The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis

Autores
Oliveira Paula, Gustavo H.; Liu, Sophia; Maira, Alishba; Ressa, Gaia; Ferreira, Graziele C.; Quintar, Amado Alfredo; Jayakumar, Smitha; Almonte, Vanessa; Parikh, Dippal; Valenta, Tomas; Basler, Konrad; Hla, Timothy; Riascos Bernal, Dario F.; Sibinga, Nicholas E. S.
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Canonical Wnt and sphingosine- 1- phosphate (S1P) signaling pathways are highly conserved systems that contribute to normal vertebrate development, with key consequences for immune, nervous, and cardiovascular system function; despite these functional overlaps, little is known about Wnt/β- catenin–S1P cross- talk. In the vascular system, both Wnt/β- catenin and S1P signals affect vessel maturation, stability, and barrier function, but information regarding their potential coordination is scant. We report an instance of functional interaction between the two pathways, including evidence that S1P receptor 1 (S1PR1) is a transcriptional target of β- catenin. By studying vascular smooth muscle cells and arterial injury response, we find a specific requirement for the β-catenin carboxyl terminus, which acts to induce S1PR1, and show that this interaction is essential for vascular remodeling. We also report that pharmacological inhibition of the β- catenin carboxyl terminus reduces S1PR1 expression, neointima formation, and atherosclerosis. These findings provide mechanistic understanding of how Wnt/β-catenin and S1P systems collaborate during vascular remodeling and inform strategies for therapeutic manipulation.
Fil: Oliveira Paula, Gustavo H.. Albert Einstein College of Medicine; Estados Unidos
Fil: Liu, Sophia. Albert Einstein College of Medicine; Estados Unidos
Fil: Maira, Alishba. Albert Einstein College of Medicine; Estados Unidos
Fil: Ressa, Gaia. Albert Einstein College of Medicine; Estados Unidos
Fil: Ferreira, Graziele C.. Albert Einstein College of Medicine; Estados Unidos. Universidade de Sao Paulo; Brasil
Fil: Quintar, Amado Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Albert Einstein College of Medicine; Estados Unidos
Fil: Jayakumar, Smitha. Albert Einstein College of Medicine; Estados Unidos
Fil: Almonte, Vanessa. Albert Einstein College of Medicine; Estados Unidos
Fil: Parikh, Dippal. Albert Einstein College of Medicine; Estados Unidos
Fil: Valenta, Tomas. Universitat Zurich; Suiza
Fil: Basler, Konrad. Universitat Zurich; Suiza
Fil: Hla, Timothy. Harvard Medical School; Estados Unidos
Fil: Riascos Bernal, Dario F.. Albert Einstein College of Medicine; Estados Unidos
Fil: Sibinga, Nicholas E. S.. Albert Einstein College of Medicine; Estados Unidos
Materia
CATENIN
ATHEROSCLEROSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/265425
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/265425
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosisOliveira Paula, Gustavo H.Liu, SophiaMaira, AlishbaRessa, GaiaFerreira, Graziele C.Quintar, Amado AlfredoJayakumar, SmithaAlmonte, VanessaParikh, DippalValenta, TomasBasler, KonradHla, TimothyRiascos Bernal, Dario F.Sibinga, Nicholas E. S.CATENINATHEROSCLEROSIShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Canonical Wnt and sphingosine- 1- phosphate (S1P) signaling pathways are highly conserved systems that contribute to normal vertebrate development, with key consequences for immune, nervous, and cardiovascular system function; despite these functional overlaps, little is known about Wnt/β- catenin–S1P cross- talk. In the vascular system, both Wnt/β- catenin and S1P signals affect vessel maturation, stability, and barrier function, but information regarding their potential coordination is scant. We report an instance of functional interaction between the two pathways, including evidence that S1P receptor 1 (S1PR1) is a transcriptional target of β- catenin. By studying vascular smooth muscle cells and arterial injury response, we find a specific requirement for the β-catenin carboxyl terminus, which acts to induce S1PR1, and show that this interaction is essential for vascular remodeling. We also report that pharmacological inhibition of the β- catenin carboxyl terminus reduces S1PR1 expression, neointima formation, and atherosclerosis. These findings provide mechanistic understanding of how Wnt/β-catenin and S1P systems collaborate during vascular remodeling and inform strategies for therapeutic manipulation.Fil: Oliveira Paula, Gustavo H.. Albert Einstein College of Medicine; Estados UnidosFil: Liu, Sophia. Albert Einstein College of Medicine; Estados UnidosFil: Maira, Alishba. Albert Einstein College of Medicine; Estados UnidosFil: Ressa, Gaia. Albert Einstein College of Medicine; Estados UnidosFil: Ferreira, Graziele C.. Albert Einstein College of Medicine; Estados Unidos. Universidade de Sao Paulo; BrasilFil: Quintar, Amado Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Albert Einstein College of Medicine; Estados UnidosFil: Jayakumar, Smitha. Albert Einstein College of Medicine; Estados UnidosFil: Almonte, Vanessa. Albert Einstein College of Medicine; Estados UnidosFil: Parikh, Dippal. Albert Einstein College of Medicine; Estados UnidosFil: Valenta, Tomas. Universitat Zurich; SuizaFil: Basler, Konrad. Universitat Zurich; SuizaFil: Hla, Timothy. Harvard Medical School; Estados UnidosFil: Riascos Bernal, Dario F.. Albert Einstein College of Medicine; Estados UnidosFil: Sibinga, Nicholas E. S.. Albert Einstein College of Medicine; Estados UnidosScience Advances is the American Association for the Advancement of Science2024-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/265425Oliveira Paula, Gustavo H.; Liu, Sophia; Maira, Alishba; Ressa, Gaia; Ferreira, Graziele C.; et al.; The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis; Science Advances is the American Association for the Advancement of Science; Science Advances; 10; 11; 3-2024; 1-182375-2548CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.science.org/doi/10.1126/sciadv.adg9278info:eu-repo/semantics/altIdentifier/doi/10.1126/sciadv.adg9278info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:22Zoai:ri.conicet.gov.ar:11336/265425instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:23.015CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis
title The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis
spellingShingle The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis
Oliveira Paula, Gustavo H.
CATENIN
ATHEROSCLEROSIS
title_short The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis
title_full The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis
title_fullStr The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis
title_full_unstemmed The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis
title_sort The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis
dc.creator.none.fl_str_mv Oliveira Paula, Gustavo H.
Liu, Sophia
Maira, Alishba
Ressa, Gaia
Ferreira, Graziele C.
Quintar, Amado Alfredo
Jayakumar, Smitha
Almonte, Vanessa
Parikh, Dippal
Valenta, Tomas
Basler, Konrad
Hla, Timothy
Riascos Bernal, Dario F.
Sibinga, Nicholas E. S.
author Oliveira Paula, Gustavo H.
author_facet Oliveira Paula, Gustavo H.
Liu, Sophia
Maira, Alishba
Ressa, Gaia
Ferreira, Graziele C.
Quintar, Amado Alfredo
Jayakumar, Smitha
Almonte, Vanessa
Parikh, Dippal
Valenta, Tomas
Basler, Konrad
Hla, Timothy
Riascos Bernal, Dario F.
Sibinga, Nicholas E. S.
author_role author
author2 Liu, Sophia
Maira, Alishba
Ressa, Gaia
Ferreira, Graziele C.
Quintar, Amado Alfredo
Jayakumar, Smitha
Almonte, Vanessa
Parikh, Dippal
Valenta, Tomas
Basler, Konrad
Hla, Timothy
Riascos Bernal, Dario F.
Sibinga, Nicholas E. S.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CATENIN
ATHEROSCLEROSIS
topic CATENIN
ATHEROSCLEROSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Canonical Wnt and sphingosine- 1- phosphate (S1P) signaling pathways are highly conserved systems that contribute to normal vertebrate development, with key consequences for immune, nervous, and cardiovascular system function; despite these functional overlaps, little is known about Wnt/β- catenin–S1P cross- talk. In the vascular system, both Wnt/β- catenin and S1P signals affect vessel maturation, stability, and barrier function, but information regarding their potential coordination is scant. We report an instance of functional interaction between the two pathways, including evidence that S1P receptor 1 (S1PR1) is a transcriptional target of β- catenin. By studying vascular smooth muscle cells and arterial injury response, we find a specific requirement for the β-catenin carboxyl terminus, which acts to induce S1PR1, and show that this interaction is essential for vascular remodeling. We also report that pharmacological inhibition of the β- catenin carboxyl terminus reduces S1PR1 expression, neointima formation, and atherosclerosis. These findings provide mechanistic understanding of how Wnt/β-catenin and S1P systems collaborate during vascular remodeling and inform strategies for therapeutic manipulation.
Fil: Oliveira Paula, Gustavo H.. Albert Einstein College of Medicine; Estados Unidos
Fil: Liu, Sophia. Albert Einstein College of Medicine; Estados Unidos
Fil: Maira, Alishba. Albert Einstein College of Medicine; Estados Unidos
Fil: Ressa, Gaia. Albert Einstein College of Medicine; Estados Unidos
Fil: Ferreira, Graziele C.. Albert Einstein College of Medicine; Estados Unidos. Universidade de Sao Paulo; Brasil
Fil: Quintar, Amado Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Albert Einstein College of Medicine; Estados Unidos
Fil: Jayakumar, Smitha. Albert Einstein College of Medicine; Estados Unidos
Fil: Almonte, Vanessa. Albert Einstein College of Medicine; Estados Unidos
Fil: Parikh, Dippal. Albert Einstein College of Medicine; Estados Unidos
Fil: Valenta, Tomas. Universitat Zurich; Suiza
Fil: Basler, Konrad. Universitat Zurich; Suiza
Fil: Hla, Timothy. Harvard Medical School; Estados Unidos
Fil: Riascos Bernal, Dario F.. Albert Einstein College of Medicine; Estados Unidos
Fil: Sibinga, Nicholas E. S.. Albert Einstein College of Medicine; Estados Unidos
description Canonical Wnt and sphingosine- 1- phosphate (S1P) signaling pathways are highly conserved systems that contribute to normal vertebrate development, with key consequences for immune, nervous, and cardiovascular system function; despite these functional overlaps, little is known about Wnt/β- catenin–S1P cross- talk. In the vascular system, both Wnt/β- catenin and S1P signals affect vessel maturation, stability, and barrier function, but information regarding their potential coordination is scant. We report an instance of functional interaction between the two pathways, including evidence that S1P receptor 1 (S1PR1) is a transcriptional target of β- catenin. By studying vascular smooth muscle cells and arterial injury response, we find a specific requirement for the β-catenin carboxyl terminus, which acts to induce S1PR1, and show that this interaction is essential for vascular remodeling. We also report that pharmacological inhibition of the β- catenin carboxyl terminus reduces S1PR1 expression, neointima formation, and atherosclerosis. These findings provide mechanistic understanding of how Wnt/β-catenin and S1P systems collaborate during vascular remodeling and inform strategies for therapeutic manipulation.
publishDate 2024
dc.date.none.fl_str_mv 2024-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/265425
Oliveira Paula, Gustavo H.; Liu, Sophia; Maira, Alishba; Ressa, Gaia; Ferreira, Graziele C.; et al.; The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis; Science Advances is the American Association for the Advancement of Science; Science Advances; 10; 11; 3-2024; 1-18
2375-2548
CONICET Digital
CONICET
url http://hdl.handle.net/11336/265425
identifier_str_mv Oliveira Paula, Gustavo H.; Liu, Sophia; Maira, Alishba; Ressa, Gaia; Ferreira, Graziele C.; et al.; The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis; Science Advances is the American Association for the Advancement of Science; Science Advances; 10; 11; 3-2024; 1-18
2375-2548
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.science.org/doi/10.1126/sciadv.adg9278
info:eu-repo/semantics/altIdentifier/doi/10.1126/sciadv.adg9278
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Science Advances is the American Association for the Advancement of Science
publisher.none.fl_str_mv Science Advances is the American Association for the Advancement of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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