Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling

Autores
Scanavachi, Gustavo; Espinosa Silva, Yanis Ricardo; Ruso, Juan; Itri, Rosangela
Año de publicación
2019
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Some proteins can undergo structural changes that may trigger an aggregation process where they self-assembly into highly ordered aggregates called amyloid fibers. In vivo, these amyloid fibers are related to more than 25 different diseases, some of them are lethal as Creutzfeldt-Jakob disease and others can lead a person to incapacities, as diabetes type II, Alzheimer's and Parkinson's diseases. With the aim of understanding the conditions and mechanisms by which proteins form amyloid fibers, we mixed bovine serum albumin (BSA) at pH 3.7 with sodium dodecyl sulfate (SDS) and sodium perfluorooctanoate (SPFO) to induce the amyloid fibers formation.
Fil: Scanavachi, Gustavo. Universidade de Sao Paulo; Brasil
Fil: Espinosa Silva, Yanis Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina
Fil: Ruso, Juan. Universidade de Sao Paulo; Brasil
Fil: Itri, Rosangela. Universidade de Sao Paulo; Brasil
63rd Annual Meeting of The Biophysical Society
Estados Unidos
Biophysical Society
Materia
bovine serum albumin
sodium dodecyl sulfate
sodium perfluorooctanoate
amyloid fibers
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/135945
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Unveiling the Role of Surfactants on Amyloid-Like Protein Self-AssemblingScanavachi, GustavoEspinosa Silva, Yanis RicardoRuso, JuanItri, Rosangelabovine serum albuminsodium dodecyl sulfatesodium perfluorooctanoateamyloid fibershttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Some proteins can undergo structural changes that may trigger an aggregation process where they self-assembly into highly ordered aggregates called amyloid fibers. In vivo, these amyloid fibers are related to more than 25 different diseases, some of them are lethal as Creutzfeldt-Jakob disease and others can lead a person to incapacities, as diabetes type II, Alzheimer's and Parkinson's diseases. With the aim of understanding the conditions and mechanisms by which proteins form amyloid fibers, we mixed bovine serum albumin (BSA) at pH 3.7 with sodium dodecyl sulfate (SDS) and sodium perfluorooctanoate (SPFO) to induce the amyloid fibers formation.Fil: Scanavachi, Gustavo. Universidade de Sao Paulo; BrasilFil: Espinosa Silva, Yanis Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; ArgentinaFil: Ruso, Juan. Universidade de Sao Paulo; BrasilFil: Itri, Rosangela. Universidade de Sao Paulo; Brasil63rd Annual Meeting of The Biophysical SocietyEstados UnidosBiophysical SocietyCell Press2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/135945Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling; 63rd Annual Meeting of The Biophysical Society; Estados Unidos; 2019; 1-10006-3495CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://doi.org/10.1016/j.bpj.2018.11.2608Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:02:37Zoai:ri.conicet.gov.ar:11336/135945instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:02:37.314CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling
title Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling
spellingShingle Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling
Scanavachi, Gustavo
bovine serum albumin
sodium dodecyl sulfate
sodium perfluorooctanoate
amyloid fibers
title_short Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling
title_full Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling
title_fullStr Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling
title_full_unstemmed Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling
title_sort Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling
dc.creator.none.fl_str_mv Scanavachi, Gustavo
Espinosa Silva, Yanis Ricardo
Ruso, Juan
Itri, Rosangela
author Scanavachi, Gustavo
author_facet Scanavachi, Gustavo
Espinosa Silva, Yanis Ricardo
Ruso, Juan
Itri, Rosangela
author_role author
author2 Espinosa Silva, Yanis Ricardo
Ruso, Juan
Itri, Rosangela
author2_role author
author
author
dc.subject.none.fl_str_mv bovine serum albumin
sodium dodecyl sulfate
sodium perfluorooctanoate
amyloid fibers
topic bovine serum albumin
sodium dodecyl sulfate
sodium perfluorooctanoate
amyloid fibers
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Some proteins can undergo structural changes that may trigger an aggregation process where they self-assembly into highly ordered aggregates called amyloid fibers. In vivo, these amyloid fibers are related to more than 25 different diseases, some of them are lethal as Creutzfeldt-Jakob disease and others can lead a person to incapacities, as diabetes type II, Alzheimer's and Parkinson's diseases. With the aim of understanding the conditions and mechanisms by which proteins form amyloid fibers, we mixed bovine serum albumin (BSA) at pH 3.7 with sodium dodecyl sulfate (SDS) and sodium perfluorooctanoate (SPFO) to induce the amyloid fibers formation.
Fil: Scanavachi, Gustavo. Universidade de Sao Paulo; Brasil
Fil: Espinosa Silva, Yanis Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina
Fil: Ruso, Juan. Universidade de Sao Paulo; Brasil
Fil: Itri, Rosangela. Universidade de Sao Paulo; Brasil
63rd Annual Meeting of The Biophysical Society
Estados Unidos
Biophysical Society
description Some proteins can undergo structural changes that may trigger an aggregation process where they self-assembly into highly ordered aggregates called amyloid fibers. In vivo, these amyloid fibers are related to more than 25 different diseases, some of them are lethal as Creutzfeldt-Jakob disease and others can lead a person to incapacities, as diabetes type II, Alzheimer's and Parkinson's diseases. With the aim of understanding the conditions and mechanisms by which proteins form amyloid fibers, we mixed bovine serum albumin (BSA) at pH 3.7 with sodium dodecyl sulfate (SDS) and sodium perfluorooctanoate (SPFO) to induce the amyloid fibers formation.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/135945
Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling; 63rd Annual Meeting of The Biophysical Society; Estados Unidos; 2019; 1-1
0006-3495
CONICET Digital
CONICET
url http://hdl.handle.net/11336/135945
identifier_str_mv Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling; 63rd Annual Meeting of The Biophysical Society; Estados Unidos; 2019; 1-1
0006-3495
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.1016/j.bpj.2018.11.2608
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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