Overview of Wnt/β-Catenin Pathway and DNA Damage/Repair in Cancer

Autores
Nadin, Silvina Beatriz; Cuello Carrión, Fernando Darío; Cayado Gutiérrez, Niubys de Los Milagros; Fanelli, Mariel Andrea
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The Wnt/β-catenin pathway takes part in important cellular processes in tumor cells, such as gene expression, adhesion, and survival. The canonical pathway is activated in several tumors, and βcatenin is its major effector. The union of Wnt to the co-receptor complex causes the inhibition of GSK3β activity, thus preventing the phosphorylation and degradation of β-catenin, which accumulates in the cytoplasm, to subsequently be transported to the nucleus to associate with transcription factors. The relationship between Wnt/β-catenin and DNA damage/repair mechanisms has been a focus for the last few years. Studying the Wnt/β-catenin network interactions with DNA damage/repair proteins has become a successful research field. This review provides an overview of the participation of Wnt/β catenin in DNA damage/repair mechanisms and their future implications as targets for cancer therapy.
Fil: Nadin, Silvina Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Cuello Carrión, Fernando Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Cayado Gutiérrez, Niubys de Los Milagros. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Fanelli, Mariel Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Materia
WNT
BETA CATENIN
DNA REPAIR
CANCER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/271547
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Overview of Wnt/β-Catenin Pathway and DNA Damage/Repair in CancerNadin, Silvina BeatrizCuello Carrión, Fernando DaríoCayado Gutiérrez, Niubys de Los MilagrosFanelli, Mariel AndreaWNTBETA CATENINDNA REPAIRCANCERhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The Wnt/β-catenin pathway takes part in important cellular processes in tumor cells, such as gene expression, adhesion, and survival. The canonical pathway is activated in several tumors, and βcatenin is its major effector. The union of Wnt to the co-receptor complex causes the inhibition of GSK3β activity, thus preventing the phosphorylation and degradation of β-catenin, which accumulates in the cytoplasm, to subsequently be transported to the nucleus to associate with transcription factors. The relationship between Wnt/β-catenin and DNA damage/repair mechanisms has been a focus for the last few years. Studying the Wnt/β-catenin network interactions with DNA damage/repair proteins has become a successful research field. This review provides an overview of the participation of Wnt/β catenin in DNA damage/repair mechanisms and their future implications as targets for cancer therapy.Fil: Nadin, Silvina Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Cuello Carrión, Fernando Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Cayado Gutiérrez, Niubys de Los Milagros. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Fanelli, Mariel Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaMDPI2025-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/271547Nadin, Silvina Beatriz; Cuello Carrión, Fernando Darío; Cayado Gutiérrez, Niubys de Los Milagros; Fanelli, Mariel Andrea; Overview of Wnt/β-Catenin Pathway and DNA Damage/Repair in Cancer; MDPI; Biology; 14; 2; 2-2025; 185-2052079-7737CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-7737/14/2/185info:eu-repo/semantics/altIdentifier/doi/10.3390/biology14020185info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:44:31Zoai:ri.conicet.gov.ar:11336/271547instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:44:32.203CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Overview of Wnt/β-Catenin Pathway and DNA Damage/Repair in Cancer
title Overview of Wnt/β-Catenin Pathway and DNA Damage/Repair in Cancer
spellingShingle Overview of Wnt/β-Catenin Pathway and DNA Damage/Repair in Cancer
Nadin, Silvina Beatriz
WNT
BETA CATENIN
DNA REPAIR
CANCER
title_short Overview of Wnt/β-Catenin Pathway and DNA Damage/Repair in Cancer
title_full Overview of Wnt/β-Catenin Pathway and DNA Damage/Repair in Cancer
title_fullStr Overview of Wnt/β-Catenin Pathway and DNA Damage/Repair in Cancer
title_full_unstemmed Overview of Wnt/β-Catenin Pathway and DNA Damage/Repair in Cancer
title_sort Overview of Wnt/β-Catenin Pathway and DNA Damage/Repair in Cancer
dc.creator.none.fl_str_mv Nadin, Silvina Beatriz
Cuello Carrión, Fernando Darío
Cayado Gutiérrez, Niubys de Los Milagros
Fanelli, Mariel Andrea
author Nadin, Silvina Beatriz
author_facet Nadin, Silvina Beatriz
Cuello Carrión, Fernando Darío
Cayado Gutiérrez, Niubys de Los Milagros
Fanelli, Mariel Andrea
author_role author
author2 Cuello Carrión, Fernando Darío
Cayado Gutiérrez, Niubys de Los Milagros
Fanelli, Mariel Andrea
author2_role author
author
author
dc.subject.none.fl_str_mv WNT
BETA CATENIN
DNA REPAIR
CANCER
topic WNT
BETA CATENIN
DNA REPAIR
CANCER
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The Wnt/β-catenin pathway takes part in important cellular processes in tumor cells, such as gene expression, adhesion, and survival. The canonical pathway is activated in several tumors, and βcatenin is its major effector. The union of Wnt to the co-receptor complex causes the inhibition of GSK3β activity, thus preventing the phosphorylation and degradation of β-catenin, which accumulates in the cytoplasm, to subsequently be transported to the nucleus to associate with transcription factors. The relationship between Wnt/β-catenin and DNA damage/repair mechanisms has been a focus for the last few years. Studying the Wnt/β-catenin network interactions with DNA damage/repair proteins has become a successful research field. This review provides an overview of the participation of Wnt/β catenin in DNA damage/repair mechanisms and their future implications as targets for cancer therapy.
Fil: Nadin, Silvina Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Cuello Carrión, Fernando Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Cayado Gutiérrez, Niubys de Los Milagros. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Fanelli, Mariel Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
description The Wnt/β-catenin pathway takes part in important cellular processes in tumor cells, such as gene expression, adhesion, and survival. The canonical pathway is activated in several tumors, and βcatenin is its major effector. The union of Wnt to the co-receptor complex causes the inhibition of GSK3β activity, thus preventing the phosphorylation and degradation of β-catenin, which accumulates in the cytoplasm, to subsequently be transported to the nucleus to associate with transcription factors. The relationship between Wnt/β-catenin and DNA damage/repair mechanisms has been a focus for the last few years. Studying the Wnt/β-catenin network interactions with DNA damage/repair proteins has become a successful research field. This review provides an overview of the participation of Wnt/β catenin in DNA damage/repair mechanisms and their future implications as targets for cancer therapy.
publishDate 2025
dc.date.none.fl_str_mv 2025-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/271547
Nadin, Silvina Beatriz; Cuello Carrión, Fernando Darío; Cayado Gutiérrez, Niubys de Los Milagros; Fanelli, Mariel Andrea; Overview of Wnt/β-Catenin Pathway and DNA Damage/Repair in Cancer; MDPI; Biology; 14; 2; 2-2025; 185-205
2079-7737
CONICET Digital
CONICET
url http://hdl.handle.net/11336/271547
identifier_str_mv Nadin, Silvina Beatriz; Cuello Carrión, Fernando Darío; Cayado Gutiérrez, Niubys de Los Milagros; Fanelli, Mariel Andrea; Overview of Wnt/β-Catenin Pathway and DNA Damage/Repair in Cancer; MDPI; Biology; 14; 2; 2-2025; 185-205
2079-7737
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-7737/14/2/185
info:eu-repo/semantics/altIdentifier/doi/10.3390/biology14020185
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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