Deleted in malignant brain tumor 1 (DMBT1) expression pattern in normal cervix and at different stages of squamous intraepithelial lesions

Autores
Valero, Andrés; Roldán, María Lorena; Ruiz, Maria Fernanda; Teijeiro, Juan Manuel; Marquez, Susana Beatriz; Marini, Patricia Estela
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Cervical cancer is one of the most frequently occurring malignancies in women worldwide, with high mortality rates. Cervical Squamous Cell Carcinoma (SCC) presents previous states of non-invasive precursor lesions, and early stage Low-Grade Squamous Intraepithelial Lesions (LSIL) regress to normal or Atypical Squamous Cells of Undetermined Significance (ASCUS) in approximately 50% of cases. Deleted in Malignant Brain Tumors 1 (DMBT1) is a tumour suppression glycoprotein, which absence is considered a malignancy marker in many epithelial cancers. Objective: To analyse DMBT1’s presence and localization in SCC and precursor lesions. Method: Immunohistochemistry for DMBT1 was performed in cervix biopsies classified as normal, LSIL, HSIL and SCC. Results: DMBT1 was detected at the supranuclear and sometimes infranuclear regions of the endocervix monolayer epithelial cells in normal and HSIL biopsies. In LSIL samples the detection of DMBT1 in endocervix was variable between patients. Also variable was DMBT1 staining in cells of glandular epithelium. The glycoprotein was not detected in the stratified epithelium of the exocervix, regardless of the lesion grade; nor in dysplastic cells. Conclusion: The absence of DMBT1 from endocervix only in some samples of LSIL is promising as a candidate for possible lesion regression potential marker.
Fil: Valero, Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Roldán, María Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Ruiz, Maria Fernanda. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Teijeiro, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnol.conicet - Rosario. Unidad de Direccion; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Marquez, Susana Beatriz. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Marini, Patricia Estela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Materia
CERVICAL SQUAMOUS CELL CARCINOMA
CERVIX
DMBT1
EPITHELIUM
GLYCOPROTEIN
SQUAMOUS INTRAEPITHELIAL LESIONS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/91953
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/91953
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Deleted in malignant brain tumor 1 (DMBT1) expression pattern in normal cervix and at different stages of squamous intraepithelial lesionsValero, AndrésRoldán, María LorenaRuiz, Maria FernandaTeijeiro, Juan ManuelMarquez, Susana BeatrizMarini, Patricia EstelaCERVICAL SQUAMOUS CELL CARCINOMACERVIXDMBT1EPITHELIUMGLYCOPROTEINSQUAMOUS INTRAEPITHELIAL LESIONShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: Cervical cancer is one of the most frequently occurring malignancies in women worldwide, with high mortality rates. Cervical Squamous Cell Carcinoma (SCC) presents previous states of non-invasive precursor lesions, and early stage Low-Grade Squamous Intraepithelial Lesions (LSIL) regress to normal or Atypical Squamous Cells of Undetermined Significance (ASCUS) in approximately 50% of cases. Deleted in Malignant Brain Tumors 1 (DMBT1) is a tumour suppression glycoprotein, which absence is considered a malignancy marker in many epithelial cancers. Objective: To analyse DMBT1’s presence and localization in SCC and precursor lesions. Method: Immunohistochemistry for DMBT1 was performed in cervix biopsies classified as normal, LSIL, HSIL and SCC. Results: DMBT1 was detected at the supranuclear and sometimes infranuclear regions of the endocervix monolayer epithelial cells in normal and HSIL biopsies. In LSIL samples the detection of DMBT1 in endocervix was variable between patients. Also variable was DMBT1 staining in cells of glandular epithelium. The glycoprotein was not detected in the stratified epithelium of the exocervix, regardless of the lesion grade; nor in dysplastic cells. Conclusion: The absence of DMBT1 from endocervix only in some samples of LSIL is promising as a candidate for possible lesion regression potential marker.Fil: Valero, Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Roldán, María Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Ruiz, Maria Fernanda. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Teijeiro, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnol.conicet - Rosario. Unidad de Direccion; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Marquez, Susana Beatriz. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Marini, Patricia Estela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaBentham Science Publishers2018-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/91953Valero, Andrés; Roldán, María Lorena; Ruiz, Maria Fernanda; Teijeiro, Juan Manuel; Marquez, Susana Beatriz; et al.; Deleted in malignant brain tumor 1 (DMBT1) expression pattern in normal cervix and at different stages of squamous intraepithelial lesions; Bentham Science Publishers; Open Biomarkers Journal; 8; 1; 1-2018; 1-81875-3183CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://benthamopen.com/FULLTEXT/TOBIOMJ-8-1info:eu-repo/semantics/altIdentifier/doi/10.2174/1875318301808010001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:14:57Zoai:ri.conicet.gov.ar:11336/91953instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:14:57.936CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Deleted in malignant brain tumor 1 (DMBT1) expression pattern in normal cervix and at different stages of squamous intraepithelial lesions
title Deleted in malignant brain tumor 1 (DMBT1) expression pattern in normal cervix and at different stages of squamous intraepithelial lesions
spellingShingle Deleted in malignant brain tumor 1 (DMBT1) expression pattern in normal cervix and at different stages of squamous intraepithelial lesions
Valero, Andrés
CERVICAL SQUAMOUS CELL CARCINOMA
CERVIX
DMBT1
EPITHELIUM
GLYCOPROTEIN
SQUAMOUS INTRAEPITHELIAL LESIONS
title_short Deleted in malignant brain tumor 1 (DMBT1) expression pattern in normal cervix and at different stages of squamous intraepithelial lesions
title_full Deleted in malignant brain tumor 1 (DMBT1) expression pattern in normal cervix and at different stages of squamous intraepithelial lesions
title_fullStr Deleted in malignant brain tumor 1 (DMBT1) expression pattern in normal cervix and at different stages of squamous intraepithelial lesions
title_full_unstemmed Deleted in malignant brain tumor 1 (DMBT1) expression pattern in normal cervix and at different stages of squamous intraepithelial lesions
title_sort Deleted in malignant brain tumor 1 (DMBT1) expression pattern in normal cervix and at different stages of squamous intraepithelial lesions
dc.creator.none.fl_str_mv Valero, Andrés
Roldán, María Lorena
Ruiz, Maria Fernanda
Teijeiro, Juan Manuel
Marquez, Susana Beatriz
Marini, Patricia Estela
author Valero, Andrés
author_facet Valero, Andrés
Roldán, María Lorena
Ruiz, Maria Fernanda
Teijeiro, Juan Manuel
Marquez, Susana Beatriz
Marini, Patricia Estela
author_role author
author2 Roldán, María Lorena
Ruiz, Maria Fernanda
Teijeiro, Juan Manuel
Marquez, Susana Beatriz
Marini, Patricia Estela
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CERVICAL SQUAMOUS CELL CARCINOMA
CERVIX
DMBT1
EPITHELIUM
GLYCOPROTEIN
SQUAMOUS INTRAEPITHELIAL LESIONS
topic CERVICAL SQUAMOUS CELL CARCINOMA
CERVIX
DMBT1
EPITHELIUM
GLYCOPROTEIN
SQUAMOUS INTRAEPITHELIAL LESIONS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Cervical cancer is one of the most frequently occurring malignancies in women worldwide, with high mortality rates. Cervical Squamous Cell Carcinoma (SCC) presents previous states of non-invasive precursor lesions, and early stage Low-Grade Squamous Intraepithelial Lesions (LSIL) regress to normal or Atypical Squamous Cells of Undetermined Significance (ASCUS) in approximately 50% of cases. Deleted in Malignant Brain Tumors 1 (DMBT1) is a tumour suppression glycoprotein, which absence is considered a malignancy marker in many epithelial cancers. Objective: To analyse DMBT1’s presence and localization in SCC and precursor lesions. Method: Immunohistochemistry for DMBT1 was performed in cervix biopsies classified as normal, LSIL, HSIL and SCC. Results: DMBT1 was detected at the supranuclear and sometimes infranuclear regions of the endocervix monolayer epithelial cells in normal and HSIL biopsies. In LSIL samples the detection of DMBT1 in endocervix was variable between patients. Also variable was DMBT1 staining in cells of glandular epithelium. The glycoprotein was not detected in the stratified epithelium of the exocervix, regardless of the lesion grade; nor in dysplastic cells. Conclusion: The absence of DMBT1 from endocervix only in some samples of LSIL is promising as a candidate for possible lesion regression potential marker.
Fil: Valero, Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Roldán, María Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Ruiz, Maria Fernanda. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Teijeiro, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnol.conicet - Rosario. Unidad de Direccion; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Marquez, Susana Beatriz. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Marini, Patricia Estela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
description Background: Cervical cancer is one of the most frequently occurring malignancies in women worldwide, with high mortality rates. Cervical Squamous Cell Carcinoma (SCC) presents previous states of non-invasive precursor lesions, and early stage Low-Grade Squamous Intraepithelial Lesions (LSIL) regress to normal or Atypical Squamous Cells of Undetermined Significance (ASCUS) in approximately 50% of cases. Deleted in Malignant Brain Tumors 1 (DMBT1) is a tumour suppression glycoprotein, which absence is considered a malignancy marker in many epithelial cancers. Objective: To analyse DMBT1’s presence and localization in SCC and precursor lesions. Method: Immunohistochemistry for DMBT1 was performed in cervix biopsies classified as normal, LSIL, HSIL and SCC. Results: DMBT1 was detected at the supranuclear and sometimes infranuclear regions of the endocervix monolayer epithelial cells in normal and HSIL biopsies. In LSIL samples the detection of DMBT1 in endocervix was variable between patients. Also variable was DMBT1 staining in cells of glandular epithelium. The glycoprotein was not detected in the stratified epithelium of the exocervix, regardless of the lesion grade; nor in dysplastic cells. Conclusion: The absence of DMBT1 from endocervix only in some samples of LSIL is promising as a candidate for possible lesion regression potential marker.
publishDate 2018
dc.date.none.fl_str_mv 2018-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/91953
Valero, Andrés; Roldán, María Lorena; Ruiz, Maria Fernanda; Teijeiro, Juan Manuel; Marquez, Susana Beatriz; et al.; Deleted in malignant brain tumor 1 (DMBT1) expression pattern in normal cervix and at different stages of squamous intraepithelial lesions; Bentham Science Publishers; Open Biomarkers Journal; 8; 1; 1-2018; 1-8
1875-3183
CONICET Digital
CONICET
url http://hdl.handle.net/11336/91953
identifier_str_mv Valero, Andrés; Roldán, María Lorena; Ruiz, Maria Fernanda; Teijeiro, Juan Manuel; Marquez, Susana Beatriz; et al.; Deleted in malignant brain tumor 1 (DMBT1) expression pattern in normal cervix and at different stages of squamous intraepithelial lesions; Bentham Science Publishers; Open Biomarkers Journal; 8; 1; 1-2018; 1-8
1875-3183
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://benthamopen.com/FULLTEXT/TOBIOMJ-8-1
info:eu-repo/semantics/altIdentifier/doi/10.2174/1875318301808010001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.221938

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