Evolution of SARS-CoV-2 during the first year of the COVID-19 pandemic in Northwestern Argentina
- Autores
- Zambrana Montaño, Romina Micaela; Culasso, Andrés Carlos Alberto; Fernández, Franco; Marquez, Nathalie; Debat, Humberto Julio; Salmerón, Mariana Beatriz; Zamora, Ana María; Ruíz de Huidobro, Gustavo; Costas, Dardo; Alabarse, Graciela; Charre, Miguel Alejandro; Fridman, Ariel David; Mamani, Claudia; Vaca, Fabiana; Maza Diaz, Claudia; Raskovsky, Viviana; Lavaque, Esteban; Lesser, Veronica; Cajal, Pamela; Agüero, Fernanda; Calvente, Cintia; Torres, Carolina; Viegas, Mariana
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Studies about the evolution of SARS-CoV-2 lineages in different backgrounds such as naive populations are still scarce, especially from South America. This work aimed to study the introduction and diversification pattern of SARS-CoV-2 during the first year of the COVID-19 pandemic in the Northwestern Argentina (NWA) region and to analyze the evolutionary dynamics of the main lineages found. In this study, we analyzed a total of 260 SARS-CoV-2 whole-genome sequences from Argentina, belonging to the Provinces of Jujuy, Salta, and Tucumán, from March 31st, 2020, to May 22nd, 2021, which covered the full first wave and the early second wave of the COVID-19 pandemic in Argentina. In the first wave, eight lineages were identified: B.1.499 (76.9%), followed by N.5 (10.2%), B.1.1.274 (3.7%), B.1.1.348 (3.7%), B.1 (2.8%), B.1.600 (0.9%), B.1.1.33 (0.9%) and N.3 (0.9%). During the early second wave, the first-wave lineages were displaced by the introduction of variants of concern (VOC) (Alpha, Gamma), or variants of interest (VOI) (Lambda, Zeta, Epsilon) and other lineages with more limited distribution. Phylodynamic analyses of the B.1.499 and N.5, the two most prevalent lineages in the NWA, revealed that the rate of evolution of lineage N.5 (7.9 × 10−4 substitutions per site per year, s/s/y) was a ∼40% faster than that of lineage B.1.499 (5.6 × 10−4 s/s/y), although both are in the same order of magnitude than other non-VOC lineages. No mutations associated with a biological characteristic of importance were observed as signatures markers of the phylogenetic groups established in Northwestern Argentina, however, single sequences in non-VOC lineages did present mutations of biological importance or associated with VOCs as sporadic events, showing that many of these mutations could emerge from circulation in the general population. This study contributed to the knowledge about the evolution of SARS-CoV-2 in a pre-vaccination and without post-exposure immunization period.
Fil: Zambrana Montaño, Romina Micaela. Instituto de Investigaciones En Bacteriologia y Virologia Molecular (ibavim) ; Facultad de Farmacia y Bioquimica ; Universidad de Buenos Aires; . Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Culasso, Andrés Carlos Alberto. Instituto de Investigaciones En Bacteriologia y Virologia Molecular (ibavim) ; Facultad de Farmacia y Bioquimica ; Universidad de Buenos Aires; . Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fernández, Franco. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias. Instituto de Patología Vegetal; Argentina
Fil: Marquez, Nathalie. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias. Instituto de Patología Vegetal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Debat, Humberto Julio. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias. Instituto de Patología Vegetal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Salmerón, Mariana Beatriz. Gobierno de la Provincia de Tucuman. Ministerio de Salud. Departamento Bioquimico. Laboratorio de Salud Publica.; Argentina
Fil: Zamora, Ana María. Gobierno de la Provincia de Tucuman. Ministerio de Salud. Departamento Bioquimico. Laboratorio de Salud Publica.; Argentina
Fil: Ruíz de Huidobro, Gustavo. Gobierno de la Provincia de Tucuman. Ministerio de Salud. Departamento Bioquimico. Laboratorio de Salud Publica.; Argentina
Fil: Costas, Dardo. Gobierno de la Provincia de Tucuman. Ministerio de Salud. Departamento Bioquimico. Laboratorio de Salud Publica.; Argentina
Fil: Alabarse, Graciela. Gobierno de la Provincia de Tucuman. Ministerio de Salud. Departamento Bioquimico. Laboratorio de Salud Publica.; Argentina
Fil: Charre, Miguel Alejandro. No especifíca;
Fil: Fridman, Ariel David. No especifíca;
Fil: Mamani, Claudia. No especifíca;
Fil: Vaca, Fabiana. No especifíca;
Fil: Maza Diaz, Claudia. No especifíca;
Fil: Raskovsky, Viviana. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; Argentina
Fil: Lavaque, Esteban. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; Argentina
Fil: Lesser, Veronica. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; Argentina
Fil: Cajal, Pamela. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; Argentina
Fil: Agüero, Fernanda. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; Argentina
Fil: Calvente, Cintia. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; Argentina
Fil: Torres, Carolina. Instituto de Investigaciones En Bacteriologia y Virologia Molecular (ibavim) ; Facultad de Farmacia y Bioquimica ; Universidad de Buenos Aires; . Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Viegas, Mariana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
ARGENTINA
COVID-19
FIRST-WAVE LINEAGES
RATE OF EVOLUTION
SARS-COV-2 - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/219802
Ver los metadatos del registro completo
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Evolution of SARS-CoV-2 during the first year of the COVID-19 pandemic in Northwestern ArgentinaZambrana Montaño, Romina MicaelaCulasso, Andrés Carlos AlbertoFernández, FrancoMarquez, NathalieDebat, Humberto JulioSalmerón, Mariana BeatrizZamora, Ana MaríaRuíz de Huidobro, GustavoCostas, DardoAlabarse, GracielaCharre, Miguel AlejandroFridman, Ariel DavidMamani, ClaudiaVaca, FabianaMaza Diaz, ClaudiaRaskovsky, VivianaLavaque, EstebanLesser, VeronicaCajal, PamelaAgüero, FernandaCalvente, CintiaTorres, CarolinaViegas, MarianaARGENTINACOVID-19FIRST-WAVE LINEAGESRATE OF EVOLUTIONSARS-COV-2https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Studies about the evolution of SARS-CoV-2 lineages in different backgrounds such as naive populations are still scarce, especially from South America. This work aimed to study the introduction and diversification pattern of SARS-CoV-2 during the first year of the COVID-19 pandemic in the Northwestern Argentina (NWA) region and to analyze the evolutionary dynamics of the main lineages found. In this study, we analyzed a total of 260 SARS-CoV-2 whole-genome sequences from Argentina, belonging to the Provinces of Jujuy, Salta, and Tucumán, from March 31st, 2020, to May 22nd, 2021, which covered the full first wave and the early second wave of the COVID-19 pandemic in Argentina. In the first wave, eight lineages were identified: B.1.499 (76.9%), followed by N.5 (10.2%), B.1.1.274 (3.7%), B.1.1.348 (3.7%), B.1 (2.8%), B.1.600 (0.9%), B.1.1.33 (0.9%) and N.3 (0.9%). During the early second wave, the first-wave lineages were displaced by the introduction of variants of concern (VOC) (Alpha, Gamma), or variants of interest (VOI) (Lambda, Zeta, Epsilon) and other lineages with more limited distribution. Phylodynamic analyses of the B.1.499 and N.5, the two most prevalent lineages in the NWA, revealed that the rate of evolution of lineage N.5 (7.9 × 10−4 substitutions per site per year, s/s/y) was a ∼40% faster than that of lineage B.1.499 (5.6 × 10−4 s/s/y), although both are in the same order of magnitude than other non-VOC lineages. No mutations associated with a biological characteristic of importance were observed as signatures markers of the phylogenetic groups established in Northwestern Argentina, however, single sequences in non-VOC lineages did present mutations of biological importance or associated with VOCs as sporadic events, showing that many of these mutations could emerge from circulation in the general population. This study contributed to the knowledge about the evolution of SARS-CoV-2 in a pre-vaccination and without post-exposure immunization period.Fil: Zambrana Montaño, Romina Micaela. Instituto de Investigaciones En Bacteriologia y Virologia Molecular (ibavim) ; Facultad de Farmacia y Bioquimica ; Universidad de Buenos Aires; . Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Culasso, Andrés Carlos Alberto. Instituto de Investigaciones En Bacteriologia y Virologia Molecular (ibavim) ; Facultad de Farmacia y Bioquimica ; Universidad de Buenos Aires; . Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fernández, Franco. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias. Instituto de Patología Vegetal; ArgentinaFil: Marquez, Nathalie. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias. Instituto de Patología Vegetal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Debat, Humberto Julio. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias. Instituto de Patología Vegetal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Salmerón, Mariana Beatriz. Gobierno de la Provincia de Tucuman. Ministerio de Salud. Departamento Bioquimico. Laboratorio de Salud Publica.; ArgentinaFil: Zamora, Ana María. Gobierno de la Provincia de Tucuman. Ministerio de Salud. Departamento Bioquimico. Laboratorio de Salud Publica.; ArgentinaFil: Ruíz de Huidobro, Gustavo. Gobierno de la Provincia de Tucuman. Ministerio de Salud. Departamento Bioquimico. Laboratorio de Salud Publica.; ArgentinaFil: Costas, Dardo. Gobierno de la Provincia de Tucuman. Ministerio de Salud. Departamento Bioquimico. Laboratorio de Salud Publica.; ArgentinaFil: Alabarse, Graciela. Gobierno de la Provincia de Tucuman. Ministerio de Salud. Departamento Bioquimico. Laboratorio de Salud Publica.; ArgentinaFil: Charre, Miguel Alejandro. No especifíca;Fil: Fridman, Ariel David. No especifíca;Fil: Mamani, Claudia. No especifíca;Fil: Vaca, Fabiana. No especifíca;Fil: Maza Diaz, Claudia. No especifíca;Fil: Raskovsky, Viviana. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; ArgentinaFil: Lavaque, Esteban. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; ArgentinaFil: Lesser, Veronica. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; ArgentinaFil: Cajal, Pamela. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; ArgentinaFil: Agüero, Fernanda. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; ArgentinaFil: Calvente, Cintia. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; ArgentinaFil: Torres, Carolina. Instituto de Investigaciones En Bacteriologia y Virologia Molecular (ibavim) ; Facultad de Farmacia y Bioquimica ; Universidad de Buenos Aires; . Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Viegas, Mariana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Science2023-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/219802Zambrana Montaño, Romina Micaela; Culasso, Andrés Carlos Alberto; Fernández, Franco; Marquez, Nathalie; Debat, Humberto Julio; et al.; Evolution of SARS-CoV-2 during the first year of the COVID-19 pandemic in Northwestern Argentina; Elsevier Science; Virus Research; 323; 1-2023; 1-130168-1702CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0168170222002647info:eu-repo/semantics/altIdentifier/doi/10.1016/j.virusres.2022.198936info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:31:13Zoai:ri.conicet.gov.ar:11336/219802instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:31:13.341CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Evolution of SARS-CoV-2 during the first year of the COVID-19 pandemic in Northwestern Argentina |
| title |
Evolution of SARS-CoV-2 during the first year of the COVID-19 pandemic in Northwestern Argentina |
| spellingShingle |
Evolution of SARS-CoV-2 during the first year of the COVID-19 pandemic in Northwestern Argentina Zambrana Montaño, Romina Micaela ARGENTINA COVID-19 FIRST-WAVE LINEAGES RATE OF EVOLUTION SARS-COV-2 |
| title_short |
Evolution of SARS-CoV-2 during the first year of the COVID-19 pandemic in Northwestern Argentina |
| title_full |
Evolution of SARS-CoV-2 during the first year of the COVID-19 pandemic in Northwestern Argentina |
| title_fullStr |
Evolution of SARS-CoV-2 during the first year of the COVID-19 pandemic in Northwestern Argentina |
| title_full_unstemmed |
Evolution of SARS-CoV-2 during the first year of the COVID-19 pandemic in Northwestern Argentina |
| title_sort |
Evolution of SARS-CoV-2 during the first year of the COVID-19 pandemic in Northwestern Argentina |
| dc.creator.none.fl_str_mv |
Zambrana Montaño, Romina Micaela Culasso, Andrés Carlos Alberto Fernández, Franco Marquez, Nathalie Debat, Humberto Julio Salmerón, Mariana Beatriz Zamora, Ana María Ruíz de Huidobro, Gustavo Costas, Dardo Alabarse, Graciela Charre, Miguel Alejandro Fridman, Ariel David Mamani, Claudia Vaca, Fabiana Maza Diaz, Claudia Raskovsky, Viviana Lavaque, Esteban Lesser, Veronica Cajal, Pamela Agüero, Fernanda Calvente, Cintia Torres, Carolina Viegas, Mariana |
| author |
Zambrana Montaño, Romina Micaela |
| author_facet |
Zambrana Montaño, Romina Micaela Culasso, Andrés Carlos Alberto Fernández, Franco Marquez, Nathalie Debat, Humberto Julio Salmerón, Mariana Beatriz Zamora, Ana María Ruíz de Huidobro, Gustavo Costas, Dardo Alabarse, Graciela Charre, Miguel Alejandro Fridman, Ariel David Mamani, Claudia Vaca, Fabiana Maza Diaz, Claudia Raskovsky, Viviana Lavaque, Esteban Lesser, Veronica Cajal, Pamela Agüero, Fernanda Calvente, Cintia Torres, Carolina Viegas, Mariana |
| author_role |
author |
| author2 |
Culasso, Andrés Carlos Alberto Fernández, Franco Marquez, Nathalie Debat, Humberto Julio Salmerón, Mariana Beatriz Zamora, Ana María Ruíz de Huidobro, Gustavo Costas, Dardo Alabarse, Graciela Charre, Miguel Alejandro Fridman, Ariel David Mamani, Claudia Vaca, Fabiana Maza Diaz, Claudia Raskovsky, Viviana Lavaque, Esteban Lesser, Veronica Cajal, Pamela Agüero, Fernanda Calvente, Cintia Torres, Carolina Viegas, Mariana |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
ARGENTINA COVID-19 FIRST-WAVE LINEAGES RATE OF EVOLUTION SARS-COV-2 |
| topic |
ARGENTINA COVID-19 FIRST-WAVE LINEAGES RATE OF EVOLUTION SARS-COV-2 |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Studies about the evolution of SARS-CoV-2 lineages in different backgrounds such as naive populations are still scarce, especially from South America. This work aimed to study the introduction and diversification pattern of SARS-CoV-2 during the first year of the COVID-19 pandemic in the Northwestern Argentina (NWA) region and to analyze the evolutionary dynamics of the main lineages found. In this study, we analyzed a total of 260 SARS-CoV-2 whole-genome sequences from Argentina, belonging to the Provinces of Jujuy, Salta, and Tucumán, from March 31st, 2020, to May 22nd, 2021, which covered the full first wave and the early second wave of the COVID-19 pandemic in Argentina. In the first wave, eight lineages were identified: B.1.499 (76.9%), followed by N.5 (10.2%), B.1.1.274 (3.7%), B.1.1.348 (3.7%), B.1 (2.8%), B.1.600 (0.9%), B.1.1.33 (0.9%) and N.3 (0.9%). During the early second wave, the first-wave lineages were displaced by the introduction of variants of concern (VOC) (Alpha, Gamma), or variants of interest (VOI) (Lambda, Zeta, Epsilon) and other lineages with more limited distribution. Phylodynamic analyses of the B.1.499 and N.5, the two most prevalent lineages in the NWA, revealed that the rate of evolution of lineage N.5 (7.9 × 10−4 substitutions per site per year, s/s/y) was a ∼40% faster than that of lineage B.1.499 (5.6 × 10−4 s/s/y), although both are in the same order of magnitude than other non-VOC lineages. No mutations associated with a biological characteristic of importance were observed as signatures markers of the phylogenetic groups established in Northwestern Argentina, however, single sequences in non-VOC lineages did present mutations of biological importance or associated with VOCs as sporadic events, showing that many of these mutations could emerge from circulation in the general population. This study contributed to the knowledge about the evolution of SARS-CoV-2 in a pre-vaccination and without post-exposure immunization period. Fil: Zambrana Montaño, Romina Micaela. Instituto de Investigaciones En Bacteriologia y Virologia Molecular (ibavim) ; Facultad de Farmacia y Bioquimica ; Universidad de Buenos Aires; . Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Culasso, Andrés Carlos Alberto. Instituto de Investigaciones En Bacteriologia y Virologia Molecular (ibavim) ; Facultad de Farmacia y Bioquimica ; Universidad de Buenos Aires; . Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Fernández, Franco. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias. Instituto de Patología Vegetal; Argentina Fil: Marquez, Nathalie. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias. Instituto de Patología Vegetal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Debat, Humberto Julio. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias. Instituto de Patología Vegetal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Salmerón, Mariana Beatriz. Gobierno de la Provincia de Tucuman. Ministerio de Salud. Departamento Bioquimico. Laboratorio de Salud Publica.; Argentina Fil: Zamora, Ana María. Gobierno de la Provincia de Tucuman. Ministerio de Salud. Departamento Bioquimico. Laboratorio de Salud Publica.; Argentina Fil: Ruíz de Huidobro, Gustavo. Gobierno de la Provincia de Tucuman. Ministerio de Salud. Departamento Bioquimico. Laboratorio de Salud Publica.; Argentina Fil: Costas, Dardo. Gobierno de la Provincia de Tucuman. Ministerio de Salud. Departamento Bioquimico. Laboratorio de Salud Publica.; Argentina Fil: Alabarse, Graciela. Gobierno de la Provincia de Tucuman. Ministerio de Salud. Departamento Bioquimico. Laboratorio de Salud Publica.; Argentina Fil: Charre, Miguel Alejandro. No especifíca; Fil: Fridman, Ariel David. No especifíca; Fil: Mamani, Claudia. No especifíca; Fil: Vaca, Fabiana. No especifíca; Fil: Maza Diaz, Claudia. No especifíca; Fil: Raskovsky, Viviana. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; Argentina Fil: Lavaque, Esteban. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; Argentina Fil: Lesser, Veronica. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; Argentina Fil: Cajal, Pamela. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; Argentina Fil: Agüero, Fernanda. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; Argentina Fil: Calvente, Cintia. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; Argentina Fil: Torres, Carolina. Instituto de Investigaciones En Bacteriologia y Virologia Molecular (ibavim) ; Facultad de Farmacia y Bioquimica ; Universidad de Buenos Aires; . Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Viegas, Mariana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
| description |
Studies about the evolution of SARS-CoV-2 lineages in different backgrounds such as naive populations are still scarce, especially from South America. This work aimed to study the introduction and diversification pattern of SARS-CoV-2 during the first year of the COVID-19 pandemic in the Northwestern Argentina (NWA) region and to analyze the evolutionary dynamics of the main lineages found. In this study, we analyzed a total of 260 SARS-CoV-2 whole-genome sequences from Argentina, belonging to the Provinces of Jujuy, Salta, and Tucumán, from March 31st, 2020, to May 22nd, 2021, which covered the full first wave and the early second wave of the COVID-19 pandemic in Argentina. In the first wave, eight lineages were identified: B.1.499 (76.9%), followed by N.5 (10.2%), B.1.1.274 (3.7%), B.1.1.348 (3.7%), B.1 (2.8%), B.1.600 (0.9%), B.1.1.33 (0.9%) and N.3 (0.9%). During the early second wave, the first-wave lineages were displaced by the introduction of variants of concern (VOC) (Alpha, Gamma), or variants of interest (VOI) (Lambda, Zeta, Epsilon) and other lineages with more limited distribution. Phylodynamic analyses of the B.1.499 and N.5, the two most prevalent lineages in the NWA, revealed that the rate of evolution of lineage N.5 (7.9 × 10−4 substitutions per site per year, s/s/y) was a ∼40% faster than that of lineage B.1.499 (5.6 × 10−4 s/s/y), although both are in the same order of magnitude than other non-VOC lineages. No mutations associated with a biological characteristic of importance were observed as signatures markers of the phylogenetic groups established in Northwestern Argentina, however, single sequences in non-VOC lineages did present mutations of biological importance or associated with VOCs as sporadic events, showing that many of these mutations could emerge from circulation in the general population. This study contributed to the knowledge about the evolution of SARS-CoV-2 in a pre-vaccination and without post-exposure immunization period. |
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2023 |
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2023-01 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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http://hdl.handle.net/11336/219802 Zambrana Montaño, Romina Micaela; Culasso, Andrés Carlos Alberto; Fernández, Franco; Marquez, Nathalie; Debat, Humberto Julio; et al.; Evolution of SARS-CoV-2 during the first year of the COVID-19 pandemic in Northwestern Argentina; Elsevier Science; Virus Research; 323; 1-2023; 1-13 0168-1702 CONICET Digital CONICET |
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http://hdl.handle.net/11336/219802 |
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Zambrana Montaño, Romina Micaela; Culasso, Andrés Carlos Alberto; Fernández, Franco; Marquez, Nathalie; Debat, Humberto Julio; et al.; Evolution of SARS-CoV-2 during the first year of the COVID-19 pandemic in Northwestern Argentina; Elsevier Science; Virus Research; 323; 1-2023; 1-13 0168-1702 CONICET Digital CONICET |
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eng |
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eng |
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Elsevier Science |
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Elsevier Science |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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