HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens

Autores
Fischer, Will; Giorgi, Elena E.; Chakraborty, Srirupa; Nguyen, Kien; Bhattacharya, Tanmoy; Theiler, James; Goloboff, Pablo Augusto; Yoon, Hyejin; Abfalterer, Werner; Foley, Brian T.; Tegally, Houriiyah; San, James Emmanuel; de Oliveira, Tulio; Gnanakaran, Sandrasegaram; Korber, Bette
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Humanity is currently facing the challenge of two devastating pandemics caused by two very different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which has swept the world in the course of a single year. The same evolutionary strategies that drive HIV-1 evolution are at play in SARS-CoV-2. Single nucleotide mutations, multi-base insertions and deletions, recombination, and variation in surface glycans all generate the variability that, guided by natural selection, enables both HIV-1’s extraordinary diversity and SARS-CoV-2’s slower pace of mutation accumulation. Even though SARS-CoV-2 diversity is more limited, recently emergent SARS-CoV-2 variants carry Spike mutations that have important phenotypic consequences in terms of both antibody resistance and enhanced infectivity. We review and compare how these mutational patterns manifest in these two distinct viruses to provide the variability that fuels their evolution by natural selection.
Fil: Fischer, Will. Los Alamos National Laboratory; Estados Unidos. New Mexico Consortium; México
Fil: Giorgi, Elena E.. New Mexico Consortium; México. Los Alamos National Laboratory; Estados Unidos
Fil: Chakraborty, Srirupa. Center For Nonlinear Studies; Estados Unidos. Los Alamos National Laboratory; Estados Unidos
Fil: Nguyen, Kien. Los Alamos National Laboratory; Estados Unidos
Fil: Bhattacharya, Tanmoy. Los Alamos National Laboratory; Estados Unidos
Fil: Theiler, James. Los Alamos National Laboratory; Estados Unidos
Fil: Goloboff, Pablo Augusto. American Museum of Natural History; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Tucumán. Unidad Ejecutora Lillo; Argentina
Fil: Yoon, Hyejin. Los Alamos National Laboratory; Estados Unidos
Fil: Abfalterer, Werner. Los Alamos National Laboratory; Estados Unidos
Fil: Foley, Brian T.. Los Alamos National Laboratory; Estados Unidos
Fil: Tegally, Houriiyah. University Of Kwazulu-natal; Sudáfrica
Fil: San, James Emmanuel. University Of Kwazulu-natal; Sudáfrica
Fil: de Oliveira, Tulio. University of KwaZulu-Natal; Sudáfrica
Fil: Gnanakaran, Sandrasegaram. Los Alamos National Laboratory; Estados Unidos
Fil: Korber, Bette. Los Alamos National Laboratory; Estados Unidos. New Mexico Consortium; México
Materia
EVOLUTION
GLYCOSYLATION
HIV-1
IMMUNE ESCAPE
INSERTIONS AND DELETIONS
RECOMBINATION
SARS-COV-2
COVID-19
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/142461
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/142461
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogensFischer, WillGiorgi, Elena E.Chakraborty, SrirupaNguyen, KienBhattacharya, TanmoyTheiler, JamesGoloboff, Pablo AugustoYoon, HyejinAbfalterer, WernerFoley, Brian T.Tegally, HouriiyahSan, James Emmanuelde Oliveira, TulioGnanakaran, SandrasegaramKorber, BetteEVOLUTIONGLYCOSYLATIONHIV-1IMMUNE ESCAPEINSERTIONS AND DELETIONSRECOMBINATIONSARS-COV-2COVID-19https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Humanity is currently facing the challenge of two devastating pandemics caused by two very different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which has swept the world in the course of a single year. The same evolutionary strategies that drive HIV-1 evolution are at play in SARS-CoV-2. Single nucleotide mutations, multi-base insertions and deletions, recombination, and variation in surface glycans all generate the variability that, guided by natural selection, enables both HIV-1’s extraordinary diversity and SARS-CoV-2’s slower pace of mutation accumulation. Even though SARS-CoV-2 diversity is more limited, recently emergent SARS-CoV-2 variants carry Spike mutations that have important phenotypic consequences in terms of both antibody resistance and enhanced infectivity. We review and compare how these mutational patterns manifest in these two distinct viruses to provide the variability that fuels their evolution by natural selection.Fil: Fischer, Will. Los Alamos National Laboratory; Estados Unidos. New Mexico Consortium; MéxicoFil: Giorgi, Elena E.. New Mexico Consortium; México. Los Alamos National Laboratory; Estados UnidosFil: Chakraborty, Srirupa. Center For Nonlinear Studies; Estados Unidos. Los Alamos National Laboratory; Estados UnidosFil: Nguyen, Kien. Los Alamos National Laboratory; Estados UnidosFil: Bhattacharya, Tanmoy. Los Alamos National Laboratory; Estados UnidosFil: Theiler, James. Los Alamos National Laboratory; Estados UnidosFil: Goloboff, Pablo Augusto. American Museum of Natural History; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Tucumán. Unidad Ejecutora Lillo; ArgentinaFil: Yoon, Hyejin. Los Alamos National Laboratory; Estados UnidosFil: Abfalterer, Werner. Los Alamos National Laboratory; Estados UnidosFil: Foley, Brian T.. Los Alamos National Laboratory; Estados UnidosFil: Tegally, Houriiyah. University Of Kwazulu-natal; SudáfricaFil: San, James Emmanuel. University Of Kwazulu-natal; SudáfricaFil: de Oliveira, Tulio. University of KwaZulu-Natal; SudáfricaFil: Gnanakaran, Sandrasegaram. Los Alamos National Laboratory; Estados UnidosFil: Korber, Bette. Los Alamos National Laboratory; Estados Unidos. New Mexico Consortium; MéxicoCell Press2021-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/142461Fischer, Will; Giorgi, Elena E.; Chakraborty, Srirupa; Nguyen, Kien; Bhattacharya, Tanmoy; et al.; HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens; Cell Press; Cell Host & Microbe; 29; 7; 7-2021; 1093-11101931-3128CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.chom.2021.05.012info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(21)00240-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1931312821002407%3Fshowall%3Dtrueinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:40:00Zoai:ri.conicet.gov.ar:11336/142461instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:40:00.776CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens
title HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens
spellingShingle HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens
Fischer, Will
EVOLUTION
GLYCOSYLATION
HIV-1
IMMUNE ESCAPE
INSERTIONS AND DELETIONS
RECOMBINATION
SARS-COV-2
COVID-19
title_short HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens
title_full HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens
title_fullStr HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens
title_full_unstemmed HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens
title_sort HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens
dc.creator.none.fl_str_mv Fischer, Will
Giorgi, Elena E.
Chakraborty, Srirupa
Nguyen, Kien
Bhattacharya, Tanmoy
Theiler, James
Goloboff, Pablo Augusto
Yoon, Hyejin
Abfalterer, Werner
Foley, Brian T.
Tegally, Houriiyah
San, James Emmanuel
de Oliveira, Tulio
Gnanakaran, Sandrasegaram
Korber, Bette
author Fischer, Will
author_facet Fischer, Will
Giorgi, Elena E.
Chakraborty, Srirupa
Nguyen, Kien
Bhattacharya, Tanmoy
Theiler, James
Goloboff, Pablo Augusto
Yoon, Hyejin
Abfalterer, Werner
Foley, Brian T.
Tegally, Houriiyah
San, James Emmanuel
de Oliveira, Tulio
Gnanakaran, Sandrasegaram
Korber, Bette
author_role author
author2 Giorgi, Elena E.
Chakraborty, Srirupa
Nguyen, Kien
Bhattacharya, Tanmoy
Theiler, James
Goloboff, Pablo Augusto
Yoon, Hyejin
Abfalterer, Werner
Foley, Brian T.
Tegally, Houriiyah
San, James Emmanuel
de Oliveira, Tulio
Gnanakaran, Sandrasegaram
Korber, Bette
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv EVOLUTION
GLYCOSYLATION
HIV-1
IMMUNE ESCAPE
INSERTIONS AND DELETIONS
RECOMBINATION
SARS-COV-2
COVID-19
topic EVOLUTION
GLYCOSYLATION
HIV-1
IMMUNE ESCAPE
INSERTIONS AND DELETIONS
RECOMBINATION
SARS-COV-2
COVID-19
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Humanity is currently facing the challenge of two devastating pandemics caused by two very different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which has swept the world in the course of a single year. The same evolutionary strategies that drive HIV-1 evolution are at play in SARS-CoV-2. Single nucleotide mutations, multi-base insertions and deletions, recombination, and variation in surface glycans all generate the variability that, guided by natural selection, enables both HIV-1’s extraordinary diversity and SARS-CoV-2’s slower pace of mutation accumulation. Even though SARS-CoV-2 diversity is more limited, recently emergent SARS-CoV-2 variants carry Spike mutations that have important phenotypic consequences in terms of both antibody resistance and enhanced infectivity. We review and compare how these mutational patterns manifest in these two distinct viruses to provide the variability that fuels their evolution by natural selection.
Fil: Fischer, Will. Los Alamos National Laboratory; Estados Unidos. New Mexico Consortium; México
Fil: Giorgi, Elena E.. New Mexico Consortium; México. Los Alamos National Laboratory; Estados Unidos
Fil: Chakraborty, Srirupa. Center For Nonlinear Studies; Estados Unidos. Los Alamos National Laboratory; Estados Unidos
Fil: Nguyen, Kien. Los Alamos National Laboratory; Estados Unidos
Fil: Bhattacharya, Tanmoy. Los Alamos National Laboratory; Estados Unidos
Fil: Theiler, James. Los Alamos National Laboratory; Estados Unidos
Fil: Goloboff, Pablo Augusto. American Museum of Natural History; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Tucumán. Unidad Ejecutora Lillo; Argentina
Fil: Yoon, Hyejin. Los Alamos National Laboratory; Estados Unidos
Fil: Abfalterer, Werner. Los Alamos National Laboratory; Estados Unidos
Fil: Foley, Brian T.. Los Alamos National Laboratory; Estados Unidos
Fil: Tegally, Houriiyah. University Of Kwazulu-natal; Sudáfrica
Fil: San, James Emmanuel. University Of Kwazulu-natal; Sudáfrica
Fil: de Oliveira, Tulio. University of KwaZulu-Natal; Sudáfrica
Fil: Gnanakaran, Sandrasegaram. Los Alamos National Laboratory; Estados Unidos
Fil: Korber, Bette. Los Alamos National Laboratory; Estados Unidos. New Mexico Consortium; México
description Humanity is currently facing the challenge of two devastating pandemics caused by two very different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which has swept the world in the course of a single year. The same evolutionary strategies that drive HIV-1 evolution are at play in SARS-CoV-2. Single nucleotide mutations, multi-base insertions and deletions, recombination, and variation in surface glycans all generate the variability that, guided by natural selection, enables both HIV-1’s extraordinary diversity and SARS-CoV-2’s slower pace of mutation accumulation. Even though SARS-CoV-2 diversity is more limited, recently emergent SARS-CoV-2 variants carry Spike mutations that have important phenotypic consequences in terms of both antibody resistance and enhanced infectivity. We review and compare how these mutational patterns manifest in these two distinct viruses to provide the variability that fuels their evolution by natural selection.
publishDate 2021
dc.date.none.fl_str_mv 2021-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/142461
Fischer, Will; Giorgi, Elena E.; Chakraborty, Srirupa; Nguyen, Kien; Bhattacharya, Tanmoy; et al.; HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens; Cell Press; Cell Host & Microbe; 29; 7; 7-2021; 1093-1110
1931-3128
CONICET Digital
CONICET
url http://hdl.handle.net/11336/142461
identifier_str_mv Fischer, Will; Giorgi, Elena E.; Chakraborty, Srirupa; Nguyen, Kien; Bhattacharya, Tanmoy; et al.; HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens; Cell Press; Cell Host & Microbe; 29; 7; 7-2021; 1093-1110
1931-3128
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.chom.2021.05.012
info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(21)00240-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1931312821002407%3Fshowall%3Dtrue
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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