Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action
- Autores
- Villalba, Maria Luisa; Palestro, Pablo Hernán; Ceruso, Mariangela; Talevi, Alan; Gonzalez Funes, Jose L.; Bruno Blanch, Luis Enrique; Supuran, Claudiu T.; Gavernet, Luciana
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A set of N,N0 -disubstituted sulfamides and sodium cyclamate have been tested for their inhibitory action against six isoforms of carbonic anhydrase (CA, EC 4.2.1.1) found in the brain, that is, CA I, CA II, CA VII, CA IX, CA XII and CA XIV, some of which are involved in epileptogenesis. The biological data showed interesting results for CA VII inhibition, the isozyme thought to be a novel antiepileptic target. Strong CA VII inhibitors, with Ki values in the low nanomolar–subnanomolar range were identified. Some of these derivatives showed selectivity for inhibition of CA VII versus the ubiquitous isoform CA II, for which the Ki values were in the micromolar range. Molecular modeling approaches were employed to understand the binding interactions between these compounds and the two CA isoforms, since the mechanism of action of such disubstituted sulfamides was not yet investigated by means of X-ray crystallography
Fil: Villalba, Maria Luisa. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina
Fil: Palestro, Pablo Hernán. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ceruso, Mariangela. Universita Degli Studi Di Firenze; Italia
Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gonzalez Funes, Jose L.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina
Fil: Bruno Blanch, Luis Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Supuran, Claudiu T.. Universita Degli Studi Di Firenze; Italia
Fil: Gavernet, Luciana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
Carbonic Anhydrase
Sulfamides
Docking
Epilepsy
Sodium Cyclamate - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/24743
Ver los metadatos del registro completo
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Sulfamide derivatives with selective carbonic anhydrase VII inhibitory actionVillalba, Maria LuisaPalestro, Pablo HernánCeruso, MariangelaTalevi, AlanGonzalez Funes, Jose L.Bruno Blanch, Luis EnriqueSupuran, Claudiu T.Gavernet, LucianaCarbonic AnhydraseSulfamidesDockingEpilepsySodium Cyclamatehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1A set of N,N0 -disubstituted sulfamides and sodium cyclamate have been tested for their inhibitory action against six isoforms of carbonic anhydrase (CA, EC 4.2.1.1) found in the brain, that is, CA I, CA II, CA VII, CA IX, CA XII and CA XIV, some of which are involved in epileptogenesis. The biological data showed interesting results for CA VII inhibition, the isozyme thought to be a novel antiepileptic target. Strong CA VII inhibitors, with Ki values in the low nanomolar–subnanomolar range were identified. Some of these derivatives showed selectivity for inhibition of CA VII versus the ubiquitous isoform CA II, for which the Ki values were in the micromolar range. Molecular modeling approaches were employed to understand the binding interactions between these compounds and the two CA isoforms, since the mechanism of action of such disubstituted sulfamides was not yet investigated by means of X-ray crystallographyFil: Villalba, Maria Luisa. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; ArgentinaFil: Palestro, Pablo Hernán. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ceruso, Mariangela. Universita Degli Studi Di Firenze; ItaliaFil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gonzalez Funes, Jose L.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; ArgentinaFil: Bruno Blanch, Luis Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Supuran, Claudiu T.. Universita Degli Studi Di Firenze; ItaliaFil: Gavernet, Luciana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaPergamon-Elsevier Science Ltd.2016-02-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24743Villalba, Maria Luisa; Palestro, Pablo Hernán; Ceruso, Mariangela; Talevi, Alan; Gonzalez Funes, Jose L.; et al.; Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action; Pergamon-Elsevier Science Ltd.; Bioorganic & Medicinal Chemistry; 24; 4; 15-2-2016; 894-9010968-0896CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.journals.elsevier.com/bioorganic-and-medicinal-chemistry/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmc.2016.01.012info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:23:19Zoai:ri.conicet.gov.ar:11336/24743instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:23:19.827CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action |
title |
Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action |
spellingShingle |
Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action Villalba, Maria Luisa Carbonic Anhydrase Sulfamides Docking Epilepsy Sodium Cyclamate |
title_short |
Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action |
title_full |
Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action |
title_fullStr |
Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action |
title_full_unstemmed |
Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action |
title_sort |
Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action |
dc.creator.none.fl_str_mv |
Villalba, Maria Luisa Palestro, Pablo Hernán Ceruso, Mariangela Talevi, Alan Gonzalez Funes, Jose L. Bruno Blanch, Luis Enrique Supuran, Claudiu T. Gavernet, Luciana |
author |
Villalba, Maria Luisa |
author_facet |
Villalba, Maria Luisa Palestro, Pablo Hernán Ceruso, Mariangela Talevi, Alan Gonzalez Funes, Jose L. Bruno Blanch, Luis Enrique Supuran, Claudiu T. Gavernet, Luciana |
author_role |
author |
author2 |
Palestro, Pablo Hernán Ceruso, Mariangela Talevi, Alan Gonzalez Funes, Jose L. Bruno Blanch, Luis Enrique Supuran, Claudiu T. Gavernet, Luciana |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
Carbonic Anhydrase Sulfamides Docking Epilepsy Sodium Cyclamate |
topic |
Carbonic Anhydrase Sulfamides Docking Epilepsy Sodium Cyclamate |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
A set of N,N0 -disubstituted sulfamides and sodium cyclamate have been tested for their inhibitory action against six isoforms of carbonic anhydrase (CA, EC 4.2.1.1) found in the brain, that is, CA I, CA II, CA VII, CA IX, CA XII and CA XIV, some of which are involved in epileptogenesis. The biological data showed interesting results for CA VII inhibition, the isozyme thought to be a novel antiepileptic target. Strong CA VII inhibitors, with Ki values in the low nanomolar–subnanomolar range were identified. Some of these derivatives showed selectivity for inhibition of CA VII versus the ubiquitous isoform CA II, for which the Ki values were in the micromolar range. Molecular modeling approaches were employed to understand the binding interactions between these compounds and the two CA isoforms, since the mechanism of action of such disubstituted sulfamides was not yet investigated by means of X-ray crystallography Fil: Villalba, Maria Luisa. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina Fil: Palestro, Pablo Hernán. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ceruso, Mariangela. Universita Degli Studi Di Firenze; Italia Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gonzalez Funes, Jose L.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina Fil: Bruno Blanch, Luis Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Supuran, Claudiu T.. Universita Degli Studi Di Firenze; Italia Fil: Gavernet, Luciana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
A set of N,N0 -disubstituted sulfamides and sodium cyclamate have been tested for their inhibitory action against six isoforms of carbonic anhydrase (CA, EC 4.2.1.1) found in the brain, that is, CA I, CA II, CA VII, CA IX, CA XII and CA XIV, some of which are involved in epileptogenesis. The biological data showed interesting results for CA VII inhibition, the isozyme thought to be a novel antiepileptic target. Strong CA VII inhibitors, with Ki values in the low nanomolar–subnanomolar range were identified. Some of these derivatives showed selectivity for inhibition of CA VII versus the ubiquitous isoform CA II, for which the Ki values were in the micromolar range. Molecular modeling approaches were employed to understand the binding interactions between these compounds and the two CA isoforms, since the mechanism of action of such disubstituted sulfamides was not yet investigated by means of X-ray crystallography |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-02-15 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/24743 Villalba, Maria Luisa; Palestro, Pablo Hernán; Ceruso, Mariangela; Talevi, Alan; Gonzalez Funes, Jose L.; et al.; Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action; Pergamon-Elsevier Science Ltd.; Bioorganic & Medicinal Chemistry; 24; 4; 15-2-2016; 894-901 0968-0896 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/24743 |
identifier_str_mv |
Villalba, Maria Luisa; Palestro, Pablo Hernán; Ceruso, Mariangela; Talevi, Alan; Gonzalez Funes, Jose L.; et al.; Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action; Pergamon-Elsevier Science Ltd.; Bioorganic & Medicinal Chemistry; 24; 4; 15-2-2016; 894-901 0968-0896 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.journals.elsevier.com/bioorganic-and-medicinal-chemistry/ info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmc.2016.01.012 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd. |
publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd. |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1846082641511579648 |
score |
13.22299 |