Chlamydia Persistence: A Survival Strategy to Evade Antimicrobial Effects in-vitro and in-vivo

• Autores: Panzetta, Maria Emilia; Valdivia, Raphael H.; Saka, Hector Alex
• Año de publicación: 2018
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: ABERRANT RETICULATE BODIES; CHLAMYDIA EVASION OF ANTIMICROBIAL STIMULI; CHLAMYDIA PERSISTENCE; CHLAMYDIA PERSISTENCE INDUCERS; GAMMA INTERFERON-INDUCED PERSISTENCE; IN-VIVO IMPLICATIONS OF CHLAMYDIA PERSISTENCE; PENICILLIN-INDUCED PERSISTENCE
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

The Chlamydiaceae comprise a group of highly adapted bacterial pathogens sharing a unique intracellular lifestyle. Three Chlamydia species are pathogenic to humans: Chlamydia trachomatis, Chlamydia pneumoniae, and Chlamydia psittaci. C. trachomatis is the leading bacterial cause of sexually-transmitted infections and infectious blindness worldwide. Chlamydia pneumoniae is a major cause of community-acquired atypical pneumonia. C. psittaci primarily affects psittacine birds and can be transmitted to humans causing psittacosis, a potentially fatal form of pneumonia. As opposed to other bacterial pathogens, the spread of clinically relevant antimicrobial resistance genes does not seem to be a major problem for the treatment of Chlamydia infections. However, when exposed to stressing conditions, like those arising from exposure to antimicrobial stimuli, these bacteria undergo a temporary interruption in their replication cycle and enter a viable but non-cultivable state known as persistence. When the stressing conditions are removed, Chlamydia resumes replication and generation of infectious particles. This review gives an overview of the different survival strategies used by Chlamydia to evade the deleterious effects of penicillin and IFNγ, with a focus on the different models used to study Chlamydia persistence, their contribution to elucidating the molecular basis of this complex phenomenon and their potential implications for studies in animal models of infection.
Fil: Panzetta, Maria Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Valdivia, Raphael H.. University of Duke; Estados Unidos
Fil: Saka, Hector Alex. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina