Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphism

Autores
Paladino, Natalia; Fainboim, Hugo; Theiler, Graciela; Schroder, Teresa; Muñoz, Alberto Eduardo; Flores, Ana Claudia; Galdame, Omar; Fainboim, Leonardo
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Elevated levels of interleukin 10 (IL-10) were previously described for chronically hepatitis C virus (HCV)-infected patients. We determined by a sequence-specific oligonucleotide probing technique the IL-10 promoter genotypes in 286 Argentinean HCV patients grouped according to disease outcome. The GG genotype (position -1082) is known to be associated with high IL-10 production, GA is considered an intermediate producer, and AA is associated with low IL-10 production. We found an increase in frequency of the GG genotype in female patients who do not eliminate the virus (RNA+). In these patients, the GG frequency was 0.19, versus 0.10 in controls (P = 0.03). This association became more significant in those RNA+ female patients with elevated hepatic transaminases (GG frequency of 0.25; P = 0.0013). Additionally, this genotype frequency was higher in noncirrhotic female patients than in controls (GG frequency for noncirrhotic female patients was 0.31; P = 0.009). In RNA - patients, the GA frequency was elevated compared with that in controls (GA frequency of 0.76 in RNA- patients versus 0.48 in controls; P = 0.01), that in all HCV patients (GA frequency of 0.43; P = 0.001), and that in RNA+ patients (GA frequency of 0.40; P = 0.0005). We conclude that a gender effect is observed with women carrying the GG high IL-10 producer genotype. The higher levels of IL-10 present in those individuals are associated with a higher risk of an inefficient clearance of the HCV and the development of a chronic HCV infection together with a lower risk of progression to cirrhosis in female patients. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Fil: Paladino, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fainboim, Hugo. Hospital de Enfermedades Infecciosas F. J. Muñiz. Unidad de Hepatología; Argentina
Fil: Theiler, Graciela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Schroder, Teresa. Hospital de Enfermedades Infecciosas F. J. Muñiz. Unidad de Hepatología; Argentina
Fil: Muñoz, Alberto Eduardo. Hospital de Gastroenterología Dr. C. Bonorino Udaondo. Unidad de Hepatología; Argentina
Fil: Flores, Ana Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Galdame, Omar. Hospital Italiano; Argentina
Fil: Fainboim, Leonardo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Hepatitis C
Polymorphism
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/150225
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/150225
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphismPaladino, NataliaFainboim, HugoTheiler, GracielaSchroder, TeresaMuñoz, Alberto EduardoFlores, Ana ClaudiaGaldame, OmarFainboim, LeonardoHepatitis CPolymorphismhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Elevated levels of interleukin 10 (IL-10) were previously described for chronically hepatitis C virus (HCV)-infected patients. We determined by a sequence-specific oligonucleotide probing technique the IL-10 promoter genotypes in 286 Argentinean HCV patients grouped according to disease outcome. The GG genotype (position -1082) is known to be associated with high IL-10 production, GA is considered an intermediate producer, and AA is associated with low IL-10 production. We found an increase in frequency of the GG genotype in female patients who do not eliminate the virus (RNA+). In these patients, the GG frequency was 0.19, versus 0.10 in controls (P = 0.03). This association became more significant in those RNA+ female patients with elevated hepatic transaminases (GG frequency of 0.25; P = 0.0013). Additionally, this genotype frequency was higher in noncirrhotic female patients than in controls (GG frequency for noncirrhotic female patients was 0.31; P = 0.009). In RNA - patients, the GA frequency was elevated compared with that in controls (GA frequency of 0.76 in RNA- patients versus 0.48 in controls; P = 0.01), that in all HCV patients (GA frequency of 0.43; P = 0.001), and that in RNA+ patients (GA frequency of 0.40; P = 0.0005). We conclude that a gender effect is observed with women carrying the GG high IL-10 producer genotype. The higher levels of IL-10 present in those individuals are associated with a higher risk of an inefficient clearance of the HCV and the development of a chronic HCV infection together with a lower risk of progression to cirrhosis in female patients. Copyright © 2006, American Society for Microbiology. All Rights Reserved.Fil: Paladino, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fainboim, Hugo. Hospital de Enfermedades Infecciosas F. J. Muñiz. Unidad de Hepatología; ArgentinaFil: Theiler, Graciela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Schroder, Teresa. Hospital de Enfermedades Infecciosas F. J. Muñiz. Unidad de Hepatología; ArgentinaFil: Muñoz, Alberto Eduardo. Hospital de Gastroenterología Dr. C. Bonorino Udaondo. Unidad de Hepatología; ArgentinaFil: Flores, Ana Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Galdame, Omar. Hospital Italiano; ArgentinaFil: Fainboim, Leonardo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAmerican Society for Microbiology2006-09-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/150225Paladino, Natalia; Fainboim, Hugo; Theiler, Graciela; Schroder, Teresa; Muñoz, Alberto Eduardo; et al.; Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphism; American Society for Microbiology; Journal of Virology; 80; 18; 15-9-2006; 9144-91500022-538X1098-5514CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1128/JVI.00339-06info:eu-repo/semantics/altIdentifier/url/https://journals.asm.org/doi/10.1128/JVI.00339-06info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:40:53Zoai:ri.conicet.gov.ar:11336/150225instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:40:53.9CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphism
title Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphism
spellingShingle Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphism
Paladino, Natalia
Hepatitis C
Polymorphism
title_short Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphism
title_full Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphism
title_fullStr Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphism
title_full_unstemmed Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphism
title_sort Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphism
dc.creator.none.fl_str_mv Paladino, Natalia
Fainboim, Hugo
Theiler, Graciela
Schroder, Teresa
Muñoz, Alberto Eduardo
Flores, Ana Claudia
Galdame, Omar
Fainboim, Leonardo
author Paladino, Natalia
author_facet Paladino, Natalia
Fainboim, Hugo
Theiler, Graciela
Schroder, Teresa
Muñoz, Alberto Eduardo
Flores, Ana Claudia
Galdame, Omar
Fainboim, Leonardo
author_role author
author2 Fainboim, Hugo
Theiler, Graciela
Schroder, Teresa
Muñoz, Alberto Eduardo
Flores, Ana Claudia
Galdame, Omar
Fainboim, Leonardo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hepatitis C
Polymorphism
topic Hepatitis C
Polymorphism
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Elevated levels of interleukin 10 (IL-10) were previously described for chronically hepatitis C virus (HCV)-infected patients. We determined by a sequence-specific oligonucleotide probing technique the IL-10 promoter genotypes in 286 Argentinean HCV patients grouped according to disease outcome. The GG genotype (position -1082) is known to be associated with high IL-10 production, GA is considered an intermediate producer, and AA is associated with low IL-10 production. We found an increase in frequency of the GG genotype in female patients who do not eliminate the virus (RNA+). In these patients, the GG frequency was 0.19, versus 0.10 in controls (P = 0.03). This association became more significant in those RNA+ female patients with elevated hepatic transaminases (GG frequency of 0.25; P = 0.0013). Additionally, this genotype frequency was higher in noncirrhotic female patients than in controls (GG frequency for noncirrhotic female patients was 0.31; P = 0.009). In RNA - patients, the GA frequency was elevated compared with that in controls (GA frequency of 0.76 in RNA- patients versus 0.48 in controls; P = 0.01), that in all HCV patients (GA frequency of 0.43; P = 0.001), and that in RNA+ patients (GA frequency of 0.40; P = 0.0005). We conclude that a gender effect is observed with women carrying the GG high IL-10 producer genotype. The higher levels of IL-10 present in those individuals are associated with a higher risk of an inefficient clearance of the HCV and the development of a chronic HCV infection together with a lower risk of progression to cirrhosis in female patients. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Fil: Paladino, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fainboim, Hugo. Hospital de Enfermedades Infecciosas F. J. Muñiz. Unidad de Hepatología; Argentina
Fil: Theiler, Graciela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Schroder, Teresa. Hospital de Enfermedades Infecciosas F. J. Muñiz. Unidad de Hepatología; Argentina
Fil: Muñoz, Alberto Eduardo. Hospital de Gastroenterología Dr. C. Bonorino Udaondo. Unidad de Hepatología; Argentina
Fil: Flores, Ana Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Galdame, Omar. Hospital Italiano; Argentina
Fil: Fainboim, Leonardo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Elevated levels of interleukin 10 (IL-10) were previously described for chronically hepatitis C virus (HCV)-infected patients. We determined by a sequence-specific oligonucleotide probing technique the IL-10 promoter genotypes in 286 Argentinean HCV patients grouped according to disease outcome. The GG genotype (position -1082) is known to be associated with high IL-10 production, GA is considered an intermediate producer, and AA is associated with low IL-10 production. We found an increase in frequency of the GG genotype in female patients who do not eliminate the virus (RNA+). In these patients, the GG frequency was 0.19, versus 0.10 in controls (P = 0.03). This association became more significant in those RNA+ female patients with elevated hepatic transaminases (GG frequency of 0.25; P = 0.0013). Additionally, this genotype frequency was higher in noncirrhotic female patients than in controls (GG frequency for noncirrhotic female patients was 0.31; P = 0.009). In RNA - patients, the GA frequency was elevated compared with that in controls (GA frequency of 0.76 in RNA- patients versus 0.48 in controls; P = 0.01), that in all HCV patients (GA frequency of 0.43; P = 0.001), and that in RNA+ patients (GA frequency of 0.40; P = 0.0005). We conclude that a gender effect is observed with women carrying the GG high IL-10 producer genotype. The higher levels of IL-10 present in those individuals are associated with a higher risk of an inefficient clearance of the HCV and the development of a chronic HCV infection together with a lower risk of progression to cirrhosis in female patients. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
publishDate 2006
dc.date.none.fl_str_mv 2006-09-15
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/150225
Paladino, Natalia; Fainboim, Hugo; Theiler, Graciela; Schroder, Teresa; Muñoz, Alberto Eduardo; et al.; Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphism; American Society for Microbiology; Journal of Virology; 80; 18; 15-9-2006; 9144-9150
0022-538X
1098-5514
CONICET Digital
CONICET
url http://hdl.handle.net/11336/150225
identifier_str_mv Paladino, Natalia; Fainboim, Hugo; Theiler, Graciela; Schroder, Teresa; Muñoz, Alberto Eduardo; et al.; Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphism; American Society for Microbiology; Journal of Virology; 80; 18; 15-9-2006; 9144-9150
0022-538X
1098-5514
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1128/JVI.00339-06
info:eu-repo/semantics/altIdentifier/url/https://journals.asm.org/doi/10.1128/JVI.00339-06
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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