Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy

Autores
Ribeiro, Andreza; Sosnik, Alejandro Dario; Chiappetta, Diego Andrés; Veiga, Francisco; Concheiro, Angel; Alvarez Lorenzo, Carmen
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Polymeric micelles of single and mixed poloxamines (Tetronic) were evaluated regarding their ability to host the antiglaucoma agent ethoxzolamide (ETOX) for topical ocular application. Three highly hydrophilic varieties of poloxamine (T908, T1107 and T1307) and a medium hydrophilic variety (T904), possessing a similar number of propylene oxide units but different contents in ethylene oxide, were chosen for the study. The critical micellar concentration and the cloud point of mixed micelles in 0.9 per cent NaCl were slightly greater than the values predicted from the additive rule, suggesting that the co-micellization is hindered. Micellar size ranged between 17 and 120 nm and it was not altered after the loading of ETOX (2.7-11.5 mg drug g-1 poloxamine). Drug solubilization ability ranked in the order: T904 (50-fold increase in the apparent solubility) > T1107 ≅ T1307 > T908. Mixed micelles showed an intermediate capability to host ETOX but a greater physical stability, maintaining almost 100 per cent drug solubilized after 28 days. Furthermore, the different structural features of poloxamines and their combination in mixed micelles enabled the tuning of drug release profiles, sustaining the release in the 1-5 days range. These findings together with promising hen's egg test-chorioallantoic membrane biocompatibility tests make poloxamine micelles promising nanocarriers for carbonic anhydrase inhibitors in the treatment of glaucoma.
Fil: Ribeiro, Andreza. Universidad de Santiago de Compostela; España
Fil: Sosnik, Alejandro Dario. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chiappetta, Diego Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Veiga, Francisco. Universidad de Coimbra; Portugal
Fil: Concheiro, Angel. Universidad de Santiago de Compostela; España
Fil: Alvarez Lorenzo, Carmen. Universidad de Santiago de Compostela; España
Materia
CARBONIC ANHYDRASE INHIBITOR SOLUBILIZATION
ETHOXZOLAMIDE
OCULAR DELIVERY
POLOXAMINE
POLY(ETHYLENE OXIDE)-POLY(PROPYLENE OXIDE) BLOCK COPOLYMER
POLYMERIC MICELLES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/197313
Acceder
id CONICETDig_39a54fb50f237bd547f5211d88f5f846
oai_identifier_str oai:ri.conicet.gov.ar:11336/197313
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapyRibeiro, AndrezaSosnik, Alejandro DarioChiappetta, Diego AndrésVeiga, FranciscoConcheiro, AngelAlvarez Lorenzo, CarmenCARBONIC ANHYDRASE INHIBITOR SOLUBILIZATIONETHOXZOLAMIDEOCULAR DELIVERYPOLOXAMINEPOLY(ETHYLENE OXIDE)-POLY(PROPYLENE OXIDE) BLOCK COPOLYMERPOLYMERIC MICELLEShttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Polymeric micelles of single and mixed poloxamines (Tetronic) were evaluated regarding their ability to host the antiglaucoma agent ethoxzolamide (ETOX) for topical ocular application. Three highly hydrophilic varieties of poloxamine (T908, T1107 and T1307) and a medium hydrophilic variety (T904), possessing a similar number of propylene oxide units but different contents in ethylene oxide, were chosen for the study. The critical micellar concentration and the cloud point of mixed micelles in 0.9 per cent NaCl were slightly greater than the values predicted from the additive rule, suggesting that the co-micellization is hindered. Micellar size ranged between 17 and 120 nm and it was not altered after the loading of ETOX (2.7-11.5 mg drug g-1 poloxamine). Drug solubilization ability ranked in the order: T904 (50-fold increase in the apparent solubility) > T1107 ≅ T1307 > T908. Mixed micelles showed an intermediate capability to host ETOX but a greater physical stability, maintaining almost 100 per cent drug solubilized after 28 days. Furthermore, the different structural features of poloxamines and their combination in mixed micelles enabled the tuning of drug release profiles, sustaining the release in the 1-5 days range. These findings together with promising hen's egg test-chorioallantoic membrane biocompatibility tests make poloxamine micelles promising nanocarriers for carbonic anhydrase inhibitors in the treatment of glaucoma.Fil: Ribeiro, Andreza. Universidad de Santiago de Compostela; EspañaFil: Sosnik, Alejandro Dario. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Chiappetta, Diego Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Veiga, Francisco. Universidad de Coimbra; PortugalFil: Concheiro, Angel. Universidad de Santiago de Compostela; EspañaFil: Alvarez Lorenzo, Carmen. Universidad de Santiago de Compostela; EspañaThe Royal Society2012-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/197313Ribeiro, Andreza; Sosnik, Alejandro Dario; Chiappetta, Diego Andrés; Veiga, Francisco; Concheiro, Angel; et al.; Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy; The Royal Society; Journal of the Royal Society Interface; 9; 74; 9-2012; 2059-20691742-5689CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://rsif.royalsocietypublishing.org/content/9/74/2059.full.pdf+htmlinfo:eu-repo/semantics/altIdentifier/doi/10.1098/rsif.2012.0102info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:09:03Zoai:ri.conicet.gov.ar:11336/197313instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:09:04.268CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy
title Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy
spellingShingle Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy
Ribeiro, Andreza
CARBONIC ANHYDRASE INHIBITOR SOLUBILIZATION
ETHOXZOLAMIDE
OCULAR DELIVERY
POLOXAMINE
POLY(ETHYLENE OXIDE)-POLY(PROPYLENE OXIDE) BLOCK COPOLYMER
POLYMERIC MICELLES
title_short Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy
title_full Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy
title_fullStr Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy
title_full_unstemmed Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy
title_sort Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy
dc.creator.none.fl_str_mv Ribeiro, Andreza
Sosnik, Alejandro Dario
Chiappetta, Diego Andrés
Veiga, Francisco
Concheiro, Angel
Alvarez Lorenzo, Carmen
author Ribeiro, Andreza
author_facet Ribeiro, Andreza
Sosnik, Alejandro Dario
Chiappetta, Diego Andrés
Veiga, Francisco
Concheiro, Angel
Alvarez Lorenzo, Carmen
author_role author
author2 Sosnik, Alejandro Dario
Chiappetta, Diego Andrés
Veiga, Francisco
Concheiro, Angel
Alvarez Lorenzo, Carmen
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CARBONIC ANHYDRASE INHIBITOR SOLUBILIZATION
ETHOXZOLAMIDE
OCULAR DELIVERY
POLOXAMINE
POLY(ETHYLENE OXIDE)-POLY(PROPYLENE OXIDE) BLOCK COPOLYMER
POLYMERIC MICELLES
topic CARBONIC ANHYDRASE INHIBITOR SOLUBILIZATION
ETHOXZOLAMIDE
OCULAR DELIVERY
POLOXAMINE
POLY(ETHYLENE OXIDE)-POLY(PROPYLENE OXIDE) BLOCK COPOLYMER
POLYMERIC MICELLES
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Polymeric micelles of single and mixed poloxamines (Tetronic) were evaluated regarding their ability to host the antiglaucoma agent ethoxzolamide (ETOX) for topical ocular application. Three highly hydrophilic varieties of poloxamine (T908, T1107 and T1307) and a medium hydrophilic variety (T904), possessing a similar number of propylene oxide units but different contents in ethylene oxide, were chosen for the study. The critical micellar concentration and the cloud point of mixed micelles in 0.9 per cent NaCl were slightly greater than the values predicted from the additive rule, suggesting that the co-micellization is hindered. Micellar size ranged between 17 and 120 nm and it was not altered after the loading of ETOX (2.7-11.5 mg drug g-1 poloxamine). Drug solubilization ability ranked in the order: T904 (50-fold increase in the apparent solubility) > T1107 ≅ T1307 > T908. Mixed micelles showed an intermediate capability to host ETOX but a greater physical stability, maintaining almost 100 per cent drug solubilized after 28 days. Furthermore, the different structural features of poloxamines and their combination in mixed micelles enabled the tuning of drug release profiles, sustaining the release in the 1-5 days range. These findings together with promising hen's egg test-chorioallantoic membrane biocompatibility tests make poloxamine micelles promising nanocarriers for carbonic anhydrase inhibitors in the treatment of glaucoma.
Fil: Ribeiro, Andreza. Universidad de Santiago de Compostela; España
Fil: Sosnik, Alejandro Dario. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chiappetta, Diego Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Veiga, Francisco. Universidad de Coimbra; Portugal
Fil: Concheiro, Angel. Universidad de Santiago de Compostela; España
Fil: Alvarez Lorenzo, Carmen. Universidad de Santiago de Compostela; España
description Polymeric micelles of single and mixed poloxamines (Tetronic) were evaluated regarding their ability to host the antiglaucoma agent ethoxzolamide (ETOX) for topical ocular application. Three highly hydrophilic varieties of poloxamine (T908, T1107 and T1307) and a medium hydrophilic variety (T904), possessing a similar number of propylene oxide units but different contents in ethylene oxide, were chosen for the study. The critical micellar concentration and the cloud point of mixed micelles in 0.9 per cent NaCl were slightly greater than the values predicted from the additive rule, suggesting that the co-micellization is hindered. Micellar size ranged between 17 and 120 nm and it was not altered after the loading of ETOX (2.7-11.5 mg drug g-1 poloxamine). Drug solubilization ability ranked in the order: T904 (50-fold increase in the apparent solubility) > T1107 ≅ T1307 > T908. Mixed micelles showed an intermediate capability to host ETOX but a greater physical stability, maintaining almost 100 per cent drug solubilized after 28 days. Furthermore, the different structural features of poloxamines and their combination in mixed micelles enabled the tuning of drug release profiles, sustaining the release in the 1-5 days range. These findings together with promising hen's egg test-chorioallantoic membrane biocompatibility tests make poloxamine micelles promising nanocarriers for carbonic anhydrase inhibitors in the treatment of glaucoma.
publishDate 2012
dc.date.none.fl_str_mv 2012-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/197313
Ribeiro, Andreza; Sosnik, Alejandro Dario; Chiappetta, Diego Andrés; Veiga, Francisco; Concheiro, Angel; et al.; Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy; The Royal Society; Journal of the Royal Society Interface; 9; 74; 9-2012; 2059-2069
1742-5689
CONICET Digital
CONICET
url http://hdl.handle.net/11336/197313
identifier_str_mv Ribeiro, Andreza; Sosnik, Alejandro Dario; Chiappetta, Diego Andrés; Veiga, Francisco; Concheiro, Angel; et al.; Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy; The Royal Society; Journal of the Royal Society Interface; 9; 74; 9-2012; 2059-2069
1742-5689
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://rsif.royalsocietypublishing.org/content/9/74/2059.full.pdf+html
info:eu-repo/semantics/altIdentifier/doi/10.1098/rsif.2012.0102
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv The Royal Society
publisher.none.fl_str_mv The Royal Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980440210669568
score 12.993085

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