Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii
- Autores
- Traglia, German Matias; Quinn, Brettni; Schramm, Sareda T. J.; Soler Bistue, Alfonso J. C.; Ramirez, Maria Soledad
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The increasing frequency of bacteria showing antimicrobial resistance (AMR) raises the menace of entering into a postantibiotic era. Horizontal gene transfer (HGT) is one of the prime reasons for AMR acquisition. Acinetobacter baumannii is a nosocomial pathogen with outstanding abilities to survive in the hospital environment and to acquire resistance determinants. Its capacity to incorporate exogenous DNA is a major source of AMR genes; however, few studies have addressed this subject. The transformation machinery as well as the factors that induce natural competence in A. baumannii are unknown. In this study, we demonstrate that naturally competent strain A118 increases its natural transformation frequency upon the addition of Ca2+or albumin. We show that comEA and pilQ are involved in this process since their expression levels are increased upon the addition of these compounds. An unspecific protein, like casein, does not reproduce this effect, showing that albumin's effect is specific. Our work describes the first specific inducers of natural competence in A. baumannii. Overall, our results suggest that the main protein in blood enhances HGT in A. baumannii, contributing to the increase of AMR in this threatening human pathogen.
Fil: Traglia, German Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Quinn, Brettni. California State University; Estados Unidos
Fil: Schramm, Sareda T. J.. California State University; Estados Unidos
Fil: Soler Bistue, Alfonso Jc. Instituto Pasteur; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ramirez, Maria Soledad. California State University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
Acinetobacter Baumannii
Natural Transformation
Albumin - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/47523
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Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumanniiTraglia, German MatiasQuinn, BrettniSchramm, Sareda T. J.Soler Bistue, Alfonso J. C.Ramirez, Maria SoledadAcinetobacter BaumanniiNatural TransformationAlbuminhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The increasing frequency of bacteria showing antimicrobial resistance (AMR) raises the menace of entering into a postantibiotic era. Horizontal gene transfer (HGT) is one of the prime reasons for AMR acquisition. Acinetobacter baumannii is a nosocomial pathogen with outstanding abilities to survive in the hospital environment and to acquire resistance determinants. Its capacity to incorporate exogenous DNA is a major source of AMR genes; however, few studies have addressed this subject. The transformation machinery as well as the factors that induce natural competence in A. baumannii are unknown. In this study, we demonstrate that naturally competent strain A118 increases its natural transformation frequency upon the addition of Ca2+or albumin. We show that comEA and pilQ are involved in this process since their expression levels are increased upon the addition of these compounds. An unspecific protein, like casein, does not reproduce this effect, showing that albumin's effect is specific. Our work describes the first specific inducers of natural competence in A. baumannii. Overall, our results suggest that the main protein in blood enhances HGT in A. baumannii, contributing to the increase of AMR in this threatening human pathogen.Fil: Traglia, German Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Quinn, Brettni. California State University; Estados UnidosFil: Schramm, Sareda T. J.. California State University; Estados UnidosFil: Soler Bistue, Alfonso Jc. Instituto Pasteur; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ramirez, Maria Soledad. California State University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAmerican Society for Microbiology2016-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47523Traglia, German Matias; Quinn, Brettni; Schramm, Sareda T. J.; Soler Bistue, Alfonso J. C.; Ramirez, Maria Soledad; Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 60; 8; 8-2016; 4920-49290066-4804CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.00529-16info:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/content/60/8/4920info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:20Zoai:ri.conicet.gov.ar:11336/47523instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:20.939CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii |
title |
Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii |
spellingShingle |
Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii Traglia, German Matias Acinetobacter Baumannii Natural Transformation Albumin |
title_short |
Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii |
title_full |
Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii |
title_fullStr |
Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii |
title_full_unstemmed |
Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii |
title_sort |
Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii |
dc.creator.none.fl_str_mv |
Traglia, German Matias Quinn, Brettni Schramm, Sareda T. J. Soler Bistue, Alfonso J. C. Ramirez, Maria Soledad |
author |
Traglia, German Matias |
author_facet |
Traglia, German Matias Quinn, Brettni Schramm, Sareda T. J. Soler Bistue, Alfonso J. C. Ramirez, Maria Soledad |
author_role |
author |
author2 |
Quinn, Brettni Schramm, Sareda T. J. Soler Bistue, Alfonso J. C. Ramirez, Maria Soledad |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Acinetobacter Baumannii Natural Transformation Albumin |
topic |
Acinetobacter Baumannii Natural Transformation Albumin |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The increasing frequency of bacteria showing antimicrobial resistance (AMR) raises the menace of entering into a postantibiotic era. Horizontal gene transfer (HGT) is one of the prime reasons for AMR acquisition. Acinetobacter baumannii is a nosocomial pathogen with outstanding abilities to survive in the hospital environment and to acquire resistance determinants. Its capacity to incorporate exogenous DNA is a major source of AMR genes; however, few studies have addressed this subject. The transformation machinery as well as the factors that induce natural competence in A. baumannii are unknown. In this study, we demonstrate that naturally competent strain A118 increases its natural transformation frequency upon the addition of Ca2+or albumin. We show that comEA and pilQ are involved in this process since their expression levels are increased upon the addition of these compounds. An unspecific protein, like casein, does not reproduce this effect, showing that albumin's effect is specific. Our work describes the first specific inducers of natural competence in A. baumannii. Overall, our results suggest that the main protein in blood enhances HGT in A. baumannii, contributing to the increase of AMR in this threatening human pathogen. Fil: Traglia, German Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina Fil: Quinn, Brettni. California State University; Estados Unidos Fil: Schramm, Sareda T. J.. California State University; Estados Unidos Fil: Soler Bistue, Alfonso Jc. Instituto Pasteur; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ramirez, Maria Soledad. California State University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
The increasing frequency of bacteria showing antimicrobial resistance (AMR) raises the menace of entering into a postantibiotic era. Horizontal gene transfer (HGT) is one of the prime reasons for AMR acquisition. Acinetobacter baumannii is a nosocomial pathogen with outstanding abilities to survive in the hospital environment and to acquire resistance determinants. Its capacity to incorporate exogenous DNA is a major source of AMR genes; however, few studies have addressed this subject. The transformation machinery as well as the factors that induce natural competence in A. baumannii are unknown. In this study, we demonstrate that naturally competent strain A118 increases its natural transformation frequency upon the addition of Ca2+or albumin. We show that comEA and pilQ are involved in this process since their expression levels are increased upon the addition of these compounds. An unspecific protein, like casein, does not reproduce this effect, showing that albumin's effect is specific. Our work describes the first specific inducers of natural competence in A. baumannii. Overall, our results suggest that the main protein in blood enhances HGT in A. baumannii, contributing to the increase of AMR in this threatening human pathogen. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/47523 Traglia, German Matias; Quinn, Brettni; Schramm, Sareda T. J.; Soler Bistue, Alfonso J. C.; Ramirez, Maria Soledad; Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 60; 8; 8-2016; 4920-4929 0066-4804 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/47523 |
identifier_str_mv |
Traglia, German Matias; Quinn, Brettni; Schramm, Sareda T. J.; Soler Bistue, Alfonso J. C.; Ramirez, Maria Soledad; Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 60; 8; 8-2016; 4920-4929 0066-4804 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.00529-16 info:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/content/60/8/4920 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Society for Microbiology |
publisher.none.fl_str_mv |
American Society for Microbiology |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842270115210461184 |
score |
13.13397 |