Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice

Autores
Funes, Samanta Celeste; Silva, Juan Eduardo; Di Genaro, Maria Silvia
Año de publicación
2021
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Fluoxetine (FLX) is a selective serotonin reuptake inhibitor (SSRIs) with antidepressant and immunomodulatory effects. Whether FLX treatment impacts gastrointestinal bacterial infections and their sequelae, such as Reactive arthritis (ReA), remains unknown. We investigated the FLX effect on Yersinia enterocolitica (Ye) O:3 infection and ReA in a TNFR1 knockout mouse model. Differences in male and female mice were also evaluated. Male and female TNFR1 KO mice were orally infected with Ye O:3 (1-5x108 colony-forming units). From infection day, FLX (20 mg/kg/day) or water (control) was administrated in drinking water. On day 5, the number CFU was determined in stool, spleen, and mesenteric lymphoid nodes. The weight, mobility, mortality, and arthritis score of the mice were recorded. On day 21, splenic dendritic cells (DCs) infiltration and their maturation markers were evaluated by flow cytometry in surviving mice. We found that male TNFR1 KO mice have lower survival and higher clinical score after Ye infection. On day 5, FLX treatment increased bacterial dissemination in males. Surviving mice developed ReA but females treated with FLX showed greater severity than controls. Furthermore, FLX mice showed a lower proportion of splenic DCs without changing in CD86 expression. We conclude that TNFR1 KO male mice are more susceptible than females to Ye infection. The modulatory effect of FLX hinders more the immune response of males increasing systemic bacterial spread. Finally, the chronic administration of FLX did not reduce the severity of ReA and, in contrast, increased it in females. Although DCs infiltration in the spleen was reduced, the expression CD86 marker did not change, so we infer that the increased arthritis severity could be related to defective DCs migration. The results contribute to understanding how antidepressant chronic treatment influences the immune responses against pathogens and the maintenance of immune homeostasis.
Fil: Funes, Samanta Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Silva, Juan Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Di Genaro, Maria Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
LXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual De La Asociación Argentina De Nanomedicinas
Argentina
Sociedad Argentina de Inmunología
Asociación Argentina de Nanomedicinas
Asociación Argentina de Farmacología Experimental
Asociación Argentina De Nanomedicinas
Materia
Yersinia enterocolitica
SSRI
antidepressant
reactive arthritis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/182390

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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient miceFunes, Samanta CelesteSilva, Juan EduardoDi Genaro, Maria SilviaYersinia enterocoliticaSSRIantidepressantreactive arthritishttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Fluoxetine (FLX) is a selective serotonin reuptake inhibitor (SSRIs) with antidepressant and immunomodulatory effects. Whether FLX treatment impacts gastrointestinal bacterial infections and their sequelae, such as Reactive arthritis (ReA), remains unknown. We investigated the FLX effect on Yersinia enterocolitica (Ye) O:3 infection and ReA in a TNFR1 knockout mouse model. Differences in male and female mice were also evaluated. Male and female TNFR1 KO mice were orally infected with Ye O:3 (1-5x108 colony-forming units). From infection day, FLX (20 mg/kg/day) or water (control) was administrated in drinking water. On day 5, the number CFU was determined in stool, spleen, and mesenteric lymphoid nodes. The weight, mobility, mortality, and arthritis score of the mice were recorded. On day 21, splenic dendritic cells (DCs) infiltration and their maturation markers were evaluated by flow cytometry in surviving mice. We found that male TNFR1 KO mice have lower survival and higher clinical score after Ye infection. On day 5, FLX treatment increased bacterial dissemination in males. Surviving mice developed ReA but females treated with FLX showed greater severity than controls. Furthermore, FLX mice showed a lower proportion of splenic DCs without changing in CD86 expression. We conclude that TNFR1 KO male mice are more susceptible than females to Ye infection. The modulatory effect of FLX hinders more the immune response of males increasing systemic bacterial spread. Finally, the chronic administration of FLX did not reduce the severity of ReA and, in contrast, increased it in females. Although DCs infiltration in the spleen was reduced, the expression CD86 marker did not change, so we infer that the increased arthritis severity could be related to defective DCs migration. The results contribute to understanding how antidepressant chronic treatment influences the immune responses against pathogens and the maintenance of immune homeostasis.Fil: Funes, Samanta Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Silva, Juan Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Di Genaro, Maria Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaLXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual De La Asociación Argentina De NanomedicinasArgentinaSociedad Argentina de InmunologíaAsociación Argentina de NanomedicinasAsociación Argentina de Farmacología ExperimentalAsociación Argentina De NanomedicinasFundación Revista MedicinaCurino, AlejandroMaccioni, MarianaSchaiquevich, PaulaDuran, Hebe2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/182390Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice; LXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual De La Asociación Argentina De Nanomedicinas; Argentina; 2021; 133-1331669-9106CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.reunionbiociencias.com.ar/wp-content/uploads/2021/11/Revista-Medicina-2021.pdfNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:53:08Zoai:ri.conicet.gov.ar:11336/182390instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:53:08.581CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice
title Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice
spellingShingle Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice
Funes, Samanta Celeste
Yersinia enterocolitica
SSRI
antidepressant
reactive arthritis
title_short Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice
title_full Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice
title_fullStr Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice
title_full_unstemmed Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice
title_sort Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice
dc.creator.none.fl_str_mv Funes, Samanta Celeste
Silva, Juan Eduardo
Di Genaro, Maria Silvia
author Funes, Samanta Celeste
author_facet Funes, Samanta Celeste
Silva, Juan Eduardo
Di Genaro, Maria Silvia
author_role author
author2 Silva, Juan Eduardo
Di Genaro, Maria Silvia
author2_role author
author
dc.contributor.none.fl_str_mv Curino, Alejandro
Maccioni, Mariana
Schaiquevich, Paula
Duran, Hebe
dc.subject.none.fl_str_mv Yersinia enterocolitica
SSRI
antidepressant
reactive arthritis
topic Yersinia enterocolitica
SSRI
antidepressant
reactive arthritis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Fluoxetine (FLX) is a selective serotonin reuptake inhibitor (SSRIs) with antidepressant and immunomodulatory effects. Whether FLX treatment impacts gastrointestinal bacterial infections and their sequelae, such as Reactive arthritis (ReA), remains unknown. We investigated the FLX effect on Yersinia enterocolitica (Ye) O:3 infection and ReA in a TNFR1 knockout mouse model. Differences in male and female mice were also evaluated. Male and female TNFR1 KO mice were orally infected with Ye O:3 (1-5x108 colony-forming units). From infection day, FLX (20 mg/kg/day) or water (control) was administrated in drinking water. On day 5, the number CFU was determined in stool, spleen, and mesenteric lymphoid nodes. The weight, mobility, mortality, and arthritis score of the mice were recorded. On day 21, splenic dendritic cells (DCs) infiltration and their maturation markers were evaluated by flow cytometry in surviving mice. We found that male TNFR1 KO mice have lower survival and higher clinical score after Ye infection. On day 5, FLX treatment increased bacterial dissemination in males. Surviving mice developed ReA but females treated with FLX showed greater severity than controls. Furthermore, FLX mice showed a lower proportion of splenic DCs without changing in CD86 expression. We conclude that TNFR1 KO male mice are more susceptible than females to Ye infection. The modulatory effect of FLX hinders more the immune response of males increasing systemic bacterial spread. Finally, the chronic administration of FLX did not reduce the severity of ReA and, in contrast, increased it in females. Although DCs infiltration in the spleen was reduced, the expression CD86 marker did not change, so we infer that the increased arthritis severity could be related to defective DCs migration. The results contribute to understanding how antidepressant chronic treatment influences the immune responses against pathogens and the maintenance of immune homeostasis.
Fil: Funes, Samanta Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Silva, Juan Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Di Genaro, Maria Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
LXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual De La Asociación Argentina De Nanomedicinas
Argentina
Sociedad Argentina de Inmunología
Asociación Argentina de Nanomedicinas
Asociación Argentina de Farmacología Experimental
Asociación Argentina De Nanomedicinas
description Fluoxetine (FLX) is a selective serotonin reuptake inhibitor (SSRIs) with antidepressant and immunomodulatory effects. Whether FLX treatment impacts gastrointestinal bacterial infections and their sequelae, such as Reactive arthritis (ReA), remains unknown. We investigated the FLX effect on Yersinia enterocolitica (Ye) O:3 infection and ReA in a TNFR1 knockout mouse model. Differences in male and female mice were also evaluated. Male and female TNFR1 KO mice were orally infected with Ye O:3 (1-5x108 colony-forming units). From infection day, FLX (20 mg/kg/day) or water (control) was administrated in drinking water. On day 5, the number CFU was determined in stool, spleen, and mesenteric lymphoid nodes. The weight, mobility, mortality, and arthritis score of the mice were recorded. On day 21, splenic dendritic cells (DCs) infiltration and their maturation markers were evaluated by flow cytometry in surviving mice. We found that male TNFR1 KO mice have lower survival and higher clinical score after Ye infection. On day 5, FLX treatment increased bacterial dissemination in males. Surviving mice developed ReA but females treated with FLX showed greater severity than controls. Furthermore, FLX mice showed a lower proportion of splenic DCs without changing in CD86 expression. We conclude that TNFR1 KO male mice are more susceptible than females to Ye infection. The modulatory effect of FLX hinders more the immune response of males increasing systemic bacterial spread. Finally, the chronic administration of FLX did not reduce the severity of ReA and, in contrast, increased it in females. Although DCs infiltration in the spleen was reduced, the expression CD86 marker did not change, so we infer that the increased arthritis severity could be related to defective DCs migration. The results contribute to understanding how antidepressant chronic treatment influences the immune responses against pathogens and the maintenance of immune homeostasis.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/182390
Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice; LXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual De La Asociación Argentina De Nanomedicinas; Argentina; 2021; 133-133
1669-9106
CONICET Digital
CONICET
url http://hdl.handle.net/11336/182390
identifier_str_mv Chronic administration of the antidepressant fluoxetine impact on yersinia. Enterocolitica oral infection and reactive arthritis development in tnfr1 deficient mice; LXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual De La Asociación Argentina De Nanomedicinas; Argentina; 2021; 133-133
1669-9106
CONICET Digital
CONICET
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language eng
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publisher.none.fl_str_mv Fundación Revista Medicina
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