A role for ΔfosB in calorie restriction-induced metabolic changes
- Autores
- Vialou, Vincent F.; Cui, Huxing; Perello, Mario; Mahgoub, Melissa A.; Yu, Hana G.; Rush, Augustus J.; Pranav, Heena; Jung, Saendy; Yangisawa, Masashi; Zigman, Jeffrey M.; Elmquist, Joel K.; Nestler, Eric J.; Lutter, Michael
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: Calorie restriction (CR) induces long-term changes in motivation to eat highly palatable food and, in body weight regulation, through an unknown mechanism. Methods: After a period of CR and refeeding, mice were assessed by behavioral and metabolic studies and for levels of the transcription factor ΔFosB. The ΔFosB levels were then increased specifically in nucleus accumbens (NAc) with viral-mediated gene transfer, and behavioral and metabolic studies were conducted. Results: We show that accumulation of ΔFosB in the NAc shell after CR in mice corresponds to a period of increased motivation for high fat reward and reduced energy expenditure. Furthermore, ΔFosB overexpression in this region increases instrumental responding for a high fat reward via an orexin-dependent mechanism while also decreasing energy expenditure and promoting adiposity. Conclusions: These results suggest that ΔFosB signaling in NAc mediates adaptive responses to CR.
Fil: Vialou, Vincent F.. Mount Sinai School of Medicine. Fishberg Department of Neuroscience; Estados Unidos
Fil: Cui, Huxing. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Perello, Mario. University of Texas. Southwestern Medical Center; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Mahgoub, Melissa A.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Yu, Hana G.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Rush, Augustus J.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Pranav, Heena. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Jung, Saendy. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Yangisawa, Masashi. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Zigman, Jeffrey M.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Elmquist, Joel K.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Nestler, Eric J.. Mount Sinai School of Medicine. Fishberg Department of Neuroscience; Estados Unidos
Fil: Lutter, Michael. University of Texas. Southwestern Medical Center; Estados Unidos - Materia
-
APPETITE
FEEDING
METABOLISM
NUCLEUS ACCUMBENS
OREXIN - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/85917
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CONICET Digital (CONICET) |
spelling |
A role for ΔfosB in calorie restriction-induced metabolic changesVialou, Vincent F.Cui, HuxingPerello, MarioMahgoub, Melissa A.Yu, Hana G.Rush, Augustus J.Pranav, HeenaJung, SaendyYangisawa, MasashiZigman, Jeffrey M.Elmquist, Joel K.Nestler, Eric J.Lutter, MichaelAPPETITEFEEDINGMETABOLISMNUCLEUS ACCUMBENSOREXINhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: Calorie restriction (CR) induces long-term changes in motivation to eat highly palatable food and, in body weight regulation, through an unknown mechanism. Methods: After a period of CR and refeeding, mice were assessed by behavioral and metabolic studies and for levels of the transcription factor ΔFosB. The ΔFosB levels were then increased specifically in nucleus accumbens (NAc) with viral-mediated gene transfer, and behavioral and metabolic studies were conducted. Results: We show that accumulation of ΔFosB in the NAc shell after CR in mice corresponds to a period of increased motivation for high fat reward and reduced energy expenditure. Furthermore, ΔFosB overexpression in this region increases instrumental responding for a high fat reward via an orexin-dependent mechanism while also decreasing energy expenditure and promoting adiposity. Conclusions: These results suggest that ΔFosB signaling in NAc mediates adaptive responses to CR.Fil: Vialou, Vincent F.. Mount Sinai School of Medicine. Fishberg Department of Neuroscience; Estados UnidosFil: Cui, Huxing. University of Texas. Southwestern Medical Center; Estados UnidosFil: Perello, Mario. University of Texas. Southwestern Medical Center; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Mahgoub, Melissa A.. University of Texas. Southwestern Medical Center; Estados UnidosFil: Yu, Hana G.. University of Texas. Southwestern Medical Center; Estados UnidosFil: Rush, Augustus J.. University of Texas. Southwestern Medical Center; Estados UnidosFil: Pranav, Heena. University of Texas. Southwestern Medical Center; Estados UnidosFil: Jung, Saendy. University of Texas. Southwestern Medical Center; Estados UnidosFil: Yangisawa, Masashi. University of Texas. Southwestern Medical Center; Estados UnidosFil: Zigman, Jeffrey M.. University of Texas. Southwestern Medical Center; Estados UnidosFil: Elmquist, Joel K.. University of Texas. Southwestern Medical Center; Estados UnidosFil: Nestler, Eric J.. Mount Sinai School of Medicine. Fishberg Department of Neuroscience; Estados UnidosFil: Lutter, Michael. University of Texas. Southwestern Medical Center; Estados UnidosElsevier Science Inc2011-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/85917Vialou, Vincent F.; Cui, Huxing; Perello, Mario; Mahgoub, Melissa A.; Yu, Hana G.; et al.; A role for ΔfosB in calorie restriction-induced metabolic changes; Elsevier Science Inc; Biological Psychiatry; 70; 2; 7-2011; 204-2070006-3223CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125466/info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0006322310012540info:eu-repo/semantics/altIdentifier/doi/10.1016/j.biopsych.2010.11.027info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:47:24Zoai:ri.conicet.gov.ar:11336/85917instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:47:24.685CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
A role for ΔfosB in calorie restriction-induced metabolic changes |
title |
A role for ΔfosB in calorie restriction-induced metabolic changes |
spellingShingle |
A role for ΔfosB in calorie restriction-induced metabolic changes Vialou, Vincent F. APPETITE FEEDING METABOLISM NUCLEUS ACCUMBENS OREXIN |
title_short |
A role for ΔfosB in calorie restriction-induced metabolic changes |
title_full |
A role for ΔfosB in calorie restriction-induced metabolic changes |
title_fullStr |
A role for ΔfosB in calorie restriction-induced metabolic changes |
title_full_unstemmed |
A role for ΔfosB in calorie restriction-induced metabolic changes |
title_sort |
A role for ΔfosB in calorie restriction-induced metabolic changes |
dc.creator.none.fl_str_mv |
Vialou, Vincent F. Cui, Huxing Perello, Mario Mahgoub, Melissa A. Yu, Hana G. Rush, Augustus J. Pranav, Heena Jung, Saendy Yangisawa, Masashi Zigman, Jeffrey M. Elmquist, Joel K. Nestler, Eric J. Lutter, Michael |
author |
Vialou, Vincent F. |
author_facet |
Vialou, Vincent F. Cui, Huxing Perello, Mario Mahgoub, Melissa A. Yu, Hana G. Rush, Augustus J. Pranav, Heena Jung, Saendy Yangisawa, Masashi Zigman, Jeffrey M. Elmquist, Joel K. Nestler, Eric J. Lutter, Michael |
author_role |
author |
author2 |
Cui, Huxing Perello, Mario Mahgoub, Melissa A. Yu, Hana G. Rush, Augustus J. Pranav, Heena Jung, Saendy Yangisawa, Masashi Zigman, Jeffrey M. Elmquist, Joel K. Nestler, Eric J. Lutter, Michael |
author2_role |
author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
APPETITE FEEDING METABOLISM NUCLEUS ACCUMBENS OREXIN |
topic |
APPETITE FEEDING METABOLISM NUCLEUS ACCUMBENS OREXIN |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Background: Calorie restriction (CR) induces long-term changes in motivation to eat highly palatable food and, in body weight regulation, through an unknown mechanism. Methods: After a period of CR and refeeding, mice were assessed by behavioral and metabolic studies and for levels of the transcription factor ΔFosB. The ΔFosB levels were then increased specifically in nucleus accumbens (NAc) with viral-mediated gene transfer, and behavioral and metabolic studies were conducted. Results: We show that accumulation of ΔFosB in the NAc shell after CR in mice corresponds to a period of increased motivation for high fat reward and reduced energy expenditure. Furthermore, ΔFosB overexpression in this region increases instrumental responding for a high fat reward via an orexin-dependent mechanism while also decreasing energy expenditure and promoting adiposity. Conclusions: These results suggest that ΔFosB signaling in NAc mediates adaptive responses to CR. Fil: Vialou, Vincent F.. Mount Sinai School of Medicine. Fishberg Department of Neuroscience; Estados Unidos Fil: Cui, Huxing. University of Texas. Southwestern Medical Center; Estados Unidos Fil: Perello, Mario. University of Texas. Southwestern Medical Center; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina Fil: Mahgoub, Melissa A.. University of Texas. Southwestern Medical Center; Estados Unidos Fil: Yu, Hana G.. University of Texas. Southwestern Medical Center; Estados Unidos Fil: Rush, Augustus J.. University of Texas. Southwestern Medical Center; Estados Unidos Fil: Pranav, Heena. University of Texas. Southwestern Medical Center; Estados Unidos Fil: Jung, Saendy. University of Texas. Southwestern Medical Center; Estados Unidos Fil: Yangisawa, Masashi. University of Texas. Southwestern Medical Center; Estados Unidos Fil: Zigman, Jeffrey M.. University of Texas. Southwestern Medical Center; Estados Unidos Fil: Elmquist, Joel K.. University of Texas. Southwestern Medical Center; Estados Unidos Fil: Nestler, Eric J.. Mount Sinai School of Medicine. Fishberg Department of Neuroscience; Estados Unidos Fil: Lutter, Michael. University of Texas. Southwestern Medical Center; Estados Unidos |
description |
Background: Calorie restriction (CR) induces long-term changes in motivation to eat highly palatable food and, in body weight regulation, through an unknown mechanism. Methods: After a period of CR and refeeding, mice were assessed by behavioral and metabolic studies and for levels of the transcription factor ΔFosB. The ΔFosB levels were then increased specifically in nucleus accumbens (NAc) with viral-mediated gene transfer, and behavioral and metabolic studies were conducted. Results: We show that accumulation of ΔFosB in the NAc shell after CR in mice corresponds to a period of increased motivation for high fat reward and reduced energy expenditure. Furthermore, ΔFosB overexpression in this region increases instrumental responding for a high fat reward via an orexin-dependent mechanism while also decreasing energy expenditure and promoting adiposity. Conclusions: These results suggest that ΔFosB signaling in NAc mediates adaptive responses to CR. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/85917 Vialou, Vincent F.; Cui, Huxing; Perello, Mario; Mahgoub, Melissa A.; Yu, Hana G.; et al.; A role for ΔfosB in calorie restriction-induced metabolic changes; Elsevier Science Inc; Biological Psychiatry; 70; 2; 7-2011; 204-207 0006-3223 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/85917 |
identifier_str_mv |
Vialou, Vincent F.; Cui, Huxing; Perello, Mario; Mahgoub, Melissa A.; Yu, Hana G.; et al.; A role for ΔfosB in calorie restriction-induced metabolic changes; Elsevier Science Inc; Biological Psychiatry; 70; 2; 7-2011; 204-207 0006-3223 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125466/ info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0006322310012540 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.biopsych.2010.11.027 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science Inc |
publisher.none.fl_str_mv |
Elsevier Science Inc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.22299 |