Tyramine modulates the systemic stress response by stimulating the release of intestinal insulin like-peptides (ILPs)

Autores
Veuthey, Tania Vanesa; Giunti, Sebastián; Florman, Jeremy; De Rosa, M.J.; Alkema, Mark; Rayes, Diego Hernán
Año de publicación
2021
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Multicellular organisms trigger a complex and coordinated response against systemic stress. We have recently shown that in C. elegans, the neural stress-hormone tyramine supplies a state-dependent neural switch between acute flight- and longterm environmental-stress responses (De Rosa et al, 2019). Tyramine release during the flight response, stimulates the DAF-2/ Insulin/IGF-1 signaling (IIS) pathway and precludes the nuclear translocation of the DAF-16/FOXO transcription factor through the activation of an adrenergic-like receptor TYRA-3 in the intestine. We hypothesize that tyramine stimulates the release of agonist ILPs from the intestine which acts as an autocrine and/or paracrine signal to systemically activate the DAF-2/IIS pathway. To test this hypothesis we are screening ILPs mutants for their resistance to environmental stressors (oxidative and thermal stress). The C. elegans genome encodes 40 ILPs, 28 of which expressed in the intestine. We performed a screening of intestinal peptides described as strong DAF-2 agonist, by silencing individual intestinal ILPs and testing worm resistance to environmental stressors (oxidative and thermal stress). Thus, so far we found that ins-3 and ins-7 mutants are resistant to environmental stress, like tyramine-deficient and tyra-3 mutants. We are further testing whether tyramine directly stimulates the release of these ILPs from the intestine through a Gq-protein mediated signaling pathway. These studies will provide insight into how a neurohormone coordinates systemic cellular stress responses
Fil: Veuthey, Tania Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Giunti, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Florman, Jeremy. University Of Massachussets. Medical School. School Of Medicine. Departament Of Neurology; Estados Unidos
Fil: De Rosa, M.J.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Alkema, Mark. University Of Massachussets. Medical School. School Of Medicine. Departament Of Neurology; Estados Unidos
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
23rd International C. elegans Conference
Rockville
Estados Unidos
Genetics Society of America
Materia
flight response
stress
insulin
intestine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/215798
Acceder
id CONICETDig_3562e522844cf5412c29cf55fbe3197f
oai_identifier_str oai:ri.conicet.gov.ar:11336/215798
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Tyramine modulates the systemic stress response by stimulating the release of intestinal insulin like-peptides (ILPs)Veuthey, Tania VanesaGiunti, SebastiánFlorman, JeremyDe Rosa, M.J.Alkema, MarkRayes, Diego Hernánflight responsestressinsulinintestinehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Multicellular organisms trigger a complex and coordinated response against systemic stress. We have recently shown that in C. elegans, the neural stress-hormone tyramine supplies a state-dependent neural switch between acute flight- and longterm environmental-stress responses (De Rosa et al, 2019). Tyramine release during the flight response, stimulates the DAF-2/ Insulin/IGF-1 signaling (IIS) pathway and precludes the nuclear translocation of the DAF-16/FOXO transcription factor through the activation of an adrenergic-like receptor TYRA-3 in the intestine. We hypothesize that tyramine stimulates the release of agonist ILPs from the intestine which acts as an autocrine and/or paracrine signal to systemically activate the DAF-2/IIS pathway. To test this hypothesis we are screening ILPs mutants for their resistance to environmental stressors (oxidative and thermal stress). The C. elegans genome encodes 40 ILPs, 28 of which expressed in the intestine. We performed a screening of intestinal peptides described as strong DAF-2 agonist, by silencing individual intestinal ILPs and testing worm resistance to environmental stressors (oxidative and thermal stress). Thus, so far we found that ins-3 and ins-7 mutants are resistant to environmental stress, like tyramine-deficient and tyra-3 mutants. We are further testing whether tyramine directly stimulates the release of these ILPs from the intestine through a Gq-protein mediated signaling pathway. These studies will provide insight into how a neurohormone coordinates systemic cellular stress responsesFil: Veuthey, Tania Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Giunti, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Florman, Jeremy. University Of Massachussets. Medical School. School Of Medicine. Departament Of Neurology; Estados UnidosFil: De Rosa, M.J.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Alkema, Mark. University Of Massachussets. Medical School. School Of Medicine. Departament Of Neurology; Estados UnidosFil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina23rd International C. elegans ConferenceRockvilleEstados UnidosGenetics Society of AmericaGenetics Society of America2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/215798Tyramine modulates the systemic stress response by stimulating the release of intestinal insulin like-peptides (ILPs); 23rd International C. elegans Conference; Rockville; Estados Unidos; 2021; 442-442CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://genetics-gsa.org/celegans-2021/Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:55:52Zoai:ri.conicet.gov.ar:11336/215798instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:55:52.536CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tyramine modulates the systemic stress response by stimulating the release of intestinal insulin like-peptides (ILPs)
title Tyramine modulates the systemic stress response by stimulating the release of intestinal insulin like-peptides (ILPs)
spellingShingle Tyramine modulates the systemic stress response by stimulating the release of intestinal insulin like-peptides (ILPs)
Veuthey, Tania Vanesa
flight response
stress
insulin
intestine
title_short Tyramine modulates the systemic stress response by stimulating the release of intestinal insulin like-peptides (ILPs)
title_full Tyramine modulates the systemic stress response by stimulating the release of intestinal insulin like-peptides (ILPs)
title_fullStr Tyramine modulates the systemic stress response by stimulating the release of intestinal insulin like-peptides (ILPs)
title_full_unstemmed Tyramine modulates the systemic stress response by stimulating the release of intestinal insulin like-peptides (ILPs)
title_sort Tyramine modulates the systemic stress response by stimulating the release of intestinal insulin like-peptides (ILPs)
dc.creator.none.fl_str_mv Veuthey, Tania Vanesa
Giunti, Sebastián
Florman, Jeremy
De Rosa, M.J.
Alkema, Mark
Rayes, Diego Hernán
author Veuthey, Tania Vanesa
author_facet Veuthey, Tania Vanesa
Giunti, Sebastián
Florman, Jeremy
De Rosa, M.J.
Alkema, Mark
Rayes, Diego Hernán
author_role author
author2 Giunti, Sebastián
Florman, Jeremy
De Rosa, M.J.
Alkema, Mark
Rayes, Diego Hernán
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv flight response
stress
insulin
intestine
topic flight response
stress
insulin
intestine
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Multicellular organisms trigger a complex and coordinated response against systemic stress. We have recently shown that in C. elegans, the neural stress-hormone tyramine supplies a state-dependent neural switch between acute flight- and longterm environmental-stress responses (De Rosa et al, 2019). Tyramine release during the flight response, stimulates the DAF-2/ Insulin/IGF-1 signaling (IIS) pathway and precludes the nuclear translocation of the DAF-16/FOXO transcription factor through the activation of an adrenergic-like receptor TYRA-3 in the intestine. We hypothesize that tyramine stimulates the release of agonist ILPs from the intestine which acts as an autocrine and/or paracrine signal to systemically activate the DAF-2/IIS pathway. To test this hypothesis we are screening ILPs mutants for their resistance to environmental stressors (oxidative and thermal stress). The C. elegans genome encodes 40 ILPs, 28 of which expressed in the intestine. We performed a screening of intestinal peptides described as strong DAF-2 agonist, by silencing individual intestinal ILPs and testing worm resistance to environmental stressors (oxidative and thermal stress). Thus, so far we found that ins-3 and ins-7 mutants are resistant to environmental stress, like tyramine-deficient and tyra-3 mutants. We are further testing whether tyramine directly stimulates the release of these ILPs from the intestine through a Gq-protein mediated signaling pathway. These studies will provide insight into how a neurohormone coordinates systemic cellular stress responses
Fil: Veuthey, Tania Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Giunti, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Florman, Jeremy. University Of Massachussets. Medical School. School Of Medicine. Departament Of Neurology; Estados Unidos
Fil: De Rosa, M.J.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Alkema, Mark. University Of Massachussets. Medical School. School Of Medicine. Departament Of Neurology; Estados Unidos
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
23rd International C. elegans Conference
Rockville
Estados Unidos
Genetics Society of America
description Multicellular organisms trigger a complex and coordinated response against systemic stress. We have recently shown that in C. elegans, the neural stress-hormone tyramine supplies a state-dependent neural switch between acute flight- and longterm environmental-stress responses (De Rosa et al, 2019). Tyramine release during the flight response, stimulates the DAF-2/ Insulin/IGF-1 signaling (IIS) pathway and precludes the nuclear translocation of the DAF-16/FOXO transcription factor through the activation of an adrenergic-like receptor TYRA-3 in the intestine. We hypothesize that tyramine stimulates the release of agonist ILPs from the intestine which acts as an autocrine and/or paracrine signal to systemically activate the DAF-2/IIS pathway. To test this hypothesis we are screening ILPs mutants for their resistance to environmental stressors (oxidative and thermal stress). The C. elegans genome encodes 40 ILPs, 28 of which expressed in the intestine. We performed a screening of intestinal peptides described as strong DAF-2 agonist, by silencing individual intestinal ILPs and testing worm resistance to environmental stressors (oxidative and thermal stress). Thus, so far we found that ins-3 and ins-7 mutants are resistant to environmental stress, like tyramine-deficient and tyra-3 mutants. We are further testing whether tyramine directly stimulates the release of these ILPs from the intestine through a Gq-protein mediated signaling pathway. These studies will provide insight into how a neurohormone coordinates systemic cellular stress responses
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/215798
Tyramine modulates the systemic stress response by stimulating the release of intestinal insulin like-peptides (ILPs); 23rd International C. elegans Conference; Rockville; Estados Unidos; 2021; 442-442
CONICET Digital
CONICET
url http://hdl.handle.net/11336/215798
identifier_str_mv Tyramine modulates the systemic stress response by stimulating the release of intestinal insulin like-peptides (ILPs); 23rd International C. elegans Conference; Rockville; Estados Unidos; 2021; 442-442
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://genetics-gsa.org/celegans-2021/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Genetics Society of America
publisher.none.fl_str_mv Genetics Society of America
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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