Ancient mitogenomes of Argentine Patagonia (6070-310 YBP) reveal the early contribution of lineages not previously found in South America

Autores
Parolin, María Laura; Fregel Lorenzo, Rosa Irene; Bravi, Claudio Marcelo; Mendez, Fernando Luis; Dahinten, Silvia Lucrecia V.; Gomez Otero, Julieta; Shapiro, Beth; Green, Richard Edward; Tamburrini, Camila; Basso, Nestor Guillermo; Bustamante, Carlos
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Patagonia, a cul-de-sac for the continental dispersal of Homo sapiens into the Americas, has been extensively analyzed by archaeologists and bioanthropologists. Despite its deep and rich archaeological record, the genetic make up of its pre-contact inhabitants is barely known. We present the analysis of 19 mitogenomes recovered by NGS from archaeological sites in Central Patagonia (Chubut, Argentina). 15 are pre-contact samples, (6,010-770YBP), and four are samples from historical times (550-310YBP). Preservation of the samples was extraordinary, with endogenous DNA values up to 68%. Preliminary analysis indicates that mtDNA genomes. Central Patagonia belong to haplogroups B2 (21%), C1b (21%), C1c (5%), D1 (47%) and D4h3a (5%). This is surprising when compared with a database of 19,000 control region sequences and >2,100 mitogenomes of Native American origin: 1) While modern indigenous populations from Northern and Central Patagonia of Argentina and Chile derive 41-54% of their maternal lineages from clades B2i2 and C1b13, none of these are present in our dataset; 2) 75% of our B2 and C1b lineages share derived polymorphism with lineages so far known to be present only in modern Central-Western Argentina; and 3) although modern Patagonians carry the highest continental frequencies of D1g, the ancient set is enriched mostly in D1g5, a lineage widely distributed from South-Central Andes to Tierra del Fuego (including two samples with private motifs not described before). The upcoming analysis of the nuclear portion of these samples will help us better understand migratory and admixture processes in the Patagonian region.
Fil: Parolin, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; Argentina
Fil: Fregel Lorenzo, Rosa Irene. University of Stanford; Estados Unidos
Fil: Bravi, Claudio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Mendez, Fernando Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; Argentina
Fil: Dahinten, Silvia Lucrecia V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; Argentina
Fil: Gomez Otero, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; Argentina
Fil: Shapiro, Beth. University Of California At Santa Cruz.; Estados Unidos
Fil: Green, Richard Edward. University Of California At Santa Cruz.; Estados Unidos
Fil: Tamburrini, Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; Argentina
Fil: Basso, Nestor Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; Argentina
Fil: Bustamante, Carlos. University of Stanford; Estados Unidos
Materia
PATAGONIA
ANCIENT DNA
MITOGENOMES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/151850
Acceder
id CONICETDig_3a944b1accfc60f4df27395ca8d4d363
oai_identifier_str oai:ri.conicet.gov.ar:11336/151850
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Ancient mitogenomes of Argentine Patagonia (6070-310 YBP) reveal the early contribution of lineages not previously found in South AmericaParolin, María LauraFregel Lorenzo, Rosa IreneBravi, Claudio MarceloMendez, Fernando LuisDahinten, Silvia Lucrecia V.Gomez Otero, JulietaShapiro, BethGreen, Richard EdwardTamburrini, CamilaBasso, Nestor GuillermoBustamante, CarlosPATAGONIAANCIENT DNAMITOGENOMEShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Patagonia, a cul-de-sac for the continental dispersal of Homo sapiens into the Americas, has been extensively analyzed by archaeologists and bioanthropologists. Despite its deep and rich archaeological record, the genetic make up of its pre-contact inhabitants is barely known. We present the analysis of 19 mitogenomes recovered by NGS from archaeological sites in Central Patagonia (Chubut, Argentina). 15 are pre-contact samples, (6,010-770YBP), and four are samples from historical times (550-310YBP). Preservation of the samples was extraordinary, with endogenous DNA values up to 68%. Preliminary analysis indicates that mtDNA genomes. Central Patagonia belong to haplogroups B2 (21%), C1b (21%), C1c (5%), D1 (47%) and D4h3a (5%). This is surprising when compared with a database of 19,000 control region sequences and >2,100 mitogenomes of Native American origin: 1) While modern indigenous populations from Northern and Central Patagonia of Argentina and Chile derive 41-54% of their maternal lineages from clades B2i2 and C1b13, none of these are present in our dataset; 2) 75% of our B2 and C1b lineages share derived polymorphism with lineages so far known to be present only in modern Central-Western Argentina; and 3) although modern Patagonians carry the highest continental frequencies of D1g, the ancient set is enriched mostly in D1g5, a lineage widely distributed from South-Central Andes to Tierra del Fuego (including two samples with private motifs not described before). The upcoming analysis of the nuclear portion of these samples will help us better understand migratory and admixture processes in the Patagonian region.Fil: Parolin, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; ArgentinaFil: Fregel Lorenzo, Rosa Irene. University of Stanford; Estados UnidosFil: Bravi, Claudio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Mendez, Fernando Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; ArgentinaFil: Dahinten, Silvia Lucrecia V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; ArgentinaFil: Gomez Otero, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; ArgentinaFil: Shapiro, Beth. University Of California At Santa Cruz.; Estados UnidosFil: Green, Richard Edward. University Of California At Santa Cruz.; Estados UnidosFil: Tamburrini, Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; ArgentinaFil: Basso, Nestor Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; ArgentinaFil: Bustamante, Carlos. University of Stanford; Estados UnidosPeerJ, Inc.2017-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/151850Parolin, María Laura; Fregel Lorenzo, Rosa Irene; Bravi, Claudio Marcelo; Mendez, Fernando Luis; Dahinten, Silvia Lucrecia V.; et al.; Ancient mitogenomes of Argentine Patagonia (6070-310 YBP) reveal the early contribution of lineages not previously found in South America; PeerJ, Inc.; PeerJ PrePrints; 2017; 7-2017; 1-12167-9843CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.7287/peerj.preprints.3098v1info:eu-repo/semantics/altIdentifier/url/https://peerj.com/preprints/3098v1/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:40:50Zoai:ri.conicet.gov.ar:11336/151850instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:40:51.024CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ancient mitogenomes of Argentine Patagonia (6070-310 YBP) reveal the early contribution of lineages not previously found in South America
title Ancient mitogenomes of Argentine Patagonia (6070-310 YBP) reveal the early contribution of lineages not previously found in South America
spellingShingle Ancient mitogenomes of Argentine Patagonia (6070-310 YBP) reveal the early contribution of lineages not previously found in South America
Parolin, María Laura
PATAGONIA
ANCIENT DNA
MITOGENOMES
title_short Ancient mitogenomes of Argentine Patagonia (6070-310 YBP) reveal the early contribution of lineages not previously found in South America
title_full Ancient mitogenomes of Argentine Patagonia (6070-310 YBP) reveal the early contribution of lineages not previously found in South America
title_fullStr Ancient mitogenomes of Argentine Patagonia (6070-310 YBP) reveal the early contribution of lineages not previously found in South America
title_full_unstemmed Ancient mitogenomes of Argentine Patagonia (6070-310 YBP) reveal the early contribution of lineages not previously found in South America
title_sort Ancient mitogenomes of Argentine Patagonia (6070-310 YBP) reveal the early contribution of lineages not previously found in South America
dc.creator.none.fl_str_mv Parolin, María Laura
Fregel Lorenzo, Rosa Irene
Bravi, Claudio Marcelo
Mendez, Fernando Luis
Dahinten, Silvia Lucrecia V.
Gomez Otero, Julieta
Shapiro, Beth
Green, Richard Edward
Tamburrini, Camila
Basso, Nestor Guillermo
Bustamante, Carlos
author Parolin, María Laura
author_facet Parolin, María Laura
Fregel Lorenzo, Rosa Irene
Bravi, Claudio Marcelo
Mendez, Fernando Luis
Dahinten, Silvia Lucrecia V.
Gomez Otero, Julieta
Shapiro, Beth
Green, Richard Edward
Tamburrini, Camila
Basso, Nestor Guillermo
Bustamante, Carlos
author_role author
author2 Fregel Lorenzo, Rosa Irene
Bravi, Claudio Marcelo
Mendez, Fernando Luis
Dahinten, Silvia Lucrecia V.
Gomez Otero, Julieta
Shapiro, Beth
Green, Richard Edward
Tamburrini, Camila
Basso, Nestor Guillermo
Bustamante, Carlos
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv PATAGONIA
ANCIENT DNA
MITOGENOMES
topic PATAGONIA
ANCIENT DNA
MITOGENOMES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Patagonia, a cul-de-sac for the continental dispersal of Homo sapiens into the Americas, has been extensively analyzed by archaeologists and bioanthropologists. Despite its deep and rich archaeological record, the genetic make up of its pre-contact inhabitants is barely known. We present the analysis of 19 mitogenomes recovered by NGS from archaeological sites in Central Patagonia (Chubut, Argentina). 15 are pre-contact samples, (6,010-770YBP), and four are samples from historical times (550-310YBP). Preservation of the samples was extraordinary, with endogenous DNA values up to 68%. Preliminary analysis indicates that mtDNA genomes. Central Patagonia belong to haplogroups B2 (21%), C1b (21%), C1c (5%), D1 (47%) and D4h3a (5%). This is surprising when compared with a database of 19,000 control region sequences and >2,100 mitogenomes of Native American origin: 1) While modern indigenous populations from Northern and Central Patagonia of Argentina and Chile derive 41-54% of their maternal lineages from clades B2i2 and C1b13, none of these are present in our dataset; 2) 75% of our B2 and C1b lineages share derived polymorphism with lineages so far known to be present only in modern Central-Western Argentina; and 3) although modern Patagonians carry the highest continental frequencies of D1g, the ancient set is enriched mostly in D1g5, a lineage widely distributed from South-Central Andes to Tierra del Fuego (including two samples with private motifs not described before). The upcoming analysis of the nuclear portion of these samples will help us better understand migratory and admixture processes in the Patagonian region.
Fil: Parolin, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; Argentina
Fil: Fregel Lorenzo, Rosa Irene. University of Stanford; Estados Unidos
Fil: Bravi, Claudio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Mendez, Fernando Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; Argentina
Fil: Dahinten, Silvia Lucrecia V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; Argentina
Fil: Gomez Otero, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; Argentina
Fil: Shapiro, Beth. University Of California At Santa Cruz.; Estados Unidos
Fil: Green, Richard Edward. University Of California At Santa Cruz.; Estados Unidos
Fil: Tamburrini, Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; Argentina
Fil: Basso, Nestor Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; Argentina
Fil: Bustamante, Carlos. University of Stanford; Estados Unidos
description Patagonia, a cul-de-sac for the continental dispersal of Homo sapiens into the Americas, has been extensively analyzed by archaeologists and bioanthropologists. Despite its deep and rich archaeological record, the genetic make up of its pre-contact inhabitants is barely known. We present the analysis of 19 mitogenomes recovered by NGS from archaeological sites in Central Patagonia (Chubut, Argentina). 15 are pre-contact samples, (6,010-770YBP), and four are samples from historical times (550-310YBP). Preservation of the samples was extraordinary, with endogenous DNA values up to 68%. Preliminary analysis indicates that mtDNA genomes. Central Patagonia belong to haplogroups B2 (21%), C1b (21%), C1c (5%), D1 (47%) and D4h3a (5%). This is surprising when compared with a database of 19,000 control region sequences and >2,100 mitogenomes of Native American origin: 1) While modern indigenous populations from Northern and Central Patagonia of Argentina and Chile derive 41-54% of their maternal lineages from clades B2i2 and C1b13, none of these are present in our dataset; 2) 75% of our B2 and C1b lineages share derived polymorphism with lineages so far known to be present only in modern Central-Western Argentina; and 3) although modern Patagonians carry the highest continental frequencies of D1g, the ancient set is enriched mostly in D1g5, a lineage widely distributed from South-Central Andes to Tierra del Fuego (including two samples with private motifs not described before). The upcoming analysis of the nuclear portion of these samples will help us better understand migratory and admixture processes in the Patagonian region.
publishDate 2017
dc.date.none.fl_str_mv 2017-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/151850
Parolin, María Laura; Fregel Lorenzo, Rosa Irene; Bravi, Claudio Marcelo; Mendez, Fernando Luis; Dahinten, Silvia Lucrecia V.; et al.; Ancient mitogenomes of Argentine Patagonia (6070-310 YBP) reveal the early contribution of lineages not previously found in South America; PeerJ, Inc.; PeerJ PrePrints; 2017; 7-2017; 1-1
2167-9843
CONICET Digital
CONICET
url http://hdl.handle.net/11336/151850
identifier_str_mv Parolin, María Laura; Fregel Lorenzo, Rosa Irene; Bravi, Claudio Marcelo; Mendez, Fernando Luis; Dahinten, Silvia Lucrecia V.; et al.; Ancient mitogenomes of Argentine Patagonia (6070-310 YBP) reveal the early contribution of lineages not previously found in South America; PeerJ, Inc.; PeerJ PrePrints; 2017; 7-2017; 1-1
2167-9843
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.7287/peerj.preprints.3098v1
info:eu-repo/semantics/altIdentifier/url/https://peerj.com/preprints/3098v1/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv PeerJ, Inc.
publisher.none.fl_str_mv PeerJ, Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613292347097088
score 13.070432

Publicaciones similares