Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer
- Autores
- Garrido, Marine F.; Martin, Nicolas J.-P.; Bertrand, Matthieu; Gaudin, Catherine; Commo, Fred Eric; Kalaany, Nassif El; Al Nakouzi, Nader; Fazli, Ladan; Nery, Elaine Del; Camonis, Jacques; Perez, Franck; Lerondel, Stéphanie; Le Pape, Alain; Compagno, Daniel Georges; Gleave, Martin; Loriot, Yohann; Desaubry, Laurent; Vagner, Stephan; Fizazi, Karim; Chauchereau, Anne
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Purpose: Targeted therapies that use the signaling path-characterize the function of human FKBP7 and explore its ways involved in prostate cancer are required to overcome role in cancer. We discovered that FKBP7 was upregulated chemoresistance and improve treatment outcomes for men. in human prostate cancers and its expression correlated Molecular chaperones play a key role in the regulation of with the recurrence observed in patients receiving doce-protein homeostasis and are potential targets for overcom-taxel. FKBP7 silencing showed that FKBP7 is required to ing chemoresistance. maintain the growth of chemoresistant cell lines and Experimental Design: We established 4 chemoresistant chemoresistant tumors in mice. Mass spectrometry analysis prostate cancer cell lines and used image-based high-content revealed that FKBP7 interacts with eIF4G, a component of siRNA functional screening, based on gene-expression signa-the eIF4F translation initiation complex, to mediate the ture, to explore mechanisms of chemoresistance and identify survival of chemoresistant cells. Using small-molecule new potential targets with potential roles in taxane resistance. inhibitors of eIF4A, the RNA helicase component of The functional role of a new target was assessed by in vitro and eIF4F, we were able to kill docetaxel- and cabazitaxel-in vivo silencing, and mass spectrometry analysis was used to resistant cells. identify its downstream effectors. Conclusions: Targeting FKBP7 or the eIF4G-containing Results: We identified FKBP7, a prolyl-peptidyl isomer-eIF4F translation initiation complex could be novel thera-ase overexpressed in docetaxel-resistant and in cabazitaxel-peutic strategies to eradicate taxane-resistant prostate cancer resistant prostate cancer cells. This is the first study to cells.
Fil: Garrido, Marine F.. Inserm; Francia
Fil: Martin, Nicolas J.-P.. Inserm; Francia
Fil: Bertrand, Matthieu. Inserm; Francia
Fil: Gaudin, Catherine. Institut Anti-cancer Gustave Roussy; Francia
Fil: Commo, Fred Eric. Inserm; Francia
Fil: Kalaany, Nassif El. Inserm; Francia
Fil: Al Nakouzi, Nader. University of British Columbia; Canadá
Fil: Fazli, Ladan. University of British Columbia; Canadá
Fil: Nery, Elaine Del. Université Pierre et Marie Curie; Francia
Fil: Camonis, Jacques. Université Pierre et Marie Curie; Francia
Fil: Perez, Franck. Université Pierre et Marie Curie; Francia
Fil: Lerondel, Stéphanie. Centre National de la Recherche Scientifique; Francia
Fil: Le Pape, Alain. Inserm; Francia
Fil: Compagno, Daniel Georges. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Gleave, Martin. University of British Columbia; Canadá
Fil: Loriot, Yohann. Inserm; Francia
Fil: Desaubry, Laurent. Centre National de la Recherche Scientifique; Francia
Fil: Vagner, Stephan. Université Pierre et Marie Curie; Francia
Fil: Fizazi, Karim. Institut Anti-cancer Gustave Roussy; Francia
Fil: Chauchereau, Anne. Inserm; Francia - Materia
-
Prostate Cancer
Chemioresistance - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/123540
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/123540 |
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Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancerGarrido, Marine F.Martin, Nicolas J.-P.Bertrand, MatthieuGaudin, CatherineCommo, Fred EricKalaany, Nassif ElAl Nakouzi, NaderFazli, LadanNery, Elaine DelCamonis, JacquesPerez, FranckLerondel, StéphanieLe Pape, AlainCompagno, Daniel GeorgesGleave, MartinLoriot, YohannDesaubry, LaurentVagner, StephanFizazi, KarimChauchereau, AnneProstate CancerChemioresistancehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Purpose: Targeted therapies that use the signaling path-characterize the function of human FKBP7 and explore its ways involved in prostate cancer are required to overcome role in cancer. We discovered that FKBP7 was upregulated chemoresistance and improve treatment outcomes for men. in human prostate cancers and its expression correlated Molecular chaperones play a key role in the regulation of with the recurrence observed in patients receiving doce-protein homeostasis and are potential targets for overcom-taxel. FKBP7 silencing showed that FKBP7 is required to ing chemoresistance. maintain the growth of chemoresistant cell lines and Experimental Design: We established 4 chemoresistant chemoresistant tumors in mice. Mass spectrometry analysis prostate cancer cell lines and used image-based high-content revealed that FKBP7 interacts with eIF4G, a component of siRNA functional screening, based on gene-expression signa-the eIF4F translation initiation complex, to mediate the ture, to explore mechanisms of chemoresistance and identify survival of chemoresistant cells. Using small-molecule new potential targets with potential roles in taxane resistance. inhibitors of eIF4A, the RNA helicase component of The functional role of a new target was assessed by in vitro and eIF4F, we were able to kill docetaxel- and cabazitaxel-in vivo silencing, and mass spectrometry analysis was used to resistant cells. identify its downstream effectors. Conclusions: Targeting FKBP7 or the eIF4G-containing Results: We identified FKBP7, a prolyl-peptidyl isomer-eIF4F translation initiation complex could be novel thera-ase overexpressed in docetaxel-resistant and in cabazitaxel-peutic strategies to eradicate taxane-resistant prostate cancer resistant prostate cancer cells. This is the first study to cells.Fil: Garrido, Marine F.. Inserm; FranciaFil: Martin, Nicolas J.-P.. Inserm; FranciaFil: Bertrand, Matthieu. Inserm; FranciaFil: Gaudin, Catherine. Institut Anti-cancer Gustave Roussy; FranciaFil: Commo, Fred Eric. Inserm; FranciaFil: Kalaany, Nassif El. Inserm; FranciaFil: Al Nakouzi, Nader. University of British Columbia; CanadáFil: Fazli, Ladan. University of British Columbia; CanadáFil: Nery, Elaine Del. Université Pierre et Marie Curie; FranciaFil: Camonis, Jacques. Université Pierre et Marie Curie; FranciaFil: Perez, Franck. Université Pierre et Marie Curie; FranciaFil: Lerondel, Stéphanie. Centre National de la Recherche Scientifique; FranciaFil: Le Pape, Alain. Inserm; FranciaFil: Compagno, Daniel Georges. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Gleave, Martin. University of British Columbia; CanadáFil: Loriot, Yohann. Inserm; FranciaFil: Desaubry, Laurent. Centre National de la Recherche Scientifique; FranciaFil: Vagner, Stephan. Université Pierre et Marie Curie; FranciaFil: Fizazi, Karim. Institut Anti-cancer Gustave Roussy; FranciaFil: Chauchereau, Anne. Inserm; FranciaAmerican Association for Cancer Research2019-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/123540Garrido, Marine F.; Martin, Nicolas J.-P.; Bertrand, Matthieu; Gaudin, Catherine; Commo, Fred Eric; et al.; Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer; American Association for Cancer Research; Clinical Cancer Research; 25; 2; 2-2019; 710-7231078-0432CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://clincancerres.aacrjournals.org/lookup/doi/10.1158/1078-0432.CCR-18-0704info:eu-repo/semantics/altIdentifier/doi/10.1158/1078-0432.CCR-18-0704info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:39:16Zoai:ri.conicet.gov.ar:11336/123540instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:39:16.597CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer |
title |
Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer |
spellingShingle |
Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer Garrido, Marine F. Prostate Cancer Chemioresistance |
title_short |
Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer |
title_full |
Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer |
title_fullStr |
Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer |
title_full_unstemmed |
Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer |
title_sort |
Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer |
dc.creator.none.fl_str_mv |
Garrido, Marine F. Martin, Nicolas J.-P. Bertrand, Matthieu Gaudin, Catherine Commo, Fred Eric Kalaany, Nassif El Al Nakouzi, Nader Fazli, Ladan Nery, Elaine Del Camonis, Jacques Perez, Franck Lerondel, Stéphanie Le Pape, Alain Compagno, Daniel Georges Gleave, Martin Loriot, Yohann Desaubry, Laurent Vagner, Stephan Fizazi, Karim Chauchereau, Anne |
author |
Garrido, Marine F. |
author_facet |
Garrido, Marine F. Martin, Nicolas J.-P. Bertrand, Matthieu Gaudin, Catherine Commo, Fred Eric Kalaany, Nassif El Al Nakouzi, Nader Fazli, Ladan Nery, Elaine Del Camonis, Jacques Perez, Franck Lerondel, Stéphanie Le Pape, Alain Compagno, Daniel Georges Gleave, Martin Loriot, Yohann Desaubry, Laurent Vagner, Stephan Fizazi, Karim Chauchereau, Anne |
author_role |
author |
author2 |
Martin, Nicolas J.-P. Bertrand, Matthieu Gaudin, Catherine Commo, Fred Eric Kalaany, Nassif El Al Nakouzi, Nader Fazli, Ladan Nery, Elaine Del Camonis, Jacques Perez, Franck Lerondel, Stéphanie Le Pape, Alain Compagno, Daniel Georges Gleave, Martin Loriot, Yohann Desaubry, Laurent Vagner, Stephan Fizazi, Karim Chauchereau, Anne |
author2_role |
author author author author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Prostate Cancer Chemioresistance |
topic |
Prostate Cancer Chemioresistance |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Purpose: Targeted therapies that use the signaling path-characterize the function of human FKBP7 and explore its ways involved in prostate cancer are required to overcome role in cancer. We discovered that FKBP7 was upregulated chemoresistance and improve treatment outcomes for men. in human prostate cancers and its expression correlated Molecular chaperones play a key role in the regulation of with the recurrence observed in patients receiving doce-protein homeostasis and are potential targets for overcom-taxel. FKBP7 silencing showed that FKBP7 is required to ing chemoresistance. maintain the growth of chemoresistant cell lines and Experimental Design: We established 4 chemoresistant chemoresistant tumors in mice. Mass spectrometry analysis prostate cancer cell lines and used image-based high-content revealed that FKBP7 interacts with eIF4G, a component of siRNA functional screening, based on gene-expression signa-the eIF4F translation initiation complex, to mediate the ture, to explore mechanisms of chemoresistance and identify survival of chemoresistant cells. Using small-molecule new potential targets with potential roles in taxane resistance. inhibitors of eIF4A, the RNA helicase component of The functional role of a new target was assessed by in vitro and eIF4F, we were able to kill docetaxel- and cabazitaxel-in vivo silencing, and mass spectrometry analysis was used to resistant cells. identify its downstream effectors. Conclusions: Targeting FKBP7 or the eIF4G-containing Results: We identified FKBP7, a prolyl-peptidyl isomer-eIF4F translation initiation complex could be novel thera-ase overexpressed in docetaxel-resistant and in cabazitaxel-peutic strategies to eradicate taxane-resistant prostate cancer resistant prostate cancer cells. This is the first study to cells. Fil: Garrido, Marine F.. Inserm; Francia Fil: Martin, Nicolas J.-P.. Inserm; Francia Fil: Bertrand, Matthieu. Inserm; Francia Fil: Gaudin, Catherine. Institut Anti-cancer Gustave Roussy; Francia Fil: Commo, Fred Eric. Inserm; Francia Fil: Kalaany, Nassif El. Inserm; Francia Fil: Al Nakouzi, Nader. University of British Columbia; Canadá Fil: Fazli, Ladan. University of British Columbia; Canadá Fil: Nery, Elaine Del. Université Pierre et Marie Curie; Francia Fil: Camonis, Jacques. Université Pierre et Marie Curie; Francia Fil: Perez, Franck. Université Pierre et Marie Curie; Francia Fil: Lerondel, Stéphanie. Centre National de la Recherche Scientifique; Francia Fil: Le Pape, Alain. Inserm; Francia Fil: Compagno, Daniel Georges. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina Fil: Gleave, Martin. University of British Columbia; Canadá Fil: Loriot, Yohann. Inserm; Francia Fil: Desaubry, Laurent. Centre National de la Recherche Scientifique; Francia Fil: Vagner, Stephan. Université Pierre et Marie Curie; Francia Fil: Fizazi, Karim. Institut Anti-cancer Gustave Roussy; Francia Fil: Chauchereau, Anne. Inserm; Francia |
description |
Purpose: Targeted therapies that use the signaling path-characterize the function of human FKBP7 and explore its ways involved in prostate cancer are required to overcome role in cancer. We discovered that FKBP7 was upregulated chemoresistance and improve treatment outcomes for men. in human prostate cancers and its expression correlated Molecular chaperones play a key role in the regulation of with the recurrence observed in patients receiving doce-protein homeostasis and are potential targets for overcom-taxel. FKBP7 silencing showed that FKBP7 is required to ing chemoresistance. maintain the growth of chemoresistant cell lines and Experimental Design: We established 4 chemoresistant chemoresistant tumors in mice. Mass spectrometry analysis prostate cancer cell lines and used image-based high-content revealed that FKBP7 interacts with eIF4G, a component of siRNA functional screening, based on gene-expression signa-the eIF4F translation initiation complex, to mediate the ture, to explore mechanisms of chemoresistance and identify survival of chemoresistant cells. Using small-molecule new potential targets with potential roles in taxane resistance. inhibitors of eIF4A, the RNA helicase component of The functional role of a new target was assessed by in vitro and eIF4F, we were able to kill docetaxel- and cabazitaxel-in vivo silencing, and mass spectrometry analysis was used to resistant cells. identify its downstream effectors. Conclusions: Targeting FKBP7 or the eIF4G-containing Results: We identified FKBP7, a prolyl-peptidyl isomer-eIF4F translation initiation complex could be novel thera-ase overexpressed in docetaxel-resistant and in cabazitaxel-peutic strategies to eradicate taxane-resistant prostate cancer resistant prostate cancer cells. This is the first study to cells. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/123540 Garrido, Marine F.; Martin, Nicolas J.-P.; Bertrand, Matthieu; Gaudin, Catherine; Commo, Fred Eric; et al.; Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer; American Association for Cancer Research; Clinical Cancer Research; 25; 2; 2-2019; 710-723 1078-0432 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/123540 |
identifier_str_mv |
Garrido, Marine F.; Martin, Nicolas J.-P.; Bertrand, Matthieu; Gaudin, Catherine; Commo, Fred Eric; et al.; Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer; American Association for Cancer Research; Clinical Cancer Research; 25; 2; 2-2019; 710-723 1078-0432 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://clincancerres.aacrjournals.org/lookup/doi/10.1158/1078-0432.CCR-18-0704 info:eu-repo/semantics/altIdentifier/doi/10.1158/1078-0432.CCR-18-0704 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Association for Cancer Research |
publisher.none.fl_str_mv |
American Association for Cancer Research |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613241858162688 |
score |
13.070432 |