Presence of human Papilloma Virus in a series of breast carcinoma from Argentina

Autores
Pereira Suárez, Ana Laura; Lorenzetti, Mario Alejandro; González Lucano, René; Cohen, Melina; Gass, Hugo; Martínez Vázquez, Paula; González, Pedro Horacio; Preciado, María Victoria; Chabay, Paola Andrea
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: The etiology and the molecular mechanisms related to breast carcinogenesis remain poorly understood. Some recent reports have examined the role of Human Papillomavirus (HPV) in this disease. The purpose of this study was to determine the prevalence of HPV in breast cancer. Methods: Sixty one fresh frozen breast cancers samples were analyzed. Samples were tested for HPV by PCR, and products were automatically sequenced. Findings were correlated with clinical and pathological characteristics. Results: The HPV DNA prevalence in the breast cancer samples was 26% (16/61). Clinical parameters were not statistically associated with HPV presence (p>0.05 χ2 test). Sequence analysis in a subgroup of cases indicates the prevalence of low risk HPV11, followed by high risk HPV16. We found no HPV transcriptional activity. Conclusion: The present study demonstrated for the first time in Argentina the presence of HPV in a proportion of the malignant breast tissues. This finding suggests that HPV may have a biological significance in breast carcinogenesis.
Fil: Pereira Suárez, Ana Laura. Universidad de Guadalajara; México
Fil: Lorenzetti, Mario Alejandro. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: González Lucano, René. Universidad de Guadalajara; México
Fil: Cohen, Melina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gass, Hugo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Magdalena Villegas de Martínez”; Argentina
Fil: Martínez Vázquez, Paula. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Magdalena Villegas de Martínez”; Argentina
Fil: González, Pedro Horacio. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Magdalena Villegas de Martínez”; Argentina
Fil: Preciado, María Victoria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chabay, Paola Andrea. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
BREAST CANCER
CARCINOGENESIS
DNA SEQUENCES
GENOTYPES
HPV-11
HPV-18
HUMAN PAPILLOMAVIRUS INFECTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/23843
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/23843
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Presence of human Papilloma Virus in a series of breast carcinoma from ArgentinaPereira Suárez, Ana LauraLorenzetti, Mario AlejandroGonzález Lucano, RenéCohen, MelinaGass, HugoMartínez Vázquez, PaulaGonzález, Pedro HoracioPreciado, María VictoriaChabay, Paola AndreaBREAST CANCERCARCINOGENESISDNA SEQUENCESGENOTYPESHPV-11HPV-18HUMAN PAPILLOMAVIRUS INFECTIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: The etiology and the molecular mechanisms related to breast carcinogenesis remain poorly understood. Some recent reports have examined the role of Human Papillomavirus (HPV) in this disease. The purpose of this study was to determine the prevalence of HPV in breast cancer. Methods: Sixty one fresh frozen breast cancers samples were analyzed. Samples were tested for HPV by PCR, and products were automatically sequenced. Findings were correlated with clinical and pathological characteristics. Results: The HPV DNA prevalence in the breast cancer samples was 26% (16/61). Clinical parameters were not statistically associated with HPV presence (p>0.05 χ2 test). Sequence analysis in a subgroup of cases indicates the prevalence of low risk HPV11, followed by high risk HPV16. We found no HPV transcriptional activity. Conclusion: The present study demonstrated for the first time in Argentina the presence of HPV in a proportion of the malignant breast tissues. This finding suggests that HPV may have a biological significance in breast carcinogenesis.Fil: Pereira Suárez, Ana Laura. Universidad de Guadalajara; MéxicoFil: Lorenzetti, Mario Alejandro. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: González Lucano, René. Universidad de Guadalajara; MéxicoFil: Cohen, Melina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gass, Hugo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Magdalena Villegas de Martínez”; ArgentinaFil: Martínez Vázquez, Paula. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Magdalena Villegas de Martínez”; ArgentinaFil: González, Pedro Horacio. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Magdalena Villegas de Martínez”; ArgentinaFil: Preciado, María Victoria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Chabay, Paola Andrea. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaPublic Library of Science2013-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23843Pereira Suárez, Ana Laura; Lorenzetti, Mario Alejandro; González Lucano, René; Cohen, Melina; Gass, Hugo; et al.; Presence of human Papilloma Virus in a series of breast carcinoma from Argentina; Public Library of Science; Plos One; 8; 4; 4-2013; 1-4; e616131932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061613info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0061613info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636204/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:05:00Zoai:ri.conicet.gov.ar:11336/23843instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:05:00.721CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Presence of human Papilloma Virus in a series of breast carcinoma from Argentina
title Presence of human Papilloma Virus in a series of breast carcinoma from Argentina
spellingShingle Presence of human Papilloma Virus in a series of breast carcinoma from Argentina
Pereira Suárez, Ana Laura
BREAST CANCER
CARCINOGENESIS
DNA SEQUENCES
GENOTYPES
HPV-11
HPV-18
HUMAN PAPILLOMAVIRUS INFECTION
title_short Presence of human Papilloma Virus in a series of breast carcinoma from Argentina
title_full Presence of human Papilloma Virus in a series of breast carcinoma from Argentina
title_fullStr Presence of human Papilloma Virus in a series of breast carcinoma from Argentina
title_full_unstemmed Presence of human Papilloma Virus in a series of breast carcinoma from Argentina
title_sort Presence of human Papilloma Virus in a series of breast carcinoma from Argentina
dc.creator.none.fl_str_mv Pereira Suárez, Ana Laura
Lorenzetti, Mario Alejandro
González Lucano, René
Cohen, Melina
Gass, Hugo
Martínez Vázquez, Paula
González, Pedro Horacio
Preciado, María Victoria
Chabay, Paola Andrea
author Pereira Suárez, Ana Laura
author_facet Pereira Suárez, Ana Laura
Lorenzetti, Mario Alejandro
González Lucano, René
Cohen, Melina
Gass, Hugo
Martínez Vázquez, Paula
González, Pedro Horacio
Preciado, María Victoria
Chabay, Paola Andrea
author_role author
author2 Lorenzetti, Mario Alejandro
González Lucano, René
Cohen, Melina
Gass, Hugo
Martínez Vázquez, Paula
González, Pedro Horacio
Preciado, María Victoria
Chabay, Paola Andrea
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BREAST CANCER
CARCINOGENESIS
DNA SEQUENCES
GENOTYPES
HPV-11
HPV-18
HUMAN PAPILLOMAVIRUS INFECTION
topic BREAST CANCER
CARCINOGENESIS
DNA SEQUENCES
GENOTYPES
HPV-11
HPV-18
HUMAN PAPILLOMAVIRUS INFECTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: The etiology and the molecular mechanisms related to breast carcinogenesis remain poorly understood. Some recent reports have examined the role of Human Papillomavirus (HPV) in this disease. The purpose of this study was to determine the prevalence of HPV in breast cancer. Methods: Sixty one fresh frozen breast cancers samples were analyzed. Samples were tested for HPV by PCR, and products were automatically sequenced. Findings were correlated with clinical and pathological characteristics. Results: The HPV DNA prevalence in the breast cancer samples was 26% (16/61). Clinical parameters were not statistically associated with HPV presence (p>0.05 χ2 test). Sequence analysis in a subgroup of cases indicates the prevalence of low risk HPV11, followed by high risk HPV16. We found no HPV transcriptional activity. Conclusion: The present study demonstrated for the first time in Argentina the presence of HPV in a proportion of the malignant breast tissues. This finding suggests that HPV may have a biological significance in breast carcinogenesis.
Fil: Pereira Suárez, Ana Laura. Universidad de Guadalajara; México
Fil: Lorenzetti, Mario Alejandro. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: González Lucano, René. Universidad de Guadalajara; México
Fil: Cohen, Melina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gass, Hugo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Magdalena Villegas de Martínez”; Argentina
Fil: Martínez Vázquez, Paula. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Magdalena Villegas de Martínez”; Argentina
Fil: González, Pedro Horacio. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Magdalena Villegas de Martínez”; Argentina
Fil: Preciado, María Victoria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chabay, Paola Andrea. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Background: The etiology and the molecular mechanisms related to breast carcinogenesis remain poorly understood. Some recent reports have examined the role of Human Papillomavirus (HPV) in this disease. The purpose of this study was to determine the prevalence of HPV in breast cancer. Methods: Sixty one fresh frozen breast cancers samples were analyzed. Samples were tested for HPV by PCR, and products were automatically sequenced. Findings were correlated with clinical and pathological characteristics. Results: The HPV DNA prevalence in the breast cancer samples was 26% (16/61). Clinical parameters were not statistically associated with HPV presence (p>0.05 χ2 test). Sequence analysis in a subgroup of cases indicates the prevalence of low risk HPV11, followed by high risk HPV16. We found no HPV transcriptional activity. Conclusion: The present study demonstrated for the first time in Argentina the presence of HPV in a proportion of the malignant breast tissues. This finding suggests that HPV may have a biological significance in breast carcinogenesis.
publishDate 2013
dc.date.none.fl_str_mv 2013-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/23843
Pereira Suárez, Ana Laura; Lorenzetti, Mario Alejandro; González Lucano, René; Cohen, Melina; Gass, Hugo; et al.; Presence of human Papilloma Virus in a series of breast carcinoma from Argentina; Public Library of Science; Plos One; 8; 4; 4-2013; 1-4; e61613
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/23843
identifier_str_mv Pereira Suárez, Ana Laura; Lorenzetti, Mario Alejandro; González Lucano, René; Cohen, Melina; Gass, Hugo; et al.; Presence of human Papilloma Virus in a series of breast carcinoma from Argentina; Public Library of Science; Plos One; 8; 4; 4-2013; 1-4; e61613
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061613
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0061613
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636204/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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