Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii

Autores
Traglia, German Matias; Quinn, Brettni; Schramm, Sareda T. J.; Soler Bistue, Alfonso J. C.; Ramirez, Maria Soledad
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The increasing frequency of bacteria showing antimicrobial resistance (AMR) raises the menace of entering into a postantibiotic era. Horizontal gene transfer (HGT) is one of the prime reasons for AMR acquisition. Acinetobacter baumannii is a nosocomial pathogen with outstanding abilities to survive in the hospital environment and to acquire resistance determinants. Its capacity to incorporate exogenous DNA is a major source of AMR genes; however, few studies have addressed this subject. The transformation machinery as well as the factors that induce natural competence in A. baumannii are unknown. In this study, we demonstrate that naturally competent strain A118 increases its natural transformation frequency upon the addition of Ca2+or albumin. We show that comEA and pilQ are involved in this process since their expression levels are increased upon the addition of these compounds. An unspecific protein, like casein, does not reproduce this effect, showing that albumin's effect is specific. Our work describes the first specific inducers of natural competence in A. baumannii. Overall, our results suggest that the main protein in blood enhances HGT in A. baumannii, contributing to the increase of AMR in this threatening human pathogen.
Fil: Traglia, German Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Quinn, Brettni. California State University; Estados Unidos
Fil: Schramm, Sareda T. J.. California State University; Estados Unidos
Fil: Soler Bistue, Alfonso Jc. Instituto Pasteur; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ramirez, Maria Soledad. California State University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Acinetobacter Baumannii
Natural Transformation
Albumin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/47523

id CONICETDig_3a704c3520f1ad60702ac11ac13b30fa
oai_identifier_str oai:ri.conicet.gov.ar:11336/47523
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumanniiTraglia, German MatiasQuinn, BrettniSchramm, Sareda T. J.Soler Bistue, Alfonso J. C.Ramirez, Maria SoledadAcinetobacter BaumanniiNatural TransformationAlbuminhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The increasing frequency of bacteria showing antimicrobial resistance (AMR) raises the menace of entering into a postantibiotic era. Horizontal gene transfer (HGT) is one of the prime reasons for AMR acquisition. Acinetobacter baumannii is a nosocomial pathogen with outstanding abilities to survive in the hospital environment and to acquire resistance determinants. Its capacity to incorporate exogenous DNA is a major source of AMR genes; however, few studies have addressed this subject. The transformation machinery as well as the factors that induce natural competence in A. baumannii are unknown. In this study, we demonstrate that naturally competent strain A118 increases its natural transformation frequency upon the addition of Ca2+or albumin. We show that comEA and pilQ are involved in this process since their expression levels are increased upon the addition of these compounds. An unspecific protein, like casein, does not reproduce this effect, showing that albumin's effect is specific. Our work describes the first specific inducers of natural competence in A. baumannii. Overall, our results suggest that the main protein in blood enhances HGT in A. baumannii, contributing to the increase of AMR in this threatening human pathogen.Fil: Traglia, German Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Quinn, Brettni. California State University; Estados UnidosFil: Schramm, Sareda T. J.. California State University; Estados UnidosFil: Soler Bistue, Alfonso Jc. Instituto Pasteur; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ramirez, Maria Soledad. California State University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAmerican Society for Microbiology2016-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47523Traglia, German Matias; Quinn, Brettni; Schramm, Sareda T. J.; Soler Bistue, Alfonso J. C.; Ramirez, Maria Soledad; Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 60; 8; 8-2016; 4920-49290066-4804CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.00529-16info:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/content/60/8/4920info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:20Zoai:ri.conicet.gov.ar:11336/47523instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:20.939CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii
title Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii
spellingShingle Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii
Traglia, German Matias
Acinetobacter Baumannii
Natural Transformation
Albumin
title_short Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii
title_full Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii
title_fullStr Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii
title_full_unstemmed Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii
title_sort Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii
dc.creator.none.fl_str_mv Traglia, German Matias
Quinn, Brettni
Schramm, Sareda T. J.
Soler Bistue, Alfonso J. C.
Ramirez, Maria Soledad
author Traglia, German Matias
author_facet Traglia, German Matias
Quinn, Brettni
Schramm, Sareda T. J.
Soler Bistue, Alfonso J. C.
Ramirez, Maria Soledad
author_role author
author2 Quinn, Brettni
Schramm, Sareda T. J.
Soler Bistue, Alfonso J. C.
Ramirez, Maria Soledad
author2_role author
author
author
author
dc.subject.none.fl_str_mv Acinetobacter Baumannii
Natural Transformation
Albumin
topic Acinetobacter Baumannii
Natural Transformation
Albumin
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The increasing frequency of bacteria showing antimicrobial resistance (AMR) raises the menace of entering into a postantibiotic era. Horizontal gene transfer (HGT) is one of the prime reasons for AMR acquisition. Acinetobacter baumannii is a nosocomial pathogen with outstanding abilities to survive in the hospital environment and to acquire resistance determinants. Its capacity to incorporate exogenous DNA is a major source of AMR genes; however, few studies have addressed this subject. The transformation machinery as well as the factors that induce natural competence in A. baumannii are unknown. In this study, we demonstrate that naturally competent strain A118 increases its natural transformation frequency upon the addition of Ca2+or albumin. We show that comEA and pilQ are involved in this process since their expression levels are increased upon the addition of these compounds. An unspecific protein, like casein, does not reproduce this effect, showing that albumin's effect is specific. Our work describes the first specific inducers of natural competence in A. baumannii. Overall, our results suggest that the main protein in blood enhances HGT in A. baumannii, contributing to the increase of AMR in this threatening human pathogen.
Fil: Traglia, German Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Quinn, Brettni. California State University; Estados Unidos
Fil: Schramm, Sareda T. J.. California State University; Estados Unidos
Fil: Soler Bistue, Alfonso Jc. Instituto Pasteur; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ramirez, Maria Soledad. California State University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The increasing frequency of bacteria showing antimicrobial resistance (AMR) raises the menace of entering into a postantibiotic era. Horizontal gene transfer (HGT) is one of the prime reasons for AMR acquisition. Acinetobacter baumannii is a nosocomial pathogen with outstanding abilities to survive in the hospital environment and to acquire resistance determinants. Its capacity to incorporate exogenous DNA is a major source of AMR genes; however, few studies have addressed this subject. The transformation machinery as well as the factors that induce natural competence in A. baumannii are unknown. In this study, we demonstrate that naturally competent strain A118 increases its natural transformation frequency upon the addition of Ca2+or albumin. We show that comEA and pilQ are involved in this process since their expression levels are increased upon the addition of these compounds. An unspecific protein, like casein, does not reproduce this effect, showing that albumin's effect is specific. Our work describes the first specific inducers of natural competence in A. baumannii. Overall, our results suggest that the main protein in blood enhances HGT in A. baumannii, contributing to the increase of AMR in this threatening human pathogen.
publishDate 2016
dc.date.none.fl_str_mv 2016-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/47523
Traglia, German Matias; Quinn, Brettni; Schramm, Sareda T. J.; Soler Bistue, Alfonso J. C.; Ramirez, Maria Soledad; Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 60; 8; 8-2016; 4920-4929
0066-4804
CONICET Digital
CONICET
url http://hdl.handle.net/11336/47523
identifier_str_mv Traglia, German Matias; Quinn, Brettni; Schramm, Sareda T. J.; Soler Bistue, Alfonso J. C.; Ramirez, Maria Soledad; Serum Albumin and Ca 2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 60; 8; 8-2016; 4920-4929
0066-4804
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.00529-16
info:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/content/60/8/4920
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270115210461184
score 13.13397