Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice
- Autores
- Funes, Samanta Celeste; Silva, Juan Eduardo; Di Genaro, Maria Silvia
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Fluoxetine (FLX) is a selective serotonin reuptake inhibitor (SSRIs) with antidepressant and immunomodulatory effects. Whether FLX treatment impacts gastrointestinal bacterial infections and their sequelae, such as Reactive arthritis (ReA), remains unknown. We investigated the FLX effect on Yersinia enterocolitica (Ye) O:3 infection and ReA in a TNFR1 knockout mouse model. Differences in male and female mice were also evaluated. Male and female TNFR1 KO mice were orally infected with Ye O:3 (1-5x108 colony-forming units). From infection day, FLX (20 mg/kg/day) or water (control) was administrated in drinking water. On day 5, the number CFU was determined in stool, spleen, and mesenteric lymphoid nodes. The weight, mobility, mortality, and arthritis score of the mice were recorded. On day 21, splenic dendritic cells (DCs) infiltration and their maturation markers were evaluated by flow cytometry in surviving mice. We found that male TNFR1 KO mice have lower survival and higher clinical score after Ye infection. On day 5, FLX treatment increased bacterial dissemination in males. Surviving mice developed ReA but females treated with FLX showed greater severity than controls. Furthermore, FLX mice showed a lower proportion of splenic DCs without changing in CD86 expression. We conclude that TNFR1 KO male mice are more susceptible than females to Ye infection. The modulatory effect of FLX hinders more the immune response of males increasing systemic bacterial spread. Finally, the chronic administration of FLX did not reduce the severity of ReA and, in contrast, increased it in females. Although DCs infiltration in the spleen was reduced, the expression CD86 marker did not change, so we infer that the increased arthritis severity could be related to defective DCs migration. The results contribute to understanding how antidepressant chronic treatment influences the immune responses against pathogens and the maintenance of immune homeostasis.
Fil: Funes, Samanta Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Silva, Juan Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Di Genaro, Maria Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
LXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual De La Asociación Argentina De Nanomedicinas
Argentina
Sociedad Argentina de Inmunología
Asociación Argentina de Nanomedicinas
Asociación Argentina de Farmacología Experimental
Asociación Argentina De Nanomedicinas - Materia
-
Yersinia enterocolitica
SSRI
antidepressant
reactive arthritis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/182390
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Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient miceFunes, Samanta CelesteSilva, Juan EduardoDi Genaro, Maria SilviaYersinia enterocoliticaSSRIantidepressantreactive arthritishttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Fluoxetine (FLX) is a selective serotonin reuptake inhibitor (SSRIs) with antidepressant and immunomodulatory effects. Whether FLX treatment impacts gastrointestinal bacterial infections and their sequelae, such as Reactive arthritis (ReA), remains unknown. We investigated the FLX effect on Yersinia enterocolitica (Ye) O:3 infection and ReA in a TNFR1 knockout mouse model. Differences in male and female mice were also evaluated. Male and female TNFR1 KO mice were orally infected with Ye O:3 (1-5x108 colony-forming units). From infection day, FLX (20 mg/kg/day) or water (control) was administrated in drinking water. On day 5, the number CFU was determined in stool, spleen, and mesenteric lymphoid nodes. The weight, mobility, mortality, and arthritis score of the mice were recorded. On day 21, splenic dendritic cells (DCs) infiltration and their maturation markers were evaluated by flow cytometry in surviving mice. We found that male TNFR1 KO mice have lower survival and higher clinical score after Ye infection. On day 5, FLX treatment increased bacterial dissemination in males. Surviving mice developed ReA but females treated with FLX showed greater severity than controls. Furthermore, FLX mice showed a lower proportion of splenic DCs without changing in CD86 expression. We conclude that TNFR1 KO male mice are more susceptible than females to Ye infection. The modulatory effect of FLX hinders more the immune response of males increasing systemic bacterial spread. Finally, the chronic administration of FLX did not reduce the severity of ReA and, in contrast, increased it in females. Although DCs infiltration in the spleen was reduced, the expression CD86 marker did not change, so we infer that the increased arthritis severity could be related to defective DCs migration. The results contribute to understanding how antidepressant chronic treatment influences the immune responses against pathogens and the maintenance of immune homeostasis.Fil: Funes, Samanta Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Silva, Juan Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Di Genaro, Maria Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaLXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual De La Asociación Argentina De NanomedicinasArgentinaSociedad Argentina de InmunologíaAsociación Argentina de NanomedicinasAsociación Argentina de Farmacología ExperimentalAsociación Argentina De NanomedicinasFundación Revista MedicinaCurino, AlejandroMaccioni, MarianaSchaiquevich, PaulaDuran, Hebe2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/182390Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice; LXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual De La Asociación Argentina De Nanomedicinas; Argentina; 2021; 133-1331669-9106CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.reunionbiociencias.com.ar/wp-content/uploads/2021/11/Revista-Medicina-2021.pdfNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:53:08Zoai:ri.conicet.gov.ar:11336/182390instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:53:08.581CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice |
title |
Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice |
spellingShingle |
Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice Funes, Samanta Celeste Yersinia enterocolitica SSRI antidepressant reactive arthritis |
title_short |
Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice |
title_full |
Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice |
title_fullStr |
Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice |
title_full_unstemmed |
Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice |
title_sort |
Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice |
dc.creator.none.fl_str_mv |
Funes, Samanta Celeste Silva, Juan Eduardo Di Genaro, Maria Silvia |
author |
Funes, Samanta Celeste |
author_facet |
Funes, Samanta Celeste Silva, Juan Eduardo Di Genaro, Maria Silvia |
author_role |
author |
author2 |
Silva, Juan Eduardo Di Genaro, Maria Silvia |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Curino, Alejandro Maccioni, Mariana Schaiquevich, Paula Duran, Hebe |
dc.subject.none.fl_str_mv |
Yersinia enterocolitica SSRI antidepressant reactive arthritis |
topic |
Yersinia enterocolitica SSRI antidepressant reactive arthritis |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Fluoxetine (FLX) is a selective serotonin reuptake inhibitor (SSRIs) with antidepressant and immunomodulatory effects. Whether FLX treatment impacts gastrointestinal bacterial infections and their sequelae, such as Reactive arthritis (ReA), remains unknown. We investigated the FLX effect on Yersinia enterocolitica (Ye) O:3 infection and ReA in a TNFR1 knockout mouse model. Differences in male and female mice were also evaluated. Male and female TNFR1 KO mice were orally infected with Ye O:3 (1-5x108 colony-forming units). From infection day, FLX (20 mg/kg/day) or water (control) was administrated in drinking water. On day 5, the number CFU was determined in stool, spleen, and mesenteric lymphoid nodes. The weight, mobility, mortality, and arthritis score of the mice were recorded. On day 21, splenic dendritic cells (DCs) infiltration and their maturation markers were evaluated by flow cytometry in surviving mice. We found that male TNFR1 KO mice have lower survival and higher clinical score after Ye infection. On day 5, FLX treatment increased bacterial dissemination in males. Surviving mice developed ReA but females treated with FLX showed greater severity than controls. Furthermore, FLX mice showed a lower proportion of splenic DCs without changing in CD86 expression. We conclude that TNFR1 KO male mice are more susceptible than females to Ye infection. The modulatory effect of FLX hinders more the immune response of males increasing systemic bacterial spread. Finally, the chronic administration of FLX did not reduce the severity of ReA and, in contrast, increased it in females. Although DCs infiltration in the spleen was reduced, the expression CD86 marker did not change, so we infer that the increased arthritis severity could be related to defective DCs migration. The results contribute to understanding how antidepressant chronic treatment influences the immune responses against pathogens and the maintenance of immune homeostasis. Fil: Funes, Samanta Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Silva, Juan Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Di Genaro, Maria Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina LXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual De La Asociación Argentina De Nanomedicinas Argentina Sociedad Argentina de Inmunología Asociación Argentina de Nanomedicinas Asociación Argentina de Farmacología Experimental Asociación Argentina De Nanomedicinas |
description |
Fluoxetine (FLX) is a selective serotonin reuptake inhibitor (SSRIs) with antidepressant and immunomodulatory effects. Whether FLX treatment impacts gastrointestinal bacterial infections and their sequelae, such as Reactive arthritis (ReA), remains unknown. We investigated the FLX effect on Yersinia enterocolitica (Ye) O:3 infection and ReA in a TNFR1 knockout mouse model. Differences in male and female mice were also evaluated. Male and female TNFR1 KO mice were orally infected with Ye O:3 (1-5x108 colony-forming units). From infection day, FLX (20 mg/kg/day) or water (control) was administrated in drinking water. On day 5, the number CFU was determined in stool, spleen, and mesenteric lymphoid nodes. The weight, mobility, mortality, and arthritis score of the mice were recorded. On day 21, splenic dendritic cells (DCs) infiltration and their maturation markers were evaluated by flow cytometry in surviving mice. We found that male TNFR1 KO mice have lower survival and higher clinical score after Ye infection. On day 5, FLX treatment increased bacterial dissemination in males. Surviving mice developed ReA but females treated with FLX showed greater severity than controls. Furthermore, FLX mice showed a lower proportion of splenic DCs without changing in CD86 expression. We conclude that TNFR1 KO male mice are more susceptible than females to Ye infection. The modulatory effect of FLX hinders more the immune response of males increasing systemic bacterial spread. Finally, the chronic administration of FLX did not reduce the severity of ReA and, in contrast, increased it in females. Although DCs infiltration in the spleen was reduced, the expression CD86 marker did not change, so we infer that the increased arthritis severity could be related to defective DCs migration. The results contribute to understanding how antidepressant chronic treatment influences the immune responses against pathogens and the maintenance of immune homeostasis. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Reunión Journal http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
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dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/182390 Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice; LXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual De La Asociación Argentina De Nanomedicinas; Argentina; 2021; 133-133 1669-9106 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/182390 |
identifier_str_mv |
Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice; LXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual De La Asociación Argentina De Nanomedicinas; Argentina; 2021; 133-133 1669-9106 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/altIdentifier/url/https://www.reunionbiociencias.com.ar/wp-content/uploads/2021/11/Revista-Medicina-2021.pdf |
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Fundación Revista Medicina |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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