Electrochemical sensing of guanine, adenine and 8-hydroxy-2′-deoxyguanosine at glassy carbon modified with single-walled carbon nanotubes covalently functionalized with lysine
- Autores
- Gutierrez, Alejandro; Gutierrez, Fabiana Andrea; Eguílaz Rubio, Marcos; González Domínguez, José M.; Hernández Ferrer, Javier; Ansón Casaos, Alejandro; Martínez, María T.; Rivas, Gustavo Adolfo
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- This work reports the synthesis and characterization of single-walled carbon nanotubes (SWCNT) covalently functionalized with l-lysine (Lys) and the analytical performance of glassy carbon electrodes (GCE) modified with a dispersion of SWCNT-Lys (GCE/SWCNT-Lys) for the highly sensitive quantification of guanine, adenine and 8-hydroxy-2′-deoxyguanosine. Detection limits of 75, 195 and 97 nM were obtained for guanine, adenine and 8-hydroxy-2′-deoxyguanosine, respectively by voltammetric adsorptive stripping with medium exchange. GCE/SWCNT-Lys was successfully used for the detection of adenine and guanine oxidation after adsorption of salmon sperm-double stranded DNA. A clear definition of 8-hydroxy-2′-deoxyguanosine oxidation signal is observed even in the presence of large excess of guanine, adenine or salmon sperm-double stranded DNA.
Fil: Gutierrez, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Gutierrez, Fabiana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Eguílaz Rubio, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: González Domínguez, José M.. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; España
Fil: Hernández Ferrer, Javier. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; España
Fil: Ansón Casaos, Alejandro. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; España
Fil: Martínez, María T.. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; España
Fil: Rivas, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina - Materia
-
CARBON NANOTUBES
ADENINE OXIDATION
GUANINE OXIDATION
GCE/SWCNT-LYS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/51985
Ver los metadatos del registro completo
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Electrochemical sensing of guanine, adenine and 8-hydroxy-2′-deoxyguanosine at glassy carbon modified with single-walled carbon nanotubes covalently functionalized with lysineGutierrez, AlejandroGutierrez, Fabiana AndreaEguílaz Rubio, MarcosGonzález Domínguez, José M.Hernández Ferrer, JavierAnsón Casaos, AlejandroMartínez, María T.Rivas, Gustavo AdolfoCARBON NANOTUBESADENINE OXIDATIONGUANINE OXIDATIONGCE/SWCNT-LYShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2This work reports the synthesis and characterization of single-walled carbon nanotubes (SWCNT) covalently functionalized with l-lysine (Lys) and the analytical performance of glassy carbon electrodes (GCE) modified with a dispersion of SWCNT-Lys (GCE/SWCNT-Lys) for the highly sensitive quantification of guanine, adenine and 8-hydroxy-2′-deoxyguanosine. Detection limits of 75, 195 and 97 nM were obtained for guanine, adenine and 8-hydroxy-2′-deoxyguanosine, respectively by voltammetric adsorptive stripping with medium exchange. GCE/SWCNT-Lys was successfully used for the detection of adenine and guanine oxidation after adsorption of salmon sperm-double stranded DNA. A clear definition of 8-hydroxy-2′-deoxyguanosine oxidation signal is observed even in the presence of large excess of guanine, adenine or salmon sperm-double stranded DNA.Fil: Gutierrez, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Gutierrez, Fabiana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Eguílaz Rubio, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: González Domínguez, José M.. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; EspañaFil: Hernández Ferrer, Javier. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; EspañaFil: Ansón Casaos, Alejandro. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; EspañaFil: Martínez, María T.. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; EspañaFil: Rivas, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaRoyal Society of Chemistry2016-01-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/51985Gutierrez, Alejandro; Gutierrez, Fabiana Andrea; Eguílaz Rubio, Marcos; González Domínguez, José M.; Hernández Ferrer, Javier; et al.; Electrochemical sensing of guanine, adenine and 8-hydroxy-2′-deoxyguanosine at glassy carbon modified with single-walled carbon nanotubes covalently functionalized with lysine; Royal Society of Chemistry; RSC Advances; 6; 16; 21-1-2016; 13469-134772046-2069CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1039/C5RA22556Finfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C5RA22556F#!divAbstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:12:45Zoai:ri.conicet.gov.ar:11336/51985instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:12:45.398CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Electrochemical sensing of guanine, adenine and 8-hydroxy-2′-deoxyguanosine at glassy carbon modified with single-walled carbon nanotubes covalently functionalized with lysine |
| title |
Electrochemical sensing of guanine, adenine and 8-hydroxy-2′-deoxyguanosine at glassy carbon modified with single-walled carbon nanotubes covalently functionalized with lysine |
| spellingShingle |
Electrochemical sensing of guanine, adenine and 8-hydroxy-2′-deoxyguanosine at glassy carbon modified with single-walled carbon nanotubes covalently functionalized with lysine Gutierrez, Alejandro CARBON NANOTUBES ADENINE OXIDATION GUANINE OXIDATION GCE/SWCNT-LYS |
| title_short |
Electrochemical sensing of guanine, adenine and 8-hydroxy-2′-deoxyguanosine at glassy carbon modified with single-walled carbon nanotubes covalently functionalized with lysine |
| title_full |
Electrochemical sensing of guanine, adenine and 8-hydroxy-2′-deoxyguanosine at glassy carbon modified with single-walled carbon nanotubes covalently functionalized with lysine |
| title_fullStr |
Electrochemical sensing of guanine, adenine and 8-hydroxy-2′-deoxyguanosine at glassy carbon modified with single-walled carbon nanotubes covalently functionalized with lysine |
| title_full_unstemmed |
Electrochemical sensing of guanine, adenine and 8-hydroxy-2′-deoxyguanosine at glassy carbon modified with single-walled carbon nanotubes covalently functionalized with lysine |
| title_sort |
Electrochemical sensing of guanine, adenine and 8-hydroxy-2′-deoxyguanosine at glassy carbon modified with single-walled carbon nanotubes covalently functionalized with lysine |
| dc.creator.none.fl_str_mv |
Gutierrez, Alejandro Gutierrez, Fabiana Andrea Eguílaz Rubio, Marcos González Domínguez, José M. Hernández Ferrer, Javier Ansón Casaos, Alejandro Martínez, María T. Rivas, Gustavo Adolfo |
| author |
Gutierrez, Alejandro |
| author_facet |
Gutierrez, Alejandro Gutierrez, Fabiana Andrea Eguílaz Rubio, Marcos González Domínguez, José M. Hernández Ferrer, Javier Ansón Casaos, Alejandro Martínez, María T. Rivas, Gustavo Adolfo |
| author_role |
author |
| author2 |
Gutierrez, Fabiana Andrea Eguílaz Rubio, Marcos González Domínguez, José M. Hernández Ferrer, Javier Ansón Casaos, Alejandro Martínez, María T. Rivas, Gustavo Adolfo |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
CARBON NANOTUBES ADENINE OXIDATION GUANINE OXIDATION GCE/SWCNT-LYS |
| topic |
CARBON NANOTUBES ADENINE OXIDATION GUANINE OXIDATION GCE/SWCNT-LYS |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 https://purl.org/becyt/ford/2.10 https://purl.org/becyt/ford/2 |
| dc.description.none.fl_txt_mv |
This work reports the synthesis and characterization of single-walled carbon nanotubes (SWCNT) covalently functionalized with l-lysine (Lys) and the analytical performance of glassy carbon electrodes (GCE) modified with a dispersion of SWCNT-Lys (GCE/SWCNT-Lys) for the highly sensitive quantification of guanine, adenine and 8-hydroxy-2′-deoxyguanosine. Detection limits of 75, 195 and 97 nM were obtained for guanine, adenine and 8-hydroxy-2′-deoxyguanosine, respectively by voltammetric adsorptive stripping with medium exchange. GCE/SWCNT-Lys was successfully used for the detection of adenine and guanine oxidation after adsorption of salmon sperm-double stranded DNA. A clear definition of 8-hydroxy-2′-deoxyguanosine oxidation signal is observed even in the presence of large excess of guanine, adenine or salmon sperm-double stranded DNA. Fil: Gutierrez, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina Fil: Gutierrez, Fabiana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina Fil: Eguílaz Rubio, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina Fil: González Domínguez, José M.. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; España Fil: Hernández Ferrer, Javier. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; España Fil: Ansón Casaos, Alejandro. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; España Fil: Martínez, María T.. Consejo Superior de Investigaciones Científicas. Instituto de Carboquímica; España Fil: Rivas, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina |
| description |
This work reports the synthesis and characterization of single-walled carbon nanotubes (SWCNT) covalently functionalized with l-lysine (Lys) and the analytical performance of glassy carbon electrodes (GCE) modified with a dispersion of SWCNT-Lys (GCE/SWCNT-Lys) for the highly sensitive quantification of guanine, adenine and 8-hydroxy-2′-deoxyguanosine. Detection limits of 75, 195 and 97 nM were obtained for guanine, adenine and 8-hydroxy-2′-deoxyguanosine, respectively by voltammetric adsorptive stripping with medium exchange. GCE/SWCNT-Lys was successfully used for the detection of adenine and guanine oxidation after adsorption of salmon sperm-double stranded DNA. A clear definition of 8-hydroxy-2′-deoxyguanosine oxidation signal is observed even in the presence of large excess of guanine, adenine or salmon sperm-double stranded DNA. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016-01-21 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/51985 Gutierrez, Alejandro; Gutierrez, Fabiana Andrea; Eguílaz Rubio, Marcos; González Domínguez, José M.; Hernández Ferrer, Javier; et al.; Electrochemical sensing of guanine, adenine and 8-hydroxy-2′-deoxyguanosine at glassy carbon modified with single-walled carbon nanotubes covalently functionalized with lysine; Royal Society of Chemistry; RSC Advances; 6; 16; 21-1-2016; 13469-13477 2046-2069 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/51985 |
| identifier_str_mv |
Gutierrez, Alejandro; Gutierrez, Fabiana Andrea; Eguílaz Rubio, Marcos; González Domínguez, José M.; Hernández Ferrer, Javier; et al.; Electrochemical sensing of guanine, adenine and 8-hydroxy-2′-deoxyguanosine at glassy carbon modified with single-walled carbon nanotubes covalently functionalized with lysine; Royal Society of Chemistry; RSC Advances; 6; 16; 21-1-2016; 13469-13477 2046-2069 CONICET Digital CONICET |
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eng |
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eng |
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Royal Society of Chemistry |
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Royal Society of Chemistry |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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