Enhanced working memory binding by direct electrical stimulation of the parietal cortex

Autores
Birba, Agustina; Hesse Rizzi, Eugenia Fátima; Sedeño, Lucas; Mikulan, Ezequiel Pablo; García, María del Carmen; Avalos, Juan Carlos; Gonzalez Adolfi, Federico; Legaz, Agustina; Bekinschtein, Tristán Andrés; Zimerman, Máximo; Parra, Mario; García, Adolfo Martín; Ibáñez Barassi, Agustín Mariano
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Recent works evince the critical role of visual short-term memory (STM) binding deficits as a clinical and preclinical marker of Alzheimer's disease (AD). These studies suggest a potential role of posterior brain regions in both the neurocognitive deficits of Alzheimer's patients and STM binding in general. Thereupon, we surmised that stimulation of the posterior parietal cortex (PPC) might be a successful approach to tackle working memory deficits in this condition, especially at early stages. To date, no causal evidence exists of the role of the parietal cortex in STM binding. A unique approach to assess this issue is afforded by single-subject direct intracranial electrical stimulation of specific brain regions during a relevant cognitive task. Electrical stimulation has been used both for clinical purposes and to causally probe brain mechanisms. Previous evidence of electrical currents spreading through white matter along well defined functional circuits indicates that visual working memory mechanisms are subserved by a specific widely distributed network. Here, we stimulated the parietal cortex of a subject with intracranial electrodes as he performed the visual STM task. We compared the ensuing results to those from a non-stimulated condition and to the performance of a matched control group. In brief, direct stimulation of the parietal cortex induced a selective improvement in STM. These results, together with previous studies, provide very preliminary but promising ground to examine behavioral changes upon parietal stimulation in AD. We discuss our results regarding: (a) the usefulness of the task to target prodromal stages of AD; (b) the role of a posterior network in STM binding and in AD; and (c) the potential opportunity to improve STM binding through brain stimulation.
Fil: Birba, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Hesse Rizzi, Eugenia Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina
Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Mikulan, Ezequiel Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: García, María del Carmen. Hospital Italiano; Argentina
Fil: Avalos, Juan Carlos. Hospital Italiano; Argentina
Fil: Gonzalez Adolfi, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Legaz, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Bekinschtein, Tristán Andrés. University of Cambridge; Reino Unido
Fil: Zimerman, Máximo. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina
Fil: Parra, Mario. Heriot-Watt University; Reino Unido. University of Edinburgh; Reino Unido. NHS Research Scotland; Reino Unido. Universidad Autónoma del Caribe; Colombia
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Nacional de Cuyo; Argentina
Fil: Ibáñez Barassi, Agustín Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Autónoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Australian Research Council ; Australia
Materia
ALZHIMER'S DISEASE
DIRECT ELECTRICAL STIMULATION
SHORT TERM MEMORY
SINGLE CASE STUDY
WORKING MEMORY BINDING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/48767
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Enhanced working memory binding by direct electrical stimulation of the parietal cortexBirba, AgustinaHesse Rizzi, Eugenia FátimaSedeño, LucasMikulan, Ezequiel PabloGarcía, María del CarmenAvalos, Juan CarlosGonzalez Adolfi, FedericoLegaz, AgustinaBekinschtein, Tristán AndrésZimerman, MáximoParra, MarioGarcía, Adolfo MartínIbáñez Barassi, Agustín MarianoALZHIMER'S DISEASEDIRECT ELECTRICAL STIMULATIONSHORT TERM MEMORYSINGLE CASE STUDYWORKING MEMORY BINDINGhttps://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5Recent works evince the critical role of visual short-term memory (STM) binding deficits as a clinical and preclinical marker of Alzheimer's disease (AD). These studies suggest a potential role of posterior brain regions in both the neurocognitive deficits of Alzheimer's patients and STM binding in general. Thereupon, we surmised that stimulation of the posterior parietal cortex (PPC) might be a successful approach to tackle working memory deficits in this condition, especially at early stages. To date, no causal evidence exists of the role of the parietal cortex in STM binding. A unique approach to assess this issue is afforded by single-subject direct intracranial electrical stimulation of specific brain regions during a relevant cognitive task. Electrical stimulation has been used both for clinical purposes and to causally probe brain mechanisms. Previous evidence of electrical currents spreading through white matter along well defined functional circuits indicates that visual working memory mechanisms are subserved by a specific widely distributed network. Here, we stimulated the parietal cortex of a subject with intracranial electrodes as he performed the visual STM task. We compared the ensuing results to those from a non-stimulated condition and to the performance of a matched control group. In brief, direct stimulation of the parietal cortex induced a selective improvement in STM. These results, together with previous studies, provide very preliminary but promising ground to examine behavioral changes upon parietal stimulation in AD. We discuss our results regarding: (a) the usefulness of the task to target prodromal stages of AD; (b) the role of a posterior network in STM binding and in AD; and (c) the potential opportunity to improve STM binding through brain stimulation.Fil: Birba, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Hesse Rizzi, Eugenia Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería; ArgentinaFil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Mikulan, Ezequiel Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: García, María del Carmen. Hospital Italiano; ArgentinaFil: Avalos, Juan Carlos. Hospital Italiano; ArgentinaFil: Gonzalez Adolfi, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Legaz, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Bekinschtein, Tristán Andrés. University of Cambridge; Reino UnidoFil: Zimerman, Máximo. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; ArgentinaFil: Parra, Mario. Heriot-Watt University; Reino Unido. University of Edinburgh; Reino Unido. NHS Research Scotland; Reino Unido. Universidad Autónoma del Caribe; ColombiaFil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Nacional de Cuyo; ArgentinaFil: Ibáñez Barassi, Agustín Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Autónoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Australian Research Council ; AustraliaFrontiers Media S.A.2017-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/48767Birba, Agustina; Hesse Rizzi, Eugenia Fátima; Sedeño, Lucas; Mikulan, Ezequiel Pablo; García, María del Carmen; et al.; Enhanced working memory binding by direct electrical stimulation of the parietal cortex; Frontiers Media S.A.; Frontiers in Aging Neuroscience; 9; 6-2017; 1-71663-4365CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fnagi.2017.00178info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnagi.2017.00178/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-03-31T15:11:53Zoai:ri.conicet.gov.ar:11336/48767instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-03-31 15:11:54.094CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Enhanced working memory binding by direct electrical stimulation of the parietal cortex
title Enhanced working memory binding by direct electrical stimulation of the parietal cortex
spellingShingle Enhanced working memory binding by direct electrical stimulation of the parietal cortex
Birba, Agustina
ALZHIMER'S DISEASE
DIRECT ELECTRICAL STIMULATION
SHORT TERM MEMORY
SINGLE CASE STUDY
WORKING MEMORY BINDING
title_short Enhanced working memory binding by direct electrical stimulation of the parietal cortex
title_full Enhanced working memory binding by direct electrical stimulation of the parietal cortex
title_fullStr Enhanced working memory binding by direct electrical stimulation of the parietal cortex
title_full_unstemmed Enhanced working memory binding by direct electrical stimulation of the parietal cortex
title_sort Enhanced working memory binding by direct electrical stimulation of the parietal cortex
dc.creator.none.fl_str_mv Birba, Agustina
Hesse Rizzi, Eugenia Fátima
Sedeño, Lucas
Mikulan, Ezequiel Pablo
García, María del Carmen
Avalos, Juan Carlos
Gonzalez Adolfi, Federico
Legaz, Agustina
Bekinschtein, Tristán Andrés
Zimerman, Máximo
Parra, Mario
García, Adolfo Martín
Ibáñez Barassi, Agustín Mariano
author Birba, Agustina
author_facet Birba, Agustina
Hesse Rizzi, Eugenia Fátima
Sedeño, Lucas
Mikulan, Ezequiel Pablo
García, María del Carmen
Avalos, Juan Carlos
Gonzalez Adolfi, Federico
Legaz, Agustina
Bekinschtein, Tristán Andrés
Zimerman, Máximo
Parra, Mario
García, Adolfo Martín
Ibáñez Barassi, Agustín Mariano
author_role author
author2 Hesse Rizzi, Eugenia Fátima
Sedeño, Lucas
Mikulan, Ezequiel Pablo
García, María del Carmen
Avalos, Juan Carlos
Gonzalez Adolfi, Federico
Legaz, Agustina
Bekinschtein, Tristán Andrés
Zimerman, Máximo
Parra, Mario
García, Adolfo Martín
Ibáñez Barassi, Agustín Mariano
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ALZHIMER'S DISEASE
DIRECT ELECTRICAL STIMULATION
SHORT TERM MEMORY
SINGLE CASE STUDY
WORKING MEMORY BINDING
topic ALZHIMER'S DISEASE
DIRECT ELECTRICAL STIMULATION
SHORT TERM MEMORY
SINGLE CASE STUDY
WORKING MEMORY BINDING
purl_subject.fl_str_mv https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
dc.description.none.fl_txt_mv Recent works evince the critical role of visual short-term memory (STM) binding deficits as a clinical and preclinical marker of Alzheimer's disease (AD). These studies suggest a potential role of posterior brain regions in both the neurocognitive deficits of Alzheimer's patients and STM binding in general. Thereupon, we surmised that stimulation of the posterior parietal cortex (PPC) might be a successful approach to tackle working memory deficits in this condition, especially at early stages. To date, no causal evidence exists of the role of the parietal cortex in STM binding. A unique approach to assess this issue is afforded by single-subject direct intracranial electrical stimulation of specific brain regions during a relevant cognitive task. Electrical stimulation has been used both for clinical purposes and to causally probe brain mechanisms. Previous evidence of electrical currents spreading through white matter along well defined functional circuits indicates that visual working memory mechanisms are subserved by a specific widely distributed network. Here, we stimulated the parietal cortex of a subject with intracranial electrodes as he performed the visual STM task. We compared the ensuing results to those from a non-stimulated condition and to the performance of a matched control group. In brief, direct stimulation of the parietal cortex induced a selective improvement in STM. These results, together with previous studies, provide very preliminary but promising ground to examine behavioral changes upon parietal stimulation in AD. We discuss our results regarding: (a) the usefulness of the task to target prodromal stages of AD; (b) the role of a posterior network in STM binding and in AD; and (c) the potential opportunity to improve STM binding through brain stimulation.
Fil: Birba, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Hesse Rizzi, Eugenia Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina
Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Mikulan, Ezequiel Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: García, María del Carmen. Hospital Italiano; Argentina
Fil: Avalos, Juan Carlos. Hospital Italiano; Argentina
Fil: Gonzalez Adolfi, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Legaz, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Bekinschtein, Tristán Andrés. University of Cambridge; Reino Unido
Fil: Zimerman, Máximo. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina
Fil: Parra, Mario. Heriot-Watt University; Reino Unido. University of Edinburgh; Reino Unido. NHS Research Scotland; Reino Unido. Universidad Autónoma del Caribe; Colombia
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Nacional de Cuyo; Argentina
Fil: Ibáñez Barassi, Agustín Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Autónoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Australian Research Council ; Australia
description Recent works evince the critical role of visual short-term memory (STM) binding deficits as a clinical and preclinical marker of Alzheimer's disease (AD). These studies suggest a potential role of posterior brain regions in both the neurocognitive deficits of Alzheimer's patients and STM binding in general. Thereupon, we surmised that stimulation of the posterior parietal cortex (PPC) might be a successful approach to tackle working memory deficits in this condition, especially at early stages. To date, no causal evidence exists of the role of the parietal cortex in STM binding. A unique approach to assess this issue is afforded by single-subject direct intracranial electrical stimulation of specific brain regions during a relevant cognitive task. Electrical stimulation has been used both for clinical purposes and to causally probe brain mechanisms. Previous evidence of electrical currents spreading through white matter along well defined functional circuits indicates that visual working memory mechanisms are subserved by a specific widely distributed network. Here, we stimulated the parietal cortex of a subject with intracranial electrodes as he performed the visual STM task. We compared the ensuing results to those from a non-stimulated condition and to the performance of a matched control group. In brief, direct stimulation of the parietal cortex induced a selective improvement in STM. These results, together with previous studies, provide very preliminary but promising ground to examine behavioral changes upon parietal stimulation in AD. We discuss our results regarding: (a) the usefulness of the task to target prodromal stages of AD; (b) the role of a posterior network in STM binding and in AD; and (c) the potential opportunity to improve STM binding through brain stimulation.
publishDate 2017
dc.date.none.fl_str_mv 2017-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/48767
Birba, Agustina; Hesse Rizzi, Eugenia Fátima; Sedeño, Lucas; Mikulan, Ezequiel Pablo; García, María del Carmen; et al.; Enhanced working memory binding by direct electrical stimulation of the parietal cortex; Frontiers Media S.A.; Frontiers in Aging Neuroscience; 9; 6-2017; 1-7
1663-4365
CONICET Digital
CONICET
url http://hdl.handle.net/11336/48767
identifier_str_mv Birba, Agustina; Hesse Rizzi, Eugenia Fátima; Sedeño, Lucas; Mikulan, Ezequiel Pablo; García, María del Carmen; et al.; Enhanced working memory binding by direct electrical stimulation of the parietal cortex; Frontiers Media S.A.; Frontiers in Aging Neuroscience; 9; 6-2017; 1-7
1663-4365
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fnagi.2017.00178
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnagi.2017.00178/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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