A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-be...

Autores
Pérez, Hiram; Ramos, Raúl; Plutín, Ana M.; Mocelo, Raúl; Erben, Mauricio Federico; Castellano, Eduardo E.; Batista, Alzir A.
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A novel mixed platinum(II) complex with general formula [Pt(PPh3)2(L1-O,S)]PF6 has been synthetized and characterized by elemental analysis, molar conductivity, and by IR and NMR (1H, 13C and 31P) spectroscopic methods. The crystal structure has been determined by single-crystal X-ray crystallography. The molecule presents an almost ideal square-planar geometry, and the crystal is stabilized by weak C?H···O and C?H···F hydrogen bonds, and C?H···π stacking interactions. The steric congestion of ligands is described by ?exact? cone and solid cone angles, and the percentage of metal surface shielded by the ligands. The results are compared to closely related palladium complexes. The X-ray structure revealed the proximity of the ortho phenyl proton of one PPh3 ligand to platinum(II) showing rare intramolecular C?H···Pt anagostic binding interaction. The title complex was determined to be active against tumor cells, and it also showed a moderate inhibitory action against mycobacterium tuberculosis.
Fil: Pérez, Hiram. Universidad de La Habana; Cuba
Fil: Ramos, Raúl. Universidad de La Habana; Cuba
Fil: Plutín, Ana M.. Universidad de La Habana; Cuba
Fil: Mocelo, Raúl. Universidad de La Habana; Cuba
Fil: Erben, Mauricio Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Castellano, Eduardo E.. Universidade de Sao Paulo; Brasil
Fil: Batista, Alzir A.. Universidade Federal do São Carlos; Brasil
Materia
ANAGOSTIC INTERACTIONS
BIOLOGICAL ACTIVITY
PHOSPHINE LIGANDS
PLATINUM
STERIC DESCRIPTORS
STRUCTURE ELUCIDATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/131656
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/131656
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea)Pérez, HiramRamos, RaúlPlutín, Ana M.Mocelo, RaúlErben, Mauricio FedericoCastellano, Eduardo E.Batista, Alzir A.ANAGOSTIC INTERACTIONSBIOLOGICAL ACTIVITYPHOSPHINE LIGANDSPLATINUMSTERIC DESCRIPTORSSTRUCTURE ELUCIDATIONhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A novel mixed platinum(II) complex with general formula [Pt(PPh3)2(L1-O,S)]PF6 has been synthetized and characterized by elemental analysis, molar conductivity, and by IR and NMR (1H, 13C and 31P) spectroscopic methods. The crystal structure has been determined by single-crystal X-ray crystallography. The molecule presents an almost ideal square-planar geometry, and the crystal is stabilized by weak C?H···O and C?H···F hydrogen bonds, and C?H···π stacking interactions. The steric congestion of ligands is described by ?exact? cone and solid cone angles, and the percentage of metal surface shielded by the ligands. The results are compared to closely related palladium complexes. The X-ray structure revealed the proximity of the ortho phenyl proton of one PPh3 ligand to platinum(II) showing rare intramolecular C?H···Pt anagostic binding interaction. The title complex was determined to be active against tumor cells, and it also showed a moderate inhibitory action against mycobacterium tuberculosis.Fil: Pérez, Hiram. Universidad de La Habana; CubaFil: Ramos, Raúl. Universidad de La Habana; CubaFil: Plutín, Ana M.. Universidad de La Habana; CubaFil: Mocelo, Raúl. Universidad de La Habana; CubaFil: Erben, Mauricio Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Castellano, Eduardo E.. Universidade de Sao Paulo; BrasilFil: Batista, Alzir A.. Universidade Federal do São Carlos; BrasilWiley VCH Verlag2019-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/131656Pérez, Hiram; Ramos, Raúl; Plutín, Ana M.; Mocelo, Raúl; Erben, Mauricio Federico; et al.; A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea); Wiley VCH Verlag; European Journal of Inorganic Chemistry; 2019; 21; 6-2019; 2583-25901434-1948CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/ejic.201900042info:eu-repo/semantics/altIdentifier/url/https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejic.201900042info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:02:38Zoai:ri.conicet.gov.ar:11336/131656instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:02:39.308CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea)
title A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea)
spellingShingle A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea)
Pérez, Hiram
ANAGOSTIC INTERACTIONS
BIOLOGICAL ACTIVITY
PHOSPHINE LIGANDS
PLATINUM
STERIC DESCRIPTORS
STRUCTURE ELUCIDATION
title_short A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea)
title_full A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea)
title_fullStr A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea)
title_full_unstemmed A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea)
title_sort A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea)
dc.creator.none.fl_str_mv Pérez, Hiram
Ramos, Raúl
Plutín, Ana M.
Mocelo, Raúl
Erben, Mauricio Federico
Castellano, Eduardo E.
Batista, Alzir A.
author Pérez, Hiram
author_facet Pérez, Hiram
Ramos, Raúl
Plutín, Ana M.
Mocelo, Raúl
Erben, Mauricio Federico
Castellano, Eduardo E.
Batista, Alzir A.
author_role author
author2 Ramos, Raúl
Plutín, Ana M.
Mocelo, Raúl
Erben, Mauricio Federico
Castellano, Eduardo E.
Batista, Alzir A.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ANAGOSTIC INTERACTIONS
BIOLOGICAL ACTIVITY
PHOSPHINE LIGANDS
PLATINUM
STERIC DESCRIPTORS
STRUCTURE ELUCIDATION
topic ANAGOSTIC INTERACTIONS
BIOLOGICAL ACTIVITY
PHOSPHINE LIGANDS
PLATINUM
STERIC DESCRIPTORS
STRUCTURE ELUCIDATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A novel mixed platinum(II) complex with general formula [Pt(PPh3)2(L1-O,S)]PF6 has been synthetized and characterized by elemental analysis, molar conductivity, and by IR and NMR (1H, 13C and 31P) spectroscopic methods. The crystal structure has been determined by single-crystal X-ray crystallography. The molecule presents an almost ideal square-planar geometry, and the crystal is stabilized by weak C?H···O and C?H···F hydrogen bonds, and C?H···π stacking interactions. The steric congestion of ligands is described by ?exact? cone and solid cone angles, and the percentage of metal surface shielded by the ligands. The results are compared to closely related palladium complexes. The X-ray structure revealed the proximity of the ortho phenyl proton of one PPh3 ligand to platinum(II) showing rare intramolecular C?H···Pt anagostic binding interaction. The title complex was determined to be active against tumor cells, and it also showed a moderate inhibitory action against mycobacterium tuberculosis.
Fil: Pérez, Hiram. Universidad de La Habana; Cuba
Fil: Ramos, Raúl. Universidad de La Habana; Cuba
Fil: Plutín, Ana M.. Universidad de La Habana; Cuba
Fil: Mocelo, Raúl. Universidad de La Habana; Cuba
Fil: Erben, Mauricio Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Castellano, Eduardo E.. Universidade de Sao Paulo; Brasil
Fil: Batista, Alzir A.. Universidade Federal do São Carlos; Brasil
description A novel mixed platinum(II) complex with general formula [Pt(PPh3)2(L1-O,S)]PF6 has been synthetized and characterized by elemental analysis, molar conductivity, and by IR and NMR (1H, 13C and 31P) spectroscopic methods. The crystal structure has been determined by single-crystal X-ray crystallography. The molecule presents an almost ideal square-planar geometry, and the crystal is stabilized by weak C?H···O and C?H···F hydrogen bonds, and C?H···π stacking interactions. The steric congestion of ligands is described by ?exact? cone and solid cone angles, and the percentage of metal surface shielded by the ligands. The results are compared to closely related palladium complexes. The X-ray structure revealed the proximity of the ortho phenyl proton of one PPh3 ligand to platinum(II) showing rare intramolecular C?H···Pt anagostic binding interaction. The title complex was determined to be active against tumor cells, and it also showed a moderate inhibitory action against mycobacterium tuberculosis.
publishDate 2019
dc.date.none.fl_str_mv 2019-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/131656
Pérez, Hiram; Ramos, Raúl; Plutín, Ana M.; Mocelo, Raúl; Erben, Mauricio Federico; et al.; A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea); Wiley VCH Verlag; European Journal of Inorganic Chemistry; 2019; 21; 6-2019; 2583-2590
1434-1948
CONICET Digital
CONICET
url http://hdl.handle.net/11336/131656
identifier_str_mv Pérez, Hiram; Ramos, Raúl; Plutín, Ana M.; Mocelo, Raúl; Erben, Mauricio Federico; et al.; A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea); Wiley VCH Verlag; European Journal of Inorganic Chemistry; 2019; 21; 6-2019; 2583-2590
1434-1948
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/ejic.201900042
info:eu-repo/semantics/altIdentifier/url/https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejic.201900042
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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