QSAR applications during last decade on inhibitors of acetylcholinesterase in Alzheimer's disease

Autores
Wong, K. Y.; Duchowicz, Pablo Román; Mercader, Andrew Gustavo; Castro, Eduardo Alberto
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This article reviews multi-criteria QSAR applications on Acetylcholinesterase inhibitors as palliative drugs for Alzheimer's Disease, published in the period 2001-2011. It includes QSAR models for different series of compounds, comparative studies, and advances in methodologies. This period is marked by a shift in focus from palliative treatment to pathogenesis. However, we believe that research into palliative treatment should continue. More comparative studies are desirable. In order to facilitate comparative and general studies on Acetylcholinesterase inhibitors, a standard experimental protocol for measuring an inhibitor's potency is needed. Finally, we recommend chemists to work closely with system and molecular biologists.
Fil: Wong, Kay Y. Imperial College, Department Of Chemical Engineering; Reino Unido
Fil: Duchowicz, Pablo Román. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Mercader, Andrew Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Castro, Eduardo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Materia
ACETYLCHOLINESTERASE
ALZHEIMER'S DISEASE
COMFA
COMSIA
MEDICINAL CHEMISTRY
MOLECULAR DESCRIPTORS
QSAR THEORY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96369
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/96369
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling QSAR applications during last decade on inhibitors of acetylcholinesterase in Alzheimer's diseaseWong, K. Y.Duchowicz, Pablo RománMercader, Andrew GustavoCastro, Eduardo AlbertoACETYLCHOLINESTERASEALZHEIMER'S DISEASECOMFACOMSIAMEDICINAL CHEMISTRYMOLECULAR DESCRIPTORSQSAR THEORYhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1This article reviews multi-criteria QSAR applications on Acetylcholinesterase inhibitors as palliative drugs for Alzheimer's Disease, published in the period 2001-2011. It includes QSAR models for different series of compounds, comparative studies, and advances in methodologies. This period is marked by a shift in focus from palliative treatment to pathogenesis. However, we believe that research into palliative treatment should continue. More comparative studies are desirable. In order to facilitate comparative and general studies on Acetylcholinesterase inhibitors, a standard experimental protocol for measuring an inhibitor's potency is needed. Finally, we recommend chemists to work closely with system and molecular biologists.Fil: Wong, Kay Y. Imperial College, Department Of Chemical Engineering; Reino UnidoFil: Duchowicz, Pablo Román. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Mercader, Andrew Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Castro, Eduardo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaBentham Science Publishers2012-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/96369Wong, K. Y.; Duchowicz, Pablo Román; Mercader, Andrew Gustavo; Castro, Eduardo Alberto; QSAR applications during last decade on inhibitors of acetylcholinesterase in Alzheimer's disease; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 12; 10; 5-2012; 936-9461389-5575CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/102502/articleinfo:eu-repo/semantics/altIdentifier/doi/10.2174/138955712802762365info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:40Zoai:ri.conicet.gov.ar:11336/96369instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:40.318CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv QSAR applications during last decade on inhibitors of acetylcholinesterase in Alzheimer's disease
title QSAR applications during last decade on inhibitors of acetylcholinesterase in Alzheimer's disease
spellingShingle QSAR applications during last decade on inhibitors of acetylcholinesterase in Alzheimer's disease
Wong, K. Y.
ACETYLCHOLINESTERASE
ALZHEIMER'S DISEASE
COMFA
COMSIA
MEDICINAL CHEMISTRY
MOLECULAR DESCRIPTORS
QSAR THEORY
title_short QSAR applications during last decade on inhibitors of acetylcholinesterase in Alzheimer's disease
title_full QSAR applications during last decade on inhibitors of acetylcholinesterase in Alzheimer's disease
title_fullStr QSAR applications during last decade on inhibitors of acetylcholinesterase in Alzheimer's disease
title_full_unstemmed QSAR applications during last decade on inhibitors of acetylcholinesterase in Alzheimer's disease
title_sort QSAR applications during last decade on inhibitors of acetylcholinesterase in Alzheimer's disease
dc.creator.none.fl_str_mv Wong, K. Y.
Duchowicz, Pablo Román
Mercader, Andrew Gustavo
Castro, Eduardo Alberto
author Wong, K. Y.
author_facet Wong, K. Y.
Duchowicz, Pablo Román
Mercader, Andrew Gustavo
Castro, Eduardo Alberto
author_role author
author2 Duchowicz, Pablo Román
Mercader, Andrew Gustavo
Castro, Eduardo Alberto
author2_role author
author
author
dc.subject.none.fl_str_mv ACETYLCHOLINESTERASE
ALZHEIMER'S DISEASE
COMFA
COMSIA
MEDICINAL CHEMISTRY
MOLECULAR DESCRIPTORS
QSAR THEORY
topic ACETYLCHOLINESTERASE
ALZHEIMER'S DISEASE
COMFA
COMSIA
MEDICINAL CHEMISTRY
MOLECULAR DESCRIPTORS
QSAR THEORY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This article reviews multi-criteria QSAR applications on Acetylcholinesterase inhibitors as palliative drugs for Alzheimer's Disease, published in the period 2001-2011. It includes QSAR models for different series of compounds, comparative studies, and advances in methodologies. This period is marked by a shift in focus from palliative treatment to pathogenesis. However, we believe that research into palliative treatment should continue. More comparative studies are desirable. In order to facilitate comparative and general studies on Acetylcholinesterase inhibitors, a standard experimental protocol for measuring an inhibitor's potency is needed. Finally, we recommend chemists to work closely with system and molecular biologists.
Fil: Wong, Kay Y. Imperial College, Department Of Chemical Engineering; Reino Unido
Fil: Duchowicz, Pablo Román. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Mercader, Andrew Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Castro, Eduardo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
description This article reviews multi-criteria QSAR applications on Acetylcholinesterase inhibitors as palliative drugs for Alzheimer's Disease, published in the period 2001-2011. It includes QSAR models for different series of compounds, comparative studies, and advances in methodologies. This period is marked by a shift in focus from palliative treatment to pathogenesis. However, we believe that research into palliative treatment should continue. More comparative studies are desirable. In order to facilitate comparative and general studies on Acetylcholinesterase inhibitors, a standard experimental protocol for measuring an inhibitor's potency is needed. Finally, we recommend chemists to work closely with system and molecular biologists.
publishDate 2012
dc.date.none.fl_str_mv 2012-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96369
Wong, K. Y.; Duchowicz, Pablo Román; Mercader, Andrew Gustavo; Castro, Eduardo Alberto; QSAR applications during last decade on inhibitors of acetylcholinesterase in Alzheimer's disease; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 12; 10; 5-2012; 936-946
1389-5575
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96369
identifier_str_mv Wong, K. Y.; Duchowicz, Pablo Román; Mercader, Andrew Gustavo; Castro, Eduardo Alberto; QSAR applications during last decade on inhibitors of acetylcholinesterase in Alzheimer's disease; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 12; 10; 5-2012; 936-946
1389-5575
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/102502/article
info:eu-repo/semantics/altIdentifier/doi/10.2174/138955712802762365
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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