A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-be...
- Autores
- Pérez, Hiram; Ramos, Raúl; Plutín, Ana M.; Mocelo, Raúl; Erben, Mauricio Federico; Castellano, Eduardo E.; Batista, Alzir A.
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A novel mixed platinum(II) complex with general formula [Pt(PPh3)2(L1-O,S)]PF6 has been synthetized and characterized by elemental analysis, molar conductivity, and by IR and NMR (1H, 13C and 31P) spectroscopic methods. The crystal structure has been determined by single-crystal X-ray crystallography. The molecule presents an almost ideal square-planar geometry, and the crystal is stabilized by weak C?H···O and C?H···F hydrogen bonds, and C?H···π stacking interactions. The steric congestion of ligands is described by ?exact? cone and solid cone angles, and the percentage of metal surface shielded by the ligands. The results are compared to closely related palladium complexes. The X-ray structure revealed the proximity of the ortho phenyl proton of one PPh3 ligand to platinum(II) showing rare intramolecular C?H···Pt anagostic binding interaction. The title complex was determined to be active against tumor cells, and it also showed a moderate inhibitory action against mycobacterium tuberculosis.
Fil: Pérez, Hiram. Universidad de La Habana; Cuba
Fil: Ramos, Raúl. Universidad de La Habana; Cuba
Fil: Plutín, Ana M.. Universidad de La Habana; Cuba
Fil: Mocelo, Raúl. Universidad de La Habana; Cuba
Fil: Erben, Mauricio Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Castellano, Eduardo E.. Universidade de Sao Paulo; Brasil
Fil: Batista, Alzir A.. Universidade Federal do São Carlos; Brasil - Materia
-
ANAGOSTIC INTERACTIONS
BIOLOGICAL ACTIVITY
PHOSPHINE LIGANDS
PLATINUM
STERIC DESCRIPTORS
STRUCTURE ELUCIDATION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/131656
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
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A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea)Pérez, HiramRamos, RaúlPlutín, Ana M.Mocelo, RaúlErben, Mauricio FedericoCastellano, Eduardo E.Batista, Alzir A.ANAGOSTIC INTERACTIONSBIOLOGICAL ACTIVITYPHOSPHINE LIGANDSPLATINUMSTERIC DESCRIPTORSSTRUCTURE ELUCIDATIONhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A novel mixed platinum(II) complex with general formula [Pt(PPh3)2(L1-O,S)]PF6 has been synthetized and characterized by elemental analysis, molar conductivity, and by IR and NMR (1H, 13C and 31P) spectroscopic methods. The crystal structure has been determined by single-crystal X-ray crystallography. The molecule presents an almost ideal square-planar geometry, and the crystal is stabilized by weak C?H···O and C?H···F hydrogen bonds, and C?H···π stacking interactions. The steric congestion of ligands is described by ?exact? cone and solid cone angles, and the percentage of metal surface shielded by the ligands. The results are compared to closely related palladium complexes. The X-ray structure revealed the proximity of the ortho phenyl proton of one PPh3 ligand to platinum(II) showing rare intramolecular C?H···Pt anagostic binding interaction. The title complex was determined to be active against tumor cells, and it also showed a moderate inhibitory action against mycobacterium tuberculosis.Fil: Pérez, Hiram. Universidad de La Habana; CubaFil: Ramos, Raúl. Universidad de La Habana; CubaFil: Plutín, Ana M.. Universidad de La Habana; CubaFil: Mocelo, Raúl. Universidad de La Habana; CubaFil: Erben, Mauricio Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Castellano, Eduardo E.. Universidade de Sao Paulo; BrasilFil: Batista, Alzir A.. Universidade Federal do São Carlos; BrasilWiley VCH Verlag2019-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/131656Pérez, Hiram; Ramos, Raúl; Plutín, Ana M.; Mocelo, Raúl; Erben, Mauricio Federico; et al.; A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea); Wiley VCH Verlag; European Journal of Inorganic Chemistry; 2019; 21; 6-2019; 2583-25901434-1948CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/ejic.201900042info:eu-repo/semantics/altIdentifier/url/https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejic.201900042info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:30:06Zoai:ri.conicet.gov.ar:11336/131656instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:30:06.879CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea) |
| title |
A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea) |
| spellingShingle |
A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea) Pérez, Hiram ANAGOSTIC INTERACTIONS BIOLOGICAL ACTIVITY PHOSPHINE LIGANDS PLATINUM STERIC DESCRIPTORS STRUCTURE ELUCIDATION |
| title_short |
A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea) |
| title_full |
A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea) |
| title_fullStr |
A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea) |
| title_full_unstemmed |
A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea) |
| title_sort |
A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea) |
| dc.creator.none.fl_str_mv |
Pérez, Hiram Ramos, Raúl Plutín, Ana M. Mocelo, Raúl Erben, Mauricio Federico Castellano, Eduardo E. Batista, Alzir A. |
| author |
Pérez, Hiram |
| author_facet |
Pérez, Hiram Ramos, Raúl Plutín, Ana M. Mocelo, Raúl Erben, Mauricio Federico Castellano, Eduardo E. Batista, Alzir A. |
| author_role |
author |
| author2 |
Ramos, Raúl Plutín, Ana M. Mocelo, Raúl Erben, Mauricio Federico Castellano, Eduardo E. Batista, Alzir A. |
| author2_role |
author author author author author author |
| dc.subject.none.fl_str_mv |
ANAGOSTIC INTERACTIONS BIOLOGICAL ACTIVITY PHOSPHINE LIGANDS PLATINUM STERIC DESCRIPTORS STRUCTURE ELUCIDATION |
| topic |
ANAGOSTIC INTERACTIONS BIOLOGICAL ACTIVITY PHOSPHINE LIGANDS PLATINUM STERIC DESCRIPTORS STRUCTURE ELUCIDATION |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
A novel mixed platinum(II) complex with general formula [Pt(PPh3)2(L1-O,S)]PF6 has been synthetized and characterized by elemental analysis, molar conductivity, and by IR and NMR (1H, 13C and 31P) spectroscopic methods. The crystal structure has been determined by single-crystal X-ray crystallography. The molecule presents an almost ideal square-planar geometry, and the crystal is stabilized by weak C?H···O and C?H···F hydrogen bonds, and C?H···π stacking interactions. The steric congestion of ligands is described by ?exact? cone and solid cone angles, and the percentage of metal surface shielded by the ligands. The results are compared to closely related palladium complexes. The X-ray structure revealed the proximity of the ortho phenyl proton of one PPh3 ligand to platinum(II) showing rare intramolecular C?H···Pt anagostic binding interaction. The title complex was determined to be active against tumor cells, and it also showed a moderate inhibitory action against mycobacterium tuberculosis. Fil: Pérez, Hiram. Universidad de La Habana; Cuba Fil: Ramos, Raúl. Universidad de La Habana; Cuba Fil: Plutín, Ana M.. Universidad de La Habana; Cuba Fil: Mocelo, Raúl. Universidad de La Habana; Cuba Fil: Erben, Mauricio Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina Fil: Castellano, Eduardo E.. Universidade de Sao Paulo; Brasil Fil: Batista, Alzir A.. Universidade Federal do São Carlos; Brasil |
| description |
A novel mixed platinum(II) complex with general formula [Pt(PPh3)2(L1-O,S)]PF6 has been synthetized and characterized by elemental analysis, molar conductivity, and by IR and NMR (1H, 13C and 31P) spectroscopic methods. The crystal structure has been determined by single-crystal X-ray crystallography. The molecule presents an almost ideal square-planar geometry, and the crystal is stabilized by weak C?H···O and C?H···F hydrogen bonds, and C?H···π stacking interactions. The steric congestion of ligands is described by ?exact? cone and solid cone angles, and the percentage of metal surface shielded by the ligands. The results are compared to closely related palladium complexes. The X-ray structure revealed the proximity of the ortho phenyl proton of one PPh3 ligand to platinum(II) showing rare intramolecular C?H···Pt anagostic binding interaction. The title complex was determined to be active against tumor cells, and it also showed a moderate inhibitory action against mycobacterium tuberculosis. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019-06 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/131656 Pérez, Hiram; Ramos, Raúl; Plutín, Ana M.; Mocelo, Raúl; Erben, Mauricio Federico; et al.; A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea); Wiley VCH Verlag; European Journal of Inorganic Chemistry; 2019; 21; 6-2019; 2583-2590 1434-1948 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/131656 |
| identifier_str_mv |
Pérez, Hiram; Ramos, Raúl; Plutín, Ana M.; Mocelo, Raúl; Erben, Mauricio Federico; et al.; A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea); Wiley VCH Verlag; European Journal of Inorganic Chemistry; 2019; 21; 6-2019; 2583-2590 1434-1948 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1002/ejic.201900042 info:eu-repo/semantics/altIdentifier/url/https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejic.201900042 |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Wiley VCH Verlag |
| publisher.none.fl_str_mv |
Wiley VCH Verlag |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614309324259328 |
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13.070432 |