A role for ΔfosB in calorie restriction-induced metabolic changes

Autores
Vialou, Vincent F.; Cui, Huxing; Perello, Mario; Mahgoub, Melissa A.; Yu, Hana G.; Rush, Augustus J.; Pranav, Heena; Jung, Saendy; Yangisawa, Masashi; Zigman, Jeffrey M.; Elmquist, Joel K.; Nestler, Eric J.; Lutter, Michael
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Calorie restriction (CR) induces long-term changes in motivation to eat highly palatable food and, in body weight regulation, through an unknown mechanism. Methods: After a period of CR and refeeding, mice were assessed by behavioral and metabolic studies and for levels of the transcription factor ΔFosB. The ΔFosB levels were then increased specifically in nucleus accumbens (NAc) with viral-mediated gene transfer, and behavioral and metabolic studies were conducted. Results: We show that accumulation of ΔFosB in the NAc shell after CR in mice corresponds to a period of increased motivation for high fat reward and reduced energy expenditure. Furthermore, ΔFosB overexpression in this region increases instrumental responding for a high fat reward via an orexin-dependent mechanism while also decreasing energy expenditure and promoting adiposity. Conclusions: These results suggest that ΔFosB signaling in NAc mediates adaptive responses to CR.
Fil: Vialou, Vincent F.. Mount Sinai School of Medicine. Fishberg Department of Neuroscience; Estados Unidos
Fil: Cui, Huxing. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Perello, Mario. University of Texas. Southwestern Medical Center; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Mahgoub, Melissa A.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Yu, Hana G.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Rush, Augustus J.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Pranav, Heena. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Jung, Saendy. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Yangisawa, Masashi. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Zigman, Jeffrey M.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Elmquist, Joel K.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Nestler, Eric J.. Mount Sinai School of Medicine. Fishberg Department of Neuroscience; Estados Unidos
Fil: Lutter, Michael. University of Texas. Southwestern Medical Center; Estados Unidos
Materia
APPETITE
FEEDING
METABOLISM
NUCLEUS ACCUMBENS
OREXIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/85917

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network_name_str CONICET Digital (CONICET)
spelling A role for ΔfosB in calorie restriction-induced metabolic changesVialou, Vincent F.Cui, HuxingPerello, MarioMahgoub, Melissa A.Yu, Hana G.Rush, Augustus J.Pranav, HeenaJung, SaendyYangisawa, MasashiZigman, Jeffrey M.Elmquist, Joel K.Nestler, Eric J.Lutter, MichaelAPPETITEFEEDINGMETABOLISMNUCLEUS ACCUMBENSOREXINhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: Calorie restriction (CR) induces long-term changes in motivation to eat highly palatable food and, in body weight regulation, through an unknown mechanism. Methods: After a period of CR and refeeding, mice were assessed by behavioral and metabolic studies and for levels of the transcription factor ΔFosB. The ΔFosB levels were then increased specifically in nucleus accumbens (NAc) with viral-mediated gene transfer, and behavioral and metabolic studies were conducted. Results: We show that accumulation of ΔFosB in the NAc shell after CR in mice corresponds to a period of increased motivation for high fat reward and reduced energy expenditure. Furthermore, ΔFosB overexpression in this region increases instrumental responding for a high fat reward via an orexin-dependent mechanism while also decreasing energy expenditure and promoting adiposity. Conclusions: These results suggest that ΔFosB signaling in NAc mediates adaptive responses to CR.Fil: Vialou, Vincent F.. Mount Sinai School of Medicine. Fishberg Department of Neuroscience; Estados UnidosFil: Cui, Huxing. University of Texas. Southwestern Medical Center; Estados UnidosFil: Perello, Mario. University of Texas. Southwestern Medical Center; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Mahgoub, Melissa A.. University of Texas. Southwestern Medical Center; Estados UnidosFil: Yu, Hana G.. University of Texas. Southwestern Medical Center; Estados UnidosFil: Rush, Augustus J.. University of Texas. Southwestern Medical Center; Estados UnidosFil: Pranav, Heena. University of Texas. Southwestern Medical Center; Estados UnidosFil: Jung, Saendy. University of Texas. Southwestern Medical Center; Estados UnidosFil: Yangisawa, Masashi. University of Texas. Southwestern Medical Center; Estados UnidosFil: Zigman, Jeffrey M.. University of Texas. Southwestern Medical Center; Estados UnidosFil: Elmquist, Joel K.. University of Texas. Southwestern Medical Center; Estados UnidosFil: Nestler, Eric J.. Mount Sinai School of Medicine. Fishberg Department of Neuroscience; Estados UnidosFil: Lutter, Michael. University of Texas. Southwestern Medical Center; Estados UnidosElsevier Science Inc2011-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/85917Vialou, Vincent F.; Cui, Huxing; Perello, Mario; Mahgoub, Melissa A.; Yu, Hana G.; et al.; A role for ΔfosB in calorie restriction-induced metabolic changes; Elsevier Science Inc; Biological Psychiatry; 70; 2; 7-2011; 204-2070006-3223CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125466/info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0006322310012540info:eu-repo/semantics/altIdentifier/doi/10.1016/j.biopsych.2010.11.027info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:47:24Zoai:ri.conicet.gov.ar:11336/85917instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:47:24.685CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A role for ΔfosB in calorie restriction-induced metabolic changes
title A role for ΔfosB in calorie restriction-induced metabolic changes
spellingShingle A role for ΔfosB in calorie restriction-induced metabolic changes
Vialou, Vincent F.
APPETITE
FEEDING
METABOLISM
NUCLEUS ACCUMBENS
OREXIN
title_short A role for ΔfosB in calorie restriction-induced metabolic changes
title_full A role for ΔfosB in calorie restriction-induced metabolic changes
title_fullStr A role for ΔfosB in calorie restriction-induced metabolic changes
title_full_unstemmed A role for ΔfosB in calorie restriction-induced metabolic changes
title_sort A role for ΔfosB in calorie restriction-induced metabolic changes
dc.creator.none.fl_str_mv Vialou, Vincent F.
Cui, Huxing
Perello, Mario
Mahgoub, Melissa A.
Yu, Hana G.
Rush, Augustus J.
Pranav, Heena
Jung, Saendy
Yangisawa, Masashi
Zigman, Jeffrey M.
Elmquist, Joel K.
Nestler, Eric J.
Lutter, Michael
author Vialou, Vincent F.
author_facet Vialou, Vincent F.
Cui, Huxing
Perello, Mario
Mahgoub, Melissa A.
Yu, Hana G.
Rush, Augustus J.
Pranav, Heena
Jung, Saendy
Yangisawa, Masashi
Zigman, Jeffrey M.
Elmquist, Joel K.
Nestler, Eric J.
Lutter, Michael
author_role author
author2 Cui, Huxing
Perello, Mario
Mahgoub, Melissa A.
Yu, Hana G.
Rush, Augustus J.
Pranav, Heena
Jung, Saendy
Yangisawa, Masashi
Zigman, Jeffrey M.
Elmquist, Joel K.
Nestler, Eric J.
Lutter, Michael
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv APPETITE
FEEDING
METABOLISM
NUCLEUS ACCUMBENS
OREXIN
topic APPETITE
FEEDING
METABOLISM
NUCLEUS ACCUMBENS
OREXIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Calorie restriction (CR) induces long-term changes in motivation to eat highly palatable food and, in body weight regulation, through an unknown mechanism. Methods: After a period of CR and refeeding, mice were assessed by behavioral and metabolic studies and for levels of the transcription factor ΔFosB. The ΔFosB levels were then increased specifically in nucleus accumbens (NAc) with viral-mediated gene transfer, and behavioral and metabolic studies were conducted. Results: We show that accumulation of ΔFosB in the NAc shell after CR in mice corresponds to a period of increased motivation for high fat reward and reduced energy expenditure. Furthermore, ΔFosB overexpression in this region increases instrumental responding for a high fat reward via an orexin-dependent mechanism while also decreasing energy expenditure and promoting adiposity. Conclusions: These results suggest that ΔFosB signaling in NAc mediates adaptive responses to CR.
Fil: Vialou, Vincent F.. Mount Sinai School of Medicine. Fishberg Department of Neuroscience; Estados Unidos
Fil: Cui, Huxing. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Perello, Mario. University of Texas. Southwestern Medical Center; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Mahgoub, Melissa A.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Yu, Hana G.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Rush, Augustus J.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Pranav, Heena. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Jung, Saendy. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Yangisawa, Masashi. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Zigman, Jeffrey M.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Elmquist, Joel K.. University of Texas. Southwestern Medical Center; Estados Unidos
Fil: Nestler, Eric J.. Mount Sinai School of Medicine. Fishberg Department of Neuroscience; Estados Unidos
Fil: Lutter, Michael. University of Texas. Southwestern Medical Center; Estados Unidos
description Background: Calorie restriction (CR) induces long-term changes in motivation to eat highly palatable food and, in body weight regulation, through an unknown mechanism. Methods: After a period of CR and refeeding, mice were assessed by behavioral and metabolic studies and for levels of the transcription factor ΔFosB. The ΔFosB levels were then increased specifically in nucleus accumbens (NAc) with viral-mediated gene transfer, and behavioral and metabolic studies were conducted. Results: We show that accumulation of ΔFosB in the NAc shell after CR in mice corresponds to a period of increased motivation for high fat reward and reduced energy expenditure. Furthermore, ΔFosB overexpression in this region increases instrumental responding for a high fat reward via an orexin-dependent mechanism while also decreasing energy expenditure and promoting adiposity. Conclusions: These results suggest that ΔFosB signaling in NAc mediates adaptive responses to CR.
publishDate 2011
dc.date.none.fl_str_mv 2011-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/85917
Vialou, Vincent F.; Cui, Huxing; Perello, Mario; Mahgoub, Melissa A.; Yu, Hana G.; et al.; A role for ΔfosB in calorie restriction-induced metabolic changes; Elsevier Science Inc; Biological Psychiatry; 70; 2; 7-2011; 204-207
0006-3223
CONICET Digital
CONICET
url http://hdl.handle.net/11336/85917
identifier_str_mv Vialou, Vincent F.; Cui, Huxing; Perello, Mario; Mahgoub, Melissa A.; Yu, Hana G.; et al.; A role for ΔfosB in calorie restriction-induced metabolic changes; Elsevier Science Inc; Biological Psychiatry; 70; 2; 7-2011; 204-207
0006-3223
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125466/
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0006322310012540
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.biopsych.2010.11.027
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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