Soy protects against cadmium induced fibrosis in lung. Role of hsps
- Autores
- Boldrini Gabriel Giezi; Perez Chaca, Maria Veronica; Martin Molinero, Glenda Daniela; Córdoba, María Evelyn; Pennacchio, Gisela Erika; Fanelli, Mariel Andrea; Gomez, Nidia Noemí; Alvarez, Silvina Monica
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Cadmium (Cd) is a toxic metal and an important environmental contaminant.We studied its effects on fibrosis and heat shock proteins (HSP) expressionunder different diets. 4 lots of female Wistar rats were used: 2 lots receivedcasein (Cas) and 2 lots received soybean (Soy) as protein sources. Within eachgroup: 1 lot received regular water (control-Co) and the other 15ppm of Cd inthe drinking water for 60days. Lungs were hydrolysated for hydroxyproline(Hyp) quantification HCl at 107°C and taken up in acetate-citrate buffer.Samples were mixed with chloramine-T solution. After 20 min,aldehyde/perchloric acid solution was added. The color was read in aspectrophotometer at 550 nm. Standard solutions of L-Hyp were used forstandard curve elaboration. Lung tissues were fixed, dehydrated, cleared inxylene, and embedded in paraffin. Sections of 5?6µm thickness were stainedwith Masson?s trichrome solution for histology assessment.Immunohistochemistry was performed by using Hsp27 and Hsp70 antibodies.Hyp showed an increase in CasCd group vs CasCo (p<0.005); in SoCd, Hyplevels were higher than SoCo (p<0.01) but lesser compared with CasCd(p<0.05). Masson's Trichromic exposed that CasCo and SoCo groups havenormal alveolar septa, without deposits of connective tissue. In CasCd,advanced pulmonary fibrosis and blue collagen deposits were evidentthroughout the lung. In SoCd, collagen deposition was observed around theintrapulmonary tree and lung vessels. Hsp27 showed an increase of itsexpression in Cd intoxicated alveoli, being only significant in CasCd vs CasCo(p<0.05); however, the levels of this protein are higher in soy-fed groups whencompared to casein groups. Hsp70 exhibited higher levels in SoCd vs SoCo,without differences among casein-fed groups. We conclude that Cd inducefibrosis in lungs, and soy might have a protective effect. It has been proven thatHsp27 promotes fibrosis in animal models. The higher expression of Hsp70induced by soy could exert a protective effect against Cd-induced fibrosis.
Fil: Boldrini Gabriel Giezi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Perez Chaca, Maria Veronica. Universidad Nacional de San Luis; Argentina
Fil: Martin Molinero, Glenda Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Córdoba, María Evelyn. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Pennacchio, Gisela Erika. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Fanelli, Mariel Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Gomez, Nidia Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Alvarez, Silvina Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica (SAIC); LXIX Reunión anual de la Sociedad Argentina de Immunología (SAI); LIII Reunión anual de la Asociación Argentina de Farmacología Experimental (AAFE) y XI Reunión anual de la Asociación Argentina de Nanomedicinas (NANOMED-AR)
Argentina
Sociedad Argentina de Investigación Clínica
Sociedad Argentina de Inmunologia
Asociación Argentina de Farmacología Experimental
Asociación Argentina de Nanomedicinas - Materia
-
CADMIUM
LUNG
SOY
HSP - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/247654
Ver los metadatos del registro completo
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Soy protects against cadmium induced fibrosis in lung. Role of hspsBoldrini Gabriel GieziPerez Chaca, Maria VeronicaMartin Molinero, Glenda DanielaCórdoba, María EvelynPennacchio, Gisela ErikaFanelli, Mariel AndreaGomez, Nidia NoemíAlvarez, Silvina MonicaCADMIUMLUNGSOYHSPhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Cadmium (Cd) is a toxic metal and an important environmental contaminant.We studied its effects on fibrosis and heat shock proteins (HSP) expressionunder different diets. 4 lots of female Wistar rats were used: 2 lots receivedcasein (Cas) and 2 lots received soybean (Soy) as protein sources. Within eachgroup: 1 lot received regular water (control-Co) and the other 15ppm of Cd inthe drinking water for 60days. Lungs were hydrolysated for hydroxyproline(Hyp) quantification HCl at 107°C and taken up in acetate-citrate buffer.Samples were mixed with chloramine-T solution. After 20 min,aldehyde/perchloric acid solution was added. The color was read in aspectrophotometer at 550 nm. Standard solutions of L-Hyp were used forstandard curve elaboration. Lung tissues were fixed, dehydrated, cleared inxylene, and embedded in paraffin. Sections of 5?6µm thickness were stainedwith Masson?s trichrome solution for histology assessment.Immunohistochemistry was performed by using Hsp27 and Hsp70 antibodies.Hyp showed an increase in CasCd group vs CasCo (p<0.005); in SoCd, Hyplevels were higher than SoCo (p<0.01) but lesser compared with CasCd(p<0.05). Masson's Trichromic exposed that CasCo and SoCo groups havenormal alveolar septa, without deposits of connective tissue. In CasCd,advanced pulmonary fibrosis and blue collagen deposits were evidentthroughout the lung. In SoCd, collagen deposition was observed around theintrapulmonary tree and lung vessels. Hsp27 showed an increase of itsexpression in Cd intoxicated alveoli, being only significant in CasCd vs CasCo(p<0.05); however, the levels of this protein are higher in soy-fed groups whencompared to casein groups. Hsp70 exhibited higher levels in SoCd vs SoCo,without differences among casein-fed groups. We conclude that Cd inducefibrosis in lungs, and soy might have a protective effect. It has been proven thatHsp27 promotes fibrosis in animal models. The higher expression of Hsp70induced by soy could exert a protective effect against Cd-induced fibrosis.Fil: Boldrini Gabriel Giezi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Perez Chaca, Maria Veronica. Universidad Nacional de San Luis; ArgentinaFil: Martin Molinero, Glenda Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Córdoba, María Evelyn. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Pennacchio, Gisela Erika. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Fanelli, Mariel Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Gomez, Nidia Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Alvarez, Silvina Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaLXVI Reunión anual de la Sociedad Argentina de Investigación Clínica (SAIC); LXIX Reunión anual de la Sociedad Argentina de Immunología (SAI); LIII Reunión anual de la Asociación Argentina de Farmacología Experimental (AAFE) y XI Reunión anual de la Asociación Argentina de Nanomedicinas (NANOMED-AR)ArgentinaSociedad Argentina de Investigación ClínicaSociedad Argentina de InmunologiaAsociación Argentina de Farmacología ExperimentalAsociación Argentina de NanomedicinasFundación Revista Medicina2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/247654Soy protects against cadmium induced fibrosis in lung. Role of hsps; LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica (SAIC); LXIX Reunión anual de la Sociedad Argentina de Immunología (SAI); LIII Reunión anual de la Asociación Argentina de Farmacología Experimental (AAFE) y XI Reunión anual de la Asociación Argentina de Nanomedicinas (NANOMED-AR); Argentina; 2021; 255-2550025-7680CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.reunionbiociencias.com.ar/wp-content/uploads/2021/11/Revista-Medicina-2021.pdfNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:16:51Zoai:ri.conicet.gov.ar:11336/247654instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:16:51.381CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Soy protects against cadmium induced fibrosis in lung. Role of hsps |
| title |
Soy protects against cadmium induced fibrosis in lung. Role of hsps |
| spellingShingle |
Soy protects against cadmium induced fibrosis in lung. Role of hsps Boldrini Gabriel Giezi CADMIUM LUNG SOY HSP |
| title_short |
Soy protects against cadmium induced fibrosis in lung. Role of hsps |
| title_full |
Soy protects against cadmium induced fibrosis in lung. Role of hsps |
| title_fullStr |
Soy protects against cadmium induced fibrosis in lung. Role of hsps |
| title_full_unstemmed |
Soy protects against cadmium induced fibrosis in lung. Role of hsps |
| title_sort |
Soy protects against cadmium induced fibrosis in lung. Role of hsps |
| dc.creator.none.fl_str_mv |
Boldrini Gabriel Giezi Perez Chaca, Maria Veronica Martin Molinero, Glenda Daniela Córdoba, María Evelyn Pennacchio, Gisela Erika Fanelli, Mariel Andrea Gomez, Nidia Noemí Alvarez, Silvina Monica |
| author |
Boldrini Gabriel Giezi |
| author_facet |
Boldrini Gabriel Giezi Perez Chaca, Maria Veronica Martin Molinero, Glenda Daniela Córdoba, María Evelyn Pennacchio, Gisela Erika Fanelli, Mariel Andrea Gomez, Nidia Noemí Alvarez, Silvina Monica |
| author_role |
author |
| author2 |
Perez Chaca, Maria Veronica Martin Molinero, Glenda Daniela Córdoba, María Evelyn Pennacchio, Gisela Erika Fanelli, Mariel Andrea Gomez, Nidia Noemí Alvarez, Silvina Monica |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
CADMIUM LUNG SOY HSP |
| topic |
CADMIUM LUNG SOY HSP |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Cadmium (Cd) is a toxic metal and an important environmental contaminant.We studied its effects on fibrosis and heat shock proteins (HSP) expressionunder different diets. 4 lots of female Wistar rats were used: 2 lots receivedcasein (Cas) and 2 lots received soybean (Soy) as protein sources. Within eachgroup: 1 lot received regular water (control-Co) and the other 15ppm of Cd inthe drinking water for 60days. Lungs were hydrolysated for hydroxyproline(Hyp) quantification HCl at 107°C and taken up in acetate-citrate buffer.Samples were mixed with chloramine-T solution. After 20 min,aldehyde/perchloric acid solution was added. The color was read in aspectrophotometer at 550 nm. Standard solutions of L-Hyp were used forstandard curve elaboration. Lung tissues were fixed, dehydrated, cleared inxylene, and embedded in paraffin. Sections of 5?6µm thickness were stainedwith Masson?s trichrome solution for histology assessment.Immunohistochemistry was performed by using Hsp27 and Hsp70 antibodies.Hyp showed an increase in CasCd group vs CasCo (p<0.005); in SoCd, Hyplevels were higher than SoCo (p<0.01) but lesser compared with CasCd(p<0.05). Masson's Trichromic exposed that CasCo and SoCo groups havenormal alveolar septa, without deposits of connective tissue. In CasCd,advanced pulmonary fibrosis and blue collagen deposits were evidentthroughout the lung. In SoCd, collagen deposition was observed around theintrapulmonary tree and lung vessels. Hsp27 showed an increase of itsexpression in Cd intoxicated alveoli, being only significant in CasCd vs CasCo(p<0.05); however, the levels of this protein are higher in soy-fed groups whencompared to casein groups. Hsp70 exhibited higher levels in SoCd vs SoCo,without differences among casein-fed groups. We conclude that Cd inducefibrosis in lungs, and soy might have a protective effect. It has been proven thatHsp27 promotes fibrosis in animal models. The higher expression of Hsp70induced by soy could exert a protective effect against Cd-induced fibrosis. Fil: Boldrini Gabriel Giezi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Perez Chaca, Maria Veronica. Universidad Nacional de San Luis; Argentina Fil: Martin Molinero, Glenda Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Córdoba, María Evelyn. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Pennacchio, Gisela Erika. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Fanelli, Mariel Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Gomez, Nidia Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Alvarez, Silvina Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica (SAIC); LXIX Reunión anual de la Sociedad Argentina de Immunología (SAI); LIII Reunión anual de la Asociación Argentina de Farmacología Experimental (AAFE) y XI Reunión anual de la Asociación Argentina de Nanomedicinas (NANOMED-AR) Argentina Sociedad Argentina de Investigación Clínica Sociedad Argentina de Inmunologia Asociación Argentina de Farmacología Experimental Asociación Argentina de Nanomedicinas |
| description |
Cadmium (Cd) is a toxic metal and an important environmental contaminant.We studied its effects on fibrosis and heat shock proteins (HSP) expressionunder different diets. 4 lots of female Wistar rats were used: 2 lots receivedcasein (Cas) and 2 lots received soybean (Soy) as protein sources. Within eachgroup: 1 lot received regular water (control-Co) and the other 15ppm of Cd inthe drinking water for 60days. Lungs were hydrolysated for hydroxyproline(Hyp) quantification HCl at 107°C and taken up in acetate-citrate buffer.Samples were mixed with chloramine-T solution. After 20 min,aldehyde/perchloric acid solution was added. The color was read in aspectrophotometer at 550 nm. Standard solutions of L-Hyp were used forstandard curve elaboration. Lung tissues were fixed, dehydrated, cleared inxylene, and embedded in paraffin. Sections of 5?6µm thickness were stainedwith Masson?s trichrome solution for histology assessment.Immunohistochemistry was performed by using Hsp27 and Hsp70 antibodies.Hyp showed an increase in CasCd group vs CasCo (p<0.005); in SoCd, Hyplevels were higher than SoCo (p<0.01) but lesser compared with CasCd(p<0.05). Masson's Trichromic exposed that CasCo and SoCo groups havenormal alveolar septa, without deposits of connective tissue. In CasCd,advanced pulmonary fibrosis and blue collagen deposits were evidentthroughout the lung. In SoCd, collagen deposition was observed around theintrapulmonary tree and lung vessels. Hsp27 showed an increase of itsexpression in Cd intoxicated alveoli, being only significant in CasCd vs CasCo(p<0.05); however, the levels of this protein are higher in soy-fed groups whencompared to casein groups. Hsp70 exhibited higher levels in SoCd vs SoCo,without differences among casein-fed groups. We conclude that Cd inducefibrosis in lungs, and soy might have a protective effect. It has been proven thatHsp27 promotes fibrosis in animal models. The higher expression of Hsp70induced by soy could exert a protective effect against Cd-induced fibrosis. |
| publishDate |
2021 |
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2021 |
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http://hdl.handle.net/11336/247654 Soy protects against cadmium induced fibrosis in lung. Role of hsps; LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica (SAIC); LXIX Reunión anual de la Sociedad Argentina de Immunología (SAI); LIII Reunión anual de la Asociación Argentina de Farmacología Experimental (AAFE) y XI Reunión anual de la Asociación Argentina de Nanomedicinas (NANOMED-AR); Argentina; 2021; 255-255 0025-7680 CONICET Digital CONICET |
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Soy protects against cadmium induced fibrosis in lung. Role of hsps; LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica (SAIC); LXIX Reunión anual de la Sociedad Argentina de Immunología (SAI); LIII Reunión anual de la Asociación Argentina de Farmacología Experimental (AAFE) y XI Reunión anual de la Asociación Argentina de Nanomedicinas (NANOMED-AR); Argentina; 2021; 255-255 0025-7680 CONICET Digital CONICET |
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