Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling
- Autores
- Scanavachi, Gustavo; Espinosa Silva, Yanis Ricardo; Ruso, Juan; Itri, Rosangela
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Some proteins can undergo structural changes that may trigger an aggregation process where they self-assembly into highly ordered aggregates called amyloid fibers. In vivo, these amyloid fibers are related to more than 25 different diseases, some of them are lethal as Creutzfeldt-Jakob disease and others can lead a person to incapacities, as diabetes type II, Alzheimer's and Parkinson's diseases. With the aim of understanding the conditions and mechanisms by which proteins form amyloid fibers, we mixed bovine serum albumin (BSA) at pH 3.7 with sodium dodecyl sulfate (SDS) and sodium perfluorooctanoate (SPFO) to induce the amyloid fibers formation.
Fil: Scanavachi, Gustavo. Universidade de Sao Paulo; Brasil
Fil: Espinosa Silva, Yanis Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina
Fil: Ruso, Juan. Universidade de Sao Paulo; Brasil
Fil: Itri, Rosangela. Universidade de Sao Paulo; Brasil
63rd Annual Meeting of The Biophysical Society
Estados Unidos
Biophysical Society - Materia
-
bovine serum albumin
sodium dodecyl sulfate
sodium perfluorooctanoate
amyloid fibers - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/135945
Ver los metadatos del registro completo
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Unveiling the Role of Surfactants on Amyloid-Like Protein Self-AssemblingScanavachi, GustavoEspinosa Silva, Yanis RicardoRuso, JuanItri, Rosangelabovine serum albuminsodium dodecyl sulfatesodium perfluorooctanoateamyloid fibershttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Some proteins can undergo structural changes that may trigger an aggregation process where they self-assembly into highly ordered aggregates called amyloid fibers. In vivo, these amyloid fibers are related to more than 25 different diseases, some of them are lethal as Creutzfeldt-Jakob disease and others can lead a person to incapacities, as diabetes type II, Alzheimer's and Parkinson's diseases. With the aim of understanding the conditions and mechanisms by which proteins form amyloid fibers, we mixed bovine serum albumin (BSA) at pH 3.7 with sodium dodecyl sulfate (SDS) and sodium perfluorooctanoate (SPFO) to induce the amyloid fibers formation.Fil: Scanavachi, Gustavo. Universidade de Sao Paulo; BrasilFil: Espinosa Silva, Yanis Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; ArgentinaFil: Ruso, Juan. Universidade de Sao Paulo; BrasilFil: Itri, Rosangela. Universidade de Sao Paulo; Brasil63rd Annual Meeting of The Biophysical SocietyEstados UnidosBiophysical SocietyCell Press2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/135945Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling; 63rd Annual Meeting of The Biophysical Society; Estados Unidos; 2019; 1-10006-3495CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://doi.org/10.1016/j.bpj.2018.11.2608Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:34:36Zoai:ri.conicet.gov.ar:11336/135945instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:34:36.325CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling |
title |
Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling |
spellingShingle |
Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling Scanavachi, Gustavo bovine serum albumin sodium dodecyl sulfate sodium perfluorooctanoate amyloid fibers |
title_short |
Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling |
title_full |
Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling |
title_fullStr |
Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling |
title_full_unstemmed |
Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling |
title_sort |
Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling |
dc.creator.none.fl_str_mv |
Scanavachi, Gustavo Espinosa Silva, Yanis Ricardo Ruso, Juan Itri, Rosangela |
author |
Scanavachi, Gustavo |
author_facet |
Scanavachi, Gustavo Espinosa Silva, Yanis Ricardo Ruso, Juan Itri, Rosangela |
author_role |
author |
author2 |
Espinosa Silva, Yanis Ricardo Ruso, Juan Itri, Rosangela |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
bovine serum albumin sodium dodecyl sulfate sodium perfluorooctanoate amyloid fibers |
topic |
bovine serum albumin sodium dodecyl sulfate sodium perfluorooctanoate amyloid fibers |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Some proteins can undergo structural changes that may trigger an aggregation process where they self-assembly into highly ordered aggregates called amyloid fibers. In vivo, these amyloid fibers are related to more than 25 different diseases, some of them are lethal as Creutzfeldt-Jakob disease and others can lead a person to incapacities, as diabetes type II, Alzheimer's and Parkinson's diseases. With the aim of understanding the conditions and mechanisms by which proteins form amyloid fibers, we mixed bovine serum albumin (BSA) at pH 3.7 with sodium dodecyl sulfate (SDS) and sodium perfluorooctanoate (SPFO) to induce the amyloid fibers formation. Fil: Scanavachi, Gustavo. Universidade de Sao Paulo; Brasil Fil: Espinosa Silva, Yanis Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina Fil: Ruso, Juan. Universidade de Sao Paulo; Brasil Fil: Itri, Rosangela. Universidade de Sao Paulo; Brasil 63rd Annual Meeting of The Biophysical Society Estados Unidos Biophysical Society |
description |
Some proteins can undergo structural changes that may trigger an aggregation process where they self-assembly into highly ordered aggregates called amyloid fibers. In vivo, these amyloid fibers are related to more than 25 different diseases, some of them are lethal as Creutzfeldt-Jakob disease and others can lead a person to incapacities, as diabetes type II, Alzheimer's and Parkinson's diseases. With the aim of understanding the conditions and mechanisms by which proteins form amyloid fibers, we mixed bovine serum albumin (BSA) at pH 3.7 with sodium dodecyl sulfate (SDS) and sodium perfluorooctanoate (SPFO) to induce the amyloid fibers formation. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Reunión Journal http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/135945 Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling; 63rd Annual Meeting of The Biophysical Society; Estados Unidos; 2019; 1-1 0006-3495 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/135945 |
identifier_str_mv |
Unveiling the Role of Surfactants on Amyloid-Like Protein Self-Assembling; 63rd Annual Meeting of The Biophysical Society; Estados Unidos; 2019; 1-1 0006-3495 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.1016/j.bpj.2018.11.2608 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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openAccess |
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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application/pdf application/pdf |
dc.coverage.none.fl_str_mv |
Internacional |
dc.publisher.none.fl_str_mv |
Cell Press |
publisher.none.fl_str_mv |
Cell Press |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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