Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer

Autores
Garrido, Marine F.; Martin, Nicolas J.-P.; Bertrand, Matthieu; Gaudin, Catherine; Commo, Fred Eric; Kalaany, Nassif El; Al Nakouzi, Nader; Fazli, Ladan; Nery, Elaine Del; Camonis, Jacques; Perez, Franck; Lerondel, Stéphanie; Le Pape, Alain; Compagno, Daniel Georges; Gleave, Martin; Loriot, Yohann; Desaubry, Laurent; Vagner, Stephan; Fizazi, Karim; Chauchereau, Anne
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose: Targeted therapies that use the signaling path-characterize the function of human FKBP7 and explore its ways involved in prostate cancer are required to overcome role in cancer. We discovered that FKBP7 was upregulated chemoresistance and improve treatment outcomes for men. in human prostate cancers and its expression correlated Molecular chaperones play a key role in the regulation of with the recurrence observed in patients receiving doce-protein homeostasis and are potential targets for overcom-taxel. FKBP7 silencing showed that FKBP7 is required to ing chemoresistance. maintain the growth of chemoresistant cell lines and Experimental Design: We established 4 chemoresistant chemoresistant tumors in mice. Mass spectrometry analysis prostate cancer cell lines and used image-based high-content revealed that FKBP7 interacts with eIF4G, a component of siRNA functional screening, based on gene-expression signa-the eIF4F translation initiation complex, to mediate the ture, to explore mechanisms of chemoresistance and identify survival of chemoresistant cells. Using small-molecule new potential targets with potential roles in taxane resistance. inhibitors of eIF4A, the RNA helicase component of The functional role of a new target was assessed by in vitro and eIF4F, we were able to kill docetaxel- and cabazitaxel-in vivo silencing, and mass spectrometry analysis was used to resistant cells. identify its downstream effectors. Conclusions: Targeting FKBP7 or the eIF4G-containing Results: We identified FKBP7, a prolyl-peptidyl isomer-eIF4F translation initiation complex could be novel thera-ase overexpressed in docetaxel-resistant and in cabazitaxel-peutic strategies to eradicate taxane-resistant prostate cancer resistant prostate cancer cells. This is the first study to cells.
Fil: Garrido, Marine F.. Inserm; Francia
Fil: Martin, Nicolas J.-P.. Inserm; Francia
Fil: Bertrand, Matthieu. Inserm; Francia
Fil: Gaudin, Catherine. Institut Anti-cancer Gustave Roussy; Francia
Fil: Commo, Fred Eric. Inserm; Francia
Fil: Kalaany, Nassif El. Inserm; Francia
Fil: Al Nakouzi, Nader. University of British Columbia; Canadá
Fil: Fazli, Ladan. University of British Columbia; Canadá
Fil: Nery, Elaine Del. Université Pierre et Marie Curie; Francia
Fil: Camonis, Jacques. Université Pierre et Marie Curie; Francia
Fil: Perez, Franck. Université Pierre et Marie Curie; Francia
Fil: Lerondel, Stéphanie. Centre National de la Recherche Scientifique; Francia
Fil: Le Pape, Alain. Inserm; Francia
Fil: Compagno, Daniel Georges. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Gleave, Martin. University of British Columbia; Canadá
Fil: Loriot, Yohann. Inserm; Francia
Fil: Desaubry, Laurent. Centre National de la Recherche Scientifique; Francia
Fil: Vagner, Stephan. Université Pierre et Marie Curie; Francia
Fil: Fizazi, Karim. Institut Anti-cancer Gustave Roussy; Francia
Fil: Chauchereau, Anne. Inserm; Francia
Materia
Prostate Cancer
Chemioresistance
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/123540
Acceder
id CONICETDig_35d8b1b88de0a92ac59d0ff1d6e6953c
oai_identifier_str oai:ri.conicet.gov.ar:11336/123540
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancerGarrido, Marine F.Martin, Nicolas J.-P.Bertrand, MatthieuGaudin, CatherineCommo, Fred EricKalaany, Nassif ElAl Nakouzi, NaderFazli, LadanNery, Elaine DelCamonis, JacquesPerez, FranckLerondel, StéphanieLe Pape, AlainCompagno, Daniel GeorgesGleave, MartinLoriot, YohannDesaubry, LaurentVagner, StephanFizazi, KarimChauchereau, AnneProstate CancerChemioresistancehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Purpose: Targeted therapies that use the signaling path-characterize the function of human FKBP7 and explore its ways involved in prostate cancer are required to overcome role in cancer. We discovered that FKBP7 was upregulated chemoresistance and improve treatment outcomes for men. in human prostate cancers and its expression correlated Molecular chaperones play a key role in the regulation of with the recurrence observed in patients receiving doce-protein homeostasis and are potential targets for overcom-taxel. FKBP7 silencing showed that FKBP7 is required to ing chemoresistance. maintain the growth of chemoresistant cell lines and Experimental Design: We established 4 chemoresistant chemoresistant tumors in mice. Mass spectrometry analysis prostate cancer cell lines and used image-based high-content revealed that FKBP7 interacts with eIF4G, a component of siRNA functional screening, based on gene-expression signa-the eIF4F translation initiation complex, to mediate the ture, to explore mechanisms of chemoresistance and identify survival of chemoresistant cells. Using small-molecule new potential targets with potential roles in taxane resistance. inhibitors of eIF4A, the RNA helicase component of The functional role of a new target was assessed by in vitro and eIF4F, we were able to kill docetaxel- and cabazitaxel-in vivo silencing, and mass spectrometry analysis was used to resistant cells. identify its downstream effectors. Conclusions: Targeting FKBP7 or the eIF4G-containing Results: We identified FKBP7, a prolyl-peptidyl isomer-eIF4F translation initiation complex could be novel thera-ase overexpressed in docetaxel-resistant and in cabazitaxel-peutic strategies to eradicate taxane-resistant prostate cancer resistant prostate cancer cells. This is the first study to cells.Fil: Garrido, Marine F.. Inserm; FranciaFil: Martin, Nicolas J.-P.. Inserm; FranciaFil: Bertrand, Matthieu. Inserm; FranciaFil: Gaudin, Catherine. Institut Anti-cancer Gustave Roussy; FranciaFil: Commo, Fred Eric. Inserm; FranciaFil: Kalaany, Nassif El. Inserm; FranciaFil: Al Nakouzi, Nader. University of British Columbia; CanadáFil: Fazli, Ladan. University of British Columbia; CanadáFil: Nery, Elaine Del. Université Pierre et Marie Curie; FranciaFil: Camonis, Jacques. Université Pierre et Marie Curie; FranciaFil: Perez, Franck. Université Pierre et Marie Curie; FranciaFil: Lerondel, Stéphanie. Centre National de la Recherche Scientifique; FranciaFil: Le Pape, Alain. Inserm; FranciaFil: Compagno, Daniel Georges. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Gleave, Martin. University of British Columbia; CanadáFil: Loriot, Yohann. Inserm; FranciaFil: Desaubry, Laurent. Centre National de la Recherche Scientifique; FranciaFil: Vagner, Stephan. Université Pierre et Marie Curie; FranciaFil: Fizazi, Karim. Institut Anti-cancer Gustave Roussy; FranciaFil: Chauchereau, Anne. Inserm; FranciaAmerican Association for Cancer Research2019-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/123540Garrido, Marine F.; Martin, Nicolas J.-P.; Bertrand, Matthieu; Gaudin, Catherine; Commo, Fred Eric; et al.; Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer; American Association for Cancer Research; Clinical Cancer Research; 25; 2; 2-2019; 710-7231078-0432CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://clincancerres.aacrjournals.org/lookup/doi/10.1158/1078-0432.CCR-18-0704info:eu-repo/semantics/altIdentifier/doi/10.1158/1078-0432.CCR-18-0704info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:07:38Zoai:ri.conicet.gov.ar:11336/123540instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:07:38.814CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer
title Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer
spellingShingle Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer
Garrido, Marine F.
Prostate Cancer
Chemioresistance
title_short Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer
title_full Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer
title_fullStr Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer
title_full_unstemmed Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer
title_sort Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer
dc.creator.none.fl_str_mv Garrido, Marine F.
Martin, Nicolas J.-P.
Bertrand, Matthieu
Gaudin, Catherine
Commo, Fred Eric
Kalaany, Nassif El
Al Nakouzi, Nader
Fazli, Ladan
Nery, Elaine Del
Camonis, Jacques
Perez, Franck
Lerondel, Stéphanie
Le Pape, Alain
Compagno, Daniel Georges
Gleave, Martin
Loriot, Yohann
Desaubry, Laurent
Vagner, Stephan
Fizazi, Karim
Chauchereau, Anne
author Garrido, Marine F.
author_facet Garrido, Marine F.
Martin, Nicolas J.-P.
Bertrand, Matthieu
Gaudin, Catherine
Commo, Fred Eric
Kalaany, Nassif El
Al Nakouzi, Nader
Fazli, Ladan
Nery, Elaine Del
Camonis, Jacques
Perez, Franck
Lerondel, Stéphanie
Le Pape, Alain
Compagno, Daniel Georges
Gleave, Martin
Loriot, Yohann
Desaubry, Laurent
Vagner, Stephan
Fizazi, Karim
Chauchereau, Anne
author_role author
author2 Martin, Nicolas J.-P.
Bertrand, Matthieu
Gaudin, Catherine
Commo, Fred Eric
Kalaany, Nassif El
Al Nakouzi, Nader
Fazli, Ladan
Nery, Elaine Del
Camonis, Jacques
Perez, Franck
Lerondel, Stéphanie
Le Pape, Alain
Compagno, Daniel Georges
Gleave, Martin
Loriot, Yohann
Desaubry, Laurent
Vagner, Stephan
Fizazi, Karim
Chauchereau, Anne
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Prostate Cancer
Chemioresistance
topic Prostate Cancer
Chemioresistance
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Purpose: Targeted therapies that use the signaling path-characterize the function of human FKBP7 and explore its ways involved in prostate cancer are required to overcome role in cancer. We discovered that FKBP7 was upregulated chemoresistance and improve treatment outcomes for men. in human prostate cancers and its expression correlated Molecular chaperones play a key role in the regulation of with the recurrence observed in patients receiving doce-protein homeostasis and are potential targets for overcom-taxel. FKBP7 silencing showed that FKBP7 is required to ing chemoresistance. maintain the growth of chemoresistant cell lines and Experimental Design: We established 4 chemoresistant chemoresistant tumors in mice. Mass spectrometry analysis prostate cancer cell lines and used image-based high-content revealed that FKBP7 interacts with eIF4G, a component of siRNA functional screening, based on gene-expression signa-the eIF4F translation initiation complex, to mediate the ture, to explore mechanisms of chemoresistance and identify survival of chemoresistant cells. Using small-molecule new potential targets with potential roles in taxane resistance. inhibitors of eIF4A, the RNA helicase component of The functional role of a new target was assessed by in vitro and eIF4F, we were able to kill docetaxel- and cabazitaxel-in vivo silencing, and mass spectrometry analysis was used to resistant cells. identify its downstream effectors. Conclusions: Targeting FKBP7 or the eIF4G-containing Results: We identified FKBP7, a prolyl-peptidyl isomer-eIF4F translation initiation complex could be novel thera-ase overexpressed in docetaxel-resistant and in cabazitaxel-peutic strategies to eradicate taxane-resistant prostate cancer resistant prostate cancer cells. This is the first study to cells.
Fil: Garrido, Marine F.. Inserm; Francia
Fil: Martin, Nicolas J.-P.. Inserm; Francia
Fil: Bertrand, Matthieu. Inserm; Francia
Fil: Gaudin, Catherine. Institut Anti-cancer Gustave Roussy; Francia
Fil: Commo, Fred Eric. Inserm; Francia
Fil: Kalaany, Nassif El. Inserm; Francia
Fil: Al Nakouzi, Nader. University of British Columbia; Canadá
Fil: Fazli, Ladan. University of British Columbia; Canadá
Fil: Nery, Elaine Del. Université Pierre et Marie Curie; Francia
Fil: Camonis, Jacques. Université Pierre et Marie Curie; Francia
Fil: Perez, Franck. Université Pierre et Marie Curie; Francia
Fil: Lerondel, Stéphanie. Centre National de la Recherche Scientifique; Francia
Fil: Le Pape, Alain. Inserm; Francia
Fil: Compagno, Daniel Georges. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Gleave, Martin. University of British Columbia; Canadá
Fil: Loriot, Yohann. Inserm; Francia
Fil: Desaubry, Laurent. Centre National de la Recherche Scientifique; Francia
Fil: Vagner, Stephan. Université Pierre et Marie Curie; Francia
Fil: Fizazi, Karim. Institut Anti-cancer Gustave Roussy; Francia
Fil: Chauchereau, Anne. Inserm; Francia
description Purpose: Targeted therapies that use the signaling path-characterize the function of human FKBP7 and explore its ways involved in prostate cancer are required to overcome role in cancer. We discovered that FKBP7 was upregulated chemoresistance and improve treatment outcomes for men. in human prostate cancers and its expression correlated Molecular chaperones play a key role in the regulation of with the recurrence observed in patients receiving doce-protein homeostasis and are potential targets for overcom-taxel. FKBP7 silencing showed that FKBP7 is required to ing chemoresistance. maintain the growth of chemoresistant cell lines and Experimental Design: We established 4 chemoresistant chemoresistant tumors in mice. Mass spectrometry analysis prostate cancer cell lines and used image-based high-content revealed that FKBP7 interacts with eIF4G, a component of siRNA functional screening, based on gene-expression signa-the eIF4F translation initiation complex, to mediate the ture, to explore mechanisms of chemoresistance and identify survival of chemoresistant cells. Using small-molecule new potential targets with potential roles in taxane resistance. inhibitors of eIF4A, the RNA helicase component of The functional role of a new target was assessed by in vitro and eIF4F, we were able to kill docetaxel- and cabazitaxel-in vivo silencing, and mass spectrometry analysis was used to resistant cells. identify its downstream effectors. Conclusions: Targeting FKBP7 or the eIF4G-containing Results: We identified FKBP7, a prolyl-peptidyl isomer-eIF4F translation initiation complex could be novel thera-ase overexpressed in docetaxel-resistant and in cabazitaxel-peutic strategies to eradicate taxane-resistant prostate cancer resistant prostate cancer cells. This is the first study to cells.
publishDate 2019
dc.date.none.fl_str_mv 2019-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/123540
Garrido, Marine F.; Martin, Nicolas J.-P.; Bertrand, Matthieu; Gaudin, Catherine; Commo, Fred Eric; et al.; Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer; American Association for Cancer Research; Clinical Cancer Research; 25; 2; 2-2019; 710-723
1078-0432
CONICET Digital
CONICET
url http://hdl.handle.net/11336/123540
identifier_str_mv Garrido, Marine F.; Martin, Nicolas J.-P.; Bertrand, Matthieu; Gaudin, Catherine; Commo, Fred Eric; et al.; Regulation of eIF4F translation initiation complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer; American Association for Cancer Research; Clinical Cancer Research; 25; 2; 2-2019; 710-723
1078-0432
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://clincancerres.aacrjournals.org/lookup/doi/10.1158/1078-0432.CCR-18-0704
info:eu-repo/semantics/altIdentifier/doi/10.1158/1078-0432.CCR-18-0704
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association for Cancer Research
publisher.none.fl_str_mv American Association for Cancer Research
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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