Dynamic RNA structures in the dengue virus genome

Autores
Iglesias, Nestor Gabriel; Gamarnik, Andrea Vanesa
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Dengue virus is an important human pathogen that belongs to the Flaviviridae family. The viral genome is a single molecule of RNA of positive polarity that plays multiple roles during the viral life cycle. Besides encoding the viral proteins, the genome contains RNA structures that regulate different viral processes. An important feature of dengue and other flavivirus genomes is the presence of inverted complementary sequences at the ends of the molecule that mediate long-range RNA-RNA interaction and genome cyclization. Recent studies have demonstrated that alternative conformations of the genome are necessary for infectivity. In this review, we discuss the current understanding of the function of different RNA elements that modulate dengue virus replication and provide new ideas of how dynamic RNA structures participate in the viral processes.
Fil: Iglesias, Nestor Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
Fil: Gamarnik, Andrea Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
Materia
Long Range Rna-Rna Interaction
Rna Structure
Genome Cyclization
Rna Synthesis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/14582
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/14582
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Dynamic RNA structures in the dengue virus genomeIglesias, Nestor GabrielGamarnik, Andrea VanesaLong Range Rna-Rna InteractionRna StructureGenome CyclizationRna Synthesishttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Dengue virus is an important human pathogen that belongs to the Flaviviridae family. The viral genome is a single molecule of RNA of positive polarity that plays multiple roles during the viral life cycle. Besides encoding the viral proteins, the genome contains RNA structures that regulate different viral processes. An important feature of dengue and other flavivirus genomes is the presence of inverted complementary sequences at the ends of the molecule that mediate long-range RNA-RNA interaction and genome cyclization. Recent studies have demonstrated that alternative conformations of the genome are necessary for infectivity. In this review, we discuss the current understanding of the function of different RNA elements that modulate dengue virus replication and provide new ideas of how dynamic RNA structures participate in the viral processes.Fil: Iglesias, Nestor Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; ArgentinaFil: Gamarnik, Andrea Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; ArgentinaLandes Bioscience2011info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14582Iglesias, Nestor Gabriel; Gamarnik, Andrea Vanesa; Dynamic RNA structures in the dengue virus genome; Landes Bioscience; Rna Biology; 8; 2; -1-2011; 249-2571555-8584enginfo:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.4161/rna.8.2.14992info:eu-repo/semantics/altIdentifier/doi/10.4161/rna.8.2.14992info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:47:51Zoai:ri.conicet.gov.ar:11336/14582instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:47:51.567CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dynamic RNA structures in the dengue virus genome
title Dynamic RNA structures in the dengue virus genome
spellingShingle Dynamic RNA structures in the dengue virus genome
Iglesias, Nestor Gabriel
Long Range Rna-Rna Interaction
Rna Structure
Genome Cyclization
Rna Synthesis
title_short Dynamic RNA structures in the dengue virus genome
title_full Dynamic RNA structures in the dengue virus genome
title_fullStr Dynamic RNA structures in the dengue virus genome
title_full_unstemmed Dynamic RNA structures in the dengue virus genome
title_sort Dynamic RNA structures in the dengue virus genome
dc.creator.none.fl_str_mv Iglesias, Nestor Gabriel
Gamarnik, Andrea Vanesa
author Iglesias, Nestor Gabriel
author_facet Iglesias, Nestor Gabriel
Gamarnik, Andrea Vanesa
author_role author
author2 Gamarnik, Andrea Vanesa
author2_role author
dc.subject.none.fl_str_mv Long Range Rna-Rna Interaction
Rna Structure
Genome Cyclization
Rna Synthesis
topic Long Range Rna-Rna Interaction
Rna Structure
Genome Cyclization
Rna Synthesis
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Dengue virus is an important human pathogen that belongs to the Flaviviridae family. The viral genome is a single molecule of RNA of positive polarity that plays multiple roles during the viral life cycle. Besides encoding the viral proteins, the genome contains RNA structures that regulate different viral processes. An important feature of dengue and other flavivirus genomes is the presence of inverted complementary sequences at the ends of the molecule that mediate long-range RNA-RNA interaction and genome cyclization. Recent studies have demonstrated that alternative conformations of the genome are necessary for infectivity. In this review, we discuss the current understanding of the function of different RNA elements that modulate dengue virus replication and provide new ideas of how dynamic RNA structures participate in the viral processes.
Fil: Iglesias, Nestor Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
Fil: Gamarnik, Andrea Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
description Dengue virus is an important human pathogen that belongs to the Flaviviridae family. The viral genome is a single molecule of RNA of positive polarity that plays multiple roles during the viral life cycle. Besides encoding the viral proteins, the genome contains RNA structures that regulate different viral processes. An important feature of dengue and other flavivirus genomes is the presence of inverted complementary sequences at the ends of the molecule that mediate long-range RNA-RNA interaction and genome cyclization. Recent studies have demonstrated that alternative conformations of the genome are necessary for infectivity. In this review, we discuss the current understanding of the function of different RNA elements that modulate dengue virus replication and provide new ideas of how dynamic RNA structures participate in the viral processes.
publishDate 2011
dc.date.none.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14582
Iglesias, Nestor Gabriel; Gamarnik, Andrea Vanesa; Dynamic RNA structures in the dengue virus genome; Landes Bioscience; Rna Biology; 8; 2; -1-2011; 249-257
1555-8584
url http://hdl.handle.net/11336/14582
identifier_str_mv Iglesias, Nestor Gabriel; Gamarnik, Andrea Vanesa; Dynamic RNA structures in the dengue virus genome; Landes Bioscience; Rna Biology; 8; 2; -1-2011; 249-257
1555-8584
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.4161/rna.8.2.14992
info:eu-repo/semantics/altIdentifier/doi/10.4161/rna.8.2.14992
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Landes Bioscience
publisher.none.fl_str_mv Landes Bioscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1848597972773765120
score 12.976206

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