Brown fat thermogenesis in cold-acclimated rats is not abolished by the suppression of thyroid function

Autores
Zaninovich, Angel Antonio; Raíces, Marcela; Rebagliati, Ines Rosa; Ricci, ConradO; Hagmüller, Karl
Año de publicación
2002
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The effects of long-term cold exposure on brown adipose tissue (BAT) thermogenesis in hypothyroid rats have been examined. Thyroid ablation was performed in normal rats after 2 mo of exposure to 4°C, when BAT hypertrophy and thermogenic activity were maximal. After ablation, hypothyroid and normal controls remained in the cold for 2 additional months. At the end of the 4-mo cold exposure, all untreated hypothyroid rats were alive, had normal body temperature, and had gained an average 12.8% more weight than normal controls. Long-term cold exposure of hypothyroid rats markedly increased BAT weight, mitochondrial proteins, uncoupling protein (UCP)-1, mRNA for UCP-1, and oxygen consumption to levels similar to those seen in cold-exposed normal rats. The results indicate that thyroid hormones are required for increased thermogenic capacity to occur as an adaptation to long-term cold exposure. However, cold adaptation can be maintained in the absence of thyroid hormone.
Fil: Zaninovich, Angel Antonio. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Raíces, Marcela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Rebagliati, Ines Rosa. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ricci, ConradO. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Hagmüller, Karl. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Materia
COLD ACCLIMATION
HYPOTHYROIDISM
NOREPINEPHRINE
OXYGEN CONSUMPTION
UNCOUPLING PROTEIN-1
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/180378
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/180378
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Brown fat thermogenesis in cold-acclimated rats is not abolished by the suppression of thyroid functionZaninovich, Angel AntonioRaíces, MarcelaRebagliati, Ines RosaRicci, ConradOHagmüller, KarlCOLD ACCLIMATIONHYPOTHYROIDISMNOREPINEPHRINEOXYGEN CONSUMPTIONUNCOUPLING PROTEIN-1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The effects of long-term cold exposure on brown adipose tissue (BAT) thermogenesis in hypothyroid rats have been examined. Thyroid ablation was performed in normal rats after 2 mo of exposure to 4°C, when BAT hypertrophy and thermogenic activity were maximal. After ablation, hypothyroid and normal controls remained in the cold for 2 additional months. At the end of the 4-mo cold exposure, all untreated hypothyroid rats were alive, had normal body temperature, and had gained an average 12.8% more weight than normal controls. Long-term cold exposure of hypothyroid rats markedly increased BAT weight, mitochondrial proteins, uncoupling protein (UCP)-1, mRNA for UCP-1, and oxygen consumption to levels similar to those seen in cold-exposed normal rats. The results indicate that thyroid hormones are required for increased thermogenic capacity to occur as an adaptation to long-term cold exposure. However, cold adaptation can be maintained in the absence of thyroid hormone.Fil: Zaninovich, Angel Antonio. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Raíces, Marcela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Rebagliati, Ines Rosa. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ricci, ConradO. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Hagmüller, Karl. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaAmerican Physiological Society2002-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/180378Zaninovich, Angel Antonio; Raíces, Marcela; Rebagliati, Ines Rosa; Ricci, ConradO; Hagmüller, Karl; Brown fat thermogenesis in cold-acclimated rats is not abolished by the suppression of thyroid function; American Physiological Society; American Journal Of Physiology-endocrinology And Metabolism; 286; 3; 5-2002; 496-5021522-1555CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1152/ajpendo.00540.2001info:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/full/10.1152/ajpendo.00540.2001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:34:16Zoai:ri.conicet.gov.ar:11336/180378instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:34:16.715CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Brown fat thermogenesis in cold-acclimated rats is not abolished by the suppression of thyroid function
title Brown fat thermogenesis in cold-acclimated rats is not abolished by the suppression of thyroid function
spellingShingle Brown fat thermogenesis in cold-acclimated rats is not abolished by the suppression of thyroid function
Zaninovich, Angel Antonio
COLD ACCLIMATION
HYPOTHYROIDISM
NOREPINEPHRINE
OXYGEN CONSUMPTION
UNCOUPLING PROTEIN-1
title_short Brown fat thermogenesis in cold-acclimated rats is not abolished by the suppression of thyroid function
title_full Brown fat thermogenesis in cold-acclimated rats is not abolished by the suppression of thyroid function
title_fullStr Brown fat thermogenesis in cold-acclimated rats is not abolished by the suppression of thyroid function
title_full_unstemmed Brown fat thermogenesis in cold-acclimated rats is not abolished by the suppression of thyroid function
title_sort Brown fat thermogenesis in cold-acclimated rats is not abolished by the suppression of thyroid function
dc.creator.none.fl_str_mv Zaninovich, Angel Antonio
Raíces, Marcela
Rebagliati, Ines Rosa
Ricci, ConradO
Hagmüller, Karl
author Zaninovich, Angel Antonio
author_facet Zaninovich, Angel Antonio
Raíces, Marcela
Rebagliati, Ines Rosa
Ricci, ConradO
Hagmüller, Karl
author_role author
author2 Raíces, Marcela
Rebagliati, Ines Rosa
Ricci, ConradO
Hagmüller, Karl
author2_role author
author
author
author
dc.subject.none.fl_str_mv COLD ACCLIMATION
HYPOTHYROIDISM
NOREPINEPHRINE
OXYGEN CONSUMPTION
UNCOUPLING PROTEIN-1
topic COLD ACCLIMATION
HYPOTHYROIDISM
NOREPINEPHRINE
OXYGEN CONSUMPTION
UNCOUPLING PROTEIN-1
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The effects of long-term cold exposure on brown adipose tissue (BAT) thermogenesis in hypothyroid rats have been examined. Thyroid ablation was performed in normal rats after 2 mo of exposure to 4°C, when BAT hypertrophy and thermogenic activity were maximal. After ablation, hypothyroid and normal controls remained in the cold for 2 additional months. At the end of the 4-mo cold exposure, all untreated hypothyroid rats were alive, had normal body temperature, and had gained an average 12.8% more weight than normal controls. Long-term cold exposure of hypothyroid rats markedly increased BAT weight, mitochondrial proteins, uncoupling protein (UCP)-1, mRNA for UCP-1, and oxygen consumption to levels similar to those seen in cold-exposed normal rats. The results indicate that thyroid hormones are required for increased thermogenic capacity to occur as an adaptation to long-term cold exposure. However, cold adaptation can be maintained in the absence of thyroid hormone.
Fil: Zaninovich, Angel Antonio. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Raíces, Marcela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Rebagliati, Ines Rosa. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ricci, ConradO. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Hagmüller, Karl. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
description The effects of long-term cold exposure on brown adipose tissue (BAT) thermogenesis in hypothyroid rats have been examined. Thyroid ablation was performed in normal rats after 2 mo of exposure to 4°C, when BAT hypertrophy and thermogenic activity were maximal. After ablation, hypothyroid and normal controls remained in the cold for 2 additional months. At the end of the 4-mo cold exposure, all untreated hypothyroid rats were alive, had normal body temperature, and had gained an average 12.8% more weight than normal controls. Long-term cold exposure of hypothyroid rats markedly increased BAT weight, mitochondrial proteins, uncoupling protein (UCP)-1, mRNA for UCP-1, and oxygen consumption to levels similar to those seen in cold-exposed normal rats. The results indicate that thyroid hormones are required for increased thermogenic capacity to occur as an adaptation to long-term cold exposure. However, cold adaptation can be maintained in the absence of thyroid hormone.
publishDate 2002
dc.date.none.fl_str_mv 2002-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/180378
Zaninovich, Angel Antonio; Raíces, Marcela; Rebagliati, Ines Rosa; Ricci, ConradO; Hagmüller, Karl; Brown fat thermogenesis in cold-acclimated rats is not abolished by the suppression of thyroid function; American Physiological Society; American Journal Of Physiology-endocrinology And Metabolism; 286; 3; 5-2002; 496-502
1522-1555
CONICET Digital
CONICET
url http://hdl.handle.net/11336/180378
identifier_str_mv Zaninovich, Angel Antonio; Raíces, Marcela; Rebagliati, Ines Rosa; Ricci, ConradO; Hagmüller, Karl; Brown fat thermogenesis in cold-acclimated rats is not abolished by the suppression of thyroid function; American Physiological Society; American Journal Of Physiology-endocrinology And Metabolism; 286; 3; 5-2002; 496-502
1522-1555
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1152/ajpendo.00540.2001
info:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/full/10.1152/ajpendo.00540.2001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Physiological Society
publisher.none.fl_str_mv American Physiological Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614359177756672
score 13.070432

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