potent inhibitors of the P. aeruginosa biofilm formation and were active against both P. aeruginosa and S.aureus. Subsequently,a computer- assisted study of the triterpenoid compounds was carried out for a better understanding of the structure-activity relationships.
Fil: Gilabert Valero, José Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Marcinkevicius, Karenina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina
Fil: Andujar, Sebastian Antonio. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Schiavone, M.. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Arena, Mario Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Bardon, Alicia del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
description Five dammarane type triterpenoids,five pentacyclictriterpenoids(three of them carrying a carboxylicacid group),and two aromadendrane-type sesquiterpenoids were isolated from an Argentinian collection of th e liverwort Lepidozia chordulifera. Compounds were characterized by comparison of their spectral data with those previously reported and tested in their ability to control bacterial growth, biofilm formation, bacterial Quorum Sensing process(QS),and elastase activity of Pseudomonas aeruginosa,as well as bacterial growth and biofilm formation of Staphylococcus aureus.The key role played by biofilm and elastase activity in bacterial virulence make them a potential target for the development of antibacterial agents.Thearomadendrane-type sesquiterpenoid viridiflorol was the most potent biofilm formation inhibitor, producing 60% inhibition in P. aeruginosa and 40% in S. aureus at 50μg/ml. Ursolic and betulinicacids(two of the pentacyclic triterpenoids isolated) were able to reduce 96 and 92% the elastase activity of P. aeruginosa at 50μg/ml,respectively.Among the analyzed triterpenoids,those that carry a dammaraneskeleton were the most potent inhibitors of the P. aeruginosa biofilm formation and were active against both P. aeruginosa and S.aureus. Subsequently,a computer- assisted study of the triterpenoid compounds was carried out for a better understanding of the structure-activity relationships.
publishDate 2015
dc.date.none.fl_str_mv 2015-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6742
Gilabert Valero, José Miguel; Marcinkevicius, Karenina; Andujar, Sebastian Antonio; Schiavone, M.; Arena, Mario Eduardo; et al.; Sesqui- and triterpenoids from the liverwort Lepidozia chordulifera inhibitors of bacterial biofilm and elastase activity of human pathogenic bacteria; Elsevier Gmbh; Phytomedicine; 22; 1; 1-2015; 77-85
0944-7113
url http://hdl.handle.net/11336/6742
identifier_str_mv Gilabert Valero, José Miguel; Marcinkevicius, Karenina; Andujar, Sebastian Antonio; Schiavone, M.; Arena, Mario Eduardo; et al.; Sesqui- and triterpenoids from the liverwort Lepidozia chordulifera inhibitors of bacterial biofilm and elastase activity of human pathogenic bacteria; Elsevier Gmbh; Phytomedicine; 22; 1; 1-2015; 77-85
0944-7113
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.phymed.2014.10.006
info:eu-repo/semantics/altIdentifier/pmid/25636875
info:eu-repo/semantics/altIdentifier/doi/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Gmbh
publisher.none.fl_str_mv Elsevier Gmbh
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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