Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells
- Autores
- Tate, Pablo Sebastián; Marazita, Mariela Claudia; Marquioni Ramella, Melisa Daniela; Suburo, Angela Maria
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Aged-related macular degeneration (AMD), a prevalent chronic disease leading to blindness, is associated with oxidative damage of the retinal pigment epithelium (RPE). Ilex paraguariensis (yerba mate, YM), widely consumed in South America, is an excellent source of antioxidants and could prevent RPE cell impairment. Therefore, we evaluated the effects of YM extracts or caffeic (CAF) and chlorogenic (CHL) acids, two major Ilex polyphenols on cell death or premature senescence in a cell line derived from human RPE (ARPE-19). Cultures were incubated with YM, CAF, CHL or appropriate controls and then exposed to H2O2. Protection was correlated with decreases of reactive oxygen species (ROS) and DNA breaks, phosphorylation of the cAMP response element (CREB) and increases of the nuclear factor erythroid 2-related factor 2 (NRF2), BCL2, superoxide dismutase (SOD2) and sirtuin 1 (SIRT1). These results support the protective role of YM and its polyphenols against oxidative stress induced RPE injury.
Fil: Tate, Pablo Sebastián. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina
Fil: Marazita, Mariela Claudia. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina
Fil: Marquioni Ramella, Melisa Daniela. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina
Fil: Suburo, Angela Maria. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina - Materia
-
YERBA MATE
SENESCENCIA
DMAE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/163867
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Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cellsTate, Pablo SebastiánMarazita, Mariela ClaudiaMarquioni Ramella, Melisa DanielaSuburo, Angela MariaYERBA MATESENESCENCIADMAEhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Aged-related macular degeneration (AMD), a prevalent chronic disease leading to blindness, is associated with oxidative damage of the retinal pigment epithelium (RPE). Ilex paraguariensis (yerba mate, YM), widely consumed in South America, is an excellent source of antioxidants and could prevent RPE cell impairment. Therefore, we evaluated the effects of YM extracts or caffeic (CAF) and chlorogenic (CHL) acids, two major Ilex polyphenols on cell death or premature senescence in a cell line derived from human RPE (ARPE-19). Cultures were incubated with YM, CAF, CHL or appropriate controls and then exposed to H2O2. Protection was correlated with decreases of reactive oxygen species (ROS) and DNA breaks, phosphorylation of the cAMP response element (CREB) and increases of the nuclear factor erythroid 2-related factor 2 (NRF2), BCL2, superoxide dismutase (SOD2) and sirtuin 1 (SIRT1). These results support the protective role of YM and its polyphenols against oxidative stress induced RPE injury.Fil: Tate, Pablo Sebastián. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; ArgentinaFil: Marazita, Mariela Claudia. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; ArgentinaFil: Marquioni Ramella, Melisa Daniela. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; ArgentinaFil: Suburo, Angela Maria. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; ArgentinaElsevier2020-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/163867Tate, Pablo Sebastián; Marazita, Mariela Claudia; Marquioni Ramella, Melisa Daniela; Suburo, Angela Maria; Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells; Elsevier; Journal of Functional Foods; 67; 4-2020; 107-8541756-4646CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1756464620300578info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jff.2020.103833info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:37:06Zoai:ri.conicet.gov.ar:11336/163867instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:37:06.995CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells |
title |
Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells |
spellingShingle |
Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells Tate, Pablo Sebastián YERBA MATE SENESCENCIA DMAE |
title_short |
Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells |
title_full |
Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells |
title_fullStr |
Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells |
title_full_unstemmed |
Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells |
title_sort |
Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells |
dc.creator.none.fl_str_mv |
Tate, Pablo Sebastián Marazita, Mariela Claudia Marquioni Ramella, Melisa Daniela Suburo, Angela Maria |
author |
Tate, Pablo Sebastián |
author_facet |
Tate, Pablo Sebastián Marazita, Mariela Claudia Marquioni Ramella, Melisa Daniela Suburo, Angela Maria |
author_role |
author |
author2 |
Marazita, Mariela Claudia Marquioni Ramella, Melisa Daniela Suburo, Angela Maria |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
YERBA MATE SENESCENCIA DMAE |
topic |
YERBA MATE SENESCENCIA DMAE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.4 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Aged-related macular degeneration (AMD), a prevalent chronic disease leading to blindness, is associated with oxidative damage of the retinal pigment epithelium (RPE). Ilex paraguariensis (yerba mate, YM), widely consumed in South America, is an excellent source of antioxidants and could prevent RPE cell impairment. Therefore, we evaluated the effects of YM extracts or caffeic (CAF) and chlorogenic (CHL) acids, two major Ilex polyphenols on cell death or premature senescence in a cell line derived from human RPE (ARPE-19). Cultures were incubated with YM, CAF, CHL or appropriate controls and then exposed to H2O2. Protection was correlated with decreases of reactive oxygen species (ROS) and DNA breaks, phosphorylation of the cAMP response element (CREB) and increases of the nuclear factor erythroid 2-related factor 2 (NRF2), BCL2, superoxide dismutase (SOD2) and sirtuin 1 (SIRT1). These results support the protective role of YM and its polyphenols against oxidative stress induced RPE injury. Fil: Tate, Pablo Sebastián. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina Fil: Marazita, Mariela Claudia. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina Fil: Marquioni Ramella, Melisa Daniela. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina Fil: Suburo, Angela Maria. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina |
description |
Aged-related macular degeneration (AMD), a prevalent chronic disease leading to blindness, is associated with oxidative damage of the retinal pigment epithelium (RPE). Ilex paraguariensis (yerba mate, YM), widely consumed in South America, is an excellent source of antioxidants and could prevent RPE cell impairment. Therefore, we evaluated the effects of YM extracts or caffeic (CAF) and chlorogenic (CHL) acids, two major Ilex polyphenols on cell death or premature senescence in a cell line derived from human RPE (ARPE-19). Cultures were incubated with YM, CAF, CHL or appropriate controls and then exposed to H2O2. Protection was correlated with decreases of reactive oxygen species (ROS) and DNA breaks, phosphorylation of the cAMP response element (CREB) and increases of the nuclear factor erythroid 2-related factor 2 (NRF2), BCL2, superoxide dismutase (SOD2) and sirtuin 1 (SIRT1). These results support the protective role of YM and its polyphenols against oxidative stress induced RPE injury. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/163867 Tate, Pablo Sebastián; Marazita, Mariela Claudia; Marquioni Ramella, Melisa Daniela; Suburo, Angela Maria; Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells; Elsevier; Journal of Functional Foods; 67; 4-2020; 107-854 1756-4646 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/163867 |
identifier_str_mv |
Tate, Pablo Sebastián; Marazita, Mariela Claudia; Marquioni Ramella, Melisa Daniela; Suburo, Angela Maria; Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells; Elsevier; Journal of Functional Foods; 67; 4-2020; 107-854 1756-4646 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1756464620300578 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jff.2020.103833 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614391520034816 |
score |
13.070432 |